Treatment of a retinal dystrophy, fundus albipunctatus, with oral 9-cis-β-carotene

British Journal of Ophthalmology

Volumn 94, Issue 5, 2010, Pages 616-621

  Rotenstreich, Ygal ^a,c   Harats, Dror ^a,c   Shaish, Aviv ^a   Pras, Eran ^b,c   Belkin, Michael ^a,c  

^a SHEBA MEDICAL CENTER   (Israel)

^b ASSAF HAROFEH MEDICAL CENTER   (Israel)

^c TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

9 BETA CAROTENE; BETA CAROTENE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; DIET SUPPLEMENTATION; ELECTRORETINOGRAM; EYE FUNDUS ALBIPUNCTATUS; FEMALE; HUMAN; MALE; NIGHT VISION; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; RETINA DYSTROPHY; VISUAL FIELD;

ADMINISTRATION, ORAL; ADOLESCENT; ADULT; BETA CAROTENE; DIETARY SUPPLEMENTS; ELECTRORETINOGRAPHY; EYE DISEASES, HEREDITARY; FEMALE; HUMANS; MALE; MIDDLE AGED; PILOT PROJECTS; PROSPECTIVE STUDIES; RETINAL DEGENERATION; TREATMENT OUTCOME; VISUAL ACUITY; VISUAL FIELDS; VITAMINS; YOUNG ADULT;

EID: 77952228897     PISSN: 00071161     EISSN: 14682079     Source Type: Journal    
DOI: 10.1136/bjo.2009.167049     Document Type: Article

References (25)

1. Wald G. The molecular basis of visual excitation. Nature 1968;219:800-807
2. Urbach J, Rando RR. Isomerization of all-trans-retinoic acid to 9-cis-retinoic acid. Biochem J 1994;299:459-465
3. Van Hooser JP, Liang Y, Maeda T, et al. Recovery of visual functions in a mouse model of Leber congenital amaurosis. J Biol Chem 2002;277:19173-19182 (Pubitemid 34952484)
4. Ablonczy Z, Crouch R, Goletz P, et al. 11-cis retinal reduces constitutive opsin phosphorylation and improves quantum catch in retinoid-deficient mouse rod photoreceptors. J Biol Chem 2002;277:40491-40498 (Pubitemid 35215626)
5. Imanishi Y, Batten ML, Piston DW, et al. Noninvasive two-photon imaging reveals retinyl ester storage structures in the eye. J Cell Biol 2004;164:373-383 (Pubitemid 38174765)
6. Cideciyan AV, Haeseleer F, Fariss RN, et al. Rod and cone visual cycle consequences of a null mutation in the 11-cis-retinol dehydrogenase gene in man. Vis Neurosci 2000;17:667-678 (Pubitemid 32046103)
7. Yamamoto H, Simon A, Eriksson U, et al. Mutations in the gene encoding 11-cis retinol dehydrogenase cause delayed dark adaptation and Fundus albipunctatus. Nat Genet 1999;22:188-191 (Pubitemid 29264816)
8. Maeda A, Maeda T, Palczewski K. Improvement in rod and cone function in mouse model of Fundus albipunctatus after pharmacologic treatment with 9-cis-retinal. Invest Ophthalmol Vis Sci 2006;47:4540-4546 (Pubitemid 46579383)
9. Berson EL, Rosner B, Sandberg MA, et al. A randomized trial of vitamin A and vitamin E supplementation for retinitis pigmentosa. Arch Ophthalmol 1993;111:761-772 (Pubitemid 23170587)
10. Ben-Amotz A, Lers A, Avron M. Stereoisomers of b-carotene and phytoene in the alga Dunaliella bardawil. Plant Physiol 1988;86:1286-1291
11. Omenn GS, Goodman GE, Thornquist MD, et al. Risk factors for lung cancer and for intervention effects in CARET, the Beta-Carotene and Retinol Efficacy Trial. J Natl Cancer Inst 1996;88:1550-1559
12. Shaish A, Harari A, Hananshvili L, et al. 9-cis beta-carotene-rich powder of the alga Dunaliella bardawil increases plasma HDL-cholesterol in fibrate-treated patients. Atherosclerosis 2006;189:215-221 (Pubitemid 44468070)
13. Brown M, Marmor M, Vaegan, et al. ISCEV standard for clinical electro-oculography (EOG). Doc Ophthalmol 2006;113:205-212 (Pubitemid 44835005)
14. Van Hooser JP, Aleman TS, He YG, et al. Rapid restoration of visual pigment and function with oral retinoid in a mouse model of childhood blindness. Proc Natl Acad Sci USA 2000;97:8623-8628
15. Harari A, Harats D, Marko D, et al. A 9-cis beta-carotene-enriched diet inhibits atherogenesis and fatty liver formation in LDL receptor knockout mice. J Nutr 2008;138:1923-1930
16. Fan J, Rohrer B, Moiseyev G, et al. Isorhodopsin rather than rhodopsin mediates rod function in RPE65 knock-out mice. Proc Natl Acad Sci USA 2003;100:13662-13667 (Pubitemid 37444796)
17. Radu RA, Han Y, Bui TV, et al. Reductions in serum vitamin A arrest accumulation of toxic retinal fluorophores: a potential therapy for treatment of lipofuscin-based retinal diseases. Invest Ophthalmol Vis Sci 2005;46:4393-4401 (Pubitemid 44264531)
18. Radu RA, Mata NL, Nusinowitz S, et al. Treatment with isotretinoin inhibits lipofuscin accumulation in a mouse model of recessive Stargardt's macular degeneration. Proc Natl Acad Sci USA 2003;100:4742-4747 (Pubitemid 36457800)
19. Heyman RA, Mangelsdort DJ, Dyck JA, et al. 9-cis retinoic acid is a high affinity ligand for the retinoid X receptor. Cell 1992;68:397-406.
20. Fain GL, Matthews HR, Cornwall MC, et al. Adaptation in vertebrate photoreceptors. Physiol Rev 2001;81:117-151
21. Collins MD, Mao GE. Teratology of retinoids. Annu Rev Pharmacol Toxicol 1999;39:399-430.
22. Travis GH, Golczak M, Moise AR, et al. Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents. Annu Rev Pharmacol Toxicol 2007;47:469-512. (Pubitemid 46272136)
23. Bendich A. The safety of beta-carotene. Nutr Cancer 1988;11:207-214
24. Maguire AM, Simonelli F, Pierce EA, et al. Safety and efficacy of gene transfer for Leber's congenital amaurosis. N Engl J Med 2008;358:2240-2248 (Pubitemid 351724453)
25. Bainbridge JW, Smith AJ, Barker SS, et al. Effect of gene therapy on visual function in Leber's congenital amaurosis. N Engl J Med 2008;358:2231-2239 (Pubitemid 351724452)