Refinement of the pharmacophore of an agonist ligand of the secretin receptor using conformationally constrained cyclic hexapeptides

Peptides

Volumn 31, Issue 6, 2010, Pages 1094-1098

  Dong, Maoqing ^a   Narang, Pooja ^a   Pinon, Delia I ^a   Bordner, Andrew J ^a   Miller, Laurence J ^a  

^a MAYO GRADUATE SCHOOL   (United States)

Author keywords

Cyclic peptide; G protein coupled receptor; Hexapeptide; Molecular modeling; Receptor activation; Secretin receptor

Indexed keywords

CYCLOPEPTIDE; HEXAPEPTIDE; HORMONE RECEPTOR; SECRETIN RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; MOLECULAR MODEL; NONHUMAN; PHARMACOPHORE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN MOTIF;

ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; CYCLIC AMP; LIGANDS; MODELS, MOLECULAR; OLIGOPEPTIDES; PEPTIDES, CYCLIC; PROTEIN CONFORMATION; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, GASTROINTESTINAL HORMONE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77952101200     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.peptides.2010.02.024     Document Type: Article

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