First principles design of derivatizing agent for direct determination of enantiomeric purity of chiral alcohols and amines by NMR spectroscopy

Chemical Communications

Volumn 46, Issue 18, 2010, Pages 3212-3214

  Orlov, Nikolay V ^a   Ananikov, Valentine P ^a  

^a N D ZELINSKY INSTITUTE OF ORGANIC CHEMISTRY   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

2 PHENYLSELENOPROPANOIC ACID; ALCOHOL DERIVATIVE; AMINE; CARBON 13; PROPIONIC ACID DERIVATIVE; SELENIUM; UNCLASSIFIED DRUG;

ARTICLE; ASSAY; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL REACTION; CHEMICAL STRUCTURE; CHIRALITY; DERIVATIZATION; DIASTEREOISOMER; ENANTIOMER; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTON NUCLEAR MAGNETIC RESONANCE; PURIFICATION;

EID: 77951834913     PISSN: 13597345     EISSN: None     Source Type: Journal    
DOI: 10.1039/b923359h     Document Type: Article

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52. See supporting information for complete details.
53. 77Se, ppm): 2-methyl-1-butylamine (0.43), 1-phenylethanol (2.06), 2-octanol (2.05), 3-butyn-2-ol (0.36), 3-amino-1-phenylbutane (2.68), 3-methyl-1-pentyn-3-ol (1.47).
54. 1H nucleus - 6.1, 0.7 and 0.2 ppm (Chart 1) are in excellent agreement with the calculated upper limits 8.7, 0.8 and 0.4 ppm, respectively (Table 1).
55. 77Se NMR.