Safety of an amino-acetonitrile derivative (AAD), monepantel, in weaned lambs following repeated oral administration

New Zealand Veterinary Journal

Volumn 57, Issue 1, 2009, Pages 10-15

  Malikides, N ^a   Helbig, R ^b   Roth, D R ^b   Alexander, A ^a   Hosking, B C ^a   Strehlau, G A ^b  

^a Novartis Animal Health Australasia Pty Limited   (Australia)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Adverse event; Amino acetonitrile derivative; Anthelmintic; Lambs; Monepantel; Overdose; Target animal safety; Toxicology

Indexed keywords

AMINOACETONITRILE; ANTHELMINTIC AGENT; DRUG DERIVATIVE; MONEPANTEL;

ANIMAL; ARTICLE; DOSE RESPONSE; FEMALE; MALE; NEWBORN; ORAL DRUG ADMINISTRATION; RANDOMIZATION; SAFETY; SHEEP; SHEEP DISEASE; TREATMENT OUTCOME;

ADMINISTRATION, ORAL; AMINOACETONITRILE; ANIMALS; ANIMALS, NEWBORN; ANTHELMINTICS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; MALE; RANDOM ALLOCATION; SAFETY; SHEEP; SHEEP DISEASES; TREATMENT OUTCOME;

ANIMALIA; OVIS ARIES;

EID: 64149121412     PISSN: 00480169     EISSN: 11760710     Source Type: Journal    
DOI: 10.1080/00480169.2009.36862     Document Type: Article

References (20)

1. Anonymous. Food and Drug Administration Center for Veterinary Medicine Guideline 33, Target Animal Safety Guideline for New Animal Drugs. Office of New Animal Drug Evaluation, CVM, FDA, US Department of Human Health Service, Rockville MD, USA, 1989
2. Anonymous. OECD Series on Principles of Good Laboratory Practice and Compliance Monitoring, No. 1. Organisation for Economic Cooperation and Development, Paris, France, 1998
3. Anonymous. Food and Drug Administration Center for Veterinary Medicine Guideline 56, Protocol Development Guideline for Clinical Effectiveness and Target Animal Safety Trials. Office of New Animal Drug Evaluation, CVM, FDA, US Department of Human Health Service, Rockville MD, USA, 2001
4. Anonymous. OECD Series on Principles of Good Laboratory Practice and Compliance Monitoring, No. 13. The Application of the OECD Principles to GLP to the Organisation and Management of Multi-site Studies. Organisation for Economic Co-operation and Development, Paris, France, 2002
5. Anonymous. VICH Guideline 43: Target Animal Safety for Veterinary Pharmaceutical Products (Draft 18). International Cooperation on Harmonisation of Technical Requirements for Registration of Veterinary Medicinal Products, Bruxelles, Belgium, 2005
6. Besier RB, Love SCJ. Anthelmintic resistance in sheep nematodes in Australia: the need for new approaches. Australian Journal of Experimental Agriculture 43, 1383–91, 2003
7. Brunsdon RV, Kissling R, Hosking BC. A survey of anthelmintic usage for sheep-a time for change. New Zealand Veterinary Journal 31, 24–9, 1983
8. Ducray P, Gauvry N, Pautrat F, Goebel T, Fruechtel J, Desaules Y, Weber SS, Bouvier J, Wagner T, Froelich O, Kaminsky R. Discovery of amino-acetonitrile derivatives, a new class of synthetic anthelmintic compounds. Bioorganic and Medicinal Chemistry Letters 18, 2935–8, 2008
9. Jackson F, Coop RL. The development of anthelmintic resistance in sheep nematodes. Parasitology 120, 95–107, 2000
10. Jain NC. Schalms Veterinary Hematology. P 1076. Lea & Febiger, Philadelphia, USA, 1986
11. Kaminsky R, Ducray P, Jung M, Clover R, Rufener L, Bouvier J, Weber SS, Wenger A, Wieland-Berghausen S, Goebel T, Gauvry N, Pautrat F, Skripsky T, Froelich O, Komoin-Oka C, Westlund B, Sluder A, Maser P. A new class of anthelmintics effective against drug-resistant nematodes. Nature 452, 176–80, 2008a
12. Kaminsky R, Gauvry N, Weber SS, Skripsky T, Bouvier J, Wenger A, Schroeder F, Desaules Y, Hotz R, Goebel T, Hosking BC, Pautrat F, Wieland-Berghausen S, Ducray P. Identification of the amino-acetonitrile derivative monepantel (AAD 1566) as a new anthelmintic drug development candidate. Parasitology Research 103, 931–9, 2008b
13. Kaneko JJ, Harvey JW Bruss ML. Clinical Biochemistry of Domestic Animals. Pp 890–9. Academic Press, San Diego, USA, 1997
14. Lawrence KE, Leathwick DM, Rhodes AP, Jackson R, Heuer C, Pomroy WE, West DM, Waghorn TS, Moffat JR. Management of gastrointestinal nematode parasites on sheep farms in New Zealand. New Zealand Veterinary Journal 55, 228–34, 2007
15. Leathwick DM. The future cost of anthelmintic resistance to the New Zealand sheep industry. New Zealand Journal of Zoology 31, 91, 2004
16. Mongan NP, Jones AK, Smith GR, Sansom MS, Sattelle DB. Novel alpha7-like nicotinic acetylcholine receptor subunits in the nematode Caenorhabditis elegans. Protein Science 11, 1162–71, 2002
17. Radostits OM, Gay CC, Blood DC, Hinchcliff KW Reference laboratory values. Veterinary Medicine. A Textbook of the Diseases of Cattle, Sheep, Pigs, Goats and Horses. Pp 1819–22. WB Saunders, London, UK, 1999
18. Stockham SL, Scott MA. Fundamentals of Veterinary Clinical Pathology. 1st Edtn. Pp 49–487. Iowa State Press, Iowa, USA, 2002
19. Welsman SJ. Keeping Sheep Alive. Australian Wool Innovation Program Review, Australian Wool Innovation, Sydney, Australia, 2001
20. Wolstenholme AJ, Fairweather I, Prichard R, Samson-Himmelstjerna G, Sangster NC. Drug resistance in veterinary helminthes. Trends in Parasitology 20, 469–76, 2004