DNase I hypersensitivity and ε-globin transcriptional3 enhancement are separable in locus control region (LCR) HS1 mutant human β-globin YAC transgenic mice

Journal of Biological Chemistry

Volumn 285, Issue 19, 2010, Pages 14495-14503

  Shimotsuma, Motoshi ^a   Okamura, Eiichi ^a   Matsuzaki, Hitomi ^a   Fukamizu, Akiyoshi ^a   Tanimoto, Keiji ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DELETION ANALYSIS; ERYTHROID CELLS; GLOBIN GENE; IN-VITRO; IN-VIVO; K562 CELLS; LOCUS CONTROL REGION; MUTANT HUMAN; MUTANT MICE; NUCLEOTIDE MUTATION; SITE FORMATION; TRANSGENIC MICE;

HEMOGLOBIN; NUCLEIC ACIDS; NUCLEOTIDES;

GENE EXPRESSION;

BETA GLOBIN; DEOXYRIBONUCLEASE I; EPSILON GLOBIN; GAMMA GLOBIN; TRANSCRIPTION FACTOR GATA 1;

ANEMIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL STRAIN K 562; CONTROLLED STUDY; ENHANCER REGION; ERYTHROID CELL; FETUS; GENE DELETION; GENE EXPRESSION; GENE MUTATION; GENE SEQUENCE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; MOUSE MUTANT; NONHUMAN; PRIORITY JOURNAL; REGULATOR GENE; TRANSCRIPTION REGULATION; TRANSGENIC MOUSE; YEAST ARTIFICIAL CHROMOSOME;

ANIMALS; BASE SEQUENCE; BETA-GLOBINS; BLOTTING, WESTERN; CHROMATIN IMMUNOPRECIPITATION; CHROMOSOMES, ARTIFICIAL, YEAST; DEOXYRIBONUCLEASE I; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ENHANCER ELEMENTS, GENETIC; EPSILON-GLOBINS; ERYTHROID CELLS; GAMMA-GLOBINS; GATA1 TRANSCRIPTION FACTOR; HUMANS; LOCUS CONTROL REGION; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; MUTATION; PROMOTER REGIONS, GENETIC; REGULATORY SEQUENCES, NUCLEIC ACID; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEQUENCE DELETION; SEQUENCE HOMOLOGY, NUCLEIC ACID; TRANSCRIPTION, GENETIC;

MUS; MUS MUSCULUS;

EID: 77951997021     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.116525     Document Type: Article

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