Mismatch repair system decreases cell survival by stabilizing the tetraploid G1 arrest in response to SN-38

International Journal of Cancer

Volumn 126, Issue 12, 2010, Pages 2813-2825

  Bhonde, Mandar Ramesh ^a,d   Hanski, Marie Luise ^a   Stehr, Jenny ^a   Jebautzke, Britta ^a   Peiró Jordán, Roser ^a   Fechner, Henry ^a   Yokoyama, Kazunari Kazushige ^b   Lin, Weei Chin ^c   Zeitz, Martin ^a   Hanski, Christoph ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^c University of Alabama at Birmingham   (United States)

^d Orchid Research Laboratories Ltd   (India)

Author keywords

Chemotherapy; Colon carcinoma cells; Irinotecan; Mismatch repair; Tetraploid G1 arrest

Indexed keywords

7 ETHYL 10 HYDROXYCAMPTOTHECIN; 7 HYDROXYSTAUROSPORINE; CHECKPOINT KINASE 1; CHECKPOINT KINASE 2; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; PROTEIN MLH1; PROTEIN P53; SMALL INTERFERING RNA; ANTINEOPLASTIC AGENT; CAMPTOTHECIN; CDK2 PROTEIN, HUMAN; CDK4 PROTEIN, HUMAN; DRUG DERIVATIVE; IRINOTECAN; MESSENGER RNA; MLH1 PROTEIN, HUMAN; NUCLEAR PROTEIN; PROTEIN KINASE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TP53 PROTEIN, HUMAN;

ADENOVIRUS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL SURVIVAL; CLONOGENESIS; DOUBLE STRANDED DNA BREAK; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENETIC TRANSDUCTION; MISMATCH REPAIR; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; TETRAPLOIDY; APOPTOSIS; CHEMISTRY; DNA DAMAGE; DRUG ANTAGONISM; DRUG EFFECT; DRUG SCREENING; GENETICS; HUMAN; METABOLISM; NEOPLASM; PATHOLOGY; PHOSPHORYLATION; PLOIDY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL CULTURE; WESTERN BLOTTING;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BLOTTING, WESTERN; CAMPTOTHECIN; CELL SURVIVAL; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASE 4; DNA DAMAGE; DNA MISMATCH REPAIR; G1 PHASE; HUMANS; NEOPLASMS; NUCLEAR PROTEINS; PHOSPHORYLATION; PLOIDIES; PROTEIN KINASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; TUMOR CELLS, CULTURED; TUMOR STEM CELL ASSAY; TUMOR SUPPRESSOR PROTEIN P53;

EID: 77951882416     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.24893     Document Type: Article

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