Michael-type addition as a convenient method for regioselective N-alkylation of ambident uracils

Synthesis

Volumn , Issue 10, 2010, Pages 1573-1589

  Boncel, Sawomir ^a   Gondela, Andrzej ^a   Walczak, Krzysztof ^a  

^a SILESIAN UNIVERSITY OF TECHNOLOGY   (Poland)

Author keywords

Alkylation; Michael addition; Nucleobases; Nucleosides; Regioselectivity

Indexed keywords

ALKYLATION REACTIONS; COVALENTLY BONDED; DRUG MOLECULES; ELECTROPHILES; FUNCTIONALISATION; GLYCOSIDIC BOND; MICHAEL ADDITIONS; N-ALKYLATION; NUCLEOBASES; NUCLEOSIDES; PYRIMIDINE NUCLEOSIDES; RADIOCHEMOTHERAPY; REGIO-SELECTIVE; SUBSTITUTED URACILS; SYNTHETIC METHODS; URACIL DERIVATIVES;

ADDITION REACTIONS; ALKYLATION; BIOMOLECULES; ELECTRONIC STRUCTURE; REGIOSELECTIVITY; SYNTHESIS (CHEMICAL);

HYDROCARBONS;

2 AMINO 3 [3 (2 CARBOXYETHYL)URACIL 1 YL]PROPIONIC ACID; 3 (3,5 DIMETHYLBENZYL) 1 CYANOMETHYLURACIL; 5 ETHYNYLURACIL; 5 MERCAPTOURACIL; 6 ARYLAMINO 3 (OMEGA HYDROXYBUTYL)URACIL DERIVATIVE; ACYCLIC NUCLEOSIDE; ANTINEOPLASTIC AGENT; CIDOFOVIR; FLUOROURACIL; GEMCITABINE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; URACIL DERIVATIVE; URAMUSTINE; ZIDOVUDINE;

ALKYLATION; BREAST CANCER; CHEMICAL MODIFICATION; COVALENT BOND; CYTOMEGALOVIRUS INFECTION; DIGESTIVE SYSTEM CANCER; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOSELECTIVITY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LEUKEMIA; MICHAEL ADDITION; PHYSICAL CHEMISTRY; RADIOCHEMISTRY; REACTION ANALYSIS; RESPIRATORY TRACT CANCER; REVIEW; STRUCTURE ACTIVITY RELATION;

EID: 77952018607     PISSN: 00397881     EISSN: 1437210X     Source Type: Journal    
DOI: 10.1055/s-0029-1218757     Document Type: Review

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