Origin of the electrocardiographic U wave: Effects of M cells and dynamic gap junction coupling

Annals of Biomedical Engineering

Volumn 38, Issue 3, 2010, Pages 1060-1070

  Hopenfeld, Bruce ^a   Ashikaga, Hiroshi ^b  

^a Angel Medical Systems Inc   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Computer modeling; Electrocardiography; Transmural dispersion of repolarization; U wave

Indexed keywords

2-D MODEL; 3D MODELS; BODY SURFACE; BODY SURFACE POTENTIALS; COMPUTER MODELING; GAP JUNCTIONS; HEART TISSUES; POTENTIAL MINIMA; T WAVES; TRANSMURAL DISPERSION OF REPOLARIZATION; WAVE MODELING;

ELECTROCARDIOGRAPHY; ELECTROCHROMIC DEVICES; THREE DIMENSIONAL; TWO DIMENSIONAL;

DISPERSION (WAVES);

ACTION POTENTIAL; ARTICLE; BIOLOGICAL MODEL; CELL COMMUNICATION; CELL JUNCTION; COMPUTER SIMULATION; ELECTROCARDIOGRAPHY; HEART MUSCLE CELL; HEART MUSCLE CONDUCTION SYSTEM; HUMAN; METHODOLOGY; PHYSIOLOGY;

ACTION POTENTIALS; CELL COMMUNICATION; COMPUTER SIMULATION; ELECTROCARDIOGRAPHY; GAP JUNCTIONS; HEART CONDUCTION SYSTEM; HUMANS; MODELS, CARDIOVASCULAR; MYOCYTES, CARDIAC;

EID: 77952011707     PISSN: 00906964     EISSN: 15739686     Source Type: Journal    
DOI: 10.1007/s10439-010-9941-5     Document Type: Conference Paper

References (32)

1. C Antzelevitch 2005 Modulation of transmural repolarization Ann. N. Y. Acad. Sci. 1047 314 323 10.1196/annals.1341.028 16093507
2. C Antzelevitch S Sicouri 1994 Clinical relevance of cardiac arrhythmias generated by after depolarizations. Role of M cells in the generation of U waves, triggered activity and torsade de pointes J. Am. Coll. Cardiol. 23 1 259 277 8277090
3. H Ashikaga BA Coppola B Hopenfeld ES Leifer ER McVeigh JH Omens 2007 Transmural dispersion of myofiber mechanics: implications for electrical heterogeneity in vivo J. Am. Coll. Cardiol. 49 8 909 916 10.1016/j.jacc.2006.07. 074 17320750
4. SG Campbell SN Flaim CH Leem AD McCulloch 2008 Mechanisms of transmurally varying myocyte electromechanics in an integrated computational model Philos. Trans. 366 1879 3361 3380 10.1098/rsta.2008.0088
5. M Depolli V Avbelj R Trobec 2008 Computer-simulated alternative modes of U-wave genesis J. Cardiovasc. Electrophysiol. 19 1 84 89 17916148
6. D di Bernardo A Murray 2000 Computer model for study of cardiac repolarization J. Cardiovasc. Electrophysiol. 11 8 895 899 10.1111/j.1540-8167. 2000.tb00069.x 10969752
7. D di Bernardo A Murray 2002 Origin on the electrocardiogram of U-waves and abnormal U-wave inversion Cardiovasc. Res. 53 1 202 208 10.1016/S0008- 6363(01)00439-4 11744029
8. E Drouin F Charpentier C Gauthier K Laurent H Le Marec 1995 Electrophysiologic characteristics of cells spanning the left ventricular wall of human heart: evidence for presence of M cells J. Am. Coll. Cardiol. 26 1 185 192 10.1016/0735-1097(95)00167-X 7797750
9. W Einthoven 1906 Le elecardiogramme Arch. Int. Physiol. 4 132 164
10. M Goernig J Haueisen M Liehr M Schlosser HR Figulla U Leder 2010 Detection of U wave activity in healthy volunteers by high-resolution magnetocardiography J. Electrocardiol. 43 1 43 47 10.1016/j.jelectrocard.2009. 06.004 19608197
11. Hoffman, J. D. The finite element method. In: Numerical Methods for Engineers and Scientists, 2nd ed, edited by J. D. Hoffman. New York: Marcel Dekker, 2001, pp. 711-774.
12. Hoffman, B. F., and P. F. Cranefield. Electrophysiology of the Heart. New York: McGraw-Hill, 1960.
13. B Hopenfeld 2007 ST segment depression: the possible role of global repolarization dynamics Biomed. Eng. Online 6 6 10.1186/1475-925X-6-6 17291348
14. Lepeschkin, E. Physiological basis of the U wave. In: Advances in Electrocardiography, edited by R. C. Schlant, and J. W. Hurst. New York: Grune and Stratton, 1972, pp. 431-447.
15. X Lin J Gemel EC Beyer RD Veenstra 2005 Dynamic model for ventricular junctional conductance during the cardiac action potential Am. J. Physiol. Heart Circ. Physiol. 288 3 H1113 H1123 10.1152/ajpheart.00882.2004 15513960
16. WT Miller DB Geselowitz 1978 Simulation studies of the electrocardiogram. I. The normal heart Circ. Res. 43 2 301 315 668061
17. AL Muzikant EW Hsu PD Wolf CS Henriquez 2002 Region specific modeling of cardiac muscle: comparison of simulated and experimental potentials Ann. Biomed. Eng. 30 7 867 883 10.1114/1.1509453 12398418
18. Nesterenko, V. V., and C. Antzelevitch. Simulation of the electrocardiographic U wave in heterogeneous myocardium: effect of local junctional resistance. Proceedings of the Computers in Cardiology. Los Alamitos, CA: IEEE Computer Society Press, pp. 43-46, 1992.
19. PM Nielsen IJ Le Grice BH Smaill PJ Hunter 1991 Mathematical model of geometry and fibrous structure of the heart Am. J. Physiol. 260 4 Pt 2 H1365 H1378 2012234
20. A Noma N Tsuboi 1987 Dependence of junctional conductance on proton, calcium and magnesium ions in cardiac paired cells of guinea pig J. Physiol. 382 193 211 2442361
21. C Oka H Matsuda N Sarai A Noma 2006 Modeling the calcium gate of cardiac gap junction channel J. Physiol. Sci. 56 1 79 85 10.2170/physiolsci.R2139 16779915
22. T Opthof R Coronel MJ Janse 2009 Is there a significant transmural gradient in repolarization time in the intact heart? Repolarization gradients in the intact heart Circ. Arrhythm. Electrophysiol. 2 89 96 10.1161/CIRCEP.108. 825356 19808447
23. HJ Ritsema van Eck JA Kors G van Herpen 2005 The U wave in the electrocardiogram: a solution for a 100-year-old riddle Cardiovasc. Res. 67 2 256 262 10.1016/j.cardiores.2005.04.010 15913583
24. S Rush H Larsen 1978 A practical algorithm for solving dynamic membrane equations IEEE Trans. Biomed. Eng. 25 4 389 392 10.1109/TBME.1978.326270 689699
25. R Schimpf C Antzelevitch D Haghi C Giustetto A Pizzuti F Gaita C Veltmann C Wolpert M Borggrefe 2008 Electromechanical coupling in patients with the short QT syndrome: further insights into the mechanoelectrical hypothesis of the U wave Heart Rhythm 5 2 241 245 10.1016/j.hrthm.2007.10.015 18242547
26. MS Spach RC Barr 1975 Ventricular intramural and epicardial potential distributions during ventricular activation and repolarization in the intact dog Circ. Res. 37 2 243 257 1149199
27. MS Spach RC Barr RB Warren DW Benson A Walston SB Edwards 1979 Isopotential body surface mapping in subjects of all ages: emphasis on low-level potentials with analysis of the method Circulation 59 4 805 821 421322
28. JG Stinstra B Hopenfeld RS Macleod 2005 On the passive cardiac conductivity Ann. Biomed. Eng. 3 12 1743 1751 10.1007/s10439-005-7257-7
29. B Surawicz 1998 U wave: facts, hypotheses, misconceptions, and misnomers J. Cardiovasc. Electrophysiol. 9 10 1117 1128 10.1111/j.1540-8167.1998.tb00890.x 9817564
30. P Taggart P Sutton T Opthof R Coronel P Kallis 2003 Electrotonic cancellation of transmural electrical gradients in the left ventricle in man Prog. Biophys. Mol. Biol. 82 1-3 243 254 10.1016/S0079-6107(03)00025-7 12732283
31. KH ten Tusscher D Noble PJ Noble AV Panfilov 2004 A model for human ventricular tissue Am. J. Physiol. Heart Circ. Physiol. 286 4 H1573 H1589 10.1152/ajpheart.00794.2003 14656705
32. GX Yan C Antzelevitch 1998 Cellular basis for the normal T wave and the electrocardiographic manifestations of the long-QT syndrome Circulation 98 18 1928 1936 9799215