Examination of the efficacy of acute L-alanyl-L-glutamine ingestion during hydration stress in endurance exercise

Journal of the International Society of Sports Nutrition

Volumn 7, Issue , 2010, Pages

  Hoffman, Jay R ^a   Ratamess, Nicholas A ^a   Kang, Jie ^a   Rashti, Stephanie L ^a   Kelly, Neil ^a   Gonzalez, Adam M ^a   Stec, Michael ^a   Anderson, Steven ^a   Bailey, Brooke L ^b   Yamamoto, Linda M ^b   Hom, Lindsay L ^b   Kupchak, Brian R ^b   Faigenbaum, Avery D ^a   Maresh, Carl M ^b  

^a The College of New Jersey   (United States)

^b UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 77952291690     PISSN: None     EISSN: 15502783     Source Type: Journal    
DOI: 10.1186/1550-2783-7-8     Document Type: Article

References (60)

1. Nose H, Morimoto T, Ogura K. Distribution of water losses among fluid compartments of tissues under thermal dehydration in the rat. Jpn J Physiol 1983, 33:1019-1029. 10.2170/jjphysiol.33.1019, 6674653.
2. Senay LC, Pivarnik JN. Fluid shifts during exercise. Exerc Sport Sci Rev 1985, 13:335-387. 10.1249/00003677-198500130-00012, 3891371.
3. Hoffman JR, Stavsky H, Falk B. The effect of water restriction on anaerobic power and vertical jumping height in basketball players. Int J Sports Med 1995, 16:214-218. 10.1055/s-2007-972994, 7657413.
4. Carter JE, Gisolfi CV. Fluid replacement during and after exercise in the heat. Med Sci Sports Exerc 1989, 21:532-539.
5. Armstrong LE, Casa DJ, Roti MW, Lee EC, Craig SA, Sutherland JW, Fiala KA, Maresh CM. Influence of betaine consumption on strenuous running and sprinting in a hot environment. J Strength Cond Res 2008, 22:851-860.
6. Lima AA, Carvalho GH, Figueiredo AA, Gifoni AR, Soares AM, Silva EA, Guerrant RL. Effects of an alanyl-glutamine-based oral rehydration and nutrition therapy solution on electrolyte and water absorption in a rat model of secretory diarrhea induced by cholera toxin. Nutrition 2002, 18:458-462. 10.1016/S0899-9007(02)00775-X, 12044816.
7. Nath SK, Dechelotte P, Darmaun D, Gotteland M, Rongier M, Desjeux JF. (15N) and (14C) glutamine fluxes across rabbit ileum in experimental diarrhea. Am J Physiol 1992, 262:G312-G318.
8. Silva AC, Santos-Neto MS, Soares AM, Fonteles MC, Guerrant RL, Lima AA. Efficacy of a glutamine-based oral rehydration solution on the electrolyte and water absorption in a rabbit model of secretory diarrhea induced by cholera toxin. J Pediatr Gastroenterol Nutr 1998, 26:513-519. 10.1097/00005176-199805000-00006, 9586761.
9. van Loon FP, Banik AK, Nath SK, Patra FC, Wahed MA, Darmaun D, Desjeux JF, Mahalanabis D. The effect of L-glutamine on salt and water absorption: a jejuna perfusion study in cholera in humans. Eur J Gastroenterol Hepatol 1996, 8:443-448.
10. Li Y, Xu B, Liu F, Tan L, Li J. The effect of glutamine-supplemented total parenteral nutrition on nutrition and intestinal absorptive function in a rat model. Pediatr Surg Int 2006, 22:508-513. 10.1007/s00383-006-1693-9, 16736219.
11. Fürst P. New developments in glutamine delivery. J Nutr 2001, 131(suppl):2562-2568.
12. Abilés J, Moreno-Torres R, Moratalla G, Castaño J, Pérez Abúd R, Mudarra A, Muchado MJ, Planells E, Perez de la Cruz A. Effects of supply with glutamine on antioxidant system and lipid peroxidation in patients with parenteral nutrition. Nutr Hosp 2008, 23:332-339.
13. Déchelotte P, Hasselmann M, Cynober L, Allaouchiche B, Coëffier M, Hecketsweiler B, Merle V, Mazerolles M, Samba D, Guillou YM, Petit J, Mansoor O, Colas G, Cohendy R, Barnoud D, Czernichow P, Bleichner G. L-alanyl-L-glutamine dipeptide-supplemented total parenteral nutrition reduces infectious complications and glucose intolerance in critically ill patients: the French controlled, randomized, double-blind, multicenter study. Crit Care Med 2006, 34:598-604. 10.1097/01.CCM.0000201004.30750.D1, 16505644.
14. Kumar HS, Anandan R. Biochemical studies on the cardioprotective effect of glutamine on tissue antioxidant defense system in isoprenaline-induced myocardial infarction in rats. J Clin Biochem Nutr 2007, 40:49-55. 10.3164/jcbn.40.49, 2291504, 18437213.
15. Castell LM, Newsholme EA. Glutamine and the effects of exhaustive exercise upon the immune response. Can J Physiol Pharmacol 1998, 76:524-532. 10.1139/cjpp-76-5-524, 9839078.
16. Favano A, Santos-Silva PR, Nakano EY, Pedrinelli A, Hernandez AJ, Greve JM. Peptide glutamine supplementation for tolerance of intermittent exercise in soccer players. Clinics 2008, 63:27-32. 10.1590/S1807-59322008000100006, 2664173, 18297203.
17. Gleeson M. Dosing and efficacy of glutamine supplementation in human exercise and sport training. J Nutr 2008, 138(suppl):2045-2049.
18. Armstrong LE, Maresh CM, Castellani JW, Bergeron MF, Kenefick RW, LaGasse KE, Riebe D. Urinary indices of hydration status. Int J sport Nutr 1994, 4:265-279.
19. Dill DB, Costill DL. Calculation of percentage changes in volume of blood, plasma and red cells in dehydration. J Appl Physiol 1974, 37:247-248.
20. Klassen P, Mazariegos M, Solomons NW, Furst P. The pharmacokinetic responses of humans to 20 g of alanyl-glutamine dipeptide differ with the dosing protocol but not with gastric acidity or in patients with acute dengue fever. J Nutr 2000, 130:177-182.
21. Ziegler TR, Benfell K, Smith RJ, Young LS, Brown E, Ferrari-Baliviera E, Lowe DK, Wilmore DW. Safety and metabolic effects of L-glutamine administration in humans. J Parenter Enteral Nutr 1990, 14:137S-146S.
22. Rhoads JM, Wu G. Glutamine, arginine and leucine signaling in the intestine. Amino Acids 2009, 37:111-122. 10.1007/s00726-008-0225-4, 19130170.
23. Rogero MM, Tirapegui J, Pedrosa RG, de Castro IA, de Olveira Pires IS, Chem B. Effect of alanyl-glutamine supplementation on plasma and tissue glutamine concentrations in rats submitted to exhaustive exercise. Nutrition 2006, 22:564-571. 10.1016/j.nut.2005.11.002, 16472983.
24. McKenna MJ, Bangsbo J, Renaud JM. Muscle K+, Na+, and Cl disturbances and Na+-K+ pump inactivation: implications for fatigue. J Appl Physiol 2008, 104:288-295. 10.1152/japplphysiol.01037.2007, 17962569.
25. Mourtzakis M, Saltin B, Graham T, Pilegaard H. Carbohydrate metabolism during prolonged exercise and recovery: interactions between pyruvate dehydrogenase, fatty acids, and amino acids. J Appl Physiol 2006, 100:1822-1830. 10.1152/japplphysiol.00571.2005, 16424076.
26. Sumida KD, Donovan CM. Enhanced hepatic gluconeogenic capacity for selected precursors after endurance training. J Appl Physiol 1995, 79:1883-1888.
27. Francesconi RP, Sawka MN, Pandolf KB, Hubbard RW, Young AJ, Muza S. Plasma renin and aldosterone responses at graded hypohydration levels during exercise-heat stress. J Appl Physiol 1985, 59:1855-1860.
28. Montain SJ, Laird JE, Latzka WA, Sawka MN. Aldosterone and vasopressin responses in the heat: hydration level and exercise intensity effects. Med Sci Sports Exerc 1997, 29:661-668.
29. Kenefick RW, Maresh CM, Armstrong LE, Riebe D, Echegaray ME, Castellani JW. Rehydration with fluid of varying tonicities: effects on fluid regulatory hormones and exercise performance in the heat. J Appl Physiol 2007, 102:1899-1905. 10.1152/japplphysiol.00920.2006, 17317877.
30. Koshimizu TA, Nasa Y, Tanoue A, Oikawa R, Kawahara Y, Kiyono Y, Adachi T, Tanaka T, Kuwaki T, Mori T, Takeo S, Okamura H, Tsujimoto G. V1a vasopressin receptors maintain normal blood pressure by regulating circulating blood volume and baroreflex sensitivity. Proc Natl Acad Sci 2006, 103:7807-7812. 10.1073/pnas.0600875103, 1472526, 16682631.
31. Brandenberger G, Candas V, Follenius M, Libert JP, Kahn JM. Vascular fluid shifts and endocrine response to exercise in the heat. Eur J Appl Physiol 1986, 55:123-129.
32. Convertino VA, Keil LC, Greenleaf JE. Plasma volume, renin, and vasopressin responses to graded exercise after training. J Appl Physiol 1983, 54:508-514.
33. Castell LM, Poortmans JR, LeClercq R, Brassuer M, Duchateau J, Newsholme EA. Some aspects of the acute phase response after a marathon race, and the effects of glutamine supplementation. Eur J Appl Physiol 1997, 75:47-53.
34. Miles MP, Andring JM, Pearson SD, Gordon LK, Kasper C, Depner CM, Kidd JR. Diurnal variation, response to eccentric exercise, and association of inflammatory mediators with muscle damage variables. J Appl Physiol 2008, 104:451-458. 10.1152/japplphysiol.00572.2007, 18079262.
35. Neubauer O, Konig D, Wagner KH. Recovery after an ironman triathlon: sustained inflammatory responses and muscular stress. Eur J Appl Physiol 2008, 104:417-426. 10.1007/s00421-008-0787-6, 18548269.
36. Mahm C, Sjodin B, Sjoberg B, Lenderi R, Renstrom P, Lundberg IE, Ekblom B. Leukocytes, cytokines, growth factors and hormones in skeletal muscle and blood after uphill or downhill running. J Physiol 2004, 556:983-1000. 10.1113/jphysiol.2003.056598, 1664987, 14766942.
37. Gleeson M, Almey J, Brooks S, Cave R, Lewis A, Griffiths H. Haematological and acute-phase responses associated with delayed-onset muscle soreness in humans. Eur J Applied Physiol Occup Physiol 1995, 71:137-142.
38. Hiscock N, Petersen EW, Krzywkowski K, Boza J, Halkjaer-Kristensen J, Pedersen BK. Glutamine supplementation further enhances exercise-induced plasma IL-6. J Appl Physiol 2003, 95:145-148.
39. Jonsdottir IH, Schjerling P, Ostrowski K, Asp S, Richter EA, Pedersen BK. Muscle contractions induce interleukin-6 mRNA production in rat skeletal muscles. J Physiol 2000, 528:157-163. 10.1111/j.1469-7793.2000.00157.x, 2270126, 11018114.
40. Nybo L, Nielsen B, Pedersen BK, Moller K, Secher NH. Interleukin-6 release from the human brain during prolonged exercise. J Physiol 2002, 542:991-995. 10.1113/jphysiol.2002.022285, 2290444, 12154196.
41. Pedersen BK, Steensberg A, Fischer C, Keller C, Ostrowski K, Schjerling P. Exercise and cytokines with particular focus on muscle derived IL-6. Exerc Immunol Rev 2001, 8:18-31.
42. Ridker PM, Cushman M, Stampfer MJ, Tracy RP, Hennekens CH. Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. N Eng J Med 1997, 336:973-979.
43. Phillips T, Childs AC, Dreon DM, Phinney S, Leeuwenburgh C. A dietary supplement attenuates IL-6 and CRP after eccentric exercise in untrained males. Med Sci Sports Exerc 2003, 35:2032-2037. 10.1249/01.MSS.0000099112.32342.10, 14652498.
44. Robson-Ansley P, Barwood M, Eglin C, Ansley L. The effect of carbohydrate ingestion on the interleukin-6 response to a 90-minute run time trial. Int J Sports Physiol Perf 2009, 4:186-194.
45. Andreasen AS, Pedersen-Skovsgaard T, Mortensen OH, van Hall G, Moseley PL, Pedersen BK. The effect of glutamine infusion on the inflammatory response and HSP70 during human experimental endotoxaemia. Crit Care 2009, (13):R7. 10.1186/cc7696, 2688119, 19173710.
46. Petersen AMW, Pedersen BK. The role of IL-6 in mediating the anti-inflammatory effects of exercise. J Physiol Pharmacol 2006, 57(Suppl):43-51.
47. Allesio HM. Exercise-induced oxidative stress. Med Sci Sports Exerc 1993, 25:218-224.
48. Paik IY, Jeong MH, Jin HE, Kim YI, Suh AR, Cho SY, Roh HT, Jin CH, Suh SH. Fluid replacement following dehydration reduces oxidative stress during recovery. Biochem Biophys Res Comm 2009, 383:103-107. 10.1016/j.bbrc.2009.03.135, 19344695.
49. Hoffman JR, Ratamess NA, Tranchina CP, Rashti SL, Kang J, Faigenbaum AD. Effect of Protein Ingestion on Recovery Indices Following a Resistance Training Protocol in Strength/Power Athletes. Amino Acids 2009,
50. Bottecchia D, Bordin D, Martino R. Effect of different kinds of physical exercise on the plasmatic testosterone level of normal adult males. Sports Med 1987, 27:1-5.
51. Galbo H, Hammer L, Peterson IB, Christensen NJ, Bic N. Thyroid and testicular hormone responses to gradual and prolonged exercise in man. J Appl Physiol 1977, 36:101-106.
52. Hoffman JR, Maresh CM, Armstrong LE, Gabaree CL, Bergeron MF, Kenefick RW, Castellani JW, Ahlquist LE, Ward A. Effects of hydration state on plasma testosterone, cortisol, and catecholamine concentrations before and during mild exercise at elevated temperature. Eur J Appl Physiol 1994, 69:294-300.
53. Brandenberger G, Candas V, Follenius M, Kahn JM. The influence of initial state of hydration on endocrine responses to exercise in the heat. Eur J Appl Physiol 1989, 58:674-679.
54. Maresh CM, Whittlesey MJ, Armstrong LE, Yamamoto LM, Judelson DA, Fish KE, Casa DJ, Kavouras SA, Castracane VD. Effect of hydration state on testosterone and cortisol responses to training-intensity exercise in collegiate runners. Int J Sports Med 2006, 27:765-770. 10.1055/s-2005-872932, 17006802.
55. Judelson DA, Maresh CM, Yamamoto LM, Ferrell MJ, Armstrong LE, Kraemer WJ, Volek JS, Spiering BA, Casa DJ, Anderson JM. Effect of hydration state on resistance exercise-induced endocrine markers of anabolism, catabolism, and metabolism. J Appl Physiol 2008, 105:816-824. 10.1152/japplphysiol.01010.2007, 18617629.
56. Gordon SE, Kraemer WJ, Vos NH, Lynch JM, Knuttgen HG. Effect of acid-base balance on the growth hormone response to acute high-intensity cycle exercise. J Appl Physiol 1994, 76:821-829.
57. Peyreigne C, Bouix D, Fédou C, Mercier J. Effect of hydration on exercise-induced growth hormone response. Eur J Endocrinol 2001, 145:445-450. 10.1530/eje.0.1450445, 11581003.
58. Suminski RR, Robertson RJ, Goss GL, Arsianian S, Kang J, DaSilva S, Utter AC, Metz KF. Acute effect of amino acid ingestion and resistance exercise on plasma growth hormone concentration in young men. Int J Sports Nutr 1997, 7:48-60.
59. Welbourne TC. Increased plasma bicarbonate and growth hormone after an oral glutamine load. Am J Clin Nutr 1995, 61:1058-1061.
60. Duska F, Fric M, Pazout J, Waldauf P, Tuma P, Pachl J. Frequent intravenous pulses of growth hormone together with alanylglutamine supplementation in prolonged critical illness after multiple trauma: effects on glucose control, plasma IGF-1 and glutamine. Growth Horm IGF Res 2008, 18:82-87. 10.1016/j.ghir.2007.07.003, 17709266.