Brain lithium levels and effects on cognition and mood in geriatric bipolar disorder: A Lithium-7 magnetic resonance spectroscopy study

American Journal of Geriatric Psychiatry

Volumn 17, Issue 1, 2009, Pages 13-23

  Forester, Brent P ^a,b   Streeter, Chris C ^a,b,c   Berlow, Yosef A ^a,b   Tian, Hua ^c   Wardrop, Megan ^a   Finn, Chelsea T ^a   Harper, David ^a,b   Renshaw, Perry F ^a,b   Moore, Constance M ^a,b  

^a MCLEAN HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Bipolar disorder; Elderly; Frontal lobe dysfunction; Lithium; MR spectroscopy

Indexed keywords

LITHIUM; LITHIUM DERIVATIVE; NEUROLEPTIC AGENT;

ADULT; AGED; ARTICLE; BIPOLAR DISORDER; BRAIN DYSFUNCTION; BRAIN FUNCTION; CLINICAL ARTICLE; COGNITION; CROSS-SECTIONAL STUDY; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG EFFECT; DRUG SAFETY; FEMALE; FRONTAL LOBE; GERONTOPSYCHIATRY; HAMILTON SCALE; HUMAN; INSTRUMENTATION; MALE; MOOD; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PSYCHOLOGIC TEST; RATING SCALE; SCORING SYSTEM; SYMPTOM; WISCONSIN CARD SORTING TEST; YOUNG MANIA RATING SCALE; AFFECT; BLOOD; BRAIN LEVEL; METABOLISM; MIDDLE AGED; NEUROPSYCHOLOGICAL TEST; ONSET AGE; PHYSIOLOGY;

ADULT; AFFECT; AGE OF ONSET; AGED; AGED, 80 AND OVER; ANTIPSYCHOTIC AGENTS; BIPOLAR DISORDER; BRAIN CHEMISTRY; COGNITION; FEMALE; FRONTAL LOBE; HUMANS; LITHIUM COMPOUNDS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS;

EID: 59149095624     PISSN: 10647481     EISSN: 15457214     Source Type: Journal    
DOI: 10.1097/JGP.0b013e318172b3d0     Document Type: Article

References (45)

1. Goldberg JF: Treatment guidelines: current and future management of bipolar disorder. J Clin Psychiatry 2000; 61(suppl 13):12-18
2. Umapathy C, Mulsant BH, Pollock BG: Bipolar disorder in the elderly. Psychiatr Ann 2000; 30:473-480
3. Gildengers AG, Mulsant BH, Begley AE, et al: A pilot study of standardized treatment in geriatric bipolar disorder. Am J Geriatr Psychiatry 2005; 13:319-323
4. Sajatovic M, Gyulai L, Calabrese JR, et al: Maintenance treatment outcomes in older patients with bipolar I disorder. Am J Geriatr Psychiatry 2005; 13:305-311
5. Nambudiri DE, Meyers BS, Young RC: Delayed recovery from lithium neurotoxicity. J Geriatr Psychiatry Neurol 1991; 4:40-43
6. Goodwin FK, Jamison KR: Psychotherapy, in Manic Depressive Illness. Edited by Goodwin FK, Jamison KR. Oxford, Oxford University Press, 1990, pp 725-745
7. Depp CA, Lindamer LA, Folsom DP, et al: Differences in clinical features and mental health service use in bipolar disorder across the lifespan. Am J Geriatr Psychiatry 2005; 13:290-298
8. Gildengers AG, Butters MA, Seligman K, et al: Cognitive functioning in late-life bipolar disorder. Am J Psychiatry 2004; 161:736-788
9. Sajatovic M: Treatment of bipolar disorder in older adults. Int J Geriatr Psychiatry 2002; 17:865-873
10. Moore CM, Demopulos CM, Henry ME, et al: Brain-to-serum lithium ratio and age: an in vivo magnetic resonance spectroscopy study. Am J Psychiatry 2002; 159:1240-1242
11. Kato T, Fujii K, Shioiri T, et al: Lithium side effects in relation to brain lithium concentration measured by lithium-7 magnetic resonance spectroscopy. Prog Neuropsychopharmacol Biol Psychiatry 1996; 20:87-97
12. Hardman TC, Dubrey SW, Soni S, et al: Relation of sodium-lithium countertransport activity to markers of cardiovascular risk in normotensive subjects. J Hum Hypertens 1995; 9:589-596
13. Hardman TC, Croft P, Morrish Z, et al: Kinetic characteristics of the erythrocyte sodium-lithium countertransporter in black normotensive subjects compared with three other ethnic groups. J Hum Hypertens 1998; 12:29-34
14. Trevisan M, Cooper R, Ostrow D, et al: Red cell cation transport: differences between black and white school children. J Hypertens 1983; 1:245-249
15. Golden C, Freshwater SM: Stroop Color and Word Test: Adult Version. Wood Dale, Ill., Stoelting, 2002
16. Army Individual Test Battery: Manual of Directions and Scoring. Washington, D.C., War Department, Adjunct General's Office, 1944
17. Kongs SK, Thompson LL, Iverson GL, et al: Wisconsin Card Sorting Test-64 Version (WCST-64) Manual. Odessa, FL, Psychological Assessment Resources, 2000
18. Lezak MD: Domains of behavior from a neuropsychological perspective: the whole story. Nebr Symp Motiv 1994; 41:23-55
19. Psychological Corporation: Wechsler Abbreviated Scale of Intelligence Manual. San Antonio, Harcourt Brace & Company, 1999
20. Welsh KA, Butters N, Mohs RC, et al: The Consortium to Establish a Registry for Alzheimer's Disease (CERAD): Part V. A normative study of the neuropsychological battery. Neurology 1994; 44:609-614
21. Kaplan E, Goodglass H, Weintraub S: The Boston Naming Test. Boston, Mass., Veterans Administration Medical Center, 1978
22. Folstein MF, Folstein SE, McHugh PR: "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975; 12:189-198
23. Gladsjo JA, Schuman CC, Evans JD, et al: Norms for letter and category fluency: demographic corrections for age, education, and ethnicity. Assessment 1999; 6:147-178
24. Tombaugh TN: Trail making test A and B: normative data stratified by age and education. Arch Clin Neuropsychol 2004; 19:203-214
25. Hamilton M: A rating scale for depression. J Neurol Neurosurg Psychiatry 1960; 23:56-62
26. Young RC, Biggs JT, Ziegler VE, et al: A rating scale for mania: reliability, validity and sensitivity. Br J Psychiatry 1978; 133:429-435
27. Ordidge R, Connelly A, Lohman J: Image-selected in-vivo spectroscopy (ISIS). A new technique for spatially selective NMR spectroscopy. J Magn Reson 1986; 66:283-294
28. Gonzalez RG, Guimaraes AR, Sachs GS, et al: Measurement of human brain lithium in vivo by MR spectroscopy. AJNR Am J Neuroradiol 1993; 14:1027-1037
29. Moore CM, Frederick BD, Henry ME, et al: Human in vivo lithium magnetic resonance spectroscopy at 4.0 Tesla: initial findings. Biol Psychiatry 2003; 53:202S
30. Sachs GS, Renshaw PF, Lafer B, et al: Variability of brain lithium levels during maintenance treatment: a magnetic resonance spectroscopy study. Biol Psychiatry 1995; 38:422-428
31. Young RC, Gyulai L, Mulsant BH, et al: Pharmacotherapy of bipolar disorder in old age: review and recommendations. Am J Geriatr Psychiatry 2004; 12:342-357
32. Pachet AK, Wisniewski AM: The effects of lithium on cognition: an updated review. Psychopharmacology (Berl) 2003; 170:225-234
33. Bearden CE, Hoffman KM, Cannon TD: The neuropsychology and neuroanatomy of bipolar affective disorder: a critical review. Bipolar Disord 2001; 3:106-150; discussion 151-153
34. Borkowska A, Rybakowski JK: Neuropsychological frontal lobe tests indicate that bipolar depressed patients are more impaired than unipolar. Bipolar Disord 2001; 3:88-94
35. Gruber SA, Rogowska J, Yurgelun-Todd DA: Decreased activation of the anterior cingulate in bipolar patients: an fMRI study. J Affect Disord 2004; 82:191-201
36. Blumberg HP, Leung HC, Skudlarski P, et al: A functional magnetic resonance imaging study of bipolar disorder: state- and trait-related dysfunction in ventral prefrontal cortices. Arch Gen Psychiatry 2003; 60:601-609
37. Dixon T, Kravariti E, Frith C, et al: Effect of symptoms on executive function in bipolar illness. Psychol Med 2004; 34:811-821
38. Murphy FC, Sahakian BJ: Neuropsychology of bipolar disorder. Br J Psychiatry 2001; 178(suppl 41):S120-S127
39. McKay AP, Tarbuck AF, Shapleske J, et al: Neuropsychological function in manic-depressive psychosis. Evidence for persistent deficits in patients with chronic, severe illness. Br J Psychiatry 1995; 167:51-57
40. Honig A, Arts BM, Ponds RW, et al: Lithium induced cognitive side-effects in bipolar disorder: a qualitative analysis and implications for daily practice. Int Clin Psychopharmacol 1999; 14:167-171
41. Sproule BA, Hardy BG, Shulman KI: Differential pharmacokinetics of lithium in elderly patients. Drugs Aging 2000; 16:165-177
42. Platman SR, Fieve RR: Biochemical aspects of lithium in affective disorders. Arch Gen Psychiatry 1968; 19:659-663
43. Mooradian AD: Potential mechanisms of the age-related changes in the blood-brain barrier. Neurobiol Aging 1994; 15:751-755; discussion 761-762, 767
44. Hewick DS, Newbury P, Hopwood S, et al: Age as a factor affecting lithium therapy. Br J Clin Pharmacol 1977; 4:201-205
45. Keevil SF: Spatial localization in nuclear magnetic resonance spectroscopy. Phys Med Biol 2006; 51:R579-R636