Exploration of the endogenous agonist mechanism for activation of secretin and VPAC1 receptors using synthetic glycosylated peptides

Journal of Molecular Neuroscience

Volumn 36, Issue 1-3, 2008, Pages 254-259

  Dong, Maoqing ^a   Pinon, Delia I ^a   Miller, Laurence J ^a  

^a MAYO GRADUATE SCHOOL   (United States)

Author keywords

G protein coupled receptors; Glycosylation; Receptor activation; Secretin receptor; VPAC1 receptor

Indexed keywords

AMINO ACID DERIVATIVE; G PROTEIN COUPLED RECEPTOR; SECRETIN; TRYPTOPHYLASPARTYLASPARAGINE; UNCLASSIFIED DRUG; VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR 1;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CELL STRAIN BHK; CHO CELL; CONTROLLED STUDY; GLYCOSYLATION; NONHUMAN; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN PROCESSING;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE; MOLECULAR SEQUENCE DATA; PEPTIDES; RATS; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, GASTROINTESTINAL HORMONE; RECEPTORS, VASOACTIVE INTESTINAL POLYPEPTIDE, TYPE I; SECRETIN;

EID: 58149084138     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12031-008-9058-6     Document Type: Article

References (22)

1. A. Bisello A. E. Adams D. F. Mierke 1998 Parathyroid hormone-receptor interactions identified directly by photocross-linking and molecular modeling studies Journal of Biological Chemistry 273 22498 22505
2. C. J. Carruthers C. G. Unson H. N. Kim T. P. Sakmar 1994 Synthesis and expression of a gene for the rat glucagon receptor. Replacement of an aspartic acid in the extracellular domain prevents glucagon binding Journal of Biological Chemistry 269 29321 29328
3. A. Couvineau P. Gaudin J. J. Maoret C. Rouyer-Fessard P. Nicole M. Laburthe 1995 Highly conserved aspartate 68, tryptophane 73 and glycine 109 in the N-terminal extracellular domain of the human VIP receptor are essential for its ability to bind VIP Biochemical and Biophysical Research Communications 206 246 252
4. M. Dong P. C. Lam F. Gao 2007 Molecular approximations between residues 21 and 23 of secretin and its receptor: Development of a model for peptide docking with the amino terminus of the secretin receptor Molecular Pharmacology 72 280 290
5. M. Dong Z. Li D. I. Pinon T. P. Lybrand L. J. Miller 2004 Spatial approximation between the amino terminus of a peptide agonist and the top of the sixth transmembrane segment of the secretin receptor Journal of Biological Chemistry 279 2894 2903
6. M. Dong D. I. Pinon Y. W. Asmann L. J. Miller 2006 Possible endogenous agonist mechanism for the activation of secretin family G protein-coupled receptors Molecular Pharmacology 70 206 213
7. M. Dong D. I. Pinon R. F. Cox L. J. Miller 2004 Molecular approximation between a residue in the amino-terminal region of calcitonin and the third extracellular loop of the class B G protein-coupled calcitonin receptor Journal of Biological Chemistry 279 31177 31182
8. P. Godfrey J. O. Rahal W. G. Beamer N. G. Copeland N. A. Jenkins K. E. Mayo 1993 GHRH receptor of little mice contains a missense mutation in the extracellular domain that disrupts receptor function Nature Genetics 4 227 232
9. C. R. Grace M. H. Perrin M. R. DiGruccio 2004 NMR structure and peptide hormone binding site of the first extracellular domain of a type B1 G protein-coupled receptor Proceedings of the National Academy of Sciences of the United States of America 101 12836 12841
10. C. R. Grace M. H. Perrin J. Gulyas 2007 Structure of the N-terminal domain of a type B1 G protein-coupled receptor in complex with a peptide ligand Proceedings of the National Academy of Sciences of the United States of America 104 4858 4863
11. K. G. Harikumar P. C. Lam M. Dong P. M. Sexton R. Abagyan L. J. Miller 2007 Fluorescence resonance energy transfer analysis of secretin docking to its receptor: Mapping distances between residues distributed throughout the ligand pharmacophore and distinct receptor residues Journal of Biological Chemistry 282 32834 32843
12. D. Horton M. L. Wolfrom 1962 Thiosugars. I. Synthesis of derivatives of 2-amino-2-deoxyl-1-thio-d-glucose Journal of Organic Chemistry 27 1794 1800
13. M. Laburthe A. Couvineau V. Tan 2007 Class II G protein-coupled receptors for VIP and PACAP: Structure, models of activation and pharmacology Peptides 28 1631 1639
14. S. C. Lin C. R. Lin I. Gukovsky A. J. Lusis P. E. Sawchenko M. G. Rosenfeld 1993 Molecular basis of the little mouse phenotype and implications for cell type-specific growth Nature 364 208 213
15. K. E. Mayo L. J. Miller D. Bataille 2003 International union of pharmacology. XXXV. The glucagon receptor family Pharmacological Reviews 55 167 194
16. C. Parthier M. Kleinschmidt P. Neumann 2007 Crystal structure of the incretin-bound extracellular domain of a G protein-coupled receptor Proceedings of the National Academy of Sciences of the United States of America 104 13942 13947
17. S. P. Powers D. I. Pinon L. J. Miller 1988 Use of N,O-bis-Fmoc-d-Tyr-ONSu for introduction of an oxidative iodination site into cholecystokinin family peptides International Journal of Peptide and Protein Research 31 429 434
18. C. Sun D. Song R. A. Davis-Taber 2007 Solution structure and mutational analysis of pituitary adenylate cyclase-activating polypeptide binding to the extracellular domain of PAC1-RS Proceedings of the National Academy of Sciences of the United States of America 104 7875 7880
19. Y. V. Tan A. Couvineau S. Murail 2006 Peptide agonist docking in the N-terminal ectodomain of a class II G protein-coupled receptor, the VPAC1 receptor. Photoaffinity, NMR, and molecular modeling Journal of Biological Chemistry 281 12792 12798
20. C. D. Ulrich 2nd I. Ferber E. Holicky E. Hadac G. Buell L. J. Miller 1993 Molecular cloning and functional expression of the human gallbladder cholecystokinin A receptor Biochemical and Biophysical Research Communications 193 204 211
21. C. D. Ulrich 2nd D. I. Pinon E. M. Hadac 1993 Intrinsic photoaffinity labeling of native and recombinant rat pancreatic secretin receptors Gastroenterology 105 1534 1543
22. A. Yamamoto C. Miyashita H. Tsukamoto 1965 Studies on amino sugars I. Preparation of N-acyl derivatives of 2-acetamido-2-deoxy-beta-d-glycosylamine Chemical and Pharmaceutical Bulletin (Tokyo) 13 1036 1041