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Volumn 10, Issue 2, 2010, Pages 176-182

A promising new inotrope: Levosimendan;Umut verici yeni bir inotropik ajan: Levosimendan

Author keywords

Clinical trials; Heart failure; Levosimendan; Positive inotropic agents

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CATECHOLAMINE DERIVATIVE; DIURETIC AGENT; DOBUTAMINE; INOTROPIC AGENT; LEVOSIMENDAN; PLACEBO; VASODILATOR AGENT; CALCIUM; CARDIOTONIC AGENT; HYDRAZONE DERIVATIVE; POTASSIUM CHANNEL; PYRIDAZINE DERIVATIVE; SIMENDAN;

EID: 77952512779     PISSN: 13028723     EISSN: None     Source Type: Journal    
DOI: 10.5152/akd.2010.045     Document Type: Review
Times cited : (11)

References (61)
  • 1
    • 0344304391 scopus 로고    scopus 로고
    • New and emerging drug therapies for the management of acute heart failure
    • Krum H, Liew D. New and emerging drug therapies for the management of acute heart failure. Intern Med J 2003; 33: 515-20.
    • (2003) Intern Med J , vol.33 , pp. 515-520
    • Krum, H.1    Liew, D.2
  • 2
    • 25144443947 scopus 로고    scopus 로고
    • Definition and epidemiology of acute heart failure syndromes
    • Nieminen MS, Harjola VP. Definition and epidemiology of acute heart failure syndromes. Am J Cardiol 2005; 96 (Suppl 6A): 5G-10G.
    • (2005) Am J Cardiol , vol.96 , Issue.6 SUPPL.A
    • Nieminen, M.S.1    Harjola, V.P.2
  • 3
    • 0036673089 scopus 로고    scopus 로고
    • The effectiveness and relative effectiveness of intravenous inotropic drugs acting through the adrenergic pathway in patients with heart failure-a meta regression analysis
    • Thackray S, Easthaugh J, Freemantle N, Cleland JG. The effectiveness and relative effectiveness of intravenous inotropic drugs acting through the adrenergic pathway in patients with heart failure-a meta regression analysis. Eur J Heart Fail 2002; 4: 515-29.
    • (2002) Eur J Heart Fail , vol.4 , pp. 515-529
    • Thackray, S.1    Easthaugh, J.2    Freemantle, N.3    Cleland, J.G.4
  • 4
    • 0027172674 scopus 로고
    • The search for the ideal positive inotropic agent
    • Packer M. The search for the ideal positive inotropic agent. N Engl J Med 1993; 329: 201-2.
    • (1993) N Engl J Med , vol.329 , pp. 201-202
    • Packer, M.1
  • 5
    • 0027942068 scopus 로고
    • Levosimendan (OR- 1259), a myofilament calcium sensitizer, enhances myocardial contractility but does not alter isovolumic relaxation in conscious and anesthetized dogs
    • Pagel PS, Harkin CP, Hettrick DA, Warltier DC. Levosimendan (OR- 1259), a myofilament calcium sensitizer, enhances myocardial contractility but does not alter isovolumic relaxation in conscious and anesthetized dogs. Anesthesiology 1994; 81: 974-87.
    • (1994) Anesthesiology , vol.81 , pp. 974-987
    • Pagel, P.S.1    Harkin, C.P.2    Hettrick, D.A.3    Warltier, D.C.4
  • 6
    • 0028908851 scopus 로고
    • Cardiovascular effects of the calcium sensitizer, levosimendan, in heart failure induced by rapid pacing in the presence of aortic constriction
    • Udvary E, Papp JG, Végh A. Cardiovascular effects of the calcium sensitizer, levosimendan, in heart failure induced by rapid pacing in the presence of aortic constriction. Br J Pharmacol 1995; 114: 656-61.
    • (1995) Br J Pharmacol , vol.114 , pp. 656-661
    • Udvary, E.1    Papp, J.G.2    Végh, A.3
  • 7
    • 33644997173 scopus 로고    scopus 로고
    • Mechanisms and use of calcium-sensitizing agents in the failing heart
    • Kass DA, Solaro RJ. Mechanisms and use of calcium-sensitizing agents in the failing heart. Circulation 2006; 113: 305-15.
    • (2006) Circulation , vol.113 , pp. 305-315
    • Kass, D.A.1    Solaro, R.J.2
  • 8
    • 0032541979 scopus 로고    scopus 로고
    • Influence of the novel inotropic agent levosimendan on isometric tension and calcium cycling in failing human myocardium
    • Hasenfuss G, Pieske B, Castell M, Kretschmann B, Maier LS, Just H. Influence of the novel inotropic agent levosimendan on isometric tension and calcium cycling in failing human myocardium. Circulation 1998; 98: 2141-7.
    • (1998) Circulation , vol.98 , pp. 2141-2147
    • Hasenfuss, G.1    Pieske, B.2    Castell, M.3    Kretschmann, B.4    Maier, L.S.5    Just, H.6
  • 9
    • 0030909430 scopus 로고    scopus 로고
    • Myocardial efficiency during calcium sensitization with levosimendan: A noninvasive study with positron emission tomography and echocardiography in healthy volunteers
    • Ukkonen H, Saraste M, Akkila J, Knuuti MJ, Lehikoinen P, Nagren K, et al. Myocardial efficiency during calcium sensitization with levosimendan: a noninvasive study with positron emission tomography and echocardiography in healthy volunteers. Clin Pharmacol Ther 1997; 61: 596-607.
    • (1997) Clin Pharmacol Ther , vol.61 , pp. 596-607
    • Ukkonen, H.1    Saraste, M.2    Akkila, J.3    Knuuti, M.J.4    Lehikoinen, P.5    Nagren, K.6
  • 10
    • 0030608872 scopus 로고    scopus 로고
    • Levosimendan, a novel Ca 2 sensitizer, activates the glibenclamide-sensitive K-channel in rat arterial myocytes
    • Yokoshiki H, Katsube Y, Sunagawa M, Sperelakis N. Levosimendan, a novel Ca 2 sensitizer, activates the glibenclamide-sensitive K-channel in rat arterial myocytes. Eur J Pharmacol 1997; 333: 249-59.
    • (1997) Eur J Pharmacol , vol.333 , pp. 249-259
    • Yokoshiki, H.1    Katsube, Y.2    Sunagawa, M.3    Sperelakis, N.4
  • 11
    • 0035088001 scopus 로고    scopus 로고
    • Levosimendan increases diastolic coronary flow in isolated guinea-pig heart by opening ATP-sensitive potassium channels
    • Kaheinen P, Pollesello P, Levijoki J, Haikala H. Levosimendan increases diastolic coronary flow in isolated guinea-pig heart by opening ATP-sensitive potassium channels. J Cardiovasc Pharmacol 2001; 37: 367-74.
    • (2001) J Cardiovasc Pharmacol , vol.37 , pp. 367-374
    • Kaheinen, P.1    Pollesello, P.2    Levijoki, J.3    Haikala, H.4
  • 12
    • 0029097331 scopus 로고
    • Systemic and coronary hemodynamic actions and left ventricular functional effects of levosimendan in conscious dogs
    • Harkin CP, Pagel PS, Tessmer JP, Warltier DC. Systemic and coronary hemodynamic actions and left ventricular functional effects of levosimendan in conscious dogs. J Cardiovasc Pharmacol 1995; 26: 179-88.
    • (1995) J Cardiovasc Pharmacol , vol.26 , pp. 179-188
    • Harkin, C.P.1    Pagel, P.S.2    Tessmer, J.P.3    Warltier, D.C.4
  • 13
    • 16344362711 scopus 로고    scopus 로고
    • Effects of intravenous levosimendan on human coronary vasomotor regulation, left ventricular wall stress and myocardial oxygen uptake
    • Michaels AD, McKeown B, Kostal M, Vakharia KT, Jordan MV, Gerber IL, et al. Effects of intravenous levosimendan on human coronary vasomotor regulation, left ventricular wall stress and myocardial oxygen uptake. Circulation 2005; 111: 1504-9.
    • (2005) Circulation , vol.111 , pp. 1504-1509
    • Michaels, A.D.1    McKeown, B.2    Kostal, M.3    Vakharia, K.T.4    Jordan, M.V.5    Gerber, I.L.6
  • 14
    • 0030771922 scopus 로고    scopus 로고
    • The novel calcium sensitizer levosimendan activates the ATP-sensitive K+ channel in rat ventricular cells
    • Yokoshiki H, Katsube Y, Sunagawa M, Sperelakis N. The novel calcium sensitizer levosimendan activates the ATP-sensitive K+ channel in rat ventricular cells. J Pharmacol Exp Ther 1997; 283: 375-83.
    • (1997) J Pharmacol Exp Ther , vol.283 , pp. 375-383
    • Yokoshiki, H.1    Katsube, Y.2    Sunagawa, M.3    Sperelakis, N.4
  • 15
    • 25144460454 scopus 로고    scopus 로고
    • Cardioprotection-a new paradigm in the acute management of decompensated heart failure
    • Maytin M, Colucci WS. Cardioprotection-a new paradigm in the acute management of decompensated heart failure. Am J Cardiol 2005; 96: 26G-31G.
    • (2005) Am J Cardiol , vol.96
    • Maytin, M.1    Colucci, W.S.2
  • 16
    • 0036795429 scopus 로고    scopus 로고
    • Pharmacokinetics of levosimendan and its metabolites during and after a 24-hour continuous infusion in patients with severe heart failure
    • Kivikko M, Antila S, Eha J, Lehtonen L, Pentikainen PJ. Pharmacokinetics of levosimendan and its metabolites during and after a 24-hour continuous infusion in patients with severe heart failure. Int J Clin Pharmacol Ther 2002; 40: 465-71.
    • (2002) Int J Clin Pharmacol Ther , vol.40 , pp. 465-471
    • Kivikko, M.1    Antila, S.2    Eha, J.3    Lehtonen, L.4    Pentikainen, P.J.5
  • 17
    • 0037422531 scopus 로고    scopus 로고
    • Sustained hemodynamic effects of intravenous levosimendan
    • Kivikko M, Lehtonen L, Colucci WS. Sustained hemodynamic effects of intravenous levosimendan. Circulation 2003;107: 81-6.
    • (2003) Circulation , vol.107 , pp. 81-86
    • Kivikko, M.1    Lehtonen, L.2    Colucci, W.S.3
  • 18
    • 33947217771 scopus 로고    scopus 로고
    • Effect of severe renal failure and haemodialysis on the pharmacokinetics of levosimendan and its metabolites
    • Puttonen J, Kantele S, Kivikko M, Hakkinen S, Harjola VP, Koskinen P, et al. Effect of severe renal failure and haemodialysis on the pharmacokinetics of levosimendan and its metabolites. Clin Pharmacokinet 2007; 46: 235-46.
    • (2007) Clin Pharmacokinet , vol.46 , pp. 235-246
    • Puttonen, J.1    Kantele, S.2    Kivikko, M.3    Hakkinen, S.4    Harjola, V.P.5    Koskinen, P.6
  • 19
    • 0037142946 scopus 로고    scopus 로고
    • Efficacy and safety of intravenous levosimendan compared with dobutamine in severe low-output heart failure (the LIDO study): A randomized double-blind trial
    • Follath F, Cleland JG, Just H, Papp JG, Scholz H, Peuhkurinen K, et al. Efficacy and safety of intravenous levosimendan compared with dobutamine in severe low-output heart failure (the LIDO study): A randomized double-blind trial. Lancet 2002; 360: 196-202.
    • (2002) Lancet , vol.360 , pp. 196-202
    • Follath, F.1    Cleland, J.G.2    Just, H.3    Papp, J.G.4    Scholz, H.5    Peuhkurinen, K.6
  • 21
    • 0036764821 scopus 로고    scopus 로고
    • Safety and efficacy of a novel calcium sensitizer, levosimendan, in patients with left ventricular failure due to an acute myocardial infarction: A randomized, placebo-controlled, doubleblind study (RUSSLAN)
    • Moiseyev VS, Poder P, Andrejevs N, Ruda MY, Golikov AP, Lazebnik LB, et al. Safety and efficacy of a novel calcium sensitizer, levosimendan, in patients with left ventricular failure due to an acute myocardial infarction: a randomized, placebo-controlled, doubleblind study (RUSSLAN). Eur Heart J 2002; 23: 1422-32.
    • (2002) Eur Heart J , vol.23 , pp. 1422-1432
    • Moiseyev, V.S.1    Poder, P.2    Andrejevs, N.3    Ruda, M.Y.4    Golikov, A.P.5    Lazebnik, L.B.6
  • 22
    • 29444454634 scopus 로고    scopus 로고
    • Clinical trials update from the American Heart Association: REPAIR-AMI, ASTAMI, JELIS, MEGA, REVIVE-II, SURVIVE, and PROACTIVE
    • Cleland JG
    • Cleland JG, Freemantle N, Coletta AP, Clark AL. Clinical trials update from the American Heart Association: REPAIR-AMI, ASTAMI, JELIS, MEGA, REVIVE-II, SURVIVE, and PROACTIVE. Eur J Heart Fail 2006; 8: 105-10.
    • (2006) Eur J Heart Fail , vol.8 , pp. 105-110
    • Cleland, J.G.1    Freemantle, N.2    Coletta, A.P.3    Clark, A.L.4
  • 24
    • 17644414685 scopus 로고    scopus 로고
    • Study design of a mortality trial with intravenous levosimendan (the SURVIVE study) in patients with acutely decompensated heart failure. (Abstract)
    • Mebazaa A, Cohen-Solal A, Kleber F. Study design of a mortality trial with intravenous levosimendan (the SURVIVE study) in patients with acutely decompensated heart failure. (Abstract). Crit Care 2004; 8 Suppl 1: 87.
    • (2004) Crit Care , vol.8 , Issue.1 SUPPL. , pp. 87
    • Mebazaa, A.1    Cohen-Solal, A.2    Kleber, F.3
  • 26
    • 66949167671 scopus 로고    scopus 로고
    • Lowered B-type natriuretic peptide in response to levosimendan or dobutamine treatment is associated with improved survival in patients with severe acutely decompensated heart failure
    • Cohen-Solal A, Logeart D, Huang B, Cai D, Nieminen MS, Mebazaa A. Lowered B-type natriuretic peptide in response to levosimendan or dobutamine treatment is associated with improved survival in patients with severe acutely decompensated heart failure. J Am Coll Cardiol 2009; 53: 2343-8.
    • (2009) J Am Coll Cardiol , vol.53 , pp. 2343-2348
    • Cohen-Solal, A.1    Logeart, D.2    Huang, B.3    Cai, D.4    Nieminen, M.S.5    Mebazaa, A.6
  • 28
    • 77953674288 scopus 로고    scopus 로고
    • Effects of levosimendan versus dobutamine on left atrial function in decompensated heart failure
    • (Abstract Supplement)
    • Duman D, Palit F, Şimşek E, Karadaǧ B. Atalay S, Akdoǧan F, et al. Effects of levosimendan versus dobutamine on left atrial function in decompensated heart failure. Eur Heart J 2008;29 (Abstract Supplement): 303.
    • (2008) Eur Heart J , vol.29 , pp. 303
    • Duman, D.1    Palit, F.2    Şimşek, E.3    Karadaǧ, B.4    Atalay, S.5    Akdoǧan, F.6
  • 29
    • 70350173278 scopus 로고    scopus 로고
    • Effects of levosimendan versus dobutamine on left atrial function in decompensated heart failure
    • Duman D, Palit F, Simsek E, Karadag B, Atalay S. Effects of levosimendan versus dobutamine on left atrial function in decompensated heart failure. Can J Cardiol 2009; 25: e353-6.
    • (2009) Can J Cardiol , vol.25
    • Duman, D.1    Palit, F.2    Simsek, E.3    Karadag, B.4    Atalay, S.5
  • 30
    • 0033609542 scopus 로고    scopus 로고
    • Left atrial relaxation and left ventricular systolic function determine left atrial reservoir function
    • Barbier P, Solomon SB, Schiller NB, Glantz SA. Left atrial relaxation and left ventricular systolic function determine left atrial reservoir function. Circulation 1999; 100: 427-36.
    • (1999) Circulation , vol.100 , pp. 427-436
    • Barbier, P.1    Solomon, S.B.2    Schiller, N.B.3    Glantz, S.A.4
  • 31
    • 0020681280 scopus 로고
    • Importance of left atrial function in patients with myocardial infarction
    • Matsuda Y, Toma Y, Ogawa H, Matsuzaki M, Katayama K, Fujii T, et al. Importance of left atrial function in patients with myocardial infarction. Circulation 1983; 67: 566-71.
    • (1983) Circulation , vol.67 , pp. 566-571
    • Matsuda, Y.1    Toma, Y.2    Ogawa, H.3    Matsuzaki, M.4    Katayama, K.5    Fujii, T.6
  • 33
    • 0034669441 scopus 로고    scopus 로고
    • Hemodynamic and neurohumoral effects of continuous infusion of levosimendan in patients with congestive heart failure
    • Nieminen MS, Akkila J, Hasenfuss G, Kleber FX, Lehtonen LA, Mitrovic V, et al. Hemodynamic and neurohumoral effects of continuous infusion of levosimendan in patients with congestive heart failure. J Am Coll Cardiol 2000; 36: 1903-12.
    • (2000) J Am Coll Cardiol , vol.36 , pp. 1903-1912
    • Nieminen, M.S.1    Akkila, J.2    Hasenfuss, G.3    Kleber, F.X.4    Lehtonen, L.A.5    Mitrovic, V.6
  • 34
    • 0034739460 scopus 로고    scopus 로고
    • Acute hemodynamic and clinical effects of levosimendan in patients with severe heart failure. Study Investigators
    • Slawsky MT, Colucci WS, Gottlieb SS, Greenberg BH, Haeusslein E, Hare J, et al. Acute hemodynamic and clinical effects of levosimendan in patients with severe heart failure. Study Investigators. Circulation 2000; 102: 2222-7.
    • (2000) Circulation , vol.102 , pp. 2222-2227
    • Slawsky, M.T.1    Colucci, W.S.2    Gottlieb, S.S.3    Greenberg, B.H.4    Haeusslein, E.5    Hare, J.6
  • 35
    • 53249090182 scopus 로고    scopus 로고
    • ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM)
    • Dickstein K, Cohen-Solal A, Filippatos G, McMurray JJ, Ponikowski P, Poole-Wilson PA, et al. ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: the Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM). Eur Heart J 2008; 29: 2388-442.
    • (2008) Eur Heart J , vol.29 , pp. 2388-2442
    • Dickstein, K.1    Cohen-Solal, A.2    Filippatos, G.3    McMurray, J.J.4    Ponikowski, P.5    Poole-Wilson, P.A.6
  • 36
    • 63849177462 scopus 로고    scopus 로고
    • Focused update incorporated into the ACC/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults. A Report of the American College of Cardiology Foundation/ American Heart Association Task Force on Practice Guidelines Developed in Collaboration With the International Society for Heart and Lung Transplantation
    • Hunt SA, Abraham WT, Chin MH, Feldman AM, Francis GS, Ganiats TG, et al. Focused update incorporated into the ACC/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults. A Report of the American College of Cardiology Foundation/ American Heart Association Task Force on Practice Guidelines Developed in Collaboration With the International Society for Heart and Lung Transplantation. J Am Coll Cardiol 2009; 53: e1-e90.
    • (2009) J Am Coll Cardiol , vol.53
    • Hunt, S.A.1    Abraham, W.T.2    Chin, M.H.3    Feldman, A.M.4    Francis, G.S.5    Ganiats, T.G.6
  • 37
    • 0027256795 scopus 로고
    • Intravenous enoximone or dobutamine for severe heart failure after acute myocardial infarction: A randomized double-blind trial
    • Caldicott LD, Hawley K, Heppel R, Woodmansey PA, Channer KS. Intravenous enoximone or dobutamine for severe heart failure after acute myocardial infarction: a randomized double-blind trial. Eur Heart J 1993; 14: 696-700.
    • (1993) Eur Heart J , vol.14 , pp. 696-700
    • Caldicott, L.D.1    Hawley, K.2    Heppel, R.3    Woodmansey, P.A.4    Channer, K.S.5
  • 38
    • 0017350710 scopus 로고
    • Effects of dobutamine in patients with acute myocardial infarction
    • Gillespie TA, Ambos HD, Sobel BE, Roberts R. Effects of dobutamine in patients with acute myocardial infarction. Am J Cardiol 1977; 39: 588-94.
    • (1977) Am J Cardiol , vol.39 , pp. 588-594
    • Gillespie, T.A.1    Ambos, H.D.2    Sobel, B.E.3    Roberts, R.4
  • 39
    • 2142835896 scopus 로고    scopus 로고
    • Considerations on the efficacy and safety of levosimendan in ischemic heart failure
    • Nieminen MS, Sandell EP. Considerations on the efficacy and safety of levosimendan in ischemic heart failure. Ital Heart J 2003;4 Suppl 2: 39S-44S.
    • (2003) Ital Heart J , vol.4 , Issue.2 SUPPL.
    • Nieminen, M.S.1    Sandell, E.P.2
  • 40
    • 2942574937 scopus 로고    scopus 로고
    • The calcium sensitizer levosimendan improves the function of stunned myocardium after percutaneous transluminal coronary angioplasty in acute myocardial ischemia
    • Sonntag S, Sundberg S, Lehtonen L, Kleber FX. The calcium sensitizer levosimendan improves the function of stunned myocardium after percutaneous transluminal coronary angioplasty in acute myocardial ischemia. J Am Coll Cardiol 2004; 43: 2177-82.
    • (2004) J Am Coll Cardiol , vol.43 , pp. 2177-2182
    • Sonntag, S.1    Sundberg, S.2    Lehtonen, L.3    Kleber, F.X.4
  • 41
    • 25144486420 scopus 로고    scopus 로고
    • Levosimendan is safe and effective in patients with severe low cardiac output heart failure and critical hypotension. (Abstract)
    • Franco F, Monteiro P, Correia J. Levosimendan is safe and effective in patients with severe low cardiac output heart failure and critical hypotension. (Abstract). J Am Coll Cardiol 2004; 43: 191A.
    • (2004) J Am Coll Cardiol , vol.191 A , pp. 43
    • Franco, F.1    Monteiro, P.2    Correia, J.3
  • 43
    • 44649131858 scopus 로고    scopus 로고
    • Effects of levosimendan versus dobutamine on long-term survival of patients with cardiogenic shock after primary coronary angioplasty
    • Samimi-Fard S, Garci-Gonziez MJ, Domiguez-Rodriuez A, Abreu-Gonzaez P. Effects of levosimendan versus dobutamine on long-term survival of patients with cardiogenic shock after primary coronary angioplasty. Int J Cardiol 2008; 127: 284-7.
    • (2008) Int J Cardiol , vol.127 , pp. 284-287
    • Samimi-Fard, S.1    Garci-Gonziez, M.J.2    Domiguez-Rodriuez, A.3    Abreu-Gonzaez, P.4
  • 44
    • 70249123176 scopus 로고    scopus 로고
    • Hemodynamic effects of levosimendan in acute myocardial infarction complicated by cardiogenic shock and high systemic vascular resistance
    • Tsagalou EP, Kanakakis J, Anastasiou-Nana MI, Drakos SG, Ntalianis AS, Malliaras K, et al. Hemodynamic effects of levosimendan in acute myocardial infarction complicated by cardiogenic shock and high systemic vascular resistance. Acute Card Care 2009;11: 99-106.
    • (2009) Acute Card Care , vol.11 , pp. 99-106
    • Tsagalou, E.P.1    Kanakakis, J.2    Anastasiou-Nana, M.I.3    Drakos, S.G.4    Ntalianis, A.S.5    Malliaras, K.6
  • 46
    • 45149132991 scopus 로고    scopus 로고
    • Levosimendan but not norepinephrine improves microvascular oxygenation during experimental septic shock
    • Fries M, Ince C, Rossaint R, Bleilevens C, Bickenbach J, Rex S, et al. Levosimendan but not norepinephrine improves microvascular oxygenation during experimental septic shock. Crit Care Med 2008; 36: 1886-91.
    • (2008) Crit Care Med , vol.36 , pp. 1886-1891
    • Fries, M.1    Ince, C.2    Rossaint, R.3    Bleilevens, C.4    Bickenbach, J.5    Rex, S.6
  • 47
    • 67650545459 scopus 로고    scopus 로고
    • Levosimendan reduces cardiac troponin release after cardiac surgery: A meta-analysis of randomized controlled studies
    • Zangrillo A, Biondi-Zoccai G, Mizzi A, Bruno G, Bignami E, Gerli C, et al. Levosimendan reduces cardiac troponin release after cardiac surgery: a meta-analysis of randomized controlled studies. J Cardiothorac Vasc Anesth 2009;23: 474-8.
    • (2009) J Cardiothorac Vasc Anesth , vol.23 , pp. 474-478
    • Zangrillo, A.1    Biondi-Zoccai, G.2    Mizzi, A.3    Bruno, G.4    Bignami, E.5    Gerli, C.6
  • 49
    • 2942596450 scopus 로고    scopus 로고
    • Treatment of acute heart failure in an infant after cardiac surgery using levosimendan
    • Braun JP, Schneider M, Kastrup M, Liu J. Treatment of acute heart failure in an infant after cardiac surgery using levosimendan. Eur J Cardiothorac Surg 2004; 26: 228-30.
    • (2004) Eur J Cardiothorac Surg , vol.26 , pp. 228-230
    • Braun, J.P.1    Schneider, M.2    Kastrup, M.3    Liu, J.4
  • 51
    • 38149032609 scopus 로고    scopus 로고
    • Effect of levosimendan on right ventricular systolic and diastolic functions in patients with ischaemic heart failure
    • Duygu H, Özerkan F, Zoghi M, Nalbantgil S, Yildiz A, Akilli A, et al. Effect of levosimendan on right ventricular systolic and diastolic functions in patients with ischaemic heart failure. Int J Clin Pract 2008; 62: 228-33.
    • (2008) Int J Clin Pract , vol.62 , pp. 228-233
    • Duygu, H.1    Özerkan, F.2    Zoghi, M.3    Nalbantgil, S.4    Yildiz, A.5    Akilli, A.6
  • 52
    • 34247105390 scopus 로고    scopus 로고
    • Do calcium sensitizers affect right ventricular functions in patients with chronic heart failure?
    • Kaşikioǧlu HA, Uyarel H, Tartan Z, Kaşikioǧlu E, Özturk R, Cam N. Do calcium sensitizers affect right ventricular functions in patients with chronic heart failure? Int J Cardiol 2007; 118: 246-8.
    • (2007) Int J Cardiol , vol.118 , pp. 246-248
    • Kaşikioǧlu, H.A.1    Uyarel, H.2    Tartan, Z.3    Kaşikioǧlu, E.4    Özturk, R.5    Cam, N.6
  • 53
    • 67649213062 scopus 로고    scopus 로고
    • Levosimendan is not effective in reducing pulmonary pressures in patients with idiopathic pulmonary arterial hypertension: Report of two cases
    • Cavuşoǧlu Y, Beyaztaş A, Birdane A, Ata N. Levosimendan is not effective in reducing pulmonary pressures in patients with idiopathic pulmonary arterial hypertension: report of two cases. J Cardiovasc Med (Hagerstown) 2009; 10: 503-7.
    • (2009) J Cardiovasc Med (Hagerstown) , vol.10 , pp. 503-507
    • Cavuşoǧlu, Y.1    Beyaztaş, A.2    Birdane, A.3    Ata, N.4
  • 54
    • 0033600181 scopus 로고    scopus 로고
    • Levosimendan, a novel myofilament calcium sensitizer, allows weaning of parenteral inotropic therapy in patients with severe congestive heart failure
    • Hosenpud JD. Levosimendan, a novel myofilament calcium sensitizer, allows weaning of parenteral inotropic therapy in patients with severe congestive heart failure. Am J Cardiol 1999; 83 (Suppl 2): 9-11.
    • (1999) Am J Cardiol , vol.83 , Issue.2 SUPPL. , pp. 9-11
    • Hosenpud, J.D.1
  • 55
    • 0033600154 scopus 로고    scopus 로고
    • Oral levosimendan improves cardiac function and hemodynamics in patients with severe congestive heart failure
    • Harjola VP, Peuhkurinen K, Nieminen MS, Niemela M, Sundberg S. Oral levosimendan improves cardiac function and hemodynamics in patients with severe congestive heart failure. Am J Cardiol 1999; 83 (Suppl 1): 4-8.
    • (1999) Am J Cardiol , vol.83 , Issue.1 SUPPL. , pp. 4-8
    • Harjola, V.P.1    Peuhkurinen, K.2    Nieminen, M.S.3    Niemela, M.4    Sundberg, S.5
  • 56
  • 57
    • 0038729527 scopus 로고    scopus 로고
    • Levosimendan: A new dual-action drug in the treatment of acute heart failure
    • Mebazaa A, Erhardt L. Levosimendan: a new dual-action drug in the treatment of acute heart failure. Int J Clin Pract 2003; 57: 410-6.
    • (2003) Int J Clin Pract , vol.57 , pp. 410-416
    • Mebazaa, A.1    Erhardt, L.2
  • 58
    • 34247857479 scopus 로고    scopus 로고
    • SURVIVE Investigators. Levosimendan vs dobutamine for patients with acute decompensated heart failure: The SURVIVE Randomized Trial
    • Mebazaa A, Nieminen MS, Packer M, Cohen-Solal A, Kleber FX, Pocock SJ, et al. SURVIVE Investigators. Levosimendan vs dobutamine for patients with acute decompensated heart failure: The SURVIVE Randomized Trial. JAMA 2007; 297: 1883-91.
    • (2007) JAMA , vol.297 , pp. 1883-1891
    • Mebazaa, A.1    Nieminen, M.S.2    Packer, M.3    Cohen-Solal, A.4    Kleber, F.X.5    Pocock, S.J.6
  • 59
    • 77953660661 scopus 로고    scopus 로고
    • Effects of levosimendan versus dobutamine on ventricular arrhythmias and autonomic indexes in patients with advanced heart failure
    • (Abstract Supplement)
    • Duman D, Palit F, Şimşek E, Yildiz O. Effects of levosimendan versus dobutamine on ventricular arrhythmias and autonomic indexes in patients with advanced heart failure. Eur Heart J 2009; 30 (Abstract Supplement): 1031.
    • (2009) Eur Heart J , vol.30 , pp. 1031
    • Duman, D.1    Palit, F.2    Şimşek, E.3    Yildiz, O.4
  • 60
    • 36849013485 scopus 로고    scopus 로고
    • Levosimendan improves renal function in patients with acute decompensated heart failure: Comparison with dobutamine
    • Yilmaz MB, Yalta K, Yontar C, Karadaş F, Erdem A, Turgut OO, et al. Levosimendan improves renal function in patients with acute decompensated heart failure: comparison with dobutamine. Cardiovasc Drugs Ther 2007; 21: 431-5.
    • (2007) Cardiovasc Drugs Ther , vol.21 , pp. 431-435
    • Yilmaz, M.B.1    Yalta, K.2    Yontar, C.3    Karadaş, F.4    Erdem, A.5    Turgut, O.O.6


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