Osthol regulates hepatic PPARα-mediated lipogenic gene expression in alcoholic fatty liver murine

Phytomedicine

Volumn 17, Issue 8-9, 2010, Pages 669-673

  Sun, Fan ^a   Xie, Mei lin ^a   Xue, Jie ^a   Wang, Heng bin ^b  

^a SOOCHOW UNIVERSITY   (China)

^b Changshu Leiyunshang Pharmaceutical Co Ltd   (China)

Author keywords

Alcoholic fatty liver; Cnidium monnieri (L.) Cusson; MK886; Osthol; Peroxisome proliferator activated receptor

Indexed keywords

3 HYDROXY 3 METHYLGLUTARYL COENZYME A; CHOLESTEROL 7ALPHA MONOOXYGENASE; DIACYLGLYCEROL ACYLTRANSFERASE; OSTHOLE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA;

ALCOHOLIC FATTY LIVER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; GENE EXPRESSION REGULATION; LIPOGENESIS; LIVER CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; CHOLESTEROL 7-ALPHA-HYDROXYLASE; CNIDIUM; COUMARINS; DIACYLGLYCEROL O-ACYLTRANSFERASE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FATTY LIVER, ALCOHOLIC; FRUIT; GENE EXPRESSION; HEPATOCYTES; HYDROXYMETHYLGLUTARYL COA REDUCTASES; HYPOLIPIDEMIC AGENTS; LIVER; MALE; MICE; MICE, INBRED STRAINS; PHYTOTHERAPY; PPAR ALPHA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

APIACEAE; CNIDIUM MONNIERI; MURINAE; MUS; RATTUS;

EID: 77952290406     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phymed.2009.10.021     Document Type: Article

References (32)

1. Berger J., and Moller D.E. The mechanisms of action of PPARs. Rev. Med. 53 (2002) 409-435
2. Braissant O., Foufelle F., Scotto C., et al. Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat. Endocrinology 137 (1996) 354-366
3. Chiang J.L. Bile acid regulation of gene expression: roles of nuclear hormone receptors. Endocrine 23 (2002) 443-463
4. Diehl A.M. Nonalcoholic fatty liver disease: implications for alcoholic liver disease pathogenesis. Alcohol Clin. Exp. Res. 25 (2001) 8S-14S
5. Diehl A.M. Liver disease in alcohol abusers: clinical perspective. Alcohol 27 (2002) 7-11
6. Duval C., Muller M., and Kersten S. PPARα and dyslipidemia. Biochim. Biophys. Acta 1771 (2007) 961-971
7. Farese Jr. R.V., Cases S., and Smith S.J. Triglyceride synthesis: insights from the cloning of diacylglycerol acyltransferase. Curr. Opin. Lipidol. 11 (2000) 229-234
8. Guo J.Y., Wang Q.J., and Wu J.H. Studies on the protective effect of saponins from polygala aureocauda on animal models of liver injury. Chin. J. Nat. Med. 4 (2006) 303-307
9. Kaikaus R.M., Chan W.K., Ortiz d., et al. Mechanisms of regulation of liver fatty acid-binding protein. Mol. Cell Biochem. 123 (1993) 93-100
10. Kehrer J.P., Biswal S.S., La E., et al. Inhibition of peroxisome-proliferator-activated receptor (PPAR) α by MK886. Biochem. J. 356 (2001) 899-906
11. Konig B., Koch A., Spielmann J., et al. Activation of PPARα lowers synthesis and concentration of cholesterol by reduction of nuclear SREBP-2. Biochem. Pharmacol. 73 (2007) 574-585
12. Kuo P.L., Hsu Y.L., Chang C.H., and Chang J.K. Osthol-mediated cell differentiation through bone morphogenetic protein-2/p38 and extracellular signal-regulated kinase 1/2 pathway in human osteoblast cells. J. Pharmacol. Exp. Ther. 314 (2005) 1290-1299
13. Kwon H.J., Hyun S.H., and Choung S.Y. Traditional Chinese medicine improves dysfunction of peroxisome proliferator-activated receptor alpha and microsomal triglyceride transfer protein on abnormalities in lipid metabolism in ethanol-fed rats. Biofactors 23 (2005) 163-176
14. Lian Q.S. Progress in study of chemical constituents and pharmacological effects of the fruit of Cnidium monnieri. Chin. Med. Mater. 26 (2003) 141-144
15. Liu J.X., Zhang W.P., Zhou L., et al. Anti-inflammatory effect and mechanism of osthol in rats. J. Chin. Med. Mater. 28 (2005) 1002-1006
16. Noshiro M., Usui E., Kawamoto T., et al. Multiple mechanisms regulate circadian expression of the gene for cholesterol 7α-hydroxylase(Cyp7a), a key enzyme in hepatic bile acid biosynthesis. J. Biol. Rhythm 22 (2007) 299-311
17. Ockner R.K., Kaikaus R.M., and Bass N.M. Fatty-acid metabolism and the pathogenesis of hepatocellular carcinoma: review and hypothesis. Hepatology 18 (1993) 669-676
18. Okamoto T., Kawasaki T., and Hino O. Osthol prevents anti-fas antibody-induced hepatitis in mice by affecting the caspase-3-mediated apoptotic pathway. Biochem. Pharmacol. 65 (2003) 677-681
19. Okamoto T., Kobavashi T., and Yoshida S. Chemical aspects of coumarin compounds for the prevention of hepatocellular carcinomas. Curr. Med. Chem. Anticancer Agents 5 (2005) 47-51
20. Qin S., Liu T.J., Kamanna V.S., and Kashyap M.L. Pioglitazone stimulates apolipoprotein A-I production without affecting HDL removal in HepG2 cells involvement of PPAR-α. Arterioscler. Thromb. Vasc. Biol. 27 (2007) 2428-2434
21. Ringseis R., Muschick A., and Eder K. Dietary oxidized fat prevents ethanol-induced triacylglycerol accumulation and increases expression of PPARα target genes in rat liver. J. Nutr. 137 (2007) 77-83
22. Schoonjans K., Staels B., and Auwerx J. Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression. J. Lipid Res. 37 (1996) 907-925
23. Siler S.Q., Neese R.A., and Hellerstein M.K. De novo lipogenesis, lipid kinetics, and whole-body lipid balances in humans after acute alcohol consumption. Am. J. Clin. Nutr. 70 (1999) 928-936
24. Song F., Xie M.L., Zhu L.J., et al. Experimental study of osthol on treatment of hyperlipidemic and alcoholic fatty liver in animals. World J. Gastroenterol. 12 (2006) 4359-4363
25. Sun F., Xie M.L., Zhu L.J., and Gu Z.L. Inhibitory effect of osthol on alcohol-induced fatty liver in mice. Digest. Liver Dis. 41 (2009) 127-133
26. Wang S.H., An F., Zhang D.S., and Zhang L. Experiment study on anti-oxidation effect of osthol. Chin. Tradit. Patent Med. 27 (2005) 488-489
27. Waterman I.J., and Zammit V.A. Differential effects of fenofibrate or simvastatin treatment of rats on hepatic microsomal overt and latent diacylglycerol acyltransferase activities. Diabetes 51 (2002) 1708-1713
28. Yuan Z., Xu H., Wang K., et al. Determination of osthol and its metabolites in a phase I reaction system and the Caco-2 cell model by HPLC-UV and LC-MS/MS. J. Pharm. Biomed. Anal. 49 (2009) 1226-1232
29. Zhang Q., Qin L., He W., et al. Coumarins from Cnidium monnieri and their antiosteoporotic activity. Planta Med. 73 (2007) 13-19
30. Zhao M., Yang X.F., and Huang J.M. Study on liver injury model induced by alcohol. Chin. J. Public Health 21 (2005) 1101-1102
31. Zhou J., Cheng W.X., and Xu Y.H. Experimental study on anti-tumour effect of osthol extracted from the fruits of Cnidium monnieri (L.) Cusson. Zhejiang J. Integr. Tradit. West Med. 12 (2002) 76-78
32. Zhou J., Wang S.W., and Sun X.L. Determination of osthol in rat plasma by high-performance liquid chromatograph using cloud-point extraction. Anal. Chim. Acta 608 (2008) 158-164