Perinatal changes in superoxide generation in the ovine lung: Alterations associated with increased pulmonary blood flow

Vascular Pharmacology

Volumn 53, Issue 1-2, 2010, Pages 38-52

  Sharma, Shruti ^a   Kumar, Sanjiv ^a   Wiseman, Dean A ^a   Kallarackal, Suphin ^a   Ponnala, Sumant ^a   Elgaish, Manal ^a   Tian, Jing ^a   Fineman, Jeffrey R ^b,c   Black, Stephen M ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

^b Department of Pediatrics San Francisco ^*  (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Allopurinol; Apocynin; NADPH oxidase; Pulmonary hypertension; Xanthine oxidase

Indexed keywords

PROTEIN P47; PROTEIN P67; RAC1 PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE; XANTHINE OXIDASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME REGULATION; ENZYME SUBUNIT; FEMALE; FETUS; LAMB; LUNG BLOOD FLOW; LUNG DEVELOPMENT; NONHUMAN; PERINATAL PERIOD; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULMONARY HYPERTENSION; SHEEP;

AGE FACTORS; ANIMALS; FEMALE; HYPERTENSION, PULMONARY; LUNG; NADPH OXIDASE; PREGNANCY; PULMONARY CIRCULATION; RAC1 GTP-BINDING PROTEIN; SHEEP; SUPEROXIDES; TIME FACTORS; XANTHINE OXIDASE;

EID: 77952428833     PISSN: 15371891     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vph.2010.03.005     Document Type: Article

References (36)

1. Archer S.L., Djaballah K., Humbert M., Weir K.E., Fartoukh M., Dall'ava-Santucci J., Mercier J.C., Simonneau G., and Dinh-Xuan A.T. Nitric oxide deficiency in fenfluramine- and dexfenfluramine-induced pulmonary hypertension. Am. J. Respir. Crit. Care Med. 158 (1998) 1061-1067
2. Brandes R.P., and Schroder K. Differential vascular functions of Nox family NADPH oxidases. Curr. Opin. Lipidol. 19 (2008) 513-518
3. Brown J.H., Del Re D.P., and Sussman M.A. The Rac and Rho hall of fame: a decade of hypertrophic signaling hits. Circ. Res. 98 (2006) 730-742
4. Cai H., and Harrison D.G. Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ. Res. 87 (2000) 840-844
5. Cooper C.J., Landzberg M.J., Anderson T.J., Charbonneau F., Creager M.A., Ganz P., and Selwyn A.P. Role of nitric oxide in the local regulation of pulmonary vascular resistance in humans. Circulation 93 (1996) 266-271
6. De Keulenaer G.W., Chappell D.C., Ishizaka N., Nerem R.M., Alexander R.W., and Griendling K.K. Oscillatory and steady laminar shear stress differentially affect human endothelial redox state: role of a superoxide-producing NADH oxidase. Circ. Res. 82 (1998) 1094-1101
7. DeMarco V.G., Habibi J., Whaley-Connell A.T., Schneider R.I., Heller R.L., Bosanquet J.P., Hayden M.R., Delcour K., Cooper S.A., Andresen B.T., Sowers J.R., and Dellsperger K.C. Oxidative stress contributes to pulmonary hypertension in the transgenic (mRen2)27 rat. Am. J. Physiol. Heart Circ. Physiol. 294 (2008) H2659-H2668
8. Fortuno A., San Jose G., Moreno M.U., Diez J., and Zalba G. Oxidative stress and vascular remodelling. Exp. Physiol. 90 (2005) 457-462
9. Garvin J.L., and Hong N.J. Cellular stretch increases superoxide production in the thick ascending limb. Hypertension 51 (2008) 488-493
10. Grobe A.C., Wells S.M., Benavidez E., Oishi P., Azakie A., Fineman J.R., and Black S.M. Increased oxidative stress in lambs with increased pulmonary blood flow and pulmonary hypertension: role of NADPH oxidase and endothelial NO synthase. Am. J. Physiol. Lung Cell Mol. Physiol. 290 (2006) L1069-L1077
11. Hayashi T., Juliet P.A., Kano-Hayashi H., Tsunekawa T., Dingqunfang D., Sumi D., Matsui-Hirai H., Fukatsu A., and Iguchi A. NADPH oxidase inhibitor, apocynin, restores the impaired endothelial-dependent and -independent responses and scavenges superoxide anion in rats with type 2 diabetes complicated by NO dysfunction. Diabetes Obes. Metab. 7 (2005) 334-343
12. Heumuller S., Wind S., Barbosa-Sicard E., Schmidt H.H., Busse R., Schroder K., and Brandes R.P. Apocynin is not an inhibitor of vascular NADPH oxidases but an antioxidant. Hypertension 51 (2008) 211-217
13. Hordijk P.L. Regulation of NADPH oxidases: the role of Rac proteins. Circ. Res. 98 (2006) 453-462
14. Hoshikawa Y., Ono S., Suzuki S., Tanita T., Chida M., Song C., Noda M., Tabata T., Voelkel N.F., and Fujimura S. Generation of oxidative stress contributes to the development of pulmonary hypertension induced by hypoxia. J. Appl. Physiol. 90 (2001) 1299-1306
15. Jankov R.P., Kantores C., Pan J., and Belik J. Contribution of xanthine oxidase-derived superoxide to chronic hypoxic pulmonary hypertension in neonatal rats. Am. J. Physiol. Lung Cell Mol. Physiol. 294 (2008) L233-L245
16. Jenkins N.T., Witkowski S., Spangenburg E.E., and Hagberg J.M. Effects of acute and chronic endurance exercise on intracellular nitric oxide in putative endothelial progenitor cells: role of NADPH oxidase. Am. J. Physiol. Heart Circ. Physiol. 297 (2009) H1798-H1805
17. Kaneko F.T., Arroliga A.C., Dweik R.A., Comhair S.A., Laskowski D., Oppedisano R., Thomassen M.J., and Erzurum S.C. Biochemical reaction products of nitric oxide as quantitative markers of primary pulmonary hypertension. Am. J. Respir. Crit. Care Med. 158 (1998) 917-923
18. Kou B., Ni J., Vatish M., and Singer D.R. Xanthine oxidase interaction with vascular endothelial growth factor in human endothelial cell angiogenesis. Microcirculation 15 (2008) 251-267
19. Landmesser U., Cai H., Dikalov S., McCann L., Hwang J., Jo H., Holland S.M., and Harrison D.G. Role of p47(phox) in vascular oxidative stress and hypertension caused by angiotensin II. Hypertension 40 (2002) 511-515
20. Liu J.Q., Zelko I.N., Erbynn E.M., Sham J.S., and Folz R.J. Hypoxic pulmonary hypertension: role of superoxide and NADPH oxidase (gp91phox). Am. J. Physiol. Lung Cell Mol. Physiol. 290 (2006) L2-L10
21. Liu P.G., He S.Q., Zhang Y.H., and Wu J. Protective effects of apocynin and allopurinol on ischemia/reperfusion-induced liver injury in mice. World J. Gastroenterol. 14 (2008) 2832-2837
22. McNally J.S., Davis M.E., Giddens D.P., Saha A., Hwang J., Dikalov S., Jo H., and Harrison D.G. Role of xanthine oxidoreductase and NAD(P)H oxidase in endothelial superoxide production in response to oscillatory shear stress. Am. J. Physiol. Heart Circ. Physiol. 285 (2003) H2290-H2297
23. Mehta S., Stewart D.J., Langleben D., and Levy R.D. Short-term pulmonary vasodilation with l-arginine in pulmonary hypertension. Circulation 92 (1995) 1539-1545
24. Mueller C.F., Laude K., McNally J.S., and Harrison D.G. ATVB in focus: redox mechanisms in blood vessels. Arterioscler. Thromb. Vasc. Biol. 25 (2005) 274-278
25. Nozik-Grayck E., and Stenmark K.R. Role of reactive oxygen species in chronic hypoxia-induced pulmonary hypertension and vascular remodeling. Adv. Exp. Med. Biol. 618 (2007) 101-112
26. Oishi P.E., Wiseman D.A., Sharma S., Kumar S., Hou Y., Datar S.A., Azakie A., Johengen M.J., Harmon C., Fratz S., Fineman J.R., and Black S.M. Progressive dysfunction of nitric oxide synthase in a lamb model of chronically increased pulmonary blood flow: a role for oxidative stress. Am. J. Physiol. Lung Cell Mol. Physiol. 295 (2008) L756-L766
27. Reddy V.M., Meyrick B., Wong J., Khoor A., Liddicoat J.R., Hanley F.L., and Fineman J.R. In utero placement of aortopulmonary shunts. A model of postnatal pulmonary hypertension with increased pulmonary blood flow in lambs. Circulation 92 (1995) 606-613
28. Sharma S., Grobe A.C., Wiseman D.A., Kumar S., Englaish M., Najwer I., Benavidez E., Oishi P., Azakie A., Fineman J.R., and Black S.M. Lung antioxidant enzymes are regulated by development and increased pulmonary blood flow. Am. J. Physiol. Lung Cell Mol. Physiol. 293 (2007) L960-L971
29. Sharma S., Sud N., Wiseman D.A., Carter A.L., Kumar S., Hou Y., Rau T., Wilham J., Harmon C., Oishi P.E., Fineman J.R., and Black S.M. Altered carnitine homeostasis is associated with decreased mitochondrial function and altered nitric oxide signaling in lambs with pulmonary hypertension. Am. J. Physiol. Lung Cell Mol. Physiol. 294 (2008) L46-L56
30. Sharma S., Kumar S., Sud N., Wiseman D.A., Tian J., Rehmani I., Datar S., Oishi P., Fratz S., Venema R.C., Fineman J.R., and Black S.M. Alterations in lung arginine metabolism in lambs with pulmonary hypertension associated with increased pulmonary blood flow. Vascul. Pharmacol. 51 (2009) 359-364
31. Steinhorn R.H., Russell J.A., Lakshminrusimha S., Gugino S.F., Black S.M., and Fineman J.R. Altered endothelium-dependent relaxations in lambs with high pulmonary blood flow and pulmonary hypertension. Am. J. Physiol. Lung Cell Mol. Physiol. 280 (2001) H311-H317
32. Sumimoto H. Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species. FEBS J. 275 (2008) 3249-3277
33. Vejrazka M., Micek R., and Stipek S. Apocynin inhibits NADPH oxidase in phagocytes but stimulates ROS production in non-phagocytic cells. Biochim. Biophys. Acta 1722 (2005) 143-147
34. Viel E.C., Benkirane K., Javeshghani D., Touyz R.M., and Schiffrin E.L. Xanthine oxidase and mitochondria contribute to vascular superoxide anion generation in DOCA-salt hypertensive rats. Am. J. Physiol. Heart. Circ. Physiol. 295 (2008) H281-H288
35. Zalba G., Beaumont F.J., San Jose G., Fortuno A., Fortuno M.A., Etayo J.C., and Diez J. Vascular NADH/NADPH oxidase is involved in enhanced superoxide production in spontaneously hypertensive rats. Hypertension 35 (2000) 1055-1061
36. Zou M.H., Cohen R., and Ullrich V. Peroxynitrite and vascular endothelial dysfunction in diabetes mellitus. Endothelium 11 (2004) 89-97