Machine perfusion or cold storage in organ transplantation: Indication, mechanisms, and future perspectives

Transplant International

Volumn 23, Issue 6, 2010, Pages 561-570

  Yuan, Xiaodong ^a,b   Theruvath, Ashok J ^a   Ge, Xupeng ^a   Floerchinger, Bernhard ^a   Jurisch, Anke ^a   García Cardeña, Guillermo ^a   Tullius, Stefan G ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG UNIVERSITY   (China)

Author keywords

Cold storage; Machine perfusion; Transplantation

Indexed keywords

ALLOPURINOL; CELSIOR; GLUCONIC ACID; GLUTATHIONE; HTK SOLUTION; IGL 1; IMMUNOSUPPRESSIVE AGENT; LACTOBIONIC ACID; MANNITOL; POLYSOL; PRESERVATION SOLUTION; UNCLASSIFIED DRUG; GLUCOSE; POTASSIUM CHLORIDE; PROCAINE;

AWARENESS; CLINICAL TRIAL; COLD ISCHEMIA; COOLING; CRYOPRESERVATION; DELAYED GRAFT FUNCTION; GRAFT PATENCY; GRAFT RECIPIENT; GRAFT REJECTION; GRAFT SURVIVAL; HEART TRANSPLANTATION; HUMAN; KIDNEY PRESERVATION; KIDNEY TRANSPLANTATION; MACHINE; NONHUMAN; ORGAN PERFUSION; ORGAN PRESERVATION; ORGAN TRANSPLANTATION; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTECTION; REVIEW; TREATMENT OUTCOME; UNITED STATES; UNIVERSITY HOSPITAL; COLD; PERFUSION; PROCEDURES; PULSATILE FLOW; TRENDS;

COLD TEMPERATURE; CRYOPRESERVATION; GLUCOSE; HUMANS; MANNITOL; ORGAN PRESERVATION; ORGAN PRESERVATION SOLUTIONS; PERFUSION; POTASSIUM CHLORIDE; PROCAINE; PULSATILE FLOW;

EID: 77951944886     PISSN: 09340874     EISSN: 14322277     Source Type: Journal    
DOI: 10.1111/j.1432-2277.2009.01047.x     Document Type: Review

References (91)

1. Kim IK, Bedi DS, Denecke C, Ge X, Tullius SG. Impact of innate and adaptive immunity on rejection and tolerance. Transplantation 2008 86 : 889.
2. Port FK, Bragg-Gresham JL, Metzger RA, et al. Donor characteristics associated with reduced graft survival: an approach to expanding the pool of kidney donors. Transplantation 2002 74 : 1281.
3. Rudich SM, Kaplan B, Magee JC, et al. Renal transplantations performed using non-heart-beating organ donors: going back to the future? Transplantation 2002 74 : 1715. (Pubitemid 36019325)
4. Maathuis MH, Leuvenink HG, Ploeg RJ. Perspectives in organ preservation. Transplantation 2007 83 : 1289.
5. Hoffman A, Burger C, Persky L. Extracorporeal renal storage. Invest Urol 1965 2 : 567.
6. Carrel A, Lindbergh CA. The culture of whole organs. Science 1935 81 : 621.
7. Belzer FO, Ashby BS, Gulyassy PF, Powell M. Successful seventeen-hour preservation and transplantation of human-cadaver kidney. N Engl J Med 1968 278 : 608.
8. Belzer FO, Ashby BS, Dunphy JE. 24-hour and 72-hour preservation of canine kidneys. Lancet 1967 2 : 536.
9. Clark EA, Terasaki PI, Opelz G, Mickey MR. Cadaver-kidney transplant failures at one month. N Engl J Med 1974 291 : 1099.
10. Opelz G, Terasaki PI. Kidney preservation: perfusion versus cold storage-1975. Transplant Proc 1976 8 : 121.
11. Opelz G, Terasaki PI. Advantage of cold storage over machine perfusion for preservation of cadaver kidneys. Transplantation 1982 33 : 64. (Pubitemid 12162773)
12. van der Vliet JA, Vroemen JP, Cohen B, Lansbergen Q, Kootstra G. Preservation of cadaveric kidneys. Cold storage or machine perfusion? Arch Surg 1983 118 : 1166. (Pubitemid 13005829)
13. Collins GM, Bravo-Shugarman M, Terasaki PI. Kidney preservation for transportation. Initial perfusion and 30 hours' ice storage. Lancet 1969 2 : 1219.
14. Opelz G, Dohler B. Multicenter analysis of kidney preservation. Transplantation 2007 83 : 247. (Pubitemid 46247850)
15. Ploeg RJ, Goossens D, Vreugdenhil P, McAnulty JF, Southard JH, Belzer FO. Successful 72-hour cold storage kidney preservation with UW solution. Transplant Proc 1988 20 : 935.
16. Groenewoud AF, Isemer FE, Stadler J, Heideche CD, Florack G, Hoelscher M. A comparison of early function between kidney grafts protected with HTK solution versus Euro-Collins solution. Transplant Proc 1989 21 : 1243. (Pubitemid 19130818)
17. Isemer FE, Ludwig A, Schunck O, Bretschneider HJ, Peiper HJ. Kidney procurement with the HTK solution of Bretschneider. Transplant Proc 1988 20 : 885. (Pubitemid 18261334)
18. Tojimbara T, Wicomb WN, Garcia-Kennedy R, et al. Liver transplantation from non-heart beating donors in rats: influence of viscosity and temperature of initial flushing solutions on graft function. Liver Transpl Surg 1997 3 : 39. (Pubitemid 27045730)
19. Morariu AM, Vd Plaats A, W VO, et al. Hyperaggregating effect of hydroxyethyl starch components and University of Wisconsin solution on human red blood cells: a risk of impaired graft perfusion in organ procurement? Transplantation 2003 76 : 37.
20. Olschewski P, Hunold G, Eipel C, et al. Improved microcirculation by low-viscosity histidine- tryptophan-ketoglutarate graft flush and subsequent cold storage in University of Wisconsin solution: results of an orthotopic rat liver transplantation model. Transpl Int 2008 21 : 1175.
21. Bachmann S, Bechstein WO, Keck H, et al. Pilot study: Carolina Rinse Solution improves graft function after orthotopic liver transplantation in humans. Transplant Proc 1997 29 : 390. (Pubitemid 27123456)
22. Wamser P, Asari R, Goetzinger P, et al. Detrimental effects of controlled reperfusion on renal function after porcine autotransplantation are fully compensated by the use of Carolina rinse solution. Transpl Int 2003 16 : 191. (Pubitemid 36682196)
23. Bessems M, Doorschodt BM, van Marle J, Vreeling H, Meijer AJ, van Gulik TM. Improved machine perfusion preservation of the non-heart-beating donor rat liver using Polysol: a new machine perfusion preservation solution. Liver Transpl 2005 11 : 1379. (Pubitemid 40459774)
24. Pienaar BH, Lindell SL, Van Gulik T, Southard JH, Belzer FO. Seventy-two-hour preservation of the canine liver by machine perfusion. Transplantation 1990 49 : 258. (Pubitemid 20088155)
25. Bretschneider HJ. Myocardial protection. Thorac Cardiovasc Surg 1980 28 : 295.
26. Muhlbacher F, Langer F, Mittermayer C. Preservation solutions for transplantation. Transplant Proc 1999 31 : 2069. (Pubitemid 29376529)
27. de Boer J, De Meester J, Smits JM, et al. Eurotransplant randomized multicenter kidney graft preservation study comparing HTK with UW and Euro-Collins. Transpl Int 1999 12 : 447. (Pubitemid 30009069)
28. Agarwal A, Murdock P, Fridell JA. Comparison of histidine-tryptophan- ketoglutarate solution and University of Wisconsin solution in prolonged cold preservation of kidney allografts. Transplantation 2006 81 : 480. (Pubitemid 43255739)
29. Lynch RJ, Kubus J, Chenault RH, Pelletier SJ, Campbell DA, Englesbe MJ. Comparison of histidine-tryptophan-ketoglutarate and University of Wisconsin preservation in renal transplantation. Am J Transplant 2008 8 : 567. (Pubitemid 351287525)
30. Roels L, Coosemans W, Donck J, et al. Inferior outcome of cadaveric kidneys preserved for more than 24 hr in histidine-tryptophan-ketoglutarate solution. Leuven Collaborative Group for Transplantation. Transplantation 1998 66 : 1660.
31. Englesbe MJ, Heidt D, Sung R, Pietroski R. Does using HTK solution for cold perfusion of cadaveric kidneys save money? Transplantation 2006 82 : 580. (Pubitemid 43948312)
32. Stewart ZA, Lonze BE, Warren DS, et al. Histidine-tryptophan- ketoglutarate (HTK) is associated with reduced graft survival of deceased donor kidney transplants. Am J Transplant 2009 9 : 1048.
33. Stewart ZA, Cameron AM, Singer AL, Dagher NN, Montgomery RA, Segev DL. Histidine-tryptophan-ketoglutarate (HTK) is associated with reduced graft survival in pancreas transplantation. Am J Transplant 2009 9 : 217.
34. Stewart ZA, Cameron AM, Singer AL, Montgomery RA, Segev DL. Histidine-Tryptophan-Ketoglutarate (HTK) is associated with reduced graft survival in deceased donor livers, especially those donated after cardiac death. Am J Transplant 2009 9 : 286.
35. Menasche P, Termignon JL, Pradier F, et al. Experimental evaluation of Celsior, a new heart preservation solution. Eur J Cardiothorac Surg 1994 8 : 207.
36. Pedotti P, Cardillo M, Rigotti P, et al. A comparative prospective study of two available solutions for kidney and liver preservation. Transplantation 2004 77 : 1540. (Pubitemid 38703034)
37. Marcen R, Burgos FJ, Ocana J, et al. Wisconsin and Celsior solutions in renal preservation: a comparative preliminary study. Transplant Proc 2005 37 : 1419. (Pubitemid 40712067)
38. Montalti R, Nardo B, Capocasale E, et al. Kidney transplantation from elderly donors: a prospective randomized study comparing celsior and UW solutions. Transplant Proc 2005 37 : 2454. (Pubitemid 40459772)
39. Nunes P, Mota A, Figueiredo A, et al. Efficacy of renal preservation: comparative study of Celsior and University of Wisconsin solutions. Transplant Proc 2007 39 : 2478. (Pubitemid 47588354)
40. Perez Sanz P, Burgos Revilla FJ, Marcen Letosa R, Pascual Santos J, Merino Rivas JL, Ortuno Mirete J. Celsior's kidney preservation in renal transplantation. Our experience. Actas Urol Esp 2004 28 : 49.
41. Eugene M. Polyethyleneglycols and immunocamouflage of the cells tissues and organs for transplantation. Cell Mol Biol (Noisy-le-grand) 2004 50 : 209.
42. Badet L, Petruzzo P, Lefrancois N, et al. Kidney preservation with IGL-1 solution: a preliminary report. Transplant Proc 2005 37 : 308. (Pubitemid 40459769)
43. Codas R, Petruzzo P, Morelon E, et al. IGL-1 solution in kidney transplantation: first multi-center study. Clin Transplant 2009 23 : 337.
44. Bessems M, Doorschodt BM, van Vliet AK, van Gulik TM. Machine perfusion preservation of the non-heart-beating donor rat livers using polysol, a new preservation solution. Transplant Proc 2005 37 : 326. (Pubitemid 40459774)
45. Bessems M, Doorschodt BM, van Vliet AK, van Gulik TM. Improved rat liver preservation by hypothermic continuous machine perfusion using polysol, a new, enriched preservation solution. Liver Transpl 2005 11 : 539. (Pubitemid 40459774)
46. Schreinemachers MC, Doorschodt BM, Florquin S, et al. Improved preservation and microcirculation with POLYSOL after transplantation in a porcine kidney autotransplantation model. Nephrol Dial Transplant 2009 24 : 816.
47. Schreinemachers MC, Doorschodt BM, Florquin S, Idu MM, Tolba RH, van Gulik TM. Improved renal function of warm ischemically damaged kidneys using Polysol. Transplant Proc 2009 41 : 32.
48. Schold JD, Kaplan B, Howard RJ, Reed AI, Foley DP, Meier-Kriesche HU. Are we frozen in time? Analysis of the utilization and efficacy of pulsatile perfusion in renal transplantation. Am J Transplant 2005 5 : 1681. (Pubitemid 40910450)
49. D'Alessandro AM, Fernandez LA, Chin LT, et al. Donation after cardiac death: the University of Wisconsin experience. Ann Transplant 2004 9 : 68.
50. Matsuoka L, Shah T, Aswad S, et al. Pulsatile perfusion reduces the incidence of delayed graft function in expanded criteria donor kidney transplantation. Am J Transplant 2006 6 : 1473. (Pubitemid 44030332)
51. Stratta RJ, Moore PS, Farney AC, et al. Influence of pulsatile perfusion preservation on outcomes in kidney transplantation from expanded criteria donors. J Am Coll Surg 2007 204 : 873. Discussion 82-4.
52. Boon RA, Horrevoets AJ. Key transcriptional regulators of the vasoprotective effects of shear stress. Hamostaseologie 2009 29 : 39. 1-3.
53. Rao RM, Yang L, Garcia-Cardena G, Luscinskas FW. Endothelial-dependent mechanisms of leukocyte recruitment to the vascular wall. Circ Res 2007 101 : 234. (Pubitemid 47344073)
54. Parmar KM, Larman HB, Dai G, et al. Integration of flow-dependent endothelial phenotypes by Kruppel-like factor 2. J Clin Invest 2006 116 : 49. (Pubitemid 43121790)
55. Sebzda E, Zou Z, Lee JS, Wang T, Kahn ML. Transcription factor KLF2 regulates the migration of naive T cells by restricting chemokine receptor expression patterns. Nat Immunol 2008 9 : 292. (Pubitemid 351267326)
56. Tullius SG, Garcia-Cardena G. Organ procurement and perfusion before transplantation. N Engl J Med 2009 360 : 78.
57. Kozaki K, Sakurai E, Tamaki I, et al. Usefulness of continuous hypothermic perfusion preservation for cadaveric renal grafts in poor condition. Transplant Proc 1995 27 : 757.
58. Kozaki K, Sakurai E, Uchiyama M, Matsuno N, Kozaki M, Nagao T. Development of hypothermic continuous perfusion preservation machine equipped with nonpulsatile pump and its clinical application. Transplant Proc 2000 32 : 5. (Pubitemid 30100731)
59. Divonin AL, Mishchenko BP, Loginova LI, Mikhailova ML. Changes in the liver circulation and kidney function during pulsatile and non-pulsatile perfusion. Anesteziol Reanimatol 1991 3 : 36.
60. Dutkowski P, Odermatt B, Heinrich T, et al. Hypothermic oscillating liver perfusion stimulates ATP synthesis prior to transplantation. J Surg Res 1998 80 : 365. (Pubitemid 29019695)
61. Fukae K, Tominaga R, Tokunaga S, Kawachi Y, Imaizumi T, Yasui H. The effects of pulsatile and nonpulsatile systemic perfusion on renal sympathetic nerve activity in anesthetized dogs. J Thorac Cardiovasc Surg 1996 111 : 478. (Pubitemid 26054051)
62. Barber WH, Deierhoi MH, Phillips MG, Diethelm AG. Preservation by pulsatile perfusion improves early renal allograft function. Transplant Proc 1988 20 : 865.
63. Burdick JF, Rosendale JD, McBride MA, Kauffman HM, Bennett LE. National impact of pulsatile perfusion on cadaveric kidney transplantation. Transplantation 1997 64 : 1730.
64. Halloran P, Aprile M. A randomized prospective trial of cold storage versus pulsatile perfusion for cadaver kidney preservation. Transplantation 1987 43 : 827. (Pubitemid 17084258)
65. Light JA, Kowalski AE, Gage F, Callender CO, Sasaki TM. Immediate function and cost comparison between ice storage and pulsatile preservation in kidney recipients at one hospital. Transplant Proc 1995 27 : 2962.
66. Sellers MT, Gallichio MH, Hudson SL, et al. Improved outcomes in cadaveric renal allografts with pulsatile preservation. Clin Transplant 2000 14 : 543.
67. Wight JP, Chilcott JB, Holmes MW, Brewer N. Pulsatile machine perfusion vs. cold storage of kidneys for transplantation: a rapid and systematic review. Clin Transplant 2003 17 : 293. (Pubitemid 36958191)
68. Wight J, Chilcott J, Holmes M, Brewer N. The clinical and cost-effectiveness of pulsatile machine perfusion versus cold storage of kidneys for transplantation retrieved from heart-beating and non-heart-beating donors. Health Technol Assess 2003 7 : 1. (Pubitemid 37203499)
69. Moers C, Smits JM, Maathuis MH, et al. Machine perfusion or cold storage in deceased-donor kidney transplantation. N Engl J Med 2009 360 : 7.
70. Fuller BJ, Pegg DE. The assessment of renal preservation by normothermic bloodless perfusion. Cryobiology 1976 13 : 177.
71. Brasile L, Stubenitsky BM, Booster MH, et al. Overcoming severe renal ischemia: the role of ex vivo warm perfusion. Transplantation 2002 73 : 897. (Pubitemid 34252351)
72. Valero R, Cabrer C, Oppenheimer F, et al. Normothermic recirculation reduces primary graft dysfunction of kidneys obtained from non-heart-beating donors. Transpl Int 2000 13 : 303.
73. McLaren AJ, Friend PJ. Trends in organ preservation. Transpl Int 2003 16 : 701.
74. Compagnon P, Clement B, Campion JP, Boudjema K. Effects of hypothermic machine perfusion on rat liver function depending on the route of perfusion. Transplantation 2001 72 : 606. (Pubitemid 32802740)
75. Clavien PA, Harvey PR, Strasberg SM. Preservation and reperfusion injuries in liver allografts. An overview and synthesis of current studies. Transplantation 1992 53 : 957.
76. Iwamoto H, Matsuno N, Narumi Y, et al. Beneficial effect of machine perfusion preservation on liver transplantation from non-heart-beating donors. Transplant Proc 2000 32 : 1645. (Pubitemid 32118514)
77. Peltz M, He TT, Adams GAt, et al. Perfusion preservation maintains myocardial ATP levels and reduces apoptosis in an ex vivo rat heart transplantation model. Surgery 2005 138 : 795. (Pubitemid 41546204)
78. Rosenbaum DH, Peltz M, DiMaio JM, et al. Perfusion preservation versus static preservation for cardiac transplantation: effects on myocardial function and metabolism. J Heart Lung Transplant 2008 27 : 93.
79. Fitton TP, Wei C, Lin R, et al. Impact of 24 h continuous hypothermic perfusion on heart preservation by assessment of oxidative stress. Clin Transplant 2004 18 (Suppl. 12 22. (Pubitemid 39214093)
80. Nickless DK, Rabinov M, Richards SM, Conyers RA, Rosenfeldt FL. Continuous perfusion improves preservation of donor rat hearts: Importance of the implantation phase. Ann Thorac Surg 1998 65 : 1265. (Pubitemid 28241678)
81. Poston RS, Gu J, Prastein D, et al. Optimizing donor heart outcome after prolonged storage with endothelial function analysis and continuous perfusion. Ann Thorac Surg 2004 78 : 1362. Discussion 70. (Pubitemid 39303864)
82. Biguzas M, Jablonski P, Howden BO, et al. Evaluation of UW solution in rat kidney preservation. II. The effect of pharmacological additives. Transplantation 1990 49 : 1051. (Pubitemid 20227626)
83. Brasile L, Stubenitsky BM, Booster MH, Arenada D, Haisch C, Kootstra G. Transfection and transgene expression in a human kidney during ex vivo warm perfusion. Transplant Proc 2002 34 : 2624. (Pubitemid 35304858)
84. Kwiatkowski A, Wszola M, Kosieradzki M, et al. Machine perfusion preservation improves renal allograft survival. Am J Transplant 2007 7 : 1942. (Pubitemid 47037987)
85. Kwiatkowski A, Wszola M, Kosieradzki M, et al. The early and long term function and survival of kidney allografts stored before transplantation by hypothermic pulsatile perfusion. A prospective randomized study. Ann Transplant 2009 14 : 14.
86. Gage F, Ali M, Alijani MR, et al. Comparison of static versus pulsatile preservation of matched-paired kidneys. Transplant Proc 1997 29 : 3644. (Pubitemid 28008633)
87. van der Vliet JA, Kievit JK, Hene RJ, Hilbrands LB, Kootstra G. Preservation of non-heart-beating donor kidneys: a clinical prospective randomised case-control study of machine perfusion versus cold storage. Transplant Proc 2001 33 : 847. (Pubitemid 32237650)
88. Shap AP, Milgrom DP, Mangus RS, Powelson JA, Goggins WC, Milgrom ML. Comparison of pulsatile perfusion and cold storage for paired kidney allografts. Transplantation 2008 86 : 1006.
89. Polyak MM, Arrington BO, Stubenbord WT, et al. The influence of pulsatile preservation on renal transplantation in the 1990s. Transplantation 2000 69 : 249.
90. Merion RM, Oh HK, Port FK, Toledo-Pereyra LH, Turcotte JG. A prospective controlled trial of cold-storage versus machine-perfusion preservation in cadaveric renal transplantation. Transplantation 1990 50 : 230.
91. Alijani MR, Cutler JA, DelValle CJ, et al. Single-donor cold storage versus machine perfusion in cadaver kidney preservation. Transplantation 1985 40 : 659.