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1
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47749154418
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The frequency of cognitive impairment in patients with anxiety, depression, and bipolar disorder: An unaccounted source of variance in clinical trials
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This interesting study compares huge samples of different patient groups and controls across five neurocognitive domains. It supports the categorization of clinically relevant impairment instead of merely calculating mean values. The frequency of cognitive impairment reflects the amount of variability in patients that needs to be considered when interpreting clinical trials
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Gualtieri CT, Morgan DW. The frequency of cognitive impairment in patients with anxiety, depression, and bipolar disorder: an unaccounted source of variance in clinical trials. J Clin Psychiatry 2008;69:1122-1130. This interesting study compares huge samples of different patient groups and controls across five neurocognitive domains. It supports the categorization of clinically relevant impairment instead of merely calculating mean values. The frequency of cognitive impairment reflects the amount of variability in patients that needs to be considered when interpreting clinical trials.
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(2008)
J. Clin. Psychiatry
, vol.69
, pp. 1122-1130
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Gualtieri, C.T.1
Morgan, D.W.2
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2
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58149178891
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Cognitive endophenotypes of bipolar disorder: A meta-analysis of neuropsychological deficits in euthymic patients and their first-degree relatives
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Bora E, Yucel M, Pantelis C. Cognitive endophenotypes of bipolar disorder: a meta-analysis of neuropsychological deficits in euthymic patients and their first-degree relatives. J Affect Disord 2009;113:1-20.
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(2009)
J. Affect Disord.
, vol.113
, pp. 1-20
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Bora, E.1
Yucel, M.2
Pantelis, C.3
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3
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55749092118
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Executive and verbal working memory dysfunction in first-degree relatives of patients with bipolar disorder
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Bora E, Vahip S, Akdeniz F, et al. Executive and verbal working memory dysfunction in first-degree relatives of patients with bipolar disorder. Psychiatry Res 2008;161:318-324.
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(2008)
Psychiatry Res.
, vol.161
, pp. 318-324
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Bora, E.1
Vahip, S.2
Akdeniz, F.3
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4
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61449122245
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Investigating the association between neurocognition and psychosis in bipolar disorder: Further evidence for the overlap with schizophrenia
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Jabben N, Arts B, Krabbendam L, van Os J. Investigating the association between neurocognition and psychosis in bipolar disorder: further evidence for the overlap with schizophrenia. Bipolar Disord 2009;11:166-177.
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(2009)
Bipolar Disord.
, vol.11
, pp. 166-177
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Jabben, N.1
Arts, B.2
Krabbendam, L.3
Van Os, J.4
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5
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61449102731
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Memory functioning in familial bipolar I disorder patients and their relatives
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Quraishi S, Walshe M, McDonald C, et al. Memory functioning in familial bipolar I disorder patients and their relatives. Bipolar Disord 2009;11:209-214.
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(2009)
Bipolar Disord.
, vol.11
, pp. 209-214
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Quraishi, S.1
Walshe, M.2
McDonald, C.3
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6
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73949134112
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Neurocognitive dysfunction in bipolar and schizophrenia spectrum disorders depends on history of psychosis rather than diagnostic group
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Epub ahead of print. This article highlights the impact of psychosis overlapping with antipsychotic medication effects as a moderator of cognitive functioning across different diagnostic groups of psychotic illnesses
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Simonsen C, Sundet K, Vaskinn A, et al. Neurocognitive dysfunction in bipolar and schizophrenia spectrum disorders depends on history of psychosis rather than diagnostic group. Schizophr Bull 2009 [Epub ahead of print]. This article highlights the impact of psychosis (overlapping with antipsychotic medication effects) as a moderator of cognitive functioning across different diagnostic groups of psychotic illnesses.
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(2009)
Schizophr Bull.
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Simonsen, C.1
Sundet, K.2
Vaskinn, A.3
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7
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62849120975
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Neurocognitive function in pediatric bipolar disorder: 3-year follow-up shows cognitive development lagging behind healthy youths
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An interesting follow-up study that illustrates the developmental course of the most prominent cognitive impairments in bipolar disorder
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Pavuluri MN, West A, Hill SK, et al. Neurocognitive function in pediatric bipolar disorder: 3-year follow-up shows cognitive development lagging behind healthy youths. J Am Acad Child Adolesc Psychiatry 2009;48:299-307. An interesting follow-up study that illustrates the developmental course of the most prominent cognitive impairments in bipolar disorder.
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(2009)
J. Am. Acad. Child Adolesc Psychiatry
, vol.48
, pp. 299-307
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Pavuluri, M.N.1
West, A.2
Hill, S.K.3
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8
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49849088733
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Short-term course of neuropsychological abilities in middle-aged and older adults with bipolar disorder
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Here you can find prospective data describing the variability of neurocognition in elderly patients
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Depp CA, Savla GN, Moore DJ, et al. Short-term course of neuropsychological abilities in middle-aged and older adults with bipolar disorder. Bipolar Disord 2008;10:684-690. Here you can find prospective data describing the variability of neurocognition in elderly patients.
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(2008)
Bipolar Disord.
, vol.10
, pp. 684-690
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Depp, C.A.1
Savla, G.N.2
Moore, D.J.3
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9
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70350528709
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The longitudinal course of cognition in older adults with bipolar disorder
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Epub ahead of print. This is a prospective study highlighting the changes of cognitive function and their intra-individual variability in old patients. Remarkably, the authors tried to minimize polypharmacy in their sample
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Gildengers AG, Mulsant BH, Begley A, et al. The longitudinal course of cognition in older adults with bipolar disorder. Bipolar Disord 2009 [Epub ahead of print]. This is a prospective study highlighting the changes of cognitive function and their intra-individual variability in old patients. Remarkably, the authors tried to minimize polypharmacy in their sample.
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(2009)
Bipolar Disord.
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Gildengers, A.G.1
Mulsant, B.H.2
Begley, A.3
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10
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53749084111
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Neuropsychological profile in bipolar disorder: A preliminary study of monotherapy lithium-treated euthymic bipolar patients evaluated at a 2-year interval
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Follow-up data of a sample of patients on monotherapy are presented; results call verbal memory dysfunctions into question
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Mur M, Portella MJ, Martínez-Aran A, et al. Neuropsychological profile in bipolar disorder: a preliminary study of monotherapy lithium-treated euthymic bipolar patients evaluated at a 2-year interval. Acta Psychiatr Scand 2008;118: 373-381. Follow-up data of a sample of patients on monotherapy are presented; results call verbal memory dysfunctions into question.
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(2008)
Acta Psychiatr. Scand.
, vol.118
, pp. 373-381
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Mur, M.1
Portella, M.J.2
Martínez-Aran, A.3
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12
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60949099213
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Differential deficit in executive control in euthymic bipolar disorder
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authors offer an explanation of verbal memory deficits using regression analyses. Verbal memory impairment was moderated by executive functioning and psychomotor speed but not by group membership patients vs. controls
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Thompson JM, Gray JM, Crawford JR, et al. Differential deficit in executive control in euthymic bipolar disorder. J Abnorm Psychol 2009;118:146-160. The authors offer an explanation of verbal memory deficits using regression analyses. Verbal memory impairment was moderated by executive functioning and psychomotor speed but not by group membership (patients vs. controls).
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(2009)
J. Abnorm Psychol.
, vol.118
, pp. 146-160
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Thompson, J.M.1
Gray, J.M.2
Crawford, J.R.3
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14
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70350532584
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Cognitive features in euthymic bipolar patients in old age
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Epub ahead of print
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Delaloye C, Moy G, Baudois S, et al. Cognitive features in euthymic bipolar patients in old age. Bipolar Disord 2009 [Epub ahead of print].
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(2009)
Bipolar Disord.
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Delaloye, C.1
Moy, G.2
Baudois, S.3
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15
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70349571876
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Is psychopharmacologic treatment associated with neuropsychological deficits in bipolar youth?
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Epub ahead of print. This work provides valuable data on differences between medicated and drug-free pediatric patients
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Henin A, Mick E, Biederman J, et al. Is psychopharmacologic treatment associated with neuropsychological deficits in bipolar youth? J Clin Psychiatry 2009 [Epub ahead of print]. This work provides valuable data on differences between medicated and drug-free pediatric patients.
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(2009)
J. Clin. Psychiatry
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Henin, A.1
Mick, E.2
Biederman, J.3
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16
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70449435377
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The neurocognitive performance of drug-free and medicated euthymic bipolar patients do not differ
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Epub ahead of print. This is one of the few studies describing the performance of drug-free euthymic bipolar patients compared with patients on mood-stabilizing medication
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Goswami U, Sharma A, Varma A, et al. The neurocognitive performance of drug-free and medicated euthymic bipolar patients do not differ. Acta Psychiatr Scand 2009 [Epub ahead of print]. This is one of the few studies describing the performance of drug-free euthymic bipolar patients compared with patients on mood-stabilizing medication.
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(2009)
Acta Psychiatr. Scand.
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Goswami, U.1
Sharma, A.2
Varma, A.3
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17
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62749097251
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Attention and psychomotor functioning in bipolar depression
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Burdick KE, Gunawardane N, Goldberg JF, et al. Attention and psychomotor functioning in bipolar depression. Psychiatry Res 2009;166:192-200.
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(2009)
Psychiatry Res.
, vol.166
, pp. 192-200
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Burdick, K.E.1
Gunawardane, N.2
Goldberg, J.F.3
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18
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53249090159
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A comparison of cognitive functioning in medicated and unmedicated subjects with bipolar depression
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Even during a depressive episode the authors revealed impairments only in patients treated with mood stabilizers compared with controls or unmedicated depressed bipolar disorder patients
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Holmes MK, Erickson K, Luckenbaugh DA, et al. A comparison of cognitive functioning in medicated and unmedicated subjects with bipolar depression. Bipolar Disord 2008;10:806-815. Even during a depressive episode the authors revealed impairments only in patients treated with mood stabilizers compared with controls or unmedicated depressed bipolar disorder patients.
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(2008)
Bipolar Disord.
, vol.10
, pp. 806-815
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Holmes, M.K.1
Erickson, K.2
Luckenbaugh, D.A.3
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19
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61449241918
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Hot and cold cognition in un-medicated depressed subjects with bipolar disorder
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This article provides evidence for task-specific impairment and unimpaired functions in symptomatic unmedicated patients
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Roiser JP, Cannon DM, Gandhi SK, et al. Hot and cold cognition in unmedicated depressed subjects with bipolar disorder. Bipolar Disord 2009;11: 178-189. This article provides evidence for task-specific impairment and unimpaired functions in symptomatic unmedicated patients.
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(2009)
Bipolar Disord.
, vol.11
, pp. 178-189
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Roiser, J.P.1
Cannon, D.M.2
Gandhi, S.K.3
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20
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42949132114
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Wisconsin card sorting test performance in bipolar disorder: Effects of mood state and early course
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Differences between euthymic, first-episode and multiepisode patients and controls are described, supporting unimpaired cognitive flexibility in euthymic patients
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Fleck DE, Shear PK, Madore M, Strakowski SM. Wisconsin Card Sorting Test performance in bipolar disorder: effects of mood state and early course. Bipolar Disord 2008;10:539-545. Differences between euthymic, first-episode and multiepisode patients and controls are described, supporting unimpaired cognitive flexibility in euthymic patients.
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(2008)
Bipolar Disord.
, vol.10
, pp. 539-545
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Fleck, D.E.1
Shear, P.K.2
Madore, M.3
Strakowski, S.M.4
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21
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70350712944
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Executive functioning in twins with bipolar I disorder and healthy co-twins
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Epub ahead of print. There are very few twin studies on bipolar disorder. Although the influence of a shared family environment could not be ruled out, results suggest a shared vulnerability for executive dysfunction
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Juselius S, Kieseppä T, Kaprio J, et al. Executive functioning in twins with bipolar i disorder and healthy co-twins. Arch Clin Neuropsychol 2009 [Epub ahead of print]. There are very few twin studies on bipolar disorder. Although the influence of a shared family environment could not be ruled out, results suggest a shared vulnerability for executive dysfunction.
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(2009)
Arch. Clin. Neuropsychol.
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Juselius, S.1
Kieseppä, T.2
Kaprio, J.3
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22
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42149103292
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Neurocognition in first-degree healthy relatives (siblings) of bipolar affective disorder patients
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Trivedi JK, Goel D, Dhyani M, et al. Neurocognition in first-degree healthy relatives (siblings) of bipolar affective disorder patients. Psychiatry Clin Neurosci 2008;62:190-196.
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(2008)
Psychiatry Clin. Neurosci.
, vol.62
, pp. 190-196
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Trivedi, J.K.1
Goel, D.2
Dhyani, M.3
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23
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59149095624
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Brain lithium levels and effects on cognition and mood in geriatric bipolar disorder: A lithium-7 magnetic resonance spectroscopy study
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This study depicts very important aspects of lithium treatment for clinical practice
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Forester BP, Streeter CC, Berlow YA, et al. Brain lithium levels and effects on cognition and mood in geriatric bipolar disorder: a lithium-7 magnetic resonance spectroscopy study. Am J Geriatr Psychiatry 2009;17:13-23. This study depicts very important aspects of lithium treatment for clinical practice.
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(2009)
Am. J. Geriatr Psychiatry
, vol.17
, pp. 13-23
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Forester, B.P.1
Streeter, C.C.2
Berlow, Y.A.3
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24
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70349622778
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Response to prophylactic lithium in bipolar disorder may be associated with a preservation of executive cognitive functions
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Epub ahead of print. Differential treatment response, as revealed by the authors, might be a source of variance in clinical trials
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Rybakowski JK, Permoda-Osip A, Borkowska A. Response to prophylactic lithium in bipolar disorder may be associated with a preservation of executive cognitive functions. Eur Neuropsychopharmacol 2009 [Epub ahead of print]. Differential treatment response, as revealed by the authors, might be a source of variance in clinical trials.
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(2009)
Eur. Neuropsychopharmacol
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Rybakowski, J.K.1
Permoda-Osip, A.2
Borkowska, A.3
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25
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65249151244
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Selective deficits in semantic verbal fluency in patients with a first affective episode with psychotic symptoms and a positive history of mania
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Kravariti E, Reichenberg A, Morgan K, et al. Selective deficits in semantic verbal fluency in patients with a first affective episode with psychotic symptoms and a positive history of mania. Bipolar Disord 2009;11:323-329.
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(2009)
Bipolar Disord.
, vol.11
, pp. 323-329
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Kravariti, E.1
Reichenberg, A.2
Morgan, K.3
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26
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70349569517
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Neurocognitive dysfunctions in euthymic bipolar patients with and Without prior history of alcohol use
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Sanchez-Moreno J, Martinez-Aran A, Colom F, et al. Neurocognitive dysfunctions in euthymic bipolar patients with and without prior history of alcohol use. J Clin Psychiatry 2009;70:1120-1127.
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(2009)
J. Clin. Psychiatry
, vol.70
, pp. 1120-1127
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Sanchez-Moreno, J.1
Martinez-Aran, A.2
Colom, F.3
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27
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67349263819
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Reduced brain activation in euthymic bipolar patients during response inhibition: An event-related fmri study
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Although performance of bipolar patients and controls is similar, different activation patterns display changes that might lead to impairment for a group of patients
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Kaladjian A, Jeanningros R, Azorin JM, et al. Reduced brain activation in euthymic bipolar patients during response inhibition: an event-related fMRI study. Psychiatry Res 2009;173:45-51. Although performance of bipolar patients and controls is similar, different activation patterns display changes that might lead to impairment for a group of patients.
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(2009)
Psychiatry Res.
, vol.173
, pp. 45-51
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Kaladjian, A.1
Jeanningros, R.2
Azorin, J.M.3
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28
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65249120164
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No altered dorsal anterior cingulate activation in bipolar II disorder patients during a go/no-go task: An fMRI study
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It is very important to document the lack of functional alterations to reliably confirm possible regions of interest
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Welander-Vatn AS, Jensen J, Lycke C, et al. No altered dorsal anterior cingulate activation in bipolar II disorder patients during a Go/No-go task: an fMRI study. Bipolar Disord 2009;11:270-279. It is very important to document the lack of functional alterations to reliably confirm possible regions of interest.
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(2009)
Bipolar Disord.
, vol.11
, pp. 270-279
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Welander-Vatn, A.S.1
Jensen, J.2
Lycke, C.3
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29
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50849110818
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Event related oscillations in euthymic patients with bipolar disorder
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This study integrates neuropsychological assessment and ERP data of unmedicated patients
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Ozerdem A, Kocaaslan S, Tunca Z, Basar E. Event related oscillations in euthymic patients with bipolar disorder. Neurosci Lett 2008;444:5-10. This study integrates neuropsychological assessment and ERP data of unmedicated patients.
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(2008)
Neurosci. Lett.
, vol.444
, pp. 5-10
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Ozerdem, A.1
Kocaaslan, S.2
Tunca, Z.3
Basar, E.4
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30
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56349121155
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Neuropsychological and electrophysiological indices of neurocognitive dysfunction in bipolar II disorder
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Andersson S, Barder HE, Hellvin T, et al. Neuropsychological and electrophysiological indices of neurocognitive dysfunction in bipolar II disorder. Bipolar Disord 2008;10:888-899.
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(2008)
Bipolar Disord.
, vol.10
, pp. 888-899
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Andersson, S.1
Barder, H.E.2
Hellvin, T.3
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31
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65249090148
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Increased trait-like impulsivity and course of illness in bipolar disorder
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Swann AC, Lijffijt M, Lane SD, et al. Increased trait-like impulsivity and course of illness in bipolar disorder. Bipolar Disord 2009;11:280-288.
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(2009)
Bipolar Disord.
, vol.11
, pp. 280-288
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Swann, A.C.1
Lijffijt, M.2
Lane, S.D.3
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32
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58149511062
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Conceptualizing impulsivity and risk taking in bipolar disorder: Importance of history of alcohol abuse
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Holmes MK, Bearden CE, Barguil M, et al. Conceptualizing impulsivity and risk taking in bipolar disorder: importance of history of alcohol abuse. Bipolar Disord 2009;11:33-40.
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(2009)
Bipolar Disord.
, vol.11
, pp. 33-40
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Holmes, M.K.1
Bearden, C.E.2
Barguil, M.3
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33
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56349109979
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An fmri investigation of working memory and sadness in females with bipolar disorder: A brief report
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Deckersbach T, Rauch SL, Buhlmann U, et al. An fMRI investigation of working memory and sadness in females with bipolar disorder: a brief report. Bipolar Disord 2008;10:928-942.
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(2008)
Bipolar Disord.
, vol.10
, pp. 928-942
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Deckersbach, T.1
Rauch, S.L.2
Buhlmann, U.3
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34
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77952240904
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Pathological amygdala activation during working memory performance: Evidence for a pathophysiological trait marker in bipolar affective disorder
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Epub ahead of print
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Gruber O, Tost H, Henseler I, et al. Pathological amygdala activation during working memory performance: evidence for a pathophysiological trait marker in bipolar affective disorder. Hum Brain Mapp 2009 [Epub ahead of print].
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(2009)
Hum Brain Mapp
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Gruber, O.1
Tost, H.2
Henseler, I.3
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35
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72549105001
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Alterations in functional activation in euthymic bipolar disorder and schizophrenia during a working memory task
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Epub ahead of print
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Hamilton LS, Altshuler LL, Townsend J, et al. Alterations in functional activation in euthymic bipolar disorder and schizophrenia during a working memory task. Hum Brain Mapp 2009 [Epub ahead of print].
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(2009)
Hum Brain Mapp
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Hamilton, L.S.1
Altshuler, L.L.2
Townsend, J.3
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36
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77952243553
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An fmri study of working memory in persons with bipolar disorder or at genetic riskfor bipolar disorder
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Epub ahead of print
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Thermenos HW, Goldstein JM, Milanovic SM, et al. An fMRI study of working memory in persons with bipolar disorder or at genetic riskfor bipolar disorder. Am J Med Genet B Neuropsychiatr Genet 2009 [Epub ahead of print].
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(2009)
Am. J. Med. Genet. B Neuropsychiatr Genet.
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Thermenos, H.W.1
Goldstein, J.M.2
Milanovic, S.M.3
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37
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58149116951
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Bridging the gap between schizophrenia and psychotic mood disorders: Relating neurocognitive deficits to psychopathology
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Smith MJ, Barch DM, Csernansky JG. Bridging the gap between schizophrenia and psychotic mood disorders: relating neurocognitive deficits to psychopathology. Schizophr Res 2009;107:69-75.
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(2009)
Schizophr Res.
, vol.107
, pp. 69-75
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Smith, M.J.1
Barch, D.M.2
Csernansky, J.G.3
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38
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58549100310
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Relation between cigarette smoking and cognitive function in euthymic individuals with bipolar disorder
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Law CW, Soczynska JK, Woldeyohannes HO, et al. Relation between cigarette smoking and cognitive function in euthymic individuals with bipolar disorder. Pharmacol Biochem Behav 2009;92:12-16.
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(2009)
Pharmacol. Biochem. Behav.
, vol.92
, pp. 12-16
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Law, C.W.1
Soczynska, J.K.2
Woldeyohannes, H.O.3
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39
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67049107964
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Amygdala volume and verbal memory performance in schizophrenia and bipolar disorder
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This article supports the role of morphometric changes for memory function in bipolar disorder
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Killgore WD, Rosso IM, Gruber SA, Yurgelun-Todd DA. Amygdala volume and verbal memory performance in schizophrenia and bipolar disorder. Cogn Behav Neurol 2009;22:28-37. This article supports the role of morphometric changes for memory function in bipolar disorder.
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(2009)
Cogn Behav. Neurol.
, vol.22
, pp. 28-37
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Killgore, W.D.1
Rosso, I.M.2
Gruber, S.A.3
Yurgelun-Todd, D.A.4
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42
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58749104984
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Serum homocysteine levels and cognitive functioning in euthymic bipolar patients
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differential impact of homocysteine levels might be useful for understanding cognitive variability in patient samples
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Dias VV, Brissos S, Cardoso C, et al. Serum homocysteine levels and cognitive functioning in euthymic bipolar patients. J Affect Disord 2009;113: 285-290. The differential impact of homocysteine levels might be useful for understanding cognitive variability in patient samples.
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(2009)
J. Affect Disord.
, vol.113
, pp. 285-290
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Dias, V.V.1
Brissos, S.2
Cardoso, C.3
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43
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56349148767
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Cognitive functioning in euthymic bipolar I and bipolar II patients
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This is a well written article that helps to clarify the impact of potential moderators on cognitive functioning
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Dittmann S, Hennig-Fast K, Gerber S, et al. Cognitive functioning in euthymic bipolar I and bipolar II patients. Bipolar Disord 2008;10:877-887. This is a well written article that helps to clarify the impact of potential moderators on cognitive functioning.
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(2008)
Bipolar Disord.
, vol.10
, pp. 877-887
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Dittmann, S.1
Hennig-Fast, K.2
Gerber, S.3
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44
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68749103456
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Cognitive function and serum levels of brain-derived neurotrophic factor in patients with bipolar disorder
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Dias VV, Brissos S, Frey BN, et al. Cognitive function and serum levels of brain-derived neurotrophic factor in patients with bipolar disorder. Bipolar Disord 2009;11:663-671.
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(2009)
Bipolar Disord.
, vol.11
, pp. 663-671
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Dias, V.V.1
Brissos, S.2
Frey, B.N.3
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46
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64349106057
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Neurocognitive functions in euthymic bipolar patients
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These analyses provide preliminary evidence for medication effects in bipolar patients or subgroups of patients with different cognitive performance levels
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Jamrozinski K, Gruber O, Kemmer C, et al. Neurocognitive functions in euthymic bipolar patients. Acta Psychiatr Scand 2009;119:365-374. These analyses provide preliminary evidence for medication effects in bipolar patients or subgroups of patients with different cognitive performance levels.
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(2009)
Acta Psychiatr. Scand.
, vol.119
, pp. 365-374
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Jamrozinski, K.1
Gruber, O.2
Kemmer, C.3
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47
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67849101387
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Neuropsychological abnormalities in schizophrenia and major mood disorders: Similarities and differences
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Barch DM. Neuropsychological abnormalities in schizophrenia and major mood disorders: similarities and differences. Curr Psychiatry Rep 2009;11: 313-319.
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(2009)
Curr. Psychiatry Rep.
, vol.11
, pp. 313-319
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Barch, D.M.1
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48
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68049137330
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A comparison of neuropsychological dysfunction in first-episode psychosis patients with unipolar depression, bipolar disorder, and schizophrenia
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Hill SK, Reilly JL, Harris MS, et al. A comparison of neuropsychological dysfunction in first-episode psychosis patients with unipolar depression, bipolar disorder, and schizophrenia. Schizophr Res 2009;113:167-175.
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Schizophr Res.
, vol.113
, pp. 167-175
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Hill, S.K.1
Reilly, J.L.2
Harris, M.S.3
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50
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60949093291
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Magnetic resonance imaging studies in early onset bipolar disorder: An updated review
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