Disrupting III3 impairs production of IL-4 specified by the linked allele

Nature Immunology

Volumn 2, Issue 5, 2001, Pages 461-466

  Guo, Liying ^a   Hu Li, Jane ^a   Zhu, Jinfang ^a   Pannetier, Christophe ^a,d   Watson, Cynthia ^a   McKenzie, Grahame J ^b   McKenzie, Andrew N J ^c   Paul, William E ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b Celldex Therapeutics Inc   (United Kingdom)

^c MEDICAL RESEARCH COUNCIL   (United Kingdom)

^d INSTITUT PASTEUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 13; INTERLEUKIN 4;

ALLELE; ANIMAL; ARTICLE; BIOSYNTHESIS; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENETIC LINKAGE; GENETICS; IMMUNOLOGY; MOUSE; MOUSE MUTANT; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TH2 CELL;

ALLELES; ANIMALS; GENE EXPRESSION; GENE EXPRESSION REGULATION; INTERLEUKIN-13; INTERLEUKIN-4; LINKAGE (GENETICS); MICE; MICE, MUTANT STRAINS; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TH2 CELLS;

EID: 0035344685     PISSN: 15292908     EISSN: None     Source Type: Journal    
DOI: 10.1038/87778     Document Type: Article

References (18)

1. Minty, A. et al. Interleukin-13 is a new human lymphokine regulating inflammatory and immune responses. Nature 362, 248-250 (1993).
2. Frazer, K. A. et al. Computational and biological analysis of 680 kb of DNA sequence from the human Sq31 cytokine gene cluster region. Genome Res. 7, 495-512 (1997).
3. Zurawski, S. M. et al. The primary binding subunit of the human interleukin-4 receptor is also a component of the interleukin-13 receptor. J. Biol. Chem. 270, 13869-13878 (1995).
4. Russell, S. M. et al. Interleukin-2 receptor γ chain: a functional component of the interleukin-4 receptor. Science 262, 1880-1883 (1993).
5. Zurawski, S. M., Vega, F. Jr, Huyghe, B. & Zurawski, G. Receptors for interleukin-13 and interleukin-4 are complex and share a novel component that functions in signal transduction. EMBO J. 12, 2663-2670 (1993).
6. Hilton, D. J. et al. Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor. Proc. Natl. Acad. Sci. USA 93, 497-501 (1996).
7. Obiri, N. I., Debinski, W., Leonard, W. J. & Puri, R. K. Receptor for interleukin 13. Interaction with interleukin 4 by a mechanism that does not involve the common gamma chain shared by receptors for interleukins 2, 4, 7, 9, and 15. J. Biol. Chem. 270, 8797-8804 (1995).
8. Nelms, K., Keegan, A. D., Zamorano, J., Ryan, J. J. & Paul, W. E. The IL-4 receptor: signaling mechanisms and biologic functions. Annu. Rev. Immunol. 17, 701-738 (1999).
9. Seder, R. A. & Paul, W. E. Acquisition of lymphokine-preducing phenotype by CD4T cells. Annu. Rev. Immunol. 12, 635-673 (1994).
10. McKenzie, G. J., Bancroft, A., Grencis, R. K. & McKenzie, A. N. A distinct role for interleukin-13 in Th2-cell-mediated immune responses. Curr. Biol. 8, 339-342 (1998).
11. McKenzie, G. J. et al. Impaired development of Th2 cells in IL-13-deficient mice. Immunity 9, 423-432 (1998).
12. Graber, P. et al. The distribution of IL-13 receptor α1 expression on B cells, T cells and monocytes and its regulation by IL-13 and IL-4. Eur. J. Immunol. 28, 4286-4298 (1998).
13. Poudrier, J. et al. A soluble form of IL-13 receptor alpha 1 promotes IgG2a and IgG2b production by murine germinal center B cells. J. Immunol. 163, 1153-1161 (1999).
14. +T cells provide an initial source of IL-4 during Th2 differentiation. J. Immunol. 165, 3620-3625 (2000).
15. Hu-Li, J. et al. Regulation of expression of IL-4 alleles: Analysis using a chimeric GFP/IL4 gene. Immunity 14, 1-11 (2001).
16. Kim, J. M. et al. Structure of the mouse IL-10 gene and chromosomal localization of the mouse and human genes. J. Immunol. 148, 3618-3623 (1992).
17. Loots, G. G. et al. Identification of a coordinate regulator of interleukins 4, 13, and 5 by cross-species sequence comparisons. Science 288, 136-140 (2000).
18. Takemoto, N. et al. Th2-specific DNase I-hypersensitive sites in the murine IL-13 and IL-4 intergenic region. Int. Immunol. 10, 1981-1985 (1998).