Impact of integrin-matrix interaction and signaling on insulin gene expression and the mesenchymal transition of human β-cells

Journal of Cellular Physiology

Volumn 224, Issue 1, 2010, Pages 101-111

  Kaido, Thomas J ^a   Yebra, Mayra ^a   Kaneto, Hideaki ^b   Cirulli, Vincenzo ^a   Hayek, Alberto ^a   Montgomery, Anthony M P ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BETA1 INTEGRIN; COLLAGEN TYPE 4; FIBRONECTIN; INSULIN; LAMININ 1; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN TYROSINE KINASE; SCATTER FACTOR; STRESS ACTIVATED PROTEIN KINASE; VERY LATE ACTIVATION ANTIGEN 1; VIMENTIN; LAMININ; PROTEIN KINASE INHIBITOR; PROTEIN TYROSINE KINASE C SRC; PROTEIN-TYROSINE KINASE C-SRC; SCLEROPROTEIN;

ADULT; AGED; ARTICLE; CELL ADHESION; CELL EXPANSION; CELL MOTILITY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; EPITHELIAL MESENCHYMAL TRANSITION; EXTRACELLULAR MATRIX; FETUS; FETUS CELL; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; CELL CULTURE; CELL MOTION; CELL TRANSDIFFERENTIATION; DOWN REGULATION; DRUG ANTAGONISM; DRUG EFFECT; GENETIC TRANSFECTION; GENETICS; GESTATIONAL AGE; MESODERM; METABOLISM; MIDDLE AGED; PANCREAS; PHENOTYPE; PHOSPHORYLATION; PRENATAL DEVELOPMENT;

AGED; CELL ADHESION; CELL MOVEMENT; CELL TRANSDIFFERENTIATION; CELLS, CULTURED; COLLAGEN TYPE IV; DOWN-REGULATION; ENZYME ACTIVATION; EXTRACELLULAR MATRIX PROTEINS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FIBRONECTINS; GESTATIONAL AGE; HEPATOCYTE GROWTH FACTOR; HUMANS; INSULIN; INSULIN-SECRETING CELLS; INTEGRIN ALPHA1BETA1; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LAMININ; MESODERM; MIDDLE AGED; PANCREAS; PHENOTYPE; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION; TRANSFECTION; VIMENTIN;

EID: 77952485176     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.22101     Document Type: Article

References (44)

1. Beattie GM, Lappi DA, Baird A, Hayek A. 1991. Functional impact of attachment and purification in the short term culture of human pancreatic islets. J Clin Endocrinol Metab 73:93-98. (Pubitemid 21901105)
2. Beattie GM, Levine F, Mally MI, Otonkoski T, O'Brien JS, Salomon DR, Hayek A. 1994. Acid beta-galactosidase: A developmentally regulated marker of endocrine cell precursors in the human fetal pancreas. J Clin Endocrinol Metab 78:1232-1240.
3. Beattie GM, Cirulli V, Lopez AD, Hayek A. 1997. Ex vivo expansion of human pancreatic endocrine cells. J Clin Endocrinol Metab 82:1852-1856. (Pubitemid 127495199)
4. Beattie GM, Montgomery AM, Lopez AD, Hao E, Perez B, Just ML, Lakey JR, Hart ME, Hayek A. 2002. A novel approach to increase human islet cell mass while preserving beta-cell function. Diabetes 51:3435-3439. (Pubitemid 35403447)
5. Bhowmick NA, Zent R, Ghiassi M, McDonnell M, Moses HL. 2001. Integrin beta 1 signaling is necessary for transforming growth factor-beta activation of p38MAPK and epithelial plasticity. J Biol Chem 276:46707-46713.
6. Bonner-Weir S, Taneja M, Weir GC, Tatarkiewicz K, Song KH, Sharma A, O'Neil JJ. 2000. In vitro cultivation of human islets from expanded ductal tissue. Proc Natl Acad Sci USA 97:7999-8004.
7. Bosco D, Meda P, Halban PA, Rouiller DG. 2000. Importance of cell-matrix interactions in rat islet beta-cell secretion in vitro: Role of alpha6beta1 integrin. Diabetes 49:233-243. (Pubitemid 30071002)
8. Boukamp P, Fusenig NE. 1993. "Trans-differentiation" from epidermal to mesenchymal/myogenic phenotype is associatedwith a drastic change in cell-cell and cell-matrix adhesion molecules. J Cell Biol 120:981-993.
9. Broome MA, Hunter T. 1996. Requirement for c-Src catalytic activity and the SH3 domain in platelet-derived growth factor BB and epidermal growth factor mitogenic signaling. J Biol Chem 271:16798-16806.
10. Choi J, Park SY, Joo CK. 2007. Transforming growth factor-beta1 represses E-cadherin production via slug expression in lens epithelial cells. Invest Ophthalmol Vis Sci 48:2708-2718.
11. Gershengorn MC, Hardikar AA, Wei C, Geras-Raaka E, Marcus-Samuels B, Raaka BM. 2004. Epithelial-to-mesenchymal transition generates proliferative human islet precursor cells. Science 306:2261-2264.
12. Gimond C, van Der Flier A, van Delft S, Brakebusch C, Kuikman I, Collard JG, Fassler R, Sonnenberg A. 1999. Induction of cell scattering by expression of beta1 integrins in beta1-deficient epithelial cells requires activation of members of the rho family of GTPases and downregulation of cadherin and catenin function. J Cell Biol 147:1325-1340.
13. Hammar EB, Irminger JC, Rickenbach K, Parnaud G, Ribaux P, Bosco D, Rouiller DG, Halban PA. 2005. Activation of NF-kappaB by extracellular matrix is involved in spreading and glucose-stimulated insulin secretion of pancreatic beta cells. J Biol Chem 280:30630-30637.
14. Imamichi Y, Menke A. 2007. Signaling pathways involved in collagen-induced disruption of the E-cadherin complex during epithelial-mesenchymal transition. Cells Tissues Organs 185:180-190.
15. Joglekar MV, Joglekar VM, Joglekar SV, Hardikar AA. 2009. Human fetal pancreatic insulin-producing cells proliferate in vitro. J Endocrinol 201:27-36.
16. Kaido T, Perez B, Yebra M, Hill J, Cirulli V, Hayek A, Montgomery AM. 2004a. Alphav-integrin utilization in human beta-cell adhesion, spreading, and motility. J Biol Chem 279:17731-17737.
17. Kaido T, Yebra M, Cirulli V, Montgomery AM. 2004b. Regulation of human beta-cell adhesion, motility, and insulin secretion by collagen IV and its receptor alpha1beta1. J Biol Chem 279:53762-53769.
18. Kaido T, Yebra M, Cirulli V, Rhodes C, Diaferia G, Montgomery AM. 2006. Impact of defined matrix interactions on insulin production by cultured human beta-cells: Effect on insulin content, secretion, and gene transcription. Diabetes 55:2723-2729.
19. Kaneto H, Xu G, Fujii N, Kim S, Bonner-Weir S, Weir GC. 2002. Involvement of c-Jun N-terminal kinase in oxidative stress-mediated suppression of insulin gene expression. J Biol Chem 277:30010-30018.
20. Koenig A, Mueller C, Hasel C, Adler G, Menke A. 2006. Collagen type I induces disruption of E-cadherin-mediated cell-cell contacts and promotes proliferation of pancreatic carcinoma cells. Cancer Res 66:4662-4671.
21. Korsching E, Packeisen J, Liedtke C, Hungermann D, Wulfing P, van Diest PJ, Brandt B, Boecker W, Buerger H. 2005. The origin of vimentin expression in invasive breast cancer: Epithelial-mesenchymal transition, myoepithelial histogenesis or histogenesis from progenitor cells with bilinear differentiation potential? J Pathol 206:451-457.
22. Lai JF, Kao SC, Jiang ST, Tang MJ, Chan PC, Chen HC. 2000. Involvement of focal adhesion kinase in hepatocyte growth factor-induced scatter of Madin-Darby canine kidney cells. J Biol Chem 275:7474-7480.
23. Lee YI, Kwon YJ, Joo CK. 2004. Integrin-linked kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition. Biochem Biophys Res Commun 316:997-1001.
24. Li Y, Yang J, Dai C, Wu C, Liu Y. 2003. Role for integrin-linked kinase in mediating tubular epithelial to mesenchymal transition and renal interstitial fibrogenesis. J Clin Invest 112:503-516.
25. Liao G, Tao Q, Kofron M, Chen JS, Schloemer A, Davis RJ, Hsieh JC, Wylie C, Heasman J, Kuan CY. 2006. Jun NH2-terminal kinase (JNK) prevents nuclear beta-catenin accumulation and regulates axis formation in Xenopus embryos. Proc Natl Acad Sci USA 103:16313-16318.
26. Lucas-Clerc C, Massart C, Campion JP, Launois B,Nicol M. 1993. Long-term culture of human pancreatic islets in an extracellular matrix: Morphological and metabolic effects. Mol Cell Endocrinol 94:9-20.
27. Matsuzaki K, Okazaki K. 2006. Transforming growth factor-beta during carcinogenesis: The shift from epithelial to mesenchymal signaling. J Gastroenterol 41:295-303. (Pubitemid 43834371)
28. Menke A, Philippi C, Vogelmann R, Seidel B, Lutz MP, Adler G, Wedlich D. 2001. Down-regulation of E-cadherin gene expression by collagen type I and type III in pancreatic cancer cell lines. Cancer Res 61:3508-3517. (Pubitemid 32695048)
29. Nikolova G, Jabs N, Konstantinova I, Domogatskaya A, Tryggvason K, Sorokin L, Fassler R, Gu G, Gerber HP, Ferrara N, Melton DA, Lammert E. 2006. The vascular basement membrane: A niche for insulin gene expression and beta cell proliferation. Dev Cell 10:397-405.
30. Oberg-Welsh C. 2001. Long-term culture in matrigel enhances the insulin secretion of fetal porcine islet-like cell clusters in vitro. Pancreas 22:157-163.
31. Prunier C, Howe PH. 2005. Disabled-2 (Dab2) is required for transforming growth factor beta-induced epithelial to mesenchymal transition (EMT). J Biol Chem 280:17540-17548.
32. Reeves R, Edberg DD, Li Y. 2001. Architectural transcription factor HMGI(Y) promotes tumor progression and mesenchymal transition of human epithelial cells. Mol Cell Biol 21:575-594.
33. Russ HA, Bar Y, Ravassard P, Efrat S. 2008. In vitro proliferation of cells derived from adult human beta-cells revealed by cell-lineage tracing. Diabetes 57:1575-1583.
34. Santibanez JF. 2006. JNK mediates TGF-beta1-induced epithelial mesenchymal transdifferentiation of mouse transformed keratinocytes. FEBS Lett 580:5385-5391.
35. Schramek H, Feifel E, Healy E, Pollack V. 1997. Constitutively active mutant of the mitogen-activated protein kinase kinase MEK1 induces epithelial dedifferentiation and growth inhibition in Madin-Darby canine kidney-C7 cells. J Biol Chem 272:11426-11433.
36. Schramek H, Feifel E, Marschitz I, Golochtchapova N, Gstraunthaler G, Montesano R. 2003. Loss of active MEK1-ERK1/2 restores epithelial phenotype and morphogenesis in transdifferentiated MDCK cells. Am J Physiol Cell Physiol 285:C652-C661. (Pubitemid 37022064)
37. Shintani Y, Hollingsworth MA, Wheelock MJ, Johnson KR. 2006a. Collagen I promotes metastasis in pancreatic cancer by activating c-Jun NH(2)-terminal kinase 1 and up-regulating N-cadherin expression. Cancer Res 66:11745-11753.
38. Shintani Y, Wheelock MJ, Johnson KR. 2006b. Phosphoinositide-3 kinase-Rac1-c-Jun NH2-terminal kinase signaling mediates collagen I-induced cell scattering and up-regulation of N-cadherin expression in mouse mammary epithelial cells. Mol Biol Cell 17:2963-2975.
39. Shintani Y, Maeda M, Chaika N, Johnson KR, Wheelock MJ. 2008. Collagen I promotes epithelial-to-mesenchymal transition in lung cancer cells via transforming growth factor-beta signaling. Am J Respir Cell Mol Biol 38:95-104.
40. Simirskii VN, Wang Y, Duncan MK. 2007. Conditional deletion of beta1-integrin from the developing lens leads to loss of the lens epithelial phenotype. Dev Biol 306:658-668.
41. Strippoli R, Benedicto I, Perez Lozano ML, Cerezo A, Lopez-Cabrera M, del Pozo MA. 2008. Epithelial-to-mesenchymal transition of peritoneal mesothelial cells is regulated by an ERK/NF-kappaB/snail1 pathway. Dis Model Mech 1:264-274.
42. Thiery JP. 2003. Epithelial-mesenchymal transitions in development and pathologies. Curr Opin Cell Biol 15:740-746.
43. Tucker RP. 2004. Antisense knockdown of the beta1 integrin subunit in the chicken embryo results in abnormal neural crest cell development. Int J Biochem Cell Biol 36:1135-1139.
44. Virtanen I, Banerjee M, Palgi J, Korsgren O, Lukinius A, Thornell LE, Kikkawa Y, Sekiguchi K, Hukkanen M, Konttinen YT, Otonkoski T. 2008. Blood vessels of human islets of Langerhans are surrounded by a double basementmembrane. Diabetologia 51:1181-1191.