Iron from nanocompounds containing iron and zinc is highly bioavailable in rats without tissue accumulation

Nature Nanotechnology

Volumn 5, Issue 5, 2010, Pages 374-380

  Hilty, Florentine M ^a   Arnold, Myrtha ^a   Hilbe, Monika ^b   Teleki, Alexandra ^a   Knijnenburg, Jesper T N ^a   Ehrensperger, Felix ^b   Hurrell, Richard F ^a   Pratsinis, Sotiris E ^a   Langhans, Wolfgang ^a   Zimmermann, Michael B ^a  

^a ETH ZURICH   (Switzerland)

^b UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; COLOR; IRON OXIDES; MAGNESIUM COMPOUNDS; PHOSPHORUS COMPOUNDS; RATS; TISSUE; WATER ABSORPTION; ZINC;

FERROUS SULPHATE; IRON BIOAVAILABILITY; IRON FORTIFICATION; IRON-CONTAINING COMPOUNDS; NANO-STRUCTURED; NUTRITIONAL VALUE; TISSUE ACCUMULATION; WATER SOLUBLE COMPOUNDS;

SULFUR COMPOUNDS;

IRON; MAGNESIUM; NANOMATERIAL; ZINC; HEMOGLOBIN; NANOPARTICLE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ABSORPTION; AEROSOL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; BIOAVAILABILITY; COLOR; HISTOLOGY; MALE; NONHUMAN; NUTRITIONAL VALUE; PRIORITY JOURNAL; RAT; SENSORY SYSTEM; TASTE; ANIMAL; ANTIBODY SPECIFICITY; CHEMISTRY; DIET SUPPLEMENTATION; ELECTROLYSIS; FEEDING BEHAVIOR; METABOLISM; SOLUBILITY; SPRAGUE DAWLEY RAT; ULTRASTRUCTURE; WEIGHT GAIN;

ANIMALS; BIOLOGICAL AVAILABILITY; COLOR; ELECTROLYSIS; FEEDING BEHAVIOR; FOOD, FORTIFIED; HEMOGLOBINS; IRON; MALE; NANOPARTICLES; ORGAN SPECIFICITY; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY; THIOBARBITURIC ACID REACTIVE SUBSTANCES; WEIGHT GAIN; ZINC;

EID: 77952292122     PISSN: 17483387     EISSN: 17483395     Source Type: Journal    
DOI: 10.1038/nnano.2010.79     Document Type: Article

References (47)

1. Allen, L., de Benoist, B., Dary, O. & Hurrell, R. F. Guidelines on Food Fortification with Micronutrients (World Health Organization, 2006).
2. Zimmermann, M. B. & Hurrell, R. F. Nutritional iron deficiency. Lancet 370, 511-520 (2007).
3. International Zinc Nutrition Consultative Group. Assessment of the risk of zinc deficiency and options for its control. Food Nutr. Bull. 25, S91-S204 (2004).
4. Zimmermann, M. B., Chaouki, N. & Hurrell, R. F. Iron deficiency due to consumption of a habitual diet low in bioavailable iron: a longitudinal cohort study in Moroccan children. Am. J. Clin. Nutr. 81, 115-121 (2005).
5. Wieringa, F. T. et al. Combined iron and zinc supplementation in infants improved iron and zinc status, but interactions reduced efficacy in a multicountry trial in southeast asia. J. Nutr. 137, 466-471 (2007).
6. Davidsson, L., Almgren, A., Sandstrom, B. & Hurrell, R. F. Zinc-absorption in adult humans-the effect of iron fortification. Br. J. Nutr. 74, 417-425 (1995).
7. Hurrell, R. F. Fortification: overcoming technical and practical barriers. J. Nutr. 132, 806S-812S (2002).
8. Motzok, I., Pennell, M. D., Davies, M. I. & Ross, H. U. Effect of particle-size on biological availability of reduced iron. J. Assoc. Off. Anal. Chem. 58, 99-103 (1975).
9. Rohner, F. et al. Synthesis, characterization and bioavailability in rats of ferric phosphate nanoparticles. J. Nutr. 137, 614-619 (2007).
10. Mueller, R., Madler, L. & Pratsinis, S. E. Nanoparticle synthesis at high production rates by flame spray pyrolysis. Chem. Eng. Sci. 58, 1969-1976 (2003).
11. Hilty, F. M. et al. Development and optimization of iron- and zinc-containing nanostructured powders for nutritional applications. Nanotechnology 20, 475101 (2009).
12. Lynch, S. R. & Bothwel, T. A comparison of physical properties, screening procedures and a human efficacy trial for predicting the bioavailability of commercial elemental iron powders used for food fortification. Int. J. Vitam. Nutr. Res. 77, 107-124 (2007).
13. Swain, J. H., Newman, S. M. & Hunt, J. R. Bioavailability of elemental iron powders to rats is less than bakery-grade ferrous sulfate and predicted by iron solubility and particle surface area. J. Nutr. 133, 3546-3552 (2003).
14. Otten, J. J., Hellwig, J. P. & Mayers, L. D. Dietary Reference Intakes: The Essential Guide to Nutrient Requirements (Institute of Medicine of the National Academies, 2006).
15. Madler, L., Stark, W. J. & Pratsinis, S. E. Flame-made ceria nanoparticles. J. Mater. Res. 17, 1356-1362 (2002).
16. Jung, I. H., Decterov, S. A. & Pelton, A. D. Critical thermodynamic evaluation and optimization of the Fe-Mg-O system. J. Phys. Chem. Solids 65, 1683-1695 (2004).
17. Dheilly, R. M., Tudo, J. & Queneudec, M. Influence of climatic conditions on the carbonation of quicklime. J. Mater. Eng. Perform. 7, 789-795 (1998).
18. Jossen, R., Pratsinis, S. E., Stark, W. J. & Madler, L. Criteria for flame-spray synthesis of hollow, shell-like or inhomogeneous oxides. J. Am. Ceram. Soc. 88, 1388-1393 (2005).
19. Cunniff, P. & AOAC. in Official Methods of Analysis of AOAC International 62-63 (AOAC International, 1997).
20. Forbes, A. L. et al. Comparison of in vitro, animal and clinical determinations of iron bioavailability: International Nutritional Anemia Consultative Group Task Force report on iron bioavailability. Am. J. Clin. Nutr. 49, 225-238 (1989).
21. Fritz, J. C., Pla, G. W., Harrison, B. N. & Clark, G. A. Collaborative study of rat hemoglobin repletion test for bioavailability of iron. J. Assoc. Off. Anal. Chem. 57, 513-517 (1974).
22. Cornell, R. M. & Schwertmann, U. The Iron Oxides Structure, Properties, Reactions, Occurences and Uses. 2nd edn (Wiley-VCH, 2003).
23. Riedel, E. Anorganische Chemie. 4th edn (de Gruyter, 1999).
24. Yoder, C. H. & Flora, N. J. Geochemical applications of the simple salt approximation to the lattice energies of complex materials. Am. Miner. 90, 488-496 (2005).
25. Lide, D. R. CRC Handbook of Chemistry and Physics (Chapman & Hall/ CRC, 2002).
26. Ifeacho, P.,Wiggers, H. & Roth, P. SnO2/TiO2 mixed oxide particles synthesized in doped premixed H2/O2/Ar flames. Proc. Combust. Inst. 30, 2577-2584 (2005).
27. Tricoli, A., Righettoni, M. & Pratsinis, S. E. Minimal cross-sensitivity to humidity during ethanol detection by SnO2-TiO2 solid solutions. Nanotechnology 20, 315502 (2009).
28. Akurati, K. K. et al. One-step flame synthesis of SnO2/TiO2 composite nanoparticles for photocatalytic applications. Int. J. Photoenergy 7, 153-161 (2005).
29. Vemury, S. & Pratsinis, S. E. Dopants in flame synthesis of titania. J. Am. Ceram. Soc. 78, 2984-2992 (1995).
30. Jani, P., Halbert, G. W., Langridge, J. & Florence, A. T. Nanoparticle uptake by the rat gastrointestinal mucosa-quantitation and particle-size dependency. J. Pharm. Pharmacol. 42, 821-826 (1990).
31. Jani, P. U., McCarthy, D. E. & Florence, A. T. Titanium-dioxide (rutile) particle uptake from the rat GI-tract and translocation to systemic organs after oraladministration. Int. J. Pharm. 105, 157-168 (1994).
32. Wheby, M. S. Site of iron absorption in man. Scand. J. Haematol. 7, 56-62 (1970).
33. Fleming, M. D. et al. Microcytic anaemia mice have a mutation in nramp2, a candidate iron transporter gene. Nature Genet. 16, 383-386 (1997).
34. Garrick, M. D. & Garrick, L. M. Cellular iron transport. Biochim. Biophys. Acta-Gen. Subj. 1790, 309-325 (2009).
35. Wang, J. X. et al. Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration. Toxicol. Lett. 168, 176-185 (2007).
36. Hussain, N., Jaitley, V. & Florence, A. T. Recent advances in the understanding of uptake of microparticulates across the gastrointestinal lymphatics. Adv. Drug Deliv. Rev. 50, 107-142 (2001).
37. Hillyer, J. F. & Albrecht, R. M. Gastrointestinal persorption and tissue distribution of differently sized colloidal gold nanoparticles. J. Pharm. Sci. 90, 1927-1936 (2001).
38. Karlsson, H. L., Cronholm, P., Gustafsson, J. & Moller, L. Copper oxide nanoparticles are highly toxic: a comparison between metal oxide nanoparticles and carbon nanotubes. Chem. Res. Toxicol. 21, 1726-1732 (2008).
39. Volkheim. G., Schulz, F. H., Lindenau, A. & Beitz, U. Persorption of metallic iron particles. Gut 10, 32-33 (1969).
40. Auffan, M. et al. Relation between the redox state of iron-based nanoparticles and their cytotoxicity toward Escherichia coli. Environ. Sci. Technol. 42, 6730-6735 (2008).
41. Hallberg, L., Brune, M. & Rossander, L. Low bioavailability of carbonyl iron in man-studies on iron fortification of wheat-flour. Am. J. Clin. Nutr. 43, 59-67 (1986).
42. Hurrell, R. How to ensure adequate iron absorption from iron-fortified food. Nutr. Rev. 60, S7-S15 (2002).
43. Fidler, M. C., Davidsson, L., Walczyk, T. & Hurrell, R. F. Iron absorption from fish sauce and soy sauce fortified with sodium iron EDTA. Am. J. Clin. Nutr. 78, 274-278 (2003).
44. Reeves, P. G., Nielsen, F. H. & Fahey, G. C. Ain-93 purified diets for laboratory rodents-final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the ain-76a rodent diet. J. Nutr. 123, 1939-1951 (1993).
45. Fluttert, M., Dalm, S. & Oitzl, M. S. A refined method for sequential blood sampling by tail incision in rats. Lab. Anim. 34, 372-378 (2000).
46. Amine, E. K., Hegsted, D. M. & Neff, R. Biological estimation of available iron using chicks or rats. J. Agric. Food Chem. 20, 246-251 (1972).
47. Finney, D. J. in Statistical Methods in Biological Assay 187-213 (Charles Griffin & Company, 1978).