The effect of mifepristone on the peripheral blood natural killer cell's cytotoxicity and expression of CD94/NKG2A and NKG2D during the implantation phase

Fertility and Sterility

Volumn 93, Issue 8, 2010, Pages 2615-2620

  Chen, Xiu Ying ^a   Zhuang, Ya Ling ^a   Li, Li ^a   Zhang, Wu Wen ^a   Huang, Li Li ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

cytotoxicity; Mifepristone; natural killer cells; peripheral blood; secretory phase

Indexed keywords

CD94 ANTIGEN; MIFEPRISTONE; NATURAL KILLER CELL RECEPTOR NKG2A; NATURAL KILLER CELL RECEPTOR NKG2D; TETRAZOLIUM;

ARTICLE; BLOOD; BLOOD SAMPLING; CELL ACTIVATION; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; IN VITRO STUDY; MENSTRUAL CYCLE; NATURAL KILLER CELL MEDIATED CYTOTOXICITY; NIDATION; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SECRETORY CELL;

CYTOTOXICITY, IMMUNOLOGIC; EMBRYO IMPLANTATION; FEMALE; HUMANS; KILLER CELLS, NATURAL; MENSTRUAL CYCLE; MIFEPRISTONE; NK CELL LECTIN-LIKE RECEPTOR SUBFAMILY C; NK CELL LECTIN-LIKE RECEPTOR SUBFAMILY D; NK CELL LECTIN-LIKE RECEPTOR SUBFAMILY K;

EID: 77952109917     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2009.09.015     Document Type: Article

References (40)

1. Rama S., and Rao A.J. Regulation of growth and function of the human placenta. Mol Cell Biochem 253 (2003) 263-268
2. Red-Horse K., Zhou Y., Genbachev O., Prakobhol A., Foulk R., McMaster M., et al. Trophoblast differentiation during embryo implantation and formation of the maternal-fetal interface. J Clin Invest 114 (2004) 744-754
3. Huddleston H., and Schust D.J. Immune interactions at the maternal-fetal interface: a focus on antigen presentation. Am J Reprod Immunol 51 (2004) 283-289
4. Sargent I.L., Borzychowski A.M., and Redman C.W. NK cells and human pregnancy-an inflammatory view. Trends Immunol 27 (2006) 399-404
5. Fauci A.S., Mavilio D., and Kottilil S. NK cells in HIV infection: paradigm for protection or targets for ambush. Nat Rev Immunol 5 (2005) 835-843
6. Johansson S., Berg L., Hall H., and Höglund P. NK cells: elusive players in autoimmunity. Trends Immunol 26 (2005) 613-618
7. Orange J.S., and Ballas Z.K. Natural killer cells in human health and disease. Clin Immunol 118 (2006) 1-10
8. Lanier L.L. NK cell recognition. Annu Rev Immunol 23 (2005) 225-274
9. Braud V.M., Allan D.S., and McMichael A.J. Functions of nonclassical MHC and non-MHC-encoded class I molecules. Curr Opin Immunol 11 (1999) 100-108
10. Masilamani M., Nguyen C., Kabat J., Borrego F., and Coligan J.E. CD94/NKG2A inhibits NK cell activation by disrupting the actin network at the immunological synapse. J Immunol 177 (2006) 3590-3596
11. Burgess S.J., Maasho K., Masilamani M., Narayanan S., Borrego F., and Coligan J.E. The NKG2D receptor: immunobiology and clinical implications. Immunol Res 40 (2008) 18-34
12. Gunturi A., Berg R.E., and Forman J. The role of CD94/NKG2 in innate and adaptive immunity. Immunol Res 30 (2004) 29-34
13. Ponte M., Cantoni C., Biassoni R., Tradori-Cappai A., Bentivoglio G., Vitale C., et al. Inhibitory receptors sensing HLA-G1 molecules in pregnancy: decidua-associated natural killer cells express LIR-1 and CD94/NKG2A and acquire p49, an HLA-G1-specific receptor. Proc Natl Acad Sci USA 96 (1999) 5674-5679
14. Ntrivalas E.I., Bowser C.R., Kwak-Kim J., Beaman K.D., and Gilman-Sachs A. Expression of killer immunoglobulin-like receptors on peripheral blood NK cell subsets of women with recurrent spontaneous abortions or implantation failures. Am J Reprod Immunol 53 (2005) 215-221
15. Narvekar N., Cameron S., Critchley H.O., Lin S., Cheng L., and Baird D.T. Low-dose mifepristone inhibits endometrial proliferation and up-regulates androgen receptor. J Clin Endocrinol Metab 89 (2004) 2491-2497
16. Ghosh D., and Sengupta J. Target-oriented anti-implantation approaches for pregnancy interception: experiences in the rhesus monkey model. Contraception 71 (2005) 294-301
17. Spitz I.M. Progesterone receptor antagonists. Curr Opin Invest Drugs 7 (2006) 882-890
18. Antonakis N., Georgoulias V., Margioris A.N., Stournaras C., and Gravanis A. In vitro differential effects of the antiglucocorticoid RU486 on the release of lymphokines from mitogen-activated normal human lymphocytes. J Steroid Biochem Mol Biol 51 (1994) 67-72
19. Lalitkumar P.G., Lalitkumar S., Meng C.X., Stavreus-Evers A., Hambiliki F., Bentin-Ley U., et al. Mifepristone, but not levonorgestrel, inhibits human blastocyst attachment to an in vitro endometrial three-dimensional cell culture model. Hum Reprod 22 (2007) 3031-3037
20. Danielsson K.G., Marions L., and Bygdeman M. Effects of mifepristone on endometrial receptivity. Steroids 68 (2003) 1069-1075
21. Zhu H.X., Zhang W.W., Zhuang Y.L., and Huang L.L. Mifepristone as an anti-implantation contraceptive drug: roles in regulation of uterine natural killer cells during implantation phase. Am J Reprod Immunol 61 (2009) 68-74
22. Sarkar N.N. The potential of mifepristone (RU486) as a female contraceptive drug. Int J Clin Pract 56 (2002) 140-144
23. Nagashima S., Mailliard R., Kashii Y., Reichert T.E., Herberman R.B., Robbins P., et al. Stable transduction of the interleukin-2 gene into human natural killer cell lines and their phenotypic and functional characterization in vitro and in vivo. Blood 91 (1998) 3850-3861
24. Guan T.J., Qin F.J., Du J.H., Geng L., Zhang Y.Y., and Li M. AICAR inhibits proliferation and induced S-phase arrest, and promotes apoptosis in CaSki cells. Acta Pharmacol Sin 28 (2007) 1984-1990
25. Niekamp S.R., Sutherland M.A., Dahl G.E., and Salak-johnson J.L. Immune responses of piglets to weaning stress: impacts of photoperiod. J Anim Sci 85 (2007) 93-100
26. Zhong-min G.U., Zhong-sen M.A., Ji-hong A.N., and Bo L.I. Determination of NK cytotoxicity by improved MTT assay. J Jilin Univ (Med Ed) 29 (2003) 119-120
27. Von Hertzen H., Piaggio G., Ding J., Chen J., Song S., and Bártfai G. Low dose mifepristone and two regimens of levonorgestrel for emergency contraception: a WHO multicentre randomized trial. Lancet 360 (2002) 1803-1810
28. Arruvito L., Giulianelli S., Flores A.C., Paladino N., Barboza M., Lanari C., et al. NK cells expressing a progesterone receptor are susceptible to progesterone-induced apoptosis. J Immunol 180 (2008) 5746-5753
29. Souza S.S., Castro F.A., Mendonca H.C., Palma P.V., Morais F.R., Ferriani R.A., et al. Influence of menstrual cycle on NK activity. J Reprod Immunol 50 (2001) 151-159
30. Yamada H., Morikawa M., Kato E.H., Shimada S., Kobashi G., and Minakami H. Pre-conceptional natural killer cell activity and percentage as predictors of biochemical pregnancy and spontaneous abortion with normal chromosome karyotype. Am J Reprod Immunol 50 (2003) 351-354
31. Hadinedoushan H., Mirahmadian M., and Aflatounian A. Increased natural killer cell cytotoxicity and IL-2 production in recurrent spontaneous abortion. Am J Reprod Immunol 58 (2007) 409-414
32. Perricone R., Di Muzio G., Perricone C., Giacomelli R., De Nardo D., Fontana L., et al. High levels of peripheral blood NK cells in women suffering from recurrent spontaneous abortion are reverted from high-dose intravenous immunoglobulins. Am J Reprod Immunol 55 (2006) 232-239
33. Matsubayashi H., Hosaka T., Sugiyama Y., Suzuki T., Arai T., Kondo A., et al. Increased natural killer-cell activity is associated with infertile women. Am J Reprod Immunol 46 (2001) 318-322
34. Moretta A., Bottino C., Mingari M.C., Biassoni R., and Moretta L. What is a natural killer cell?. Nat Immunol 3 (2002) 6-8
35. Hersey P., and Bolhuis R. "Nonspecific" MHC-unrestricted killer cells and their receptors. Immunol Today 8 (1987) 233-239
36. Mcmahon C.W., Zajac A.J., Jamieson A.M., Corral L., Hammer G.E., Ahmed R., et al. Viral and bacterial infections induce expression of multiple NK cell receptors in responding CD8 (+) T cells. J Immunol 169 (2002) 1444-1452
37. Masilamani M., Narayanan S., Prieto M., Borrego F., and Coligan J.E. Uncommon endocytic and trafficking pathway of the natural killer cell CD94/NKG2A inhibitory receptor. Traffic 9 (2008) 1019-1034
38. McGrath E., Ryan E.J., Lynch L., Golden-Mason L., Mooney E., Eogan M., et al. Changes in endometrial natural killer cell expression of CD94, CD158a and CD158b are associated with infertility. Am J Reprod Immunol 61 (2009) 265-276
39. Zhang Y., Zhao A., Wang X., Shi G., Jin H., and Lin Q. Expressions of natural cytotoxicity receptors and NKG2D on decidual natural killer cells in patients having spontaneous abortions. Fertil Steril 90 (2008) 1931-1937
40. Moretta A., Bottino C., Vitale M., Pende D., Cantoni C., Mingari M.C., et al. Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis. Annu Rev Immunol 19 (2001) 197-223