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Volumn 38, Issue 10, 2008, Pages 1099-1109

Frequent recombination events generate diversity within the multi-copy variant antigen gene families of Plasmodium falciparum

Author keywords

Antigenic diversity; Gene conversion; Malaria; Recombination

Indexed keywords

ANTIBODY; ANTIGEN; GENE EXPRESSION; GENETIC VARIATION; MALARIA; PROTEIN; PROTOZOAN; RECOMBINATION;

EID: 44349099316     PISSN: 00207519     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpara.2008.01.010     Document Type: Article
Times cited : (52)

References (53)
  • 1
    • 0242318279 scopus 로고    scopus 로고
    • Antibodies to Plasmodium falciparum rifin proteins are associated with rapid parasite clearance and asymptomatic infections
    • Abdel-Latif M.S., Dietz K., Issifou S., Kremsner P.G., and Klinkert M.Q. Antibodies to Plasmodium falciparum rifin proteins are associated with rapid parasite clearance and asymptomatic infections. Infect. Immun. 71 (2003) 6229-6233
    • (2003) Infect. Immun. , vol.71 , pp. 6229-6233
    • Abdel-Latif, M.S.1    Dietz, K.2    Issifou, S.3    Kremsner, P.G.4    Klinkert, M.Q.5
  • 2
    • 0036892283 scopus 로고    scopus 로고
    • Recognition of variant Rifin antigens by human antibodies induced during natural Plasmodium falciparum infections
    • Abdel-Latif M.S., Khattab A., Lindenthal C., Kremsner P.G., and Klinkert M.Q. Recognition of variant Rifin antigens by human antibodies induced during natural Plasmodium falciparum infections. Infect. Immun. 70 (2002) 7013-7021
    • (2002) Infect. Immun. , vol.70 , pp. 7013-7021
    • Abdel-Latif, M.S.1    Khattab, A.2    Lindenthal, C.3    Kremsner, P.G.4    Klinkert, M.Q.5
  • 3
    • 33645067647 scopus 로고    scopus 로고
    • Antigenic variation in Babesia bovis occurs through segmental gene conversion of the ves multigene family, within a bidirectional locus of active transcription
    • al Khedery B., and Allred D.R. Antigenic variation in Babesia bovis occurs through segmental gene conversion of the ves multigene family, within a bidirectional locus of active transcription. Mol. Microbiol. 59 (2006) 402-414
    • (2006) Mol. Microbiol. , vol.59 , pp. 402-414
    • al Khedery, B.1    Allred, D.R.2
  • 5
    • 0029052741 scopus 로고
    • Cloning the P. falciparum gene encoding PfEMP1, a malarial variant antigen and adherence receptor on the surface of parasitized human erythrocytes
    • Baruch D.I., Pasloske B.L., Singh H.B., Bi X., Ma X.C., Feldman M., Taraschi T.F., and Howard R.J. Cloning the P. falciparum gene encoding PfEMP1, a malarial variant antigen and adherence receptor on the surface of parasitized human erythrocytes. Cell 82 (1995) 77-87
    • (1995) Cell , vol.82 , pp. 77-87
    • Baruch, D.I.1    Pasloske, B.L.2    Singh, H.B.3    Bi, X.4    Ma, X.C.5    Feldman, M.6    Taraschi, T.F.7    Howard, R.J.8
  • 8
    • 26944500834 scopus 로고    scopus 로고
    • The frequency and rate of pilin antigenic variation in Neisseria gonorrhoeae
    • Criss A.K., Kline K.A., and Seifert H.S. The frequency and rate of pilin antigenic variation in Neisseria gonorrhoeae. Mol. Microbiol. 58 (2005) 510-519
    • (2005) Mol. Microbiol. , vol.58 , pp. 510-519
    • Criss, A.K.1    Kline, K.A.2    Seifert, H.S.3
  • 10
    • 33645777010 scopus 로고    scopus 로고
    • Mutually exclusive expression of virulence genes by malaria parasites is regulated independently of antigen production
    • Dzikowski R., Frank M., and Deitsch K. Mutually exclusive expression of virulence genes by malaria parasites is regulated independently of antigen production. PLoS Pathog. 2 (2006) e22
    • (2006) PLoS Pathog. , vol.2
    • Dzikowski, R.1    Frank, M.2    Deitsch, K.3
  • 12
    • 0037083982 scopus 로고    scopus 로고
    • A central role for Plasmodium falciparum subtelomeric regions in spatial positioning and telomere length regulation
    • Figueiredo L.M., Freitas-Junior L.H., Bottius E., Olivo-Marin J.C., and Scherf A. A central role for Plasmodium falciparum subtelomeric regions in spatial positioning and telomere length regulation. EMBO J. 21 (2002) 815-824
    • (2002) EMBO J. , vol.21 , pp. 815-824
    • Figueiredo, L.M.1    Freitas-Junior, L.H.2    Bottius, E.3    Olivo-Marin, J.C.4    Scherf, A.5
  • 13
    • 0036008446 scopus 로고    scopus 로고
    • Genetic diversity of the DBLalpha region in Plasmodium falciparum var genes among Asia-Pacific isolates
    • Fowler E.V., Peters J.M., Gatton M.L., Chen N., and Cheng Q. Genetic diversity of the DBLalpha region in Plasmodium falciparum var genes among Asia-Pacific isolates. Mol. Biochem. Parasitol. 120 (2002) 117-126
    • (2002) Mol. Biochem. Parasitol. , vol.120 , pp. 117-126
    • Fowler, E.V.1    Peters, J.M.2    Gatton, M.L.3    Chen, N.4    Cheng, Q.5
  • 14
    • 33746288393 scopus 로고    scopus 로고
    • Activation, silencing and mutually exclusive expression within the var gene family of Plasmodium falciparum
    • Frank M., and Deitsch K. Activation, silencing and mutually exclusive expression within the var gene family of Plasmodium falciparum. Int. J. Parasitol. 36 (2006) 975-985
    • (2006) Int. J. Parasitol. , vol.36 , pp. 975-985
    • Frank, M.1    Deitsch, K.2
  • 15
    • 34250009026 scopus 로고    scopus 로고
    • Variable switching rates of malaria virulence genes are associated with chromosomal position
    • Frank M., Dzikowski R., Amulic B., and Deitsch K. Variable switching rates of malaria virulence genes are associated with chromosomal position. Mol. Microbiol. 64 (2007) 1486-1498
    • (2007) Mol. Microbiol. , vol.64 , pp. 1486-1498
    • Frank, M.1    Dzikowski, R.2    Amulic, B.3    Deitsch, K.4
  • 16
    • 33744524946 scopus 로고    scopus 로고
    • Strict pairing of var promoters and introns is required for var gene silencing in the malaria parasite Plasmodium falciparum
    • Frank M., Dzikowski R., Constantini D., Amulic B., Burdougo E., and Deitsch K. Strict pairing of var promoters and introns is required for var gene silencing in the malaria parasite Plasmodium falciparum. J. Biol. Chem. 281 (2006) 9942-9952
    • (2006) J. Biol. Chem. , vol.281 , pp. 9942-9952
    • Frank, M.1    Dzikowski, R.2    Constantini, D.3    Amulic, B.4    Burdougo, E.5    Deitsch, K.6
  • 22
    • 0030176163 scopus 로고    scopus 로고
    • Plasmodium falciparum: isolation of large numbers of parasite clones from infected blood samples
    • Kirkman L.A., Su X.Z., and Wellems T.E. Plasmodium falciparum: isolation of large numbers of parasite clones from infected blood samples. Exp. Parasitol. 83 (1996) 147-149
    • (1996) Exp. Parasitol. , vol.83 , pp. 147-149
    • Kirkman, L.A.1    Su, X.Z.2    Wellems, T.E.3
  • 24
    • 0347517765 scopus 로고    scopus 로고
    • Evidence for the importance of genetic structuring to the structural and functional specialization of the Plasmodium falciparum var gene family
    • Kraemer S.M., and Smith J.D. Evidence for the importance of genetic structuring to the structural and functional specialization of the Plasmodium falciparum var gene family. Mol. Microbiol. 50 (2003) 1527-1538
    • (2003) Mol. Microbiol. , vol.50 , pp. 1527-1538
    • Kraemer, S.M.1    Smith, J.D.2
  • 25
    • 0030744266 scopus 로고    scopus 로고
    • Genomic representation of var gene sequences in Plasmodium falciparum field isolates from different geographic regions
    • Kyes S., Taylor H., Craig A.G., Marsh K., and Newbold C.I. Genomic representation of var gene sequences in Plasmodium falciparum field isolates from different geographic regions. Mol. Biochem. Parasitol. 87 (1997) 235-238
    • (1997) Mol. Biochem. Parasitol. , vol.87 , pp. 235-238
    • Kyes, S.1    Taylor, H.2    Craig, A.G.3    Marsh, K.4    Newbold, C.I.5
  • 26
    • 33845877955 scopus 로고    scopus 로고
    • Hypervariability within the Rifin, Stevor and Pfmc-2TM superfamilies in Plasmodium falciparum
    • Lavazec C., Sanyal S., and Templeton T.J. Hypervariability within the Rifin, Stevor and Pfmc-2TM superfamilies in Plasmodium falciparum. Nucleic Acids Res. 34 (2006) 6696-6707
    • (2006) Nucleic Acids Res. , vol.34 , pp. 6696-6707
    • Lavazec, C.1    Sanyal, S.2    Templeton, T.J.3
  • 27
    • 34250013347 scopus 로고    scopus 로고
    • Expression switching in the stevor and Pfmc-2TM superfamilies in Plasmodium falciparum
    • Lavazec C., Sanyal S., and Templeton T.J. Expression switching in the stevor and Pfmc-2TM superfamilies in Plasmodium falciparum. Mol. Microbiol. 64 (2007) 1621-1634
    • (2007) Mol. Microbiol. , vol.64 , pp. 1621-1634
    • Lavazec, C.1    Sanyal, S.2    Templeton, T.J.3
  • 28
    • 3042642153 scopus 로고    scopus 로고
    • Sub-grouping of Plasmodium falciparum 3D7 var genes based on sequence analysis of coding and non-coding regions
    • Lavstsen T., Salanti A., Jensen A.T.R., Arnot D.E., and Theander T.G. Sub-grouping of Plasmodium falciparum 3D7 var genes based on sequence analysis of coding and non-coding regions. Malar. J. 2 (2003) 27
    • (2003) Malar. J. , vol.2 , pp. 27
    • Lavstsen, T.1    Salanti, A.2    Jensen, A.T.R.3    Arnot, D.E.4    Theander, T.G.5
  • 29
    • 33748669022 scopus 로고    scopus 로고
    • Evidence that Plasmodium falciparum chromosome end clusters are cross-linked by protein and are the sites of both virulence gene silencing and activation
    • Marty A.J., Thompson J.K., Duffy M.F., Voss T.S., Cowman A.F., and Crabb B.S. Evidence that Plasmodium falciparum chromosome end clusters are cross-linked by protein and are the sites of both virulence gene silencing and activation. Mol. Microbiol. 62 (2006) 72-83
    • (2006) Mol. Microbiol. , vol.62 , pp. 72-83
    • Marty, A.J.1    Thompson, J.K.2    Duffy, M.F.3    Voss, T.S.4    Cowman, A.F.5    Crabb, B.S.6
  • 30
  • 32
    • 33845914565 scopus 로고    scopus 로고
    • Genome-wide variation and identification of vaccine targets in the Plasmodium falciparum genome
    • Mu J., Awadalla P., Duan J., McGee K.M., Keebler J., Seydel K., McVean G.A., and Su X.Z. Genome-wide variation and identification of vaccine targets in the Plasmodium falciparum genome. Nat. Genet. 39 (2007) 126-130
    • (2007) Nat. Genet. , vol.39 , pp. 126-130
    • Mu, J.1    Awadalla, P.2    Duan, J.3    McGee, K.M.4    Keebler, J.5    Seydel, K.6    McVean, G.A.7    Su, X.Z.8
  • 34
    • 0024276515 scopus 로고
    • Large deletions result from breakage and healing of P. falciparum chromosomes
    • Pologe L.G., and Ravetch J.V. Large deletions result from breakage and healing of P. falciparum chromosomes. Cell 55 (1988) 869-874
    • (1988) Cell , vol.55 , pp. 869-874
    • Pologe, L.G.1    Ravetch, J.V.2
  • 35
    • 0019395570 scopus 로고
    • Chloroquine sensitivity of isolates of Plasmodium falciparum adapted to in vitro culture
    • Ponnudurai T., Leeuwenberg A.D., and Meuwissen J.H. Chloroquine sensitivity of isolates of Plasmodium falciparum adapted to in vitro culture. Trop. Geogr. Med. 33 (1981) 50-54
    • (1981) Trop. Geogr. Med. , vol.33 , pp. 50-54
    • Ponnudurai, T.1    Leeuwenberg, A.D.2    Meuwissen, J.H.3
  • 38
    • 0037342720 scopus 로고    scopus 로고
    • Widespread functional specialization of Plasmodium falciparum erythrocyte membrane protein 1 family members to bind CD36 analysed across a parasite genome
    • Robinson B.A., Welch T.L., and Smith J.D. Widespread functional specialization of Plasmodium falciparum erythrocyte membrane protein 1 family members to bind CD36 analysed across a parasite genome. Mol Microbiol 47 (2003) 1265-1278
    • (2003) Mol Microbiol , vol.47 , pp. 1265-1278
    • Robinson, B.A.1    Welch, T.L.2    Smith, J.D.3
  • 40
    • 0038046769 scopus 로고    scopus 로고
    • Selective upregulation of a single distinctly structured var gene in chondroitin sulphate A-adhering Plasmodium falciparum involved in pregnancy-associated malaria
    • Salanti A., Staalsoe T., Lavstsen T., Jensen A.T.R., Sowa M.P.K., Arnot D.E., Hviid L., and Theander T.G. Selective upregulation of a single distinctly structured var gene in chondroitin sulphate A-adhering Plasmodium falciparum involved in pregnancy-associated malaria. Mol. Microbiol. 49 (2003) 179-191
    • (2003) Mol. Microbiol. , vol.49 , pp. 179-191
    • Salanti, A.1    Staalsoe, T.2    Lavstsen, T.3    Jensen, A.T.R.4    Sowa, M.P.K.5    Arnot, D.E.6    Hviid, L.7    Theander, T.G.8
  • 41
    • 0028982168 scopus 로고
    • Switches in expression of Plasmodium falciparum var genes correlate with changes in antigenic and cytoadherent phenotypes of infected erythrocytes
    • Smith J.D., Chitnis C.E., Craig A.G., Roberts D.J., Hudson-Taylor D.E., Peterson D.S., Pinches R., Newbold C.I., and Miller L.H. Switches in expression of Plasmodium falciparum var genes correlate with changes in antigenic and cytoadherent phenotypes of infected erythrocytes. Cell 82 (1995) 101-110
    • (1995) Cell , vol.82 , pp. 101-110
    • Smith, J.D.1    Chitnis, C.E.2    Craig, A.G.3    Roberts, D.J.4    Hudson-Taylor, D.E.5    Peterson, D.S.6    Pinches, R.7    Newbold, C.I.8    Miller, L.H.9
  • 42
    • 8644256896 scopus 로고    scopus 로고
    • Pregnancy-associated malaria and the prospects for syndrome-specific antimalaria vaccines
    • Smith J.D., and Deitsch K.W. Pregnancy-associated malaria and the prospects for syndrome-specific antimalaria vaccines. J. Exp. Med. 200 (2004) 1093-1097
    • (2004) J. Exp. Med. , vol.200 , pp. 1093-1097
    • Smith, J.D.1    Deitsch, K.W.2
  • 44
    • 0029070914 scopus 로고
    • A large and diverse gene family (var) encodes 200-350 kD proteins implicated in the antigenic variation and cytoadherence of Plasmodium falciparum-infected erythrocytes
    • Su X., Heatwole V.M., Wertheimer S.P., Guinet F., Herrfeldt J.V., Peterson D.S., Ravetch J.V., and Wellems T.E. A large and diverse gene family (var) encodes 200-350 kD proteins implicated in the antigenic variation and cytoadherence of Plasmodium falciparum-infected erythrocytes. Cell 82 (1995) 89-100
    • (1995) Cell , vol.82 , pp. 89-100
    • Su, X.1    Heatwole, V.M.2    Wertheimer, S.P.3    Guinet, F.4    Herrfeldt, J.V.5    Peterson, D.S.6    Ravetch, J.V.7    Wellems, T.E.8
  • 45
    • 3042642140 scopus 로고    scopus 로고
    • Sympatric Plasmodium falciparum isolates from Venezuela have structured var gene repertoires
    • Tami A., Ord R., Targett G.A., and Sutherland C.J. Sympatric Plasmodium falciparum isolates from Venezuela have structured var gene repertoires. Malar. J. 2 (2003) 7
    • (2003) Malar. J. , vol.2 , pp. 7
    • Tami, A.1    Ord, R.2    Targett, G.A.3    Sutherland, C.J.4
  • 47
    • 0033737488 scopus 로고    scopus 로고
    • Var gene diversity in Plasmodium falciparum is generated by frequent recombination events
    • Taylor H.M., Kyes S.A., and Newbold C.I. Var gene diversity in Plasmodium falciparum is generated by frequent recombination events. Mol. Biochem. Parasitol. 110 (2000) 391-397
    • (2000) Mol. Biochem. Parasitol. , vol.110 , pp. 391-397
    • Taylor, H.M.1    Kyes, S.A.2    Newbold, C.I.3
  • 51
    • 34548683717 scopus 로고    scopus 로고
    • Alterations in local chromatin environment are involved in silencing and activation of subtelomeric var genes in Plasmodium falciparum
    • Voss T.S., Tonkin C.J., Marty A.J., Thompson J.K., Healer J., Crabb B.S., and Cowman A.F. Alterations in local chromatin environment are involved in silencing and activation of subtelomeric var genes in Plasmodium falciparum. Mol. Microbiol. 66 (2007) 139-150
    • (2007) Mol. Microbiol. , vol.66 , pp. 139-150
    • Voss, T.S.1    Tonkin, C.J.2    Marty, A.J.3    Thompson, J.K.4    Healer, J.5    Crabb, B.S.6    Cowman, A.F.7
  • 53
    • 0032805381 scopus 로고    scopus 로고
    • Analysis of Plasmodium falciparum PfEMP-1/var genes suggests that recombination rearranges constrained sequences
    • Ward C.P., Clottey G.T., Dorris M., Ji D.D., and Arnot D.E. Analysis of Plasmodium falciparum PfEMP-1/var genes suggests that recombination rearranges constrained sequences. Mol. Biochem. Parasitol. 102 (1999) 167-177
    • (1999) Mol. Biochem. Parasitol. , vol.102 , pp. 167-177
    • Ward, C.P.1    Clottey, G.T.2    Dorris, M.3    Ji, D.D.4    Arnot, D.E.5


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