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Volumn 398, Issue 4, 2010, Pages 530-541

Molecular Basis for the High Degree of Antigenic Cross-Reactivity between Hepatitis B Virus Capsids (HBcAg) and Dimeric Capsid-Related Protein (HBeAg): Insights into the Enigmatic Nature of the e-Antigen

Author keywords

Core antigen; E antigen; Hepatitis B virus; Monoclonal antibody; Surface plasmon resonance

Indexed keywords

DIMER; EPITOPE; HEPATITIS B CORE ANTIGEN; HEPATITIS B(E) ANTIGEN; MONOCLONAL ANTIBODY; HEPATITIS B ANTIBODY;

EID: 77951885559     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2010.03.026     Document Type: Article
Times cited : (19)

References (40)
  • 2
    • 33750726385 scopus 로고    scopus 로고
    • Management of chronic hepatitis B: an evolving issue
    • Liaw Y.F. Management of chronic hepatitis B: an evolving issue. Liver Int. 2006, 26(Suppl. 2):1-2.
    • (2006) Liver Int. , vol.26 , Issue.2 SUPPL. , pp. 1-2
    • Liaw, Y.F.1
  • 5
    • 0030782534 scopus 로고    scopus 로고
    • Molecular biology of hepatitis B virus e antigen
    • Ou J.H. Molecular biology of hepatitis B virus e antigen. J. Gastroenterol. Hepatol. 1997, 12:S178-S187.
    • (1997) J. Gastroenterol. Hepatol. , vol.12
    • Ou, J.H.1
  • 6
    • 33845957338 scopus 로고    scopus 로고
    • Human hepatitis B viral e antigen interacts with cellular interleukin-1 receptor accessory protein and triggers interleukin-1 response
    • Yang C.Y., Kuo T.H., Ting L.P. Human hepatitis B viral e antigen interacts with cellular interleukin-1 receptor accessory protein and triggers interleukin-1 response. J. Biol. Chem. 2006, 281:34525-34536.
    • (2006) J. Biol. Chem. , vol.281 , pp. 34525-34536
    • Yang, C.Y.1    Kuo, T.H.2    Ting, L.P.3
  • 7
    • 0142151773 scopus 로고    scopus 로고
    • Exploring the biological basis of hepatitis B e antigen in hepatitis B virus infection
    • Milich D., Liang T.J. Exploring the biological basis of hepatitis B e antigen in hepatitis B virus infection. Hepatology 2003, 38:1075-1086.
    • (2003) Hepatology , vol.38 , pp. 1075-1086
    • Milich, D.1    Liang, T.J.2
  • 8
    • 0033152857 scopus 로고    scopus 로고
    • The crystal structure of the human hepatitis B virus capsid
    • Wynne S.A., Crowther R.A., Leslie A.G. The crystal structure of the human hepatitis B virus capsid. Mol. Cell 1999, 3:771-780.
    • (1999) Mol. Cell , vol.3 , pp. 771-780
    • Wynne, S.A.1    Crowther, R.A.2    Leslie, A.G.3
  • 10
    • 0027463464 scopus 로고
    • Structure of hepatitis B virus core and e-antigen. A single precore amino acid prevents nucleocapsid assembly
    • Schödel F., Peterson D., Zheng J., Jones J.E., Hughes J.L., Milich D.R. Structure of hepatitis B virus core and e-antigen. A single precore amino acid prevents nucleocapsid assembly. J. Biol. Chem. 1993, 268:1332-1337.
    • (1993) J. Biol. Chem. , vol.268 , pp. 1332-1337
    • Schödel, F.1    Peterson, D.2    Zheng, J.3    Jones, J.E.4    Hughes, J.L.5    Milich, D.R.6
  • 11
    • 0026787615 scopus 로고
    • A cysteine and a hydrophobic sequence in the noncleaved portion of the pre-C leader peptide determine the biophysical properties of the secretory core protein (HBe protein) of human hepatitis B virus
    • Wasenauer G., Kock J., Schlicht H.J. A cysteine and a hydrophobic sequence in the noncleaved portion of the pre-C leader peptide determine the biophysical properties of the secretory core protein (HBe protein) of human hepatitis B virus. J. Virol. 1993, 66:5338-5346.
    • (1993) J. Virol. , vol.66 , pp. 5338-5346
    • Wasenauer, G.1    Kock, J.2    Schlicht, H.J.3
  • 12
    • 0027264123 scopus 로고
    • An intramolecular disulfide bridge between Cys-7 and Cys61 determines the structure of the secretory core gene product (e antigen) of hepatitis B virus
    • Nassal M., Rieger A. An intramolecular disulfide bridge between Cys-7 and Cys61 determines the structure of the secretory core gene product (e antigen) of hepatitis B virus. J. Virol. 1993, 67:4307-4315.
    • (1993) J. Virol. , vol.67 , pp. 4307-4315
    • Nassal, M.1    Rieger, A.2
  • 13
    • 0024500103 scopus 로고
    • Antigenic determinants and functional domains in core antigen and e antigen from hepatitis B virus
    • Salfeld J., Pfaff E., Noah M., Schaller H. Antigenic determinants and functional domains in core antigen and e antigen from hepatitis B virus. J. Virol. 1989, 63:798-808.
    • (1989) J. Virol. , vol.63 , pp. 798-808
    • Salfeld, J.1    Pfaff, E.2    Noah, M.3    Schaller, H.4
  • 14
    • 0028953769 scopus 로고
    • Hepatitis core antigen produced in Escherichia coli: subunit composition, conformational analysis, and in vitro capsid assembly
    • Wingfield P.T., Stahl S.J., Williams R.W., Steven A.C. Hepatitis core antigen produced in Escherichia coli: subunit composition, conformational analysis, and in vitro capsid assembly. Biochemistry 1995, 34:4919-4932.
    • (1995) Biochemistry , vol.34 , pp. 4919-4932
    • Wingfield, P.T.1    Stahl, S.J.2    Williams, R.W.3    Steven, A.C.4
  • 15
    • 0029123370 scopus 로고
    • The humoral immune response in acute and chronic hepatitis B virus infection
    • Milich D.R., Sällberg M., Maruyama T. The humoral immune response in acute and chronic hepatitis B virus infection. Springer Semin. Immunopathol. 1995, 17:149-166.
    • (1995) Springer Semin. Immunopathol. , vol.17 , pp. 149-166
    • Milich, D.R.1    Sällberg, M.2    Maruyama, T.3
  • 17
    • 0027295474 scopus 로고
    • Immunochemical structure of the carboxy-terminal part of hepatitis B e antigen: identification of internal and surface-exposed sequences
    • Sällberg M., Pushko P., Berzinsh I., Bichko V., Sillekens P., Noah M., et al. Immunochemical structure of the carboxy-terminal part of hepatitis B e antigen: identification of internal and surface-exposed sequences. J. Gen. Virol. 1993, 74:1335-1340.
    • (1993) J. Gen. Virol. , vol.74 , pp. 1335-1340
    • Sällberg, M.1    Pushko, P.2    Berzinsh, I.3    Bichko, V.4    Sillekens, P.5    Noah, M.6
  • 18
    • 0022500336 scopus 로고
    • Human and monoclonal antibodies to hepatitis B core antigen recognise a single immunodominant epitope
    • Ferns R.B., Tedder R.S. Human and monoclonal antibodies to hepatitis B core antigen recognise a single immunodominant epitope. J. Med. Virol. 1986, 19:193-203.
    • (1986) J. Med. Virol. , vol.19 , pp. 193-203
    • Ferns, R.B.1    Tedder, R.S.2
  • 19
    • 0021249068 scopus 로고
    • Monoclonal antibodies to hepatitis Be antigen (HBeAg) derived from hepatitis B core antigen (HBcAg): their use in characterization and detection of HBeAg
    • Ferns R.B., Tedder R.S. Monoclonal antibodies to hepatitis Be antigen (HBeAg) derived from hepatitis B core antigen (HBcAg): their use in characterization and detection of HBeAg. J. Gen. Virol. 1984, 65:899-908.
    • (1984) J. Gen. Virol. , vol.65 , pp. 899-908
    • Ferns, R.B.1    Tedder, R.S.2
  • 21
    • 0020079344 scopus 로고
    • Demonstration of two distinct antigenic determinants on hepatitis B e antigen by monoclonal antibodies
    • Imai M., Nomura M., Gotanda T., Sano T., Tachibana K., Miyamoto H., et al. Demonstration of two distinct antigenic determinants on hepatitis B e antigen by monoclonal antibodies. J. Immunol. 1982, 128:69-72.
    • (1982) J. Immunol. , vol.128 , pp. 69-72
    • Imai, M.1    Nomura, M.2    Gotanda, T.3    Sano, T.4    Tachibana, K.5    Miyamoto, H.6
  • 22
    • 0030827730 scopus 로고    scopus 로고
    • A monoclonal antibody against a hepatitis B e antigen epitope borne by six amino acids encoded by the precore region
    • Usuda S., Okamoto H., Ohnuma H., Tanaka T., Machida A., Miyakawa Y., Mayumi M. A monoclonal antibody against a hepatitis B e antigen epitope borne by six amino acids encoded by the precore region. J. Virol. Methods 1997, 68:207-215.
    • (1997) J. Virol. Methods , vol.68 , pp. 207-215
    • Usuda, S.1    Okamoto, H.2    Ohnuma, H.3    Tanaka, T.4    Machida, A.5    Miyakawa, Y.6    Mayumi, M.7
  • 23
    • 44349168170 scopus 로고    scopus 로고
    • Non-canonical binding of an antibody resembling a naive B cell receptor immunoglobulin to hepatitis B virus capsids
    • Watts N.R., Cardone G., Vethanayagam J.G., Cheng N., Hultgren C., Stahl S.J., et al. Non-canonical binding of an antibody resembling a naive B cell receptor immunoglobulin to hepatitis B virus capsids. J. Mol. Biol. 2008, 379:1119-1129.
    • (2008) J. Mol. Biol. , vol.379 , pp. 1119-1129
    • Watts, N.R.1    Cardone, G.2    Vethanayagam, J.G.3    Cheng, N.4    Hultgren, C.5    Stahl, S.J.6
  • 24
    • 28944446740 scopus 로고    scopus 로고
    • Epitope diversity of hepatitis B virus capsids: quasi-equivalent variations in spike epitopes and binding of different antibodies to the same epitope
    • Harris A., Belnap D.M., Watts N.R., Conway J.F., Cheng N., Stahl S.J., et al. Epitope diversity of hepatitis B virus capsids: quasi-equivalent variations in spike epitopes and binding of different antibodies to the same epitope. J. Mol. Biol. 2006, 355:562-576.
    • (2006) J. Mol. Biol. , vol.355 , pp. 562-576
    • Harris, A.1    Belnap, D.M.2    Watts, N.R.3    Conway, J.F.4    Cheng, N.5    Stahl, S.J.6
  • 26
    • 0037688298 scopus 로고    scopus 로고
    • Characterization of a conformational epitope on hepatitis B virus core antigen and quasi-equivalent variations in antibody binding
    • Conway J.F., Watts N.R., Belnap D.M., Cheng N., Stahl S.J., Wingfield P.T., Steven A.C. Characterization of a conformational epitope on hepatitis B virus core antigen and quasi-equivalent variations in antibody binding. J. Virol. 2003, 77:6466-6473.
    • (2003) J. Virol. , vol.77 , pp. 6466-6473
    • Conway, J.F.1    Watts, N.R.2    Belnap, D.M.3    Cheng, N.4    Stahl, S.J.5    Wingfield, P.T.6    Steven, A.C.7
  • 27
    • 0032568864 scopus 로고    scopus 로고
    • Hepatitis B virus capsid: localization of the putative immunodominant loop (residues 78 to 83) on the capsid surface, and implications for the distinction between c and e-antigens
    • Conway J.F., Cheng N., Zlotnick A., Stahl S.J., Wingfield P.T., Belnap D.M., et al. Hepatitis B virus capsid: localization of the putative immunodominant loop (residues 78 to 83) on the capsid surface, and implications for the distinction between c and e-antigens. J. Mol. Biol. 1998, 279:1111-1121.
    • (1998) J. Mol. Biol. , vol.279 , pp. 1111-1121
    • Conway, J.F.1    Cheng, N.2    Zlotnick, A.3    Stahl, S.J.4    Wingfield, P.T.5    Belnap, D.M.6
  • 28
    • 0026793044 scopus 로고
    • The structure of hepadnaviral core antigens: identification of free thiols and determination of the disulfide bonding pattern
    • Zheng J., Schödel F., Peterson D.L. The structure of hepadnaviral core antigens: identification of free thiols and determination of the disulfide bonding pattern. J. Biol. Chem. 1992, 267:9422-9429.
    • (1992) J. Biol. Chem. , vol.267 , pp. 9422-9429
    • Zheng, J.1    Schödel, F.2    Peterson, D.L.3
  • 29
    • 73949118464 scopus 로고    scopus 로고
    • Conformational changes in the hepatitis B virus core protein are consistent with a role for allostery in virus assembly
    • Packianathan C., Katen S.P., Zlotnick A. Conformational changes in the hepatitis B virus core protein are consistent with a role for allostery in virus assembly. J. Virol. 2009, 84:1607-1615.
    • (2009) J. Virol. , vol.84 , pp. 1607-1615
    • Packianathan, C.1    Katen, S.P.2    Zlotnick, A.3
  • 30
    • 1542374062 scopus 로고    scopus 로고
    • Valency of antibody binding to virions and its determination by surface plasmon resonance
    • Dimmock N.J., Hardy S.A. Valency of antibody binding to virions and its determination by surface plasmon resonance. Rev. Med. Virol. 2004, 14:123-135.
    • (2004) Rev. Med. Virol. , vol.14 , pp. 123-135
    • Dimmock, N.J.1    Hardy, S.A.2
  • 31
    • 0030007379 scopus 로고    scopus 로고
    • Structure of a neutralizing antibody bound bivalently to human rhinovirus 2
    • Hewat E.A., Blaas D. Structure of a neutralizing antibody bound bivalently to human rhinovirus 2. EMBO J. 1996, 15:1515-1523.
    • (1996) EMBO J. , vol.15 , pp. 1515-1523
    • Hewat, E.A.1    Blaas, D.2
  • 32
    • 0018147002 scopus 로고
    • Duality of hepatitis B e antigen in serum of persons infected with hepatitis B virus: evidence for the nonidentity of e antigen with immunoglobulins
    • Takahashi K., Imai M., Miyakawa Y., Iwakiri S., Mayumi M. Duality of hepatitis B e antigen in serum of persons infected with hepatitis B virus: evidence for the nonidentity of e antigen with immunoglobulins. Proc. Natl Acad. Sci. USA 1978, 75:1952-1956.
    • (1978) Proc. Natl Acad. Sci. USA , vol.75 , pp. 1952-1956
    • Takahashi, K.1    Imai, M.2    Miyakawa, Y.3    Iwakiri, S.4    Mayumi, M.5
  • 33
    • 0025775267 scopus 로고
    • IgG subclasses in circulating immune complexes with hepatitis B e antigen in chronic hepatitis B
    • Sallberg M., Norder H., Lindh G., Magnius L.O. IgG subclasses in circulating immune complexes with hepatitis B e antigen in chronic hepatitis B. Clin. Exp. Immunol. 1991, 84:116-121.
    • (1991) Clin. Exp. Immunol. , vol.84 , pp. 116-121
    • Sallberg, M.1    Norder, H.2    Lindh, G.3    Magnius, L.O.4
  • 34
    • 0036667741 scopus 로고    scopus 로고
    • Crystallisation of membrane proteins mediated by antibody fragments
    • Hunte C., Michel H. Crystallisation of membrane proteins mediated by antibody fragments. Curr. Opin. Struct. Biol. 2002, 12:503-508.
    • (2002) Curr. Opin. Struct. Biol. , vol.12 , pp. 503-508
    • Hunte, C.1    Michel, H.2
  • 35
    • 0028821810 scopus 로고
    • Assembly and antigenicity of hepatitis B virus core particles
    • Seifer M., Standring D.N. Assembly and antigenicity of hepatitis B virus core particles. Intervirology 1995, 38:47-62.
    • (1995) Intervirology , vol.38 , pp. 47-62
    • Seifer, M.1    Standring, D.N.2
  • 36
    • 0026153423 scopus 로고
    • Quantitative determination of surface concentration of protein with surface plasmon resonance using radiolabeled proteins
    • Stenberg E., Persson B., Roos H., Urbaniczky C. Quantitative determination of surface concentration of protein with surface plasmon resonance using radiolabeled proteins. J. Colloid Interface Sci. 1991, 143:513-526.
    • (1991) J. Colloid Interface Sci. , vol.143 , pp. 513-526
    • Stenberg, E.1    Persson, B.2    Roos, H.3    Urbaniczky, C.4
  • 38
    • 0002498995 scopus 로고
    • Computer-aided interpretation of analytical sedimentation data for proteins
    • Royal Society for Chemistry, Cambridge, UK, S.E. Harding, A.J. Rowe, J.C. Horton (Eds.)
    • Laue T.M., Shah B.D., Ridgeway T.M., Pelletier S.L. Computer-aided interpretation of analytical sedimentation data for proteins. Analytical Centrifugation in Biochemistry and Polymer Science 1992, 90-125. Royal Society for Chemistry, Cambridge, UK. S.E. Harding, A.J. Rowe, J.C. Horton (Eds.).
    • (1992) Analytical Centrifugation in Biochemistry and Polymer Science , pp. 90-125
    • Laue, T.M.1    Shah, B.D.2    Ridgeway, T.M.3    Pelletier, S.L.4
  • 39
    • 48249109172 scopus 로고    scopus 로고
    • High-resolution mass spectrometry of viral assemblies: molecular composition and stability of dimorphic hepatitis B virus capsids
    • Uetrecht C., Versluis C., Watts N.R., Roos W.H., Wuite G.J., Wingfield P.T., et al. High-resolution mass spectrometry of viral assemblies: molecular composition and stability of dimorphic hepatitis B virus capsids. Proc. Natl Acad. Sci. USA 2008, 105:9216-9220.
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 9216-9220
    • Uetrecht, C.1    Versluis, C.2    Watts, N.R.3    Roos, W.H.4    Wuite, G.J.5    Wingfield, P.T.6
  • 40
    • 0005857894 scopus 로고
    • A signal peptide encoded within the precore region of hepatitis B virus directs the secretion of a heterogeneous population of e antigens in Xenopus oocytes
    • Standring D.N., Ou J.H., Masiarz F.R., Rutter W.J. A signal peptide encoded within the precore region of hepatitis B virus directs the secretion of a heterogeneous population of e antigens in Xenopus oocytes. Proc. Natl Acad. Sci. USA 1988, 85:8405-8409.
    • (1988) Proc. Natl Acad. Sci. USA , vol.85 , pp. 8405-8409
    • Standring, D.N.1    Ou, J.H.2    Masiarz, F.R.3    Rutter, W.J.4


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