Efficacy of the amino-acetonitrile derivative, monepantel, against experimental and natural adult stage gastro-intestinal nematode infections in sheep

Veterinary Parasitology

Volumn 159, Issue 1, 2009, Pages 49-54

  Sager, Heinz ^a   Hosking, Barry ^b   Bapst, Béatrice ^a   Stein, Philip ^b   Vanhoff, Kathleen ^b   Kaminsky, Ronald ^a  

^a Centre de Recherche Sante Animale   (Switzerland)

^b Novartis Animal Health Australasia Pty Limited   (Australia)

Author keywords

Amino acetonitrile derivatives, AAD; Anthelmintics; Gastro intestinal nematodes; Monepantel; Sheep

Indexed keywords

ACETONITRILE DERIVATIVE; AMINOACETONITRILE DERIVATIVE; ANTINEMATODAL AGENT; BENZIMIDAZOLE; LEVAMISOLE; MONEPANTEL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTHELMINTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG SENSITIVITY; FECES ANALYSIS; NEMATODE; NEMATODIASIS; NEMATODIRUS; NONHUMAN; OESOPHAGOSTOMUM VENULOSUM; SHEEP; TRICHURIS;

ANIMALIA; NEMATODA; NEMATODIRUS SPATHIGER; OESOPHAGOSTOMUM VENULOSUM; OVIS ARIES; TRICHURIS OVIS;

EID: 57749201828     PISSN: 03044017     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vetpar.2008.10.006     Document Type: Article

References (25)

1. Anon. Efficacy of anthelmintics: specific recommendations for ovines. VICH GL 13 (1999) 1-5
2. Anon. Efficacy of anthelmintics: general requirements. VICH GL 7 (2000) 1-9
3. Blake N., and Coles G. Flock cull due to anthelmintic-resistant nematodes. Vet. Rec. 161 (2007) 36
4. Coles G.C., Giordano-Fenton D.J., and Tritschler J.P. Efficacy of moxidectin against nematodes in naturally infected sheep. Vet. Rec. 135 (1994) 38-39
5. Coles G.C., Jackson F., Pomroy W.E., Prichard R.K., von Samson-Himmelstjerna G., Silvestre A., Taylor M.A., and Vercruysse J. The detection of anthelmintic resistance in nematodes of veterinary importance. Vet. Parasitol. 136 (2006) 167-185
6. Corba J., Krupicer I., Legény J., Juris P., and Veselý L. Effect of a controlled-release albendazole capsule on parasitism and productivity of sheep. Vet. Parasitol. 40 (1991) 273-279
7. Getachew T., Dorchies P., and Jacquiet P. Trends and challenges in the effective and sustainable control of Haemonchus contortus infection in sheep. Parasite 14 (2007) 3-14
8. Hosking B.C., Stein P.A., Mosimann D., Seewald W., Strehlau G., and Kaminsky R. Dose determination studies for monepantel, an amino-acetonitrile derivative, against fourth stage gastro-intestinal nematode larvae infecting sheep. Vet. Parasitol. 157 (2008) 72-80
9. Kaminsky R., Ducray P., Jung M., Clover R., Rufener L., Bouvier J., Schorderet Weber S., Wenger A., Wieland-Berghausen S., Goebel T., Gauvry N., Pautrat F., Skripsky T., Froelich O., Komoin-Oka C., Westlund B., Sluder A., and Mäser P. A new class of anthelmintics effective against drug-resistant nematodes. Nature 452 (2008) 176-180
10. Kaminsky R., Gauvry N., Schorderet Weber S., Skripsky T., Bouvier J., Wenger A., Schroeder F., Desaules Y., Hotz R., Goebel T., Hosking B.C., Pautrat F., Wieland-Berghausen S., and Ducray P. Identification of the amino-acetonitrile derivative monepantel (AAD 1566) as a new anthelmintic drug development candidate. Parasitol. Res. 103 (2008) 931-939
11. Kaminsky, R., Mosimann, D., Sager, H., Stein, P., Hosking, B. 2008c. Determination of the effective dose rate for monepantel (AAD 1566) against adult gastro-intestinal nematodes in sheep. Int. J. Parasitol., submitted for publication, doi:10.1016/j.ijpara.2008.09.009.
12. In: Kaufmann J. (Ed). Parasitic Infections of Domestic Animals: A Diagnostic Manual (1996), Birkhauser, Berlin 7 pp.
13. Love S.J.C., and Coles G.C. Anthelmintic resistance in sheep worms in New South Wales, Australia. Vet. Rec. 150 (2002) 87
14. Lyons E.T., Drudge J.H., and Tolliver S.C. Activity of febantel on natural infections of gastrointestinal helminths in lambs in a controlled test. Am. J. Vet. Res. 49 (1988) 901-902
15. Meana A., Luzón-Peña M., Santiago-Moreno J., De Bulnes A., and Gómez-Bautista M. Natural infection by gastrointestinal and bronchopulmonary nematodes in mouflons (Ovis musimon) and their response to netobimin treatment. J. Wildl. Dis. 32 (1996) 39-43
16. Miller J.E., and Horohov D.W. Immunological aspects of nematode parasite control in sheep. J. Anim. Sci. 84 Suppl. (2006) E124-E132
17. Sargison N.D., Scott P.R., and Jackson E. Multiple anthelmintic resistance in sheep. Vet. Rec. 149 (2001) 778-779
18. Sargison N.D., Jackson F., Bartley D.J., and Moir A.C. Failure of moxidectin to control benzimidazole-, levamisole- and ivermectin-resistant Teladorsagia circumcincta in a sheep flock. Vet. Rec. 156 (2005) 105-109
19. Traversa D., Paoletti B., Otranto D., and Miller J. First report of multiple drug resistance in trichostrongyles affecting sheep under field conditions in Italy. Parasitol. Res. 101 (2007) 1713-1716
20. van Wyk J.A., Stenson S.O., Van der Mrewe J.S., Vordsetr R.J., and Vilijoen P.G. Anthelmintic resistance in South Africa: surveys indicate an extremely serious situation in sheep and goat farming. Onderstepoort J. Vet. Res. 66 (1999) 273-284
21. van Wyk J.A., Cabaret J., and Michael L.M. Morphological identification of nematode larvae of small ruminants and cattle simplified. Vet. Parasitol. 119 (2004) 277-306
22. Waller P.J., Echevarria E., Eddi C., Maciel S., Nari A., and Hansen J.W. The prevalence of anthelmintic resistance in nematode parasites of sheep in southern Latin America: general overview. Vet. Parasitol. 62 (1996) 181-187
23. Wescott R.B., and LeaMaster B.R. Efficacy of ivermectin against naturally acquired and experimentally induced nematode infections in sheep. Am. J. Vet. Res. 43 (1982) 531-533
24. Wood I.B., Amaral N.K., Bairden K., Duncan J.L., Kassai T., Malone Jr. J.B., Pankavich J.A., Reinecke R.K., Slocombe O., Taylor S.M., and Vercruysse J. World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) second edition of guidelines for evaluating the efficacy of anthelmintics in ruminants (bovine, ovine, caprine). Vet. Parasitol. 58 (1995) 181-213
25. Wrigley J., McArthur M., McKenna P.B., and Mariadass B. Resistance to a triple combination of broad-spectrum anthelmintics in naturally-acquired Ostertagia circumcincta infections in sheep. N.Z. Vet. J. 54 (2006) 47-49