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Volumn 208, Issue 1, 2010, Pages 96-105

Altered neuroligin expression is involved in social deficits in a mouse model of the fragile X syndrome

Author keywords

FMRP; Fragile X syndrome; MRNA interactions; Neuroligin; Social behaviour; Synaptogenesis

Indexed keywords

FRAGILE X MENTAL RETARDATION PROTEIN; MESSENGER RNA; NEUREXIN; NEUROLIGIN; NEUROLIGIN 1; NEUROLIGIN 2; NEUROLIGIN 3; UNCLASSIFIED DRUG; CARRIER PROTEIN; DLGH4 PROTEIN, MOUSE; FMR1 PROTEIN, MOUSE; GEPHYRIN; MEMBRANE PROTEIN; NERVE CELL ADHESION MOLECULE; NERVE PROTEIN; PARVALBUMIN; SIGNAL PEPTIDE; SLC17A7 PROTEIN, MOUSE; VESICULAR GLUTAMATE TRANSPORTER 1; VOLTAGE DEPENDENT ANION CHANNEL;

EID: 77951897264     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2009.11.019     Document Type: Article
Times cited : (84)

References (81)
  • 1
    • 0036301947 scopus 로고    scopus 로고
    • A decade of molecular studies on the fragile X syndrome
    • O'Donnell W.T., Warren S.T. A decade of molecular studies on the fragile X syndrome. Annu Rev Neurosci 2002, 25:3115-3138.
    • (2002) Annu Rev Neurosci , vol.25 , pp. 3115-3138
    • O'Donnell, W.T.1    Warren, S.T.2
  • 2
    • 53849110899 scopus 로고    scopus 로고
    • Fragile X syndrome: loss of local mRNA regulation alters synaptic development and function
    • Bassell D.J., Warren S.T. Fragile X syndrome: loss of local mRNA regulation alters synaptic development and function. Neuron 2008, 60:201-214.
    • (2008) Neuron , vol.60 , pp. 201-214
    • Bassell, D.J.1    Warren, S.T.2
  • 3
    • 18044379515 scopus 로고    scopus 로고
    • Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome
    • Brown V., Jin P., Ceman S., Darnell J.C., O'Donnell W.T., Tenenbaum S.A., et al. Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome. Cell 2001, 107:477-487.
    • (2001) Cell , vol.107 , pp. 477-487
    • Brown, V.1    Jin, P.2    Ceman, S.3    Darnell, J.C.4    O'Donnell, W.T.5    Tenenbaum, S.A.6
  • 4
    • 0035900649 scopus 로고    scopus 로고
    • Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function
    • Darnell J.C., Jensen K.B., Jin P., Brown V., Warren S.T., Darnell R.B. Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function. Cell 2001, 107:489-499.
    • (2001) Cell , vol.107 , pp. 489-499
    • Darnell, J.C.1    Jensen, K.B.2    Jin, P.3    Brown, V.4    Warren, S.T.5    Darnell, R.B.6
  • 5
    • 55749088807 scopus 로고    scopus 로고
    • Quantitative proteomic analysis of primary neurons reveals diverse changes in synaptic protein content in fmr1 knockout mice
    • Liao L., Park S.K., Xu T., Vanderklish P., Yates Y.R. Quantitative proteomic analysis of primary neurons reveals diverse changes in synaptic protein content in fmr1 knockout mice. PNAS 2008, 105:15281-15286.
    • (2008) PNAS , vol.105 , pp. 15281-15286
    • Liao, L.1    Park, S.K.2    Xu, T.3    Vanderklish, P.4    Yates, Y.R.5
  • 6
    • 0345492360 scopus 로고    scopus 로고
    • The fragile X mental retardation protein is required for type-I metabotropic glutamate receptor-dependent translation of PSD-95
    • Todd P.K., Mack K.J., Malter J.S. The fragile X mental retardation protein is required for type-I metabotropic glutamate receptor-dependent translation of PSD-95. PNAS 2003, 100:14374-14378.
    • (2003) PNAS , vol.100 , pp. 14374-14378
    • Todd, P.K.1    Mack, K.J.2    Malter, J.S.3
  • 7
    • 34247485947 scopus 로고    scopus 로고
    • A new function for the fragile X mental retardation protein in regulation of PSD-95mRNA stability
    • Zalfa F., Eleuteri B., Dickson K.S., Mercaldo V., De Rubeis S., di Penta A., et al. A new function for the fragile X mental retardation protein in regulation of PSD-95mRNA stability. Nat Neurosci 2007, 10:578-587.
    • (2007) Nat Neurosci , vol.10 , pp. 578-587
    • Zalfa, F.1    Eleuteri, B.2    Dickson, K.S.3    Mercaldo, V.4    De Rubeis, S.5    di Penta, A.6
  • 8
    • 34249064936 scopus 로고    scopus 로고
    • Dysregulated metabotropic glutamate receptor-dependent translation of AMPA receptor and postsynaptic density-95 mRNAs at synapses in a mouse model of fragile X syndrome
    • Muddashetty R.S., Kelic S., Gross C., Xu M., Bassell G.J. Dysregulated metabotropic glutamate receptor-dependent translation of AMPA receptor and postsynaptic density-95 mRNAs at synapses in a mouse model of fragile X syndrome. J Neurosci 2007, 27:5338-5348.
    • (2007) J Neurosci , vol.27 , pp. 5338-5348
    • Muddashetty, R.S.1    Kelic, S.2    Gross, C.3    Xu, M.4    Bassell, G.J.5
  • 9
    • 2942637528 scopus 로고    scopus 로고
    • Distinct spatiotemporal expression of SAPAP transcripts in the developing rat brain: a novel dendritically localized mRNA
    • Kindler S., Rehbein M., Classen B., Richter D., Boeckers T.M. Distinct spatiotemporal expression of SAPAP transcripts in the developing rat brain: a novel dendritically localized mRNA. Mol Brain Res 2004, 126:14-21.
    • (2004) Mol Brain Res , vol.126 , pp. 14-21
    • Kindler, S.1    Rehbein, M.2    Classen, B.3    Richter, D.4    Boeckers, T.M.5
  • 10
    • 37549044298 scopus 로고    scopus 로고
    • FMRP phosphorylation reveals an immediate-early signalling pathway triggered by group I mGluR and mediated by PP2A
    • Narayanan U., Nalavadi V., Nakamoto M., Pallas D.C., Ceman S., Bassell G.J., et al. FMRP phosphorylation reveals an immediate-early signalling pathway triggered by group I mGluR and mediated by PP2A. J Neurosci 2007, 27:14349-14357.
    • (2007) J Neurosci , vol.27 , pp. 14349-14357
    • Narayanan, U.1    Nalavadi, V.2    Nakamoto, M.3    Pallas, D.C.4    Ceman, S.5    Bassell, G.J.6
  • 11
    • 44449121279 scopus 로고    scopus 로고
    • A direct role for FMRP in activity dependent dendritic mRNA transport links filopodial spine morphogenesis to fragile X syndrome
    • Dictenberg J.B., Swanger S.A., Antar L.B., Singer R.H., Bassell G.J. A direct role for FMRP in activity dependent dendritic mRNA transport links filopodial spine morphogenesis to fragile X syndrome. Dev Cell 2008, 14:926-939.
    • (2008) Dev Cell , vol.14 , pp. 926-939
    • Dictenberg, J.B.1    Swanger, S.A.2    Antar, L.B.3    Singer, R.H.4    Bassell, G.J.5
  • 12
    • 0036210068 scopus 로고    scopus 로고
    • Analysis of the human neurexin genes: alternative splicing and the generation of protein diversity
    • Rowen L., Young J., Birditt B., Kaur A., Madan A., Philipps D.L., et al. Analysis of the human neurexin genes: alternative splicing and the generation of protein diversity. Genomics 2002, 79:587-597.
    • (2002) Genomics , vol.79 , pp. 587-597
    • Rowen, L.1    Young, J.2    Birditt, B.3    Kaur, A.4    Madan, A.5    Philipps, D.L.6
  • 13
    • 0036270811 scopus 로고    scopus 로고
    • Structure and evolution of neurexin genes: insight into the mechanism of alternative splicing
    • Tabuchi K., Südhof T.C. Structure and evolution of neurexin genes: insight into the mechanism of alternative splicing. Genomics 2002, 79:849-859.
    • (2002) Genomics , vol.79 , pp. 849-859
    • Tabuchi, K.1    Südhof, T.C.2
  • 15
    • 0033914984 scopus 로고    scopus 로고
    • Neuroligation: building synapses around the neurexin-neuroligin link
    • Rao A., Harms K.J., Craig A.M. Neuroligation: building synapses around the neurexin-neuroligin link. Nat Neurosci 2000, 3(8):747-749.
    • (2000) Nat Neurosci , vol.3 , Issue.8 , pp. 747-749
    • Rao, A.1    Harms, K.J.2    Craig, A.M.3
  • 16
    • 0037109042 scopus 로고    scopus 로고
    • Direct interactions between PSD95 and stargazin control synaptic AMPA receptor number
    • Schnell E., Sizemore M., Karimzadegan S., Chen L., Bredt D.S., Nicoll R.A. Direct interactions between PSD95 and stargazin control synaptic AMPA receptor number. PNAS 2002, 99(1390):2-7.
    • (2002) PNAS , vol.99 , Issue.1390 , pp. 2-7
    • Schnell, E.1    Sizemore, M.2    Karimzadegan, S.3    Chen, L.4    Bredt, D.S.5    Nicoll, R.A.6
  • 17
    • 0037319324 scopus 로고    scopus 로고
    • PSD-95 regulates synaptic transmission and plasticity in rat cerebral cortex
    • Beique J.C., Andrade R. PSD-95 regulates synaptic transmission and plasticity in rat cerebral cortex. J Physiol 2003, 546(Pt 3):859-867.
    • (2003) J Physiol , vol.546 , Issue.PART 3 , pp. 859-867
    • Beique, J.C.1    Andrade, R.2
  • 19
    • 0038045645 scopus 로고    scopus 로고
    • Postsynaptic density-95 mimics and occludes hippocampal long-term potentiation and enhances long-term depression
    • Stein V., House D.R., Bredt D.S., Nicoll R.A. Postsynaptic density-95 mimics and occludes hippocampal long-term potentiation and enhances long-term depression. J Neurosci 2003, 23(13):5503-5506.
    • (2003) J Neurosci , vol.23 , Issue.13 , pp. 5503-5506
    • Stein, V.1    House, D.R.2    Bredt, D.S.3    Nicoll, R.A.4
  • 20
    • 0742322856 scopus 로고    scopus 로고
    • Postsynaptic density 95 controls AMPA receptor incorporation during long-term potentiation and experience-driven synaptic plasticity
    • Ehrlich I., Malinow R. Postsynaptic density 95 controls AMPA receptor incorporation during long-term potentiation and experience-driven synaptic plasticity. J Neurosci 2004, 24(4):916-927.
    • (2004) J Neurosci , vol.24 , Issue.4 , pp. 916-927
    • Ehrlich, I.1    Malinow, R.2
  • 21
    • 4644353516 scopus 로고    scopus 로고
    • A balance between excitatory and inhibitory synapses is controlled by PSD-95 and neuroligin
    • Prange O., Wong T.P., Gerrow K., Wang Y.T., El-Husseini A. A balance between excitatory and inhibitory synapses is controlled by PSD-95 and neuroligin. PNAS 2004, 101(38):13915-13920.
    • (2004) PNAS , vol.101 , Issue.38 , pp. 13915-13920
    • Prange, O.1    Wong, T.P.2    Gerrow, K.3    Wang, Y.T.4    El-Husseini, A.5
  • 22
    • 34247237148 scopus 로고    scopus 로고
    • PSD-95 is required for activity-driven synapse stabilization
    • Ehrlich I., Klein M., Rumpel S., Malinow R. PSD-95 is required for activity-driven synapse stabilization. PNAS 2007, 104(10):4176-4181.
    • (2007) PNAS , vol.104 , Issue.10 , pp. 4176-4181
    • Ehrlich, I.1    Klein, M.2    Rumpel, S.3    Malinow, R.4
  • 23
    • 33846564563 scopus 로고    scopus 로고
    • Retrograde modulation of presynaptic release probability through signalling mediated by PSD-95-neuroligin
    • Futai K., Kim M.J., Hashikawa T., Scheiffele P., Sheng M., Hayashi Y. Retrograde modulation of presynaptic release probability through signalling mediated by PSD-95-neuroligin. Nat Neurosci 2007, 10(2):186-195.
    • (2007) Nat Neurosci , vol.10 , Issue.2 , pp. 186-195
    • Futai, K.1    Kim, M.J.2    Hashikawa, T.3    Scheiffele, P.4    Sheng, M.5    Hayashi, Y.6
  • 26
    • 37049028145 scopus 로고    scopus 로고
    • Structural analysis of the synaptic protein neuroligin and its β-neurexin complex: determinants for folding and cell adhesion
    • Fabrichny I.P., Leone P., Sulzenbacher G., Comoletti D., Miller M.T., Taylor P., et al. Structural analysis of the synaptic protein neuroligin and its β-neurexin complex: determinants for folding and cell adhesion. Neuron 2007, 56:979-991.
    • (2007) Neuron , vol.56 , pp. 979-991
    • Fabrichny, I.P.1    Leone, P.2    Sulzenbacher, G.3    Comoletti, D.4    Miller, M.T.5    Taylor, P.6
  • 28
    • 37849021314 scopus 로고    scopus 로고
    • Structural basis for synaptic adhesion mediated by neuroligin-neurexin interactions
    • Chen X., Liu H., Shim A.H.R., Focia P.J., He X. Structural basis for synaptic adhesion mediated by neuroligin-neurexin interactions. Nat Struct Mol Biol 2008, 15:50-56.
    • (2008) Nat Struct Mol Biol , vol.15 , pp. 50-56
    • Chen, X.1    Liu, H.2    Shim, A.H.R.3    Focia, P.J.4    He, X.5
  • 29
    • 2442713977 scopus 로고    scopus 로고
    • The Arg451Cys neuroligin-3 mutation associated with autism reveals a defect in protein processing
    • Comoletti D., De Jaco A., Jennings L.L., Flynn R.E., Gaietta G., Tsigelny I., et al. The Arg451Cys neuroligin-3 mutation associated with autism reveals a defect in protein processing. J Neurosci 2004, 24:4889-4893.
    • (2004) J Neurosci , vol.24 , pp. 4889-4893
    • Comoletti, D.1    De Jaco, A.2    Jennings, L.L.3    Flynn, R.E.4    Gaietta, G.5    Tsigelny, I.6
  • 30
    • 69749113369 scopus 로고    scopus 로고
    • A neuroligin-4 missense mutation associated with autism impairs neuroligin-4 folding and endoplasmic reticulum export
    • Zhang C., Milunsky J.M., Newton S., Ko J., Zhao G., Maher T.A., et al. A neuroligin-4 missense mutation associated with autism impairs neuroligin-4 folding and endoplasmic reticulum export. J Neurosci 2009, (35):10843-10854.
    • (2009) J Neurosci , Issue.35 , pp. 10843-10854
    • Zhang, C.1    Milunsky, J.M.2    Newton, S.3    Ko, J.4    Zhao, G.5    Maher, T.A.6
  • 31
    • 0037656313 scopus 로고    scopus 로고
    • Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism
    • Jamain S., Quach H., Betancur C., Rastam M., Colineaux C., Gillberg I.C., et al. Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism. Nat Genet 2003, 34:27-29.
    • (2003) Nat Genet , vol.34 , pp. 27-29
    • Jamain, S.1    Quach, H.2    Betancur, C.3    Rastam, M.4    Colineaux, C.5    Gillberg, I.C.6
  • 33
    • 15744363782 scopus 로고    scopus 로고
    • Synaptogenesis: a balancing act between excitation and inhibition
    • Cline H. Synaptogenesis: a balancing act between excitation and inhibition. Curr Biol 2005, 15:R203-R205.
    • (2005) Curr Biol , vol.15
    • Cline, H.1
  • 34
    • 54049091941 scopus 로고    scopus 로고
    • Neuroligins and neurexins link synaptic function to cognitive disease
    • Südhof T.C. Neuroligins and neurexins link synaptic function to cognitive disease. Nature 2008, 455:903-911.
    • (2008) Nature , vol.455 , pp. 903-911
    • Südhof, T.C.1
  • 35
    • 40349096250 scopus 로고    scopus 로고
    • Reduced social interaction and ultrasonic communication in a mouse model of monogenic heritable autism
    • Jamain S., Radyushkin K., Hammerschmidt K., Granon S., Boretius S., Varoqueaux F., et al. Reduced social interaction and ultrasonic communication in a mouse model of monogenic heritable autism. PNAS 2008, 105(5):1710-1715.
    • (2008) PNAS , vol.105 , Issue.5 , pp. 1710-1715
    • Jamain, S.1    Radyushkin, K.2    Hammerschmidt, K.3    Granon, S.4    Boretius, S.5    Varoqueaux, F.6
  • 36
    • 42649125261 scopus 로고    scopus 로고
    • Familial deletion within NLGN4 associated with autism and Tourette syndrome
    • Lawson-Yuen A., Saldivar J.S., Sommer S., Picker J. Familial deletion within NLGN4 associated with autism and Tourette syndrome. Eur J Hum Genet 2008, 16(5):614-618.
    • (2008) Eur J Hum Genet , vol.16 , Issue.5 , pp. 614-618
    • Lawson-Yuen, A.1    Saldivar, J.S.2    Sommer, S.3    Picker, J.4
  • 37
    • 75149113269 scopus 로고    scopus 로고
    • Over-expression of the cell adhesion protein neuroligin-1 induces learning deficits and impairs synaptic plasticity by altering the ration of excitation to inhibition in the hippocampus
    • in press.
    • Dahlhaus R, Hines RM, Eadie B, Kannangara T, Hines DJ, Brown CE, et al. Over-expression of the cell adhesion protein neuroligin-1 induces learning deficits and impairs synaptic plasticity by altering the ration of excitation to inhibition in the hippocampus. Hippocampus, in press.
    • Hippocampus
    • Dahlhaus, R.1    Hines, R.M.2    Eadie, B.3    Kannangara, T.4    Hines, D.J.5    Brown, C.E.6
  • 38
    • 4644333560 scopus 로고    scopus 로고
    • Automated apparatus for quantisation of social approach behaviours in mice
    • Nadler J.J., Moy S.S., Dold G., Trang D., Simmons N., Perez A., et al. Automated apparatus for quantisation of social approach behaviours in mice. Genes Brain Behav 2004, 3:303-314.
    • (2004) Genes Brain Behav , vol.3 , pp. 303-314
    • Nadler, J.J.1    Moy, S.S.2    Dold, G.3    Trang, D.4    Simmons, N.5    Perez, A.6
  • 39
    • 26444548563 scopus 로고    scopus 로고
    • Altered anxiety-related and social behaviours in the Fmr1 knockout mouse model of fragile X syndrome
    • Spencer C.M., Alekseyenko O., Serysheva E., Yuva-Paylor L.A., Paylor R. Altered anxiety-related and social behaviours in the Fmr1 knockout mouse model of fragile X syndrome. Genes Brain Behav 2005, 4:420-430.
    • (2005) Genes Brain Behav , vol.4 , pp. 420-430
    • Spencer, C.M.1    Alekseyenko, O.2    Serysheva, E.3    Yuva-Paylor, L.A.4    Paylor, R.5
  • 40
    • 31444443968 scopus 로고    scopus 로고
    • Social behaviour deficits in the Fmr1 mutant mouse
    • Mineur Y.S., Huynh L.X., Crusio W.E. Social behaviour deficits in the Fmr1 mutant mouse. Behav. Brain Res 2006, 168:172-175.
    • (2006) Behav. Brain Res , vol.168 , pp. 172-175
    • Mineur, Y.S.1    Huynh, L.X.2    Crusio, W.E.3
  • 41
    • 49749143326 scopus 로고    scopus 로고
    • Impaired spatial learning strategies and novel object recognition in mice haploinsufficient for the dual specificity tyrosine-regulated Kinase 1a (Dyrk1a)
    • Arque G., Fotaki V., Fernandez D., Lagran M.M., Arbones M.L., Dierssen M. Impaired spatial learning strategies and novel object recognition in mice haploinsufficient for the dual specificity tyrosine-regulated Kinase 1a (Dyrk1a). PLOS One 2008, 3(7):e2575.
    • (2008) PLOS One , vol.3 , Issue.7
    • Arque, G.1    Fotaki, V.2    Fernandez, D.3    Lagran, M.M.4    Arbones, M.L.5    Dierssen, M.6
  • 42
  • 43
    • 0024551137 scopus 로고
    • Experimental observations on the development of polarity by hippocampal neurons in culture
    • Goslin K., Banker G. Experimental observations on the development of polarity by hippocampal neurons in culture. J Cell Biol 1989, 108(4):1507-1516.
    • (1989) J Cell Biol , vol.108 , Issue.4 , pp. 1507-1516
    • Goslin, K.1    Banker, G.2
  • 44
    • 46749119818 scopus 로고    scopus 로고
    • Synaptic imbalance, stereotypies, and impaired social interactions in mice with altered neuroligin 2 expression
    • Hines R.M., Wu L., Hines D.J., Steenland H., Mansour S., Dahlhaus R., et al. Synaptic imbalance, stereotypies, and impaired social interactions in mice with altered neuroligin 2 expression. J Neurosci 2008, (24):6055-6067.
    • (2008) J Neurosci , Issue.24 , pp. 6055-6067
    • Hines, R.M.1    Wu, L.2    Hines, D.J.3    Steenland, H.4    Mansour, S.5    Dahlhaus, R.6
  • 45
    • 0033514448 scopus 로고    scopus 로고
    • Neuroligin1 is a postsynaptic cell adhesion molecule of excitatory synapses
    • Song J.Y., Ichtchenko K., Südhof T.C., Brose N. Neuroligin1 is a postsynaptic cell adhesion molecule of excitatory synapses. PNAS 1999, 96:1100-1125.
    • (1999) PNAS , vol.96 , pp. 1100-1125
    • Song, J.Y.1    Ichtchenko, K.2    Südhof, T.C.3    Brose, N.4
  • 46
    • 7244261850 scopus 로고    scopus 로고
    • Synaptic targeting of neuroligin is independent of neurexin and SAP90/PSD95 binding
    • Dresbach T., Neeb A., Meyer G., Gundelfinger E.D., Brose N. Synaptic targeting of neuroligin is independent of neurexin and SAP90/PSD95 binding. Mol Cell Neurosci 2004, 27(3):227-235.
    • (2004) Mol Cell Neurosci , vol.27 , Issue.3 , pp. 227-235
    • Dresbach, T.1    Neeb, A.2    Meyer, G.3    Gundelfinger, E.D.4    Brose, N.5
  • 47
    • 3042812471 scopus 로고    scopus 로고
    • Localisation of synapsin-1 and PSD-95 in developing postnatal rat cerebellar cortex
    • Castejon O.J., Fuller L., Dailey M.E. Localisation of synapsin-1 and PSD-95 in developing postnatal rat cerebellar cortex. Brain Res Dev Brain Res 2004, 151:25-32.
    • (2004) Brain Res Dev Brain Res , vol.151 , pp. 25-32
    • Castejon, O.J.1    Fuller, L.2    Dailey, M.E.3
  • 48
    • 27844451078 scopus 로고    scopus 로고
    • A cytoplasmic motif targets neuroligin-1 exclusively to dendrites of cultured hippocampal neurons
    • Rosales C.R., Osborne K.D., Zuccarino G.V., Scheiffele P., Silverman M.A. A cytoplasmic motif targets neuroligin-1 exclusively to dendrites of cultured hippocampal neurons. Eur J Neurosci 2005, 22(9):2381-2386.
    • (2005) Eur J Neurosci , vol.22 , Issue.9 , pp. 2381-2386
    • Rosales, C.R.1    Osborne, K.D.2    Zuccarino, G.V.3    Scheiffele, P.4    Silverman, M.A.5
  • 49
    • 0034625250 scopus 로고    scopus 로고
    • Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons
    • Scheiffele P., Fan J., Choih J., Fetter R., Serafini T. Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons. Cell 2000, 101(6):657-669.
    • (2000) Cell , vol.101 , Issue.6 , pp. 657-669
    • Scheiffele, P.1    Fan, J.2    Choih, J.3    Fetter, R.4    Serafini, T.5
  • 50
    • 33748981282 scopus 로고    scopus 로고
    • Fmr1 KO mice as a possible model of autistic features
    • Bernardet M., Crusio W.E. Fmr1 KO mice as a possible model of autistic features. Scientific World J 2006, 6:1164-1176.
    • (2006) Scientific World J , vol.6 , pp. 1164-1176
    • Bernardet, M.1    Crusio, W.E.2
  • 52
    • 0036197452 scopus 로고    scopus 로고
    • Behavioural and neuroanatomical characterization of the Fmr1 knockout mouse
    • Mineur Y.S., Sluyter F., de Wit S., Oostra B.A., Crusio W.E. Behavioural and neuroanatomical characterization of the Fmr1 knockout mouse. Hippocampus 2002, 12:39-46.
    • (2002) Hippocampus , vol.12 , pp. 39-46
    • Mineur, Y.S.1    Sluyter, F.2    de Wit, S.3    Oostra, B.A.4    Crusio, W.E.5
  • 53
    • 0034194228 scopus 로고    scopus 로고
    • (Over)correction of FMR1 deficiency with YAC transgenics: behavioural and physical features
    • Peier A.M., McIlwain K.L., Kenneson A., Warren S.T., Paylor R., Nelson D.L. (Over)correction of FMR1 deficiency with YAC transgenics: behavioural and physical features. Hum Mol Genet 2000, 9:1145-1159.
    • (2000) Hum Mol Genet , vol.9 , pp. 1145-1159
    • Peier, A.M.1    McIlwain, K.L.2    Kenneson, A.3    Warren, S.T.4    Paylor, R.5    Nelson, D.L.6
  • 54
    • 48249156612 scopus 로고    scopus 로고
    • Neuroligin-1 is required for normal expression of LTP and associative fear memory in the amygdala of adult animals
    • Kim J., Jung S.Y., Lee Y.K., Park S., Choi J.S., Lee C.J., et al. Neuroligin-1 is required for normal expression of LTP and associative fear memory in the amygdala of adult animals. PNAS 2008, 105(26):9087-9092.
    • (2008) PNAS , vol.105 , Issue.26 , pp. 9087-9092
    • Kim, J.1    Jung, S.Y.2    Lee, Y.K.3    Park, S.4    Choi, J.S.5    Lee, C.J.6
  • 55
    • 0034694851 scopus 로고    scopus 로고
    • Spatial learning, contextual fear conditioning and conditioned emotional response in Fmr1 knockout mice
    • Van Dam D., D'Hooge R., Hauben E., Reyniers E., Gantois I., Bakker C.E., et al. Spatial learning, contextual fear conditioning and conditioned emotional response in Fmr1 knockout mice. Behav Brain Res 2000, 117:127-136.
    • (2000) Behav Brain Res , vol.117 , pp. 127-136
    • Van Dam, D.1    D'Hooge, R.2    Hauben, E.3    Reyniers, E.4    Gantois, I.5    Bakker, C.E.6
  • 57
    • 33745994650 scopus 로고    scopus 로고
    • Alternative splicing controls selective trans-synaptic interactions of the neuroligin-neurexin complex
    • Chih B., Gollan L., Scheiffele P. Alternative splicing controls selective trans-synaptic interactions of the neuroligin-neurexin complex. Neuron 2006, 51(2):171-178.
    • (2006) Neuron , vol.51 , Issue.2 , pp. 171-178
    • Chih, B.1    Gollan, L.2    Scheiffele, P.3
  • 58
    • 34250211762 scopus 로고    scopus 로고
    • Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2
    • Chubykin A.A., Atasoy D., Etherton M.R., Brose N., Kavalali E.T., Gibson J.R., et al. Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2. Neuron 2007, 54(6):919-931.
    • (2007) Neuron , vol.54 , Issue.6 , pp. 919-931
    • Chubykin, A.A.1    Atasoy, D.2    Etherton, M.R.3    Brose, N.4    Kavalali, E.T.5    Gibson, J.R.6
  • 59
    • 32344434917 scopus 로고    scopus 로고
    • A preformed complex of postsynaptic proteins is involved in excitatory synapse development
    • Gerrow K., Romorini S., Nabi S.M., Colicos M.A., Sala C., El-Husseini A. A preformed complex of postsynaptic proteins is involved in excitatory synapse development. Neuron 2006, 49:547-562.
    • (2006) Neuron , vol.49 , pp. 547-562
    • Gerrow, K.1    Romorini, S.2    Nabi, S.M.3    Colicos, M.A.4    Sala, C.5    El-Husseini, A.6
  • 60
    • 11144352245 scopus 로고    scopus 로고
    • Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins
    • Graf E.R., Zhang X., Jin S.X., Linhoff M.W., Craig A.M. Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins. Cell 2004, 119:1013-1026.
    • (2004) Cell , vol.119 , pp. 1013-1026
    • Graf, E.R.1    Zhang, X.2    Jin, S.X.3    Linhoff, M.W.4    Craig, A.M.5
  • 61
    • 20444434316 scopus 로고    scopus 로고
    • Neuroligins mediate excitatory and inhibitory synapse formation: involvement of PSD-95 and neurexin-1beta in neuroligin-induced synaptic specificity
    • Levinson J.N., Chery N., Huang K., Wong T.P., Gerrow K., Kang R., et al. Neuroligins mediate excitatory and inhibitory synapse formation: involvement of PSD-95 and neurexin-1beta in neuroligin-induced synaptic specificity. J Biol Chem 2005, 280(17):17312-17319.
    • (2005) J Biol Chem , vol.280 , Issue.17 , pp. 17312-17319
    • Levinson, J.N.1    Chery, N.2    Huang, K.3    Wong, T.P.4    Gerrow, K.5    Kang, R.6
  • 62
    • 17844363471 scopus 로고    scopus 로고
    • Postsynaptic assembly induced by neurexin-neuroligin interaction and neurotransmitter
    • Nam C.I., Chen L. Postsynaptic assembly induced by neurexin-neuroligin interaction and neurotransmitter. PNAS 2005, 102(17):6137-6142.
    • (2005) PNAS , vol.102 , Issue.17 , pp. 6137-6142
    • Nam, C.I.1    Chen, L.2
  • 63
    • 38349098974 scopus 로고    scopus 로고
    • Induction of GABAergic postsynaptic differentiation by alpha-neurexins
    • Kang Y., Zhang X., Dobie F., Wu H., Craig A.M. Induction of GABAergic postsynaptic differentiation by alpha-neurexins. J Biol Chem 2008, 283(4):2323-2334.
    • (2008) J Biol Chem , vol.283 , Issue.4 , pp. 2323-2334
    • Kang, Y.1    Zhang, X.2    Dobie, F.3    Wu, H.4    Craig, A.M.5
  • 64
    • 20044388939 scopus 로고    scopus 로고
    • Sequence of abnormal dendritic spine development in primary somatosensory cortex of a mouse model of the fragile X mental retardation syndrome
    • Galvez R., Greenough W.T. Sequence of abnormal dendritic spine development in primary somatosensory cortex of a mouse model of the fragile X mental retardation syndrome. Am J Genet 2005, 135(2):155-160.
    • (2005) Am J Genet , vol.135 , Issue.2 , pp. 155-160
    • Galvez, R.1    Greenough, W.T.2
  • 65
    • 33746892681 scopus 로고    scopus 로고
    • Hippocampal pyramidal cells in adult Fmr1 knockout mice exhibit an immature-appearing profile of dendritic spines
    • Grossman A.W., Elissou N.M., McKinney B.C., Greenough W.T. Hippocampal pyramidal cells in adult Fmr1 knockout mice exhibit an immature-appearing profile of dendritic spines. Brain Res 2006, 1084:160-166.
    • (2006) Brain Res , vol.1084 , pp. 160-166
    • Grossman, A.W.1    Elissou, N.M.2    McKinney, B.C.3    Greenough, W.T.4
  • 66
    • 33746196574 scopus 로고    scopus 로고
    • Local protein synthesis and spine morphogenesis: fragile X syndrome and beyond
    • Grossman A.W., Aldridge G.M., Weiler I.J., Greenough W.T. Local protein synthesis and spine morphogenesis: fragile X syndrome and beyond. J Neurosci. 2006, 26(27):7151-7155.
    • (2006) J Neurosci. , vol.26 , Issue.27 , pp. 7151-7155
    • Grossman, A.W.1    Aldridge, G.M.2    Weiler, I.J.3    Greenough, W.T.4
  • 67
    • 17444384228 scopus 로고    scopus 로고
    • Kissing complex RNAs mediate interaction between the fragile-X mental retardation protein KH2 domain and brain polyribosomes
    • Darnell J.C., Fraser C.E., Mostovetsky O., Stefani G., Jones T.A., Eddy S.R., et al. Kissing complex RNAs mediate interaction between the fragile-X mental retardation protein KH2 domain and brain polyribosomes. Genes Dev 2005, 19:903-918.
    • (2005) Genes Dev , vol.19 , pp. 903-918
    • Darnell, J.C.1    Fraser, C.E.2    Mostovetsky, O.3    Stefani, G.4    Jones, T.A.5    Eddy, S.R.6
  • 68
    • 0141514471 scopus 로고    scopus 로고
    • Deja a vu all over again: FMRP binds U-rich target mRNAs
    • Denman R.B. Deja a vu all over again: FMRP binds U-rich target mRNAs. Biochem Biophys Res Commun 2003, 310:1-7.
    • (2003) Biochem Biophys Res Commun , vol.310 , pp. 1-7
    • Denman, R.B.1
  • 70
    • 58849130167 scopus 로고    scopus 로고
    • A novel function for fragile X mental retardation protein in translational activation
    • doi:10.1371/journal.pbio.1000016
    • Bechara EG, Didiot MC, Melko M, Davidovic L, Bensaid M, Patrick M, et al. A novel function for fragile X mental retardation protein in translational activation. PLoS Biol 7 (1) (2009), e1000016. doi:10.1371/journal.pbio.1000016.
    • (2009) PLoS Biol , vol.7 , Issue.1
    • Bechara, E.G.1    Didiot, M.C.2    Melko, M.3    Davidovic, L.4    Bensaid, M.5    Patrick, M.6
  • 71
    • 56349139112 scopus 로고    scopus 로고
    • Fragile X mental retardation protein recognition of G quadruplex structure per se is sufficient for high affinity binding to RNA
    • Bole M., Menon L., Mihailescu M.R. Fragile X mental retardation protein recognition of G quadruplex structure per se is sufficient for high affinity binding to RNA. Mol BioSyst 2008, 4:1212-1219.
    • (2008) Mol BioSyst , vol.4 , pp. 1212-1219
    • Bole, M.1    Menon, L.2    Mihailescu, M.R.3
  • 72
    • 3042647610 scopus 로고    scopus 로고
    • The mGluR theory of fragile X mental retardation
    • Bear M.F., Huber K.M., Warren S.T. The mGluR theory of fragile X mental retardation. Trends Neurosci 2004, 27:370-377.
    • (2004) Trends Neurosci , vol.27 , pp. 370-377
    • Bear, M.F.1    Huber, K.M.2    Warren, S.T.3
  • 73
    • 33750079257 scopus 로고    scopus 로고
    • High frequency of neurexin 1beta signal peptide structural variants in patients with autism
    • Feng J., Schroer R., Yan J., Song W., Yang C., Bockholt A., et al. High frequency of neurexin 1beta signal peptide structural variants in patients with autism. Neurosci Lett 2006, 409:10-13.
    • (2006) Neurosci Lett , vol.409 , pp. 10-13
    • Feng, J.1    Schroer, R.2    Yan, J.3    Song, W.4    Yang, C.5    Bockholt, A.6
  • 74
  • 75
    • 33845889998 scopus 로고    scopus 로고
    • Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are associated with autism spectrum disorders
    • Durand C.M., Betancur C., Boeckers T.M., Bockmann J., Chaste P., Faucherau F., et al. Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are associated with autism spectrum disorders. Nat Genet 2007, 39:25-27.
    • (2007) Nat Genet , vol.39 , pp. 25-27
    • Durand, C.M.1    Betancur, C.2    Boeckers, T.M.3    Bockmann, J.4    Chaste, P.5    Faucherau, F.6
  • 77
    • 84859432194 scopus 로고    scopus 로고
    • Autism as synaptopathy: animal models based on genetic mutations in trans-synaptic cell adhesion molecules
    • INSAR, Chicago, 8th annual international meeting for autism research, abstract 122.01
    • Powell C. Autism as synaptopathy: animal models based on genetic mutations in trans-synaptic cell adhesion molecules. INSAR, Chicago, 8th annual international meeting for autism research, abstract 122.01; 2009.
    • (2009)
    • Powell, C.1
  • 79
    • 59149088359 scopus 로고    scopus 로고
    • Increased anxiety-like behaviour in mice lacking the inhibitory cell adhesion molecule neuroligin 2
    • Blundell J., Tabuchi K., Bolliger M.F., Blaiss C.A., Brose N., Liu X., et al. Increased anxiety-like behaviour in mice lacking the inhibitory cell adhesion molecule neuroligin 2. Genes Brain Behavior 2009, 8(1):114-126.
    • (2009) Genes Brain Behavior , vol.8 , Issue.1 , pp. 114-126
    • Blundell, J.1    Tabuchi, K.2    Bolliger, M.F.3    Blaiss, C.A.4    Brose, N.5    Liu, X.6
  • 81
    • 69449089134 scopus 로고    scopus 로고
    • Regionalized loss of parvalbumin interneurons in the cerebral cortex of mice with deficits in GFRalpha1 signaling
    • Canty A.J., Dietze J., Harvey M., Enomoto H., Milbrandt J., Ibáñez C.F. Regionalized loss of parvalbumin interneurons in the cerebral cortex of mice with deficits in GFRalpha1 signaling. J Neurosci 2009, 29(34):10695-10705.
    • (2009) J Neurosci , vol.29 , Issue.34 , pp. 10695-10705
    • Canty, A.J.1    Dietze, J.2    Harvey, M.3    Enomoto, H.4    Milbrandt, J.5    Ibáñez, C.F.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.