Commentary: Vitamin D and autoimmunity. Is there an association?

Journal of the American Academy of Dermatology

Volumn 62, Issue 6, 2010, Pages 942-944

  Ersoy Evans, Sibel ^a  

^a HACETTEPE UNIVERSITY   (Turkey)

Author keywords

autoimmunity; lupus erythematosus; multiple sclerosis; rheumatoid arthritis; vitamin; vitamin D; vitiligo

Indexed keywords

ALFACALCIDOL; CALCITRIOL; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 17; INTERLEUKIN 21; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; VITAMIN D;

ADAPTIVE IMMUNITY; ANTIGEN PRESENTATION; AUTOIMMUNITY; DISEASE ACTIVITY; DRUG MEGADOSE; EDITORIAL; HUMAN; IMMUNE FUNCTION TEST; IMMUNOREGULATION; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; RISK FACTOR; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE; TH17 CELL; VITAMIN INTAKE;

AUTOIMMUNE DISEASES; HUMANS; VITAMIN D; VITAMIN D DEFICIENCY; VITILIGO;

EID: 77951905865     PISSN: 01909622     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaad.2010.02.009     Document Type: Editorial

References (28)

1. Agmon-Levin N., and Shoenfeld Y. Prediction and prevention of autoimmune skin disorders. Arch Dermatol Res 301 (2009) 57-64
2. Silverberg J.I., Silverberg A.I., Malka E., and Silverberg N. A pilot study assessing the role of 25 hydroxy vitamin D levels in patients with vitiligo vulgaris. J Am Acad Dermatol 62 (2010) 937-941
3. Mora J.R., Iwata M., and von Adrian U.H. Vitamin effects on the immune system: vitamins A and D take center stage. Nat Rev Immunol 8 (2008) 685-698
4. Cantorna M.T., and Mahon B.D. Mounting evidence for vitamin D as an environmental factor affecting autoimmune disease prevalence. Exp Biol Med 229 (2004) 1136-1142
5. Jahnsen J., Falch J.A., Mowinckel P., and Aadland E. Vitamin D status, parathyroid hormone and bone mineral density in patients with inflammatory bowel disease. Scand J Gastroenterol 37 (2002) 192-199
6. Froicu M., Weaver V., Wynn T.A., McDowell M.A., Welsh J.E., and Cantorna M.T. A crucial role for the vitamin D receptor in experimental inflammatory bowel diseases. Mol Endocrinol 17 (2003) 2386-2392
7. Munger K.L., Zhang S.M., O'Reilly E., Hernán M.A., Olek M.J., Willett W.C., et al. Vitamin D intake and incidence of multiple sclerosis. Neurology 62 (2004) 60-65
8. Smolders J., Menheere P., Kessels A., Damoiseaux J., and Hupperts R. Association of vitamin D metabolite levels with relapse rate and disability in multiple sclerosis. Mult Scler 14 (2008) 1220-1224
9. Correale J., Ysrraelit M.C., and Gaitan M.I. Immunomodulatory effects of vitamin D in multiple sclerosis. Brain 132 (2009) 1146-1160
10. Kamen D.L., Cooper G.S., Bouali H., Shaftman S.R., Hollis B.W., and Gilkeson G.S. Vitamin D deficiency in systemic lupus erythematosus. Autoimmun Rev 5 (2006) 114-117
11. Zipitis C.S., and Akobeng A.K. Vitamin D supplementation in early childhood and risk of type 1 diabetes: a systematic review and meta-analysis. Arch Dis Child 93 (2008) 512-517
12. Borkar VV, Verma S, Bhalla A. Low levels of vitamin D in North Indian children with newly diagnosed type 1 diabetes. Pediatr Diabetes doi:10.1111/j.1399-5448.2009.00589.x. Published online November 9, 2009.
13. Cutolo M., Otsa K., Uprus M., Paolino S., and Seriolo B. Vitamin D in rheumatoid arthritis. Autoimmun Rev 7 (2007) 59-64
14. Andjelkovic Z., Vojinovic J., Pejnovic N., Popovic M., Dujic A., Mitrovic D., et al. Disease modifying and immunomodulatory effects of high dose 1 alpha (OH) D3 in rheumatoid arthritis patients. Clin Exp Rheumatol 17 (1999) 453-456
15. Fritsche J., Mondal K., Ehrnsperger A., Andreesen R., and Kreutz M. Regulation of 25 hydroxyvitamin D3-1 alpha-hydroxylase and production of 1 alpha 25-dihyroxyvitamin D3 by human dendritic cells. Blood 102 (2003) 3314-3316
16. 3: basic concepts. J Steroid Biochem Mol Biol 97 (2005) 93-101
17. Roncarolo M.G., Levings M.K., and Traversari C. Differentiation of T regulatory cells by immature dendritic cells. J Exp Med 193 (2001) F5-F9
18. Vila J., Isaacs J.D., and Anderson A.E. Regulatory T cells and autoimmunity. Curr Opin Hematol 16 (2009) 274-279
19. Penna G., and Adorini L. 1{alpha},25-Dihydroxyvitamin D3 inhibits differentiation, maturation, activation, and survival of dendritic cells leading to impaired alloreactive T cell activation. J Immunol 164 (2000) 2405-2411
20. D'Ambrosio D., Cippitelli M., Cocciolo M.G., Mazzeo D., Di Lucia P., Lang R., et al. Inhibition of IL-12 production by 1,25-dihydroxyvitamin D3: involvement of NF-kappa B downregulation in transcriptional repression of the p40 gene. J Clin Invest 101 (1998) 252-262
21. Cippitelli M., Santoni A., and Vitamin D. a transcriptional modulator of the interferon-gamma gene. Eur J Immunol 10 (1998) 3017-3030
22. 3-mediated effects. J Immunol 160 (1998) 209-218
23. + T cells to enhance the development of Th2 cells. J Immunol 167 (2001) 4974-4980
24. Loser K., Mehling A., Loeser S., Apelt J., Kuhn A., Grabbe S., et al. Epidermal RANKL controls regulatory T-cell numbers via activation of dendritic cells. Nat Med 12 (2006) 1372-1379
25. Spach K.M., Nashold F.E., Dittel B.N., and Hayes C.E. IL-10 signaling is essential for 1,25-dihydroxyvitamin D3-mediated inhibition of experimental autoimmune encephalomyelitis. J Immunol 177 (2006) 6030-6037
26. Bettelli E., Korn T., Oukka M., and Kuchroo V.K. Induction and effector functions of Th17 cells. Nature 453 (2009) 1051-1057
27. Dardalhon V., Korn T., Kuchroo V.K., and Anderson A.C. Role of Th1 and Th17 cells in organ-specific autoimmunity. J Autoimmun 31 (2008) 252-256
28. Langrish C.L., Chen Y., Blumenschein W.M., Mattson J., Basham B., Sedgwick J.D., et al. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J Exp Med 201 (2005) 233-240