A novel polysaccharide, isolated from Angelica sinensis (Oliv.) Diels induces the apoptosis of cervical cancer HeLa cells through an intrinsic apoptotic pathway

Phytomedicine

Volumn 17, Issue 8-9, 2010, Pages 598-605

  Cao, W ^a   Li, X Q ^a   Wang, X ^b   Fan, H T ^a   Zhang, X N ^a   Hou, Y ^a   Liu, S B ^a   Mei, Q B ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b XI'AN MEDICAL UNIVERSITY   (China)

Author keywords

Angelica sinensis; Antitumor; Apoptosis; HeLa cell; Polysaccharide

Indexed keywords

ALCOHOL; ANGELICA SINENSIS EXTRACT; APS 1D POLYSACCHARIDE; BENZYLOXYCARBONYLLEUCYLGLUTAMYLHISTIDYLASPARTYL FLUOROMETHYL KETONE; CASPASE 3; CASPASE 8; CASPASE 9; CYTOCHROME C; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; POLYSACCHARIDE; PROTEIN BCL 2; PROTEIN BID; UNCLASSIFIED DRUG; WATER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; ENZYME ACTIVATION; FEMALE; FLOW CYTOMETRY; HELA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOSIS INHIBITION; MOUSE; NICK END LABELING; NONHUMAN; NUDE MOUSE; PLANT ROOT; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TUMOR XENOGRAFT; UTERINE CERVIX CANCER; WESTERN BLOTTING;

ANGELICA SINENSIS; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BLOTTING, WESTERN; CASPASES; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CYTOCHROMES C; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FLOW CYTOMETRY; HELA CELLS; HUMANS; IN SITU NICK-END LABELING; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, INBRED BALB C; MICE, NUDE; OLIGOPEPTIDES; PHYTOTHERAPY; PLANT EXTRACTS; POLY(ADP-RIBOSE) POLYMERASES; POLYSACCHARIDES; PROTO-ONCOGENE PROTEINS C-BCL-2; SIGNAL TRANSDUCTION; UTERINE CERVICAL NEOPLASMS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

ANGELICA SINENSIS; MUS MUSCULUS;

EID: 77952287178     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phymed.2009.12.014     Document Type: Article

References (28)

1. Burlacu A. Regulation of apoptosis by Bcl-2 family proteins. J. Cell. Mol. Med. 7 (2003) 249-257
2. Cao W., Li X.Q., Liu L., Wang M., Fan H.T., Li C., Lv Z., Wang X., and Mei Q. Structural analysis of water-soluble glucans from the root of Angelica sinensis (Oliv.) Diels. Carbohydr. Res. 341 (2006) 1870-1877
3. Cao W., Li X.Q., Liu L., Yang T.H., Li C., Fan H.T., Jia M., Lv Z.G., and Mei Q.B. Structure of an anti-tumor polysaccharide from Angelica sinensis (Oliv.) Diels. Carbohydr. Polym. 66 (2006) 149-159
4. Chihara G., Maeda Y., Hamuro J., Sasaki T., and Fukuoka F. Inhibition of mouse sarcoma 180 by polysaccharides from Lentinus edodes (Berk.) sing. Nature 222 (1969) 687-688
5. Desagher S., and Martinou J.C. Mitochondria as the central control point of apoptosis. Trends Cell Biol. 10 (2000) 369-377
6. Fullerton S.A., Samadi A.A., Tortorelis D.G., Choudhury M.S., Mallouh C., Tazaki H., and Konno S. Induction of apoptosis in human prostatic cancer cells with beta-glucan (Maitake mushroom polysaccharide). Mol. Urol. 4 (2000) 7-13
7. Hao Z., Duncan G.S., Chang C.C., Elia A., Fang M., Wakeham A., Okada H., Calzascia T., Jang Y., You-Ten A., Yeh W.C., Ohashi P., Wang X., and Mak T.W. Specific ablation of the apoptotic functions of cytochrome C reveals a differential requirement for cytochrome C and Apaf-1 in apoptosis. Cell 121 (2005) 579-591
8. Kiho T., Yoshida I., Nagai K., Ukai S., and Hara C. (1-3)-alpha-d-glucan from an alkaline extract of Agrocybe cylindracea, and antitumor activity of its O-(carboxymethyl)ated derivatives. Carbohydr. Res. 189 (1989) 273-279
9. Kobayashi H., Yoshida R., Kanada Y., Fukuda Y., Yagyu T., Inagaki K., Kondo T., Kurita N., Suzuki M., Kanayama N., and Terao T. Suppressing effects of daily oral supplementation of beta-glucan extracted from Agaricus blazei Murill on spontaneous and peritoneal disseminated metastasis in mouse model. J. Cancer Res. Clin. Oncol. 131 (2005) 527-538
10. Kodama N., Komuta K., and Nanba H. Can maitake MD-fraction aid cancer patients?. Altern. Med. Rev. 7 (2002) 236-239
11. Lin X., Cai Y.J., Li Z.X., Liu Z.L., Yin S.F., and Zhao J.C. Cladonia furcata polysaccharide induced apoptosis in human leukemia K562 cells. Acta Pharmacol. Sin. 22 (2001) 716-720
12. Liu X., Kim C.N., Yang J., Jemmerson R., and Wang X. Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell 86 (1996) 147-157
13. Lowe S.W., and Lin A.W. Apoptosis in cancer. Carcinogenesis 21 (2000) 485-495
14. Mehmet H. Caspases find a new place to hide. Nature 403 (2000) 29-30
15. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 65 (1983) 55-63
16. Nakazato H., Koike A., Saji S., Ogawa N., and Sakamoto J. Efficacy of immunochemotherapy as adjuvant treatment after curative resection of gastric cancer. Study Group of Immunochemotherapy with PSK for Gastric Cancer. Lancet 343 (1994) 1122-1126
17. Ooi V.E., and Liu F. Immunomodulation and anti-cancer activity of polysaccharide-protein complexes. Curr. Med. Chem. 7 (2000) 715-729
18. Park M.T., Choi J.A., Kim M.J., Um H.D., Bae S., Kang C.M., Cho C.K., Kang S., Chung H.Y., Lee Y.S., and Lee S.J. Suppression of extracellular signal-related kinase and activation of p38 MAPK are two critical events leading to caspase-8- and mitochondria-mediated cell death in phytosphingosine-treated human cancer cells. J. Biol. Chem. 278 (2003) 50624-50634
19. Rein D.T., and Kurbacher C.M. The role of chemotherapy in invasive cancer of the cervix uteri: current standards and future prospects. Anticancer Drugs 12 (2001) 787-795
20. Salvesen G.S., and Dixit V.M. Caspases: intracellular signaling by proteolysis. Cell 91 (1997) 443-446
21. Sarker S.D., and Nahar L. Natural medicine: the genus Angelica. Curr. Med. Chem. 11 (2004) 1479-1500
22. Shang P., Qian A.R., Yang T.H., Jia M., Mei Q.B., Cho C.H., Zhao W.M., and Chen Z.N. Experimental study of anti-tumor effects of polysaccharides from Angelica sinensis. World J. Gastroenterol. 9 (2003) 1963-1967
23. Shin J.Y., Song J.Y., Yun Y.S., Yang H.O., Rhee D.K., and Pyo S. Immunostimulating effects of acidic polysaccharides extract of Panax ginseng on macrophage function. Immunopharmacol. Immunotoxicol. 24 (2002) 469-482
24. Wajant H. The Fas signaling pathway: more than a paradigm. Science 296 (2002) 1635-1636
25. Wasser S.P. Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides. Appl. Microbiol. Biotechnol. 60 (2002) 258-274
26. Zaidman B.Z., Yassin M., Mahajna J., and Wasser S.P. Medicinal mushroom modulators of molecular targets as cancer therapeutics. Appl. Microbiol. Biotechnol. 67 (2005) 453-468
27. Zhang M., Chen H., Huang J., Li Z., Zhu C., and Zhang S. Effect of lycium barbarum polysaccharide on human hepatoma QGY7703 cells: inhibition of proliferation and induction of apoptosis. Life Sciences 76 (2005) 2115-2124
28. Zou H., Li Y., Liu X., and Wang X. An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9. J. Biol. Chem. 274 (1999) 11549-11556