Dose determination studies for monepantel, an amino-acetonitrile derivative, against fourth stage gastro-intestinal nematode larvae infecting sheep

Veterinary Parasitology

Volumn 157, Issue 1-2, 2008, Pages 72-80

  Hosking, B C ^a   Stein, P A ^a   Mosimann, D ^b   Seewald, W ^c   Strehlau, G ^c   Kaminsky, R ^b  

^a Novartis Animal Health Australasia Pty Limited   (Australia)

^b Centre de Recherche Sante Animale   (Switzerland)

^c NOVARTIS PHARMA AG   (Switzerland)

Author keywords

AAD; Amino acetonitrile derivative; Anthelmintic; Efficacy; Fourth stage larvae; Gastro intestinal; Monepantel; Nematode; Sheep

Indexed keywords

ANTHELMINTIC AGENT; BENZIMIDAZOLE; LEVAMISOLE; MACROLIDE; MONEPANTEL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUSTRALIA; CHABERTIA OVINA; CONTROLLED STUDY; COOPERIA ONCOPHORA; DOSE CALCULATION; DOSE RESPONSE; DRUG EFFICACY; EUTHANASIA; FEMALE; GASTROINTESTINAL INFECTION; HAEMONCHUS CONTORTUS; LARVA; MALE; NEMATODE; NEMATODIASIS; NEMATODIRUS; NEMATODIRUS FILICOLLIS; NEMATODIRUS SPATHIGER; NONHUMAN; OESOPHAGOSTOMUM VENULOSUM; OSTERTAGIA; PARASITE IDENTIFICATION; SHEEP; SWITZERLAND; TELADORSAGIA CIRCUMCINTA; TELADORSAGIA TRIFURCATA; TREATMENT OUTCOME; TRICHOSTRONGYLUS; TRICHOSTRONGYLUS AXEI; TRICHOSTRONGYLUS COLUBRIFORMIS; TRICHOSTRONGYLUS VITRINUS;

CHABERTIA OVINA; COOPERIA CURTICEI; COOPERIA ONCOPHORA; HAEMONCHUS CONTORTUS; NEMATODA; NEMATODIRUS BATTUS; NEMATODIRUS FILICOLLIS; NEMATODIRUS SPATHIGER; OESOPHAGOSTOMUM VENULOSUM; OVIS ARIES; TELADORSAGIA; TELADORSAGIA CIRCUMCINCTA; TRICHOSTRONGYLUS AXEI; TRICHOSTRONGYLUS COLUBRIFORMIS; TRICHOSTRONGYLUS VITRINUS;

EID: 51249089444     PISSN: 03044017     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vetpar.2008.07.014     Document Type: Article

References (30)

1. Artho R., Schnyder M., Kohler L., Torgerson P.R., and Hertzberg H. Avermectin-resistance in gastrointestinal nematodes of Boer goats and Dorper sheep in Switzerland. Vet. Parasitol. 144 1-2 (2007) 68-73
2. Bartley D.J., Donnan A.A., Jackson E., Sargison N., Mitchell G.B.B., and Jackson F. A small scale survey of ivermectin resistance in sheep nematodes using the faecal egg count reduction test on samples collected from Scottish sheep. Vet. Parasitol. 137 (2006) 112-118
3. Besier R.B., and Love S.C.J. Anthelmintic resistance in sheep nematodes in Australia: the need for new approaches. Aust. J. Exp. Agric. 43 (2003) 1383-1391
4. Borgsteede F.H.M., Dercksen D.D., and Huijbers R. Doramectin and albendazole resistance in sheep in The Netherlands. Vet. Parasitol. 144 1-2 (2007) 180-183
5. Coles G.C., Hong C., and Hunt K.R. Benzimidazole resistant nematodes in sheep in southern England. Vet. Rec. 128 (1991) 44
6. Downey, N.E., 1981. Recovery of Ostertagia from the bovine abomasal mucosa by immersion in warm normal saline, in: P. Nansen, R.J. Jorgensen, E.J.L. Soulsby (Eds.), Epidemiology and Control of Nematodiasis in Cattle. Brussels, Luxembourg, pp. 69-72.
7. Ducray P., Gauvry N., Pautrat F., Goebel T., Fruechtel J., Desaules Y., Schorderet Weber S., Bouvier J., Wagner T., Froelich O., and Kaminsky R. Discovery of amino-acetonitrile derivatives, a new class of synthetic anthelmintic compounds. Bio. Med. Chem. Lett. 18 (2008) 2935-2938
8. Echevarria F., Borba M.F.S., Pinheiro A.C., Waller P.J., and Hansen J.W. The prevalence of anthelmintic resistance in nematode parasites of sheep in Southern Latin America: Brazil. Vet. Parasitol. 62 (1996) 199-206
9. Eddi C., Caracostantogolo J., Peña M., Schapiro J., Marangunich L., Waller P.J., and Hansen J.W. The prevalence of anthelmintic resistance in nematode parasites of sheep in Southern Latin America: Argentina. Vet. Parasitol. 62 (1996) 189-197
10. Hong C., Hunt K.R., Harris T.J., Coles G.C., Grimshaw W.T., and McMullin P.F. A survey of benzimidazole resistant nematodes in sheep in three counties of southern England. Vet. Rec. 131 (1992) 5-7
11. Hong C., Hunt K.R., and Coles G.C. Occurrence of anthelmintic resistant nematodes on sheep farms in England and goat farms in England and Wales. Vet. Rec. 139 (1996) 83-86
12. Kaminsky R., Ducray P., Jung M., Clover R., Rufener L., Bouvier J., Schorderet Weber S., Wenger A., Wieland-Berghausen S., Goebel T., Gauvry N., Pautrat F., Skripsky T., Froelich O., Komoin-Oka C., Westlund B., Sluder A., and Mäser P. A new class of anthelmintics effective against drug-resistant nematodes. Nature 452 (2008) 176-180
13. Kaminsky R., Gauvry N., Schorderet Weber S., Skripsky T., Bouvier J., Wenger A., Schroeder F., Desaules Y., Hotz R., Goebel T., Hosking B.C., Pautrat F., Wieland-Berghausen S., and Ducray P. Identification of the amino-acetonitrile derivative monepantel (AAD 1566) as a new anthelmintic drug development candidate. Parasitol. Res. 103 4 (2008) 931-939
14. Leathwick D.M. The future cost of anthelmintic resistance to the New Zealand sheep industry. NZ. J. Zool. 31 (2004) 91
15. Love S.C.J., Neilson F.J.A., Biddle A.J., and McKinnon R. Moxidectin-resistant Haemonchus contortus in sheep in northern New South Wales. Aust. Vet. J. 81 (2003) 359-360
16. Maciel S., Giménez A.M., Gaona C., Waller P.J., and Hansen J.W. The prevalence of anthelmintic resistance in nematode parasites of sheep in Southern Latin America: Paraguay. Vet. Parasitol. 62 (1996) 207-212
17. Nari A., Salles J., Gil A., Waller P.J., and Hansen J.W. The prevalence of anthelmintic resistance in nematode parasites of sheep in Southern Latin America: Uruguay. Vet. Parasitol. 62 (1996) 213-222
18. Sangster N.C. Anthelmintic resistance: past, present and future. Int. J. Parasitol. 29 (1999) 115-124
19. Sargison N.D., Jackson F., Bartley D.J., Wilson D.J., Stenhouse L.J., and Penny C.D. Observations on the emergence of multiple anthelmintic resistance in sheep flocks in the south-east of Scotland. Vet. Parasitol. 145 1-2 (2007) 65-76
20. SAS, 1999. SAS Online Doc Version 8, Cary, NC, SAS Institute Inc.
21. Swiss Ordinance on Good Laboratory Practice, adopted 18th May 2005 [RS 813.112.1]. This Ordinance is based on the OECD Principles of Good Laboratory Practice, as revised in 1997 and adopted 26th November 1997 by decision of the OECD Council [C(97) 186/Final].
22. van Wyk J.A., Malan F.S., and Randles J.L. How long before resistance makes it impossible to control some field strains of Haemonchus contortus in South Africa with any of the modern anthelmintics?. Vet. Parasitol. 70 (1997) 111-122
23. VICH Guideline for efficacy of anthelmintics: general requirements. VICH GL7, November 2000.
24. VICH Guideline for Good Clinical Practice. VICH GL9, June 2000.
25. Waghorn T.S., Leathwick D.M., Rhodes A.P., Lawrence K.E., Jackson R., Pomroy W.E., West D.M., and Moffat J.R. Prevalence of anthelmintic resistance on sheep farms in New Zealand. NZ. Vet. J. 54 6 (2006) 271-277
26. Waller P.J., Dash K.M., Barger I.A., Le Jambre L.F., and Plant J. Anthelmintic resistance in nematode parasites of sheep: learning from the Australian experience. Vet. Rec. 136 (1995) 411-413
27. Waller P.J. Anthelmintic resistance. Vet. Parasitol. 72 (1997) 391-412
28. Welsman, S.J., 2001. 'Keeping sheep alive'. Australian Wool Innovations Program review, Australian Wool Innovations, Sydney, Australia.
29. Wood I.B., Amaral N.K., Bairden K., Duncan J.L., Kassai T., Malone Jr. J.B., Pankavich J.A., Reinecke R.K., Slocombe O., Taylor S.M., and Vercruysse J. World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P) second edition of guidelines for evaluating the efficacy of anthelmintics in ruminants (bovine, ovine, caprine). Vet. Parasitol. 58 (1995) 181-213
30. Wrigley J., McArthur M., McKenna P.B., and Mariadass B. Resistance to a triple combination of broad-spectrum anthelmintics in naturally-acquired Ostertagia circumcincta infections in sheep. NZ. Vet. J. 54 1 (2006) 47-49