Increased genetic risk or protection for canine autoimmune lymphocytic thyroiditis in Giant Schnauzers depends on DLA class II genotype

Tissue Antigens

Volumn 75, Issue 6, 2010, Pages 712-719

  Wilbe, M ^a   Sundberg, K ^a   Hansen, I R ^a   Strandberg, E ^a   Nachreiner, R F ^b   Hedhammar, A ^a   Kennedy, L J ^c   Andersson, G ^a   Bjornerfeldt S ^a,d  

^a SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^b MICHIGAN STATE UNIVERSITY   (United States)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

^d UPPSALA UNIVERSITY   (Sweden)

Author keywords

Canine lymphocytic thyroiditis; Canis familiaris; Disease association; Dog; Hypothyroidism; Major histocompatibility complex class II

Indexed keywords

DLA DQA1 ANTIGEN; DLA DQB1 ANTIGEN; DLA DRB1 ANTIGEN; DOG LEUKOCYTE ANTIGEN CLASS II; LEUKOCYTE ANTIGEN; UNCLASSIFIED DRUG; HLA DQ ANTIGEN; HLA DR ANTIGEN; HLA DRB1 ANTIGEN; HLA-DQA1 ANTIGEN; HLA-DQB1 ANTIGEN;

ARTICLE; AUTOIMMUNE THYROIDITIS; CONTROLLED STUDY; DOG; GENETIC PREDISPOSITION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HETEROZYGOTE; LYMPHOCYTIC THYROIDITIS; MAJOR HISTOCOMPATIBILITY COMPLEX; NONHUMAN; PRIORITY JOURNAL; RISK FACTOR; ANIMAL; DOG DISEASE; FEMALE; GENETICS; MALE; RISK; VETERINARY;

CANIS FAMILIARIS;

ANIMALS; DOG DISEASES; DOGS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HLA-DQ ALPHA-CHAINS; HLA-DQ ANTIGENS; HLA-DQ BETA-CHAINS; HLA-DR ANTIGENS; HLA-DRB1 CHAINS; MALE; RISK; THYROIDITIS, AUTOIMMUNE;

EID: 77952218024     PISSN: 00012815     EISSN: 13990039     Source Type: Journal    
DOI: 10.1111/j.1399-0039.2010.01449.x     Document Type: Article

References (33)

1. Lindblad-Toh K, Wade CM, Mikkelsen TS et al. Genome sequence, comparative analysis and haplotype structure of the domestic dog. Nature 2005 : 438 : 803 819.
2. Wilbe M, Jokinen P, Hermanrud C et al. MHC class II polymorphism is associated with a canine SLE-related disease complex. Immunogenetics 2009 : 61 : 557 564.
3. Kennedy LJ, Huson HJ, Leonard J et al. Association of hypothyroid disease in Doberman Pinscher dogs with a rare major histocompatibility complex DLA class II haplotype. Tissue Antigens 2006 : 67 : 53 6.
4. Kennedy LJ, Quarmby S, Happ GM et al. Association of canine hypothyroidism with a common major histocompatibility complex DLA class II allele. Tissue Antigens 2006 : 68 : 82 6.
5. Lucke VM, Gaskell CJ, Wotton PR. Thyroid pathology in canine hypothyroidism. J Comp Pathol 1983 : 93 : 415 421.
6. Happ GM. Thyroiditis-A model canine autoimmune disease. Adv Vet Sci Comp Med 1995 : 39 : 97 139.
7. Graham PA, Nachreiner RF, Refsal KR, Provencher-Bolliger AL. Lymphocytic thyroiditis. Vet Clin North Am Small Anim Pract 2001 : 31 : 915 933, vi-vii.
8. Kemppainen RJ, Behrend EN. Diagnosis of canine hypothyroidism. Perspectives from a testing laboratory. Vet Clin North Am Small Anim Pract 2001 : 31 : 951 962, vii.
9. Scott-Moncrieff JR, Guptil-Yoran L. Hypothyroidism. In: Ettinger SJ, Feldman EC eds. Textbook of Veterinary Internal Medicine, 5th edn.
10. Nachreiner RF, Refsal KR, Graham PA, Hauptman J, Watson GL. Prevalence of autoantibodies to thyroglobulin in dogs with nonthyroidal illness. Am J Vet Res 1998 : 59 : 951 955.
11. Dixon RM, Mooney CT. Canine serum thyroglobulin autoantibodies in health, hypothyroidism and non-thyroidal illness. Res Vet Sci 1999 : 66 : 243 246.
12. Benjamin SA, Stephens LC, Hamilton BF, Saunders WJ, Lee AC, Angleton GM, Mallinckrodt Ch. Associations between lymphocytic thyroiditis, hypothyroidism, and thyroid neoplasia in beagles. Vet Pathol 1996 : 33 : 486 494.
13. Egenvall A, Bonnett BN, Olson P, Hedhammar A. Gender, age, breed and distribution of morbidity and mortality in insured dogs in Sweden during 1995 and 1996. Vet Rec 2000 : 146 : 519 525.
14. Roman SH, Greenberg D, Rubinstein P, Wallenstein S, Davies TS. Genetics of autoimmune thyroid disease: lack of evidence for linkage to HLA within families. J Clin Endocrinol Metab 1992 : 74 : 496 503.
15. Ban Y, Davies TF, Greenberg DA, Concepcion ES, Tomer Y. The influence of human leucocyte antigen (HLA) genes on autoimmune thyroid disease (AITD): results of studies in HLA-DR3 positive AITD families. Clin Endocrinol (Oxf) 2002 : 57 : 81 8.
16. Levin L, Ban Y, Concepcion E, Davies TF, Greenberg DA, Tomer Y. Analysis of HLA genes in families with autoimmune diabetes and thyroiditis. Hum Immunol 2004 : 65 : 640 647.
17. Kong YC, Lomo LC, Motte RW et al. HLA-DRB1 polymorphism determines susceptibility to autoimmune thyroiditis in transgenic mice: definitive association with HLA-DRB1*0301 (DR3) gene. J Exp Med 1996 : 184 : 1167 1172.
18. Thacker EL, Refsal KR, Bull RW. Prevalence of autoantibodies to thyroglobulin, thyroxine, or triiodothyronine and relationship of autoantibodies and serum concentrations of iodothyronines in dogs. Am J Vet Res 1992 : 53 : 449 453.
19. Bresson D, Rebuffat SA, Nguyen B, Banga JP, Gardas A, Peraldi-Roux S. New insights into the conformational dominant epitopes on thyroid peroxidase recognized by human autoantibodies. Endocrinology 2005 : 146 : 2834 2844.
20. Skopek E, Patzl M, Nachreiner RF. Detection of autoantibodies against thyroid peroxidase in serum samples of hypothyroid dogs. Am J Vet Res 2006 : 67 : 809 814.
21. Kennedy LJ, Angles JM, Barnes A et al. Nomenclature for factors of the dog major histocompatibility system (DLA), 2000: second report of the ISAG DLA Nomenclature Committee. Tissue Antigens 2001 : 58 : 55 70. (Pubitemid 32955002)
22. Debenham SL, Hart EA, Ashurst JL et al. Genomic sequence of the class II region of the canine MHC: comparison with the MHC of other mammalian species. Genomics 2005 : 85 : 48 59.
23. Ferm K, Bjornerfeldt S, Karlsson A, Andersson G, Nachreiner R, Hedhammar A. Prevalence of diagnostic characteristics indicating canine autoimmune lymphocytic thyroiditis in giant schnauzer and hovawart dogs. J Small Anim Pract 2009 : 50 : 176 179.
24. Iversen L, Jensen AL, Hoier R, Skydsgaard M, Kristensen F. Development and validation of an improved enzyme-linked immunosorbent assay for the detection of thyroglobulin autoantibodies in canine serum samples. Domest Anim Endocrinol 1998 : 15 : 525 536.
25. Kennedy LJ, Angles JM, Barnes A et al. Nomenclature for factors of the dog major histocompatibility system (DLA), 2000: second report of the ISAG DLA Nomenclature Committee. Anim Genet 2001 : 32 : 193 199. (Pubitemid 32824407)
26. Ellis SA, Bontrop RE, Antczak DF et al. ISAG/IUIS-VIC Comparative MHC Nomenclature Committee report, 2005. Immunogenetics 2006 : 57 : 953 958.
27. Ferguson DC. Testing for hypothyroidism in dogs. Vet Clin North Am Small Anim Pract 2007 : 37 : 647 669.
28. Kennedy LJ, Barnes A, Happ GM et al. Evidence for extensive DLA polymorphism in different dog populations. Tissue Antigens 2002 : 60 : 43 52.
29. Kennedy LJ, Barnes A, Happ GM et al. Extensive interbreed, but minimal intrabreed, variation of DLA class II alleles and haplotypes in dogs. Tissue Antigens 2002 : 59 : 194 204.
30. Seddon JM, Ellegren H. MHC class II genes in European wolves: a comparison with dogs. Immunogenetics 2002 : 54 : 490 500.
31. Angles JM, Kennedy LJ, Pedersen NC. Frequency and distribution of alleles of canine MHC-II DLA-DQB1, DLA-DQA1 and DLA-DRB1 in 25 representative American Kennel Club breeds. Tissue Antigens 2005 : 66 : 173 184.
32. Milne KL, Hayes HM Jr. Epidemiologic features of canine hypothyroidism. Cornell Vet 1981 : 71 : 3 14.
33. Karlsson EK, Baranowska I, Wade CM et al. Efficient mapping of mendelian traits in dogs through genome-wide association. Nat Genet 2007 : 39 : 1321 1328.