Glutamine supplementation further enhances exercise-induced plasma IL-6

Journal of Applied Physiology

Volumn 95, Issue 1, 2003, Pages 145-148

  Hiscock, N ^a   Petersen, E W ^a   Krzywkowski, K ^a   Boza, J ^b   Halkjaer Kristensen, J ^a   Pedersen, B K ^a  

^a Rigshospitalet   (Denmark)

^b NESTLÉ RESEARCH CENTER   (Switzerland)

Author keywords

Acute exercise; Cytokines; Skeletal muscle

Indexed keywords

GLUTAMINE; INTERLEUKIN 6; OXYGEN; PROTEIN;

ADULT; AMINO ACID BLOOD LEVEL; ARTICLE; BICYCLE ERGOMETRY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; EXERCISE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN INTAKE; PROTEIN SYNTHESIS; RANDOMIZED CONTROLLED TRIAL; SKELETAL MUSCLE;

EID: 0037633265     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/japplphysiol.00471.2002     Document Type: Article

References (18)

1. Dill DB and Costill DL. Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. J Appl Physiol 37: 247-248, 1974.
2. Fischer CP, Bode BP, Takahashi K, Tanabe KK, and Souba WW. Glucocorticoid-dependent induction of interleukin-6 receptor expression in human hepatocytes facilitates interleukin-6 stimulation of amino acid transport. Ann Surg 223: 610-618, 1996.
3. Heinrikson RL and Meredith SC. Amino acid analysis by reverse-phase high-performance liquid chromatography: precolumn derivatization with phenylisothiocyanate. Anal Biochem 136: 65-74, 1984.
4. Hundal HS, Rennie MJ, and Watt PW. Characteristics of L-glutamine transport in perfused rat skeletal muscle. J Physiol 393: 283-305, 1987.
5. Keller C, Steensberg A, Pilegaard H, Osada T, Saltin B, Pedersen BK, and Neufer PD. Transcriptional activation of the IL-6 gene in human contracting skeletal muscle: influence of muscle glycogen content. FASEB J 15: 2748-2750, 2001.
6. Krzywkowski K, Petersen EW, Ostrowski K, Kristensen JH, Boza J, and Pedersen BK. Effect of glutamine supplementation on exercise-induced changes in lymphocyte function. Am J Physiol Cell Physiol 281: C1259-C1265, 2001.
7. Lyngsø D, Simonsen L, and Bülow J. Metabolic effects of interleukin-6 in human splanchnic and adipose tissue. J Physiol 543:379-386, 2002.
8. Matthews DE, Marano MA, and Campbell RG. Splanchnic bed utilization of glutamine and glutamic acid in humans. Am J Physiol Endocrinol Metab 264: E848-E854, 1993.
9. Mittendorfer B, Volpi E, and Wolfe RR. Whole body and skeletal muscle glutamine metabolism in healthy subjects. Am J Physiol Endocrinol Metab 280: E323-E333, 2001.
10. Nehlsen-Cannarella SL, Fagoaga OR, Nieman DC, Henson DA, Butterworth DE, Schmitt RL, Bailey EM, Warren BJ, Utter A, and Davis JM. Carbohydrate and the cytokine response to 25 h of running. J Appl Physiol 82: 1662-1667, 1997.
11. Nieman DC, Fagoaga OR, Butterworth DE, Warren BJ, Utter A, Davis JM, Henson DA, and Nehlsen-Cannarella SL. Carbohydrate supplementation affects blood granulocyte and monocyte trafficking but not function after 25 h of running. Am J Clin Nutr 66: 153-159, 1997.
12. Ostrowski K, Rohde T, Zacho M, Asp S, and Pedersen BK. Evidence that interleukin-6 is produced in human skeletal muscle during prolonged running. J Physiol 583: 949-953, 1998.
13. Pedersen BK, Steensberg A, and Schjerling P. Exercise and interleukin-6. Curr Opin Hematol 8: 137-141, 2001.
14. Rennie MJ, MacLennan DA, Hundal HS, Weryk B, Smith K, Taylor PM, Egan C, and Watt PW. Skeletal muscle glutamine transport, intramuscular glutamine concentration, and muscle protein turnover. Metabolism 38: 47-51, 1989.
15. Rohde T, Asp S, McLean DA, and Pedersen BK. Competitive sustained exercise in humans, lymphokine-activated killer cell activity, and glutamine - an intervention study. Eur J Appl Physiol 78: 448-453, 1998.
16. Rohde T, MacLean DA, Hartkopp A, and Pedersen BK. The immune system and serum glutamine during a triathlon. Eur J Appl Physiol 74: 428-434, 1996.
17. Steensberg A, van Hall G, Osada T, Sacchetti M, Saltin B, and Pedersen BK. Production of interleukin-6 in contracting human skeletal muscles can account for the exercise-induced increase in plasma interleukin-6. J Physiol 529: 237-242, 2000.
18. Watkins KT, Dudrick PS, Copeland EM, and Souba WW. Interleukin-6 and dexamethasone work coordinately to augment hepatic amino acid transport. J Trauma 36: 523-528, 1994.