메뉴 건너뛰기




Volumn 70, Issue 9, 2010, Pages 3803-3812

Activation of endothelial ras signaling bypasses senescence and causes abnormal vascular morphogenesis

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RAS PROTEIN;

EID: 77951758529     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-09-2648     Document Type: Article
Times cited : (22)

References (47)
  • 1
    • 0034076189 scopus 로고    scopus 로고
    • Mechanisms of angiogenesis and arteriogenesis
    • Carmeliet P. Mechanisms of angiogenesis and arteriogenesis. Nat Med 2000;6:389-395
    • (2000) Nat Med , vol.6 , pp. 389-395
    • Carmeliet, P.1
  • 2
    • 30744479430 scopus 로고    scopus 로고
    • Angiogenesis in life, disease and medicine
    • Carmeliet P. Angiogenesis in life, disease and medicine. Nature 2005;438:932-936
    • (2005) Nature , vol.438 , pp. 932-936
    • Carmeliet, P.1
  • 3
    • 59649117924 scopus 로고    scopus 로고
    • Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization
    • Mazzone M, Dettori D, Leite de Oliveira R, et al. Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization. Cell 2009;136:839-851
    • (2009) Cell , vol.136 , pp. 839-851
    • Mazzone, M.1    Dettori, D.2    De Leite Oliveira, R.3
  • 4
    • 0347362524 scopus 로고    scopus 로고
    • Capillary malformation-arteriovenous malformation, a new clinical and genetic disorder caused by RASA1 mutations
    • Eerola I, Boon LM, Mulliken JB, et al. Capillary malformation- arteriovenous malformation, a new clinical and genetic disorder caused by RASA1 mutations. Am J Hum Genet 2003;73:1240-1249
    • (2003) Am J Hum Genet , vol.73 , pp. 1240-1249
    • Eerola, I.1    Boon, L.M.2    Mulliken, J.B.3
  • 5
    • 0012376721 scopus 로고    scopus 로고
    • Cardiovascular disease in neurofibromatosis 1: Report of the NF1 Cardiovascular Task Force
    • Friedman JM, Arbiser J, Epstein JA, et al. Cardiovascular disease in neurofibromatosis 1: report of the NF1 Cardiovascular Task Force. Genet Med 2002;4:105-111
    • (2002) Genet Med , vol.4 , pp. 105-111
    • Friedman, J.M.1    Arbiser, J.2    Epstein, J.A.3
  • 6
    • 0028349997 scopus 로고
    • Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues
    • Brannan CI, Perkins AS, Vogel KS, et al. Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues. Genes Dev 1994;8:1019-1029
    • (1994) Genes Dev , vol.8 , pp. 1019-1029
    • Brannan, C.I.1    Perkins, A.S.2    Vogel, K.S.3
  • 7
    • 0028788570 scopus 로고
    • Vascular system defects and neuronal apoptosis in mice lacking ras GTPase-activating protein
    • Henkemeyer M, Rossi DJ, Holmyard DP, et al. Vascular system defects and neuronal apoptosis in mice lacking ras GTPase-activating protein. Nature 1995;377:695-701.
    • (1995) Nature , vol.377 , pp. 695-701
    • Henkemeyer, M.1    Rossi, D.J.2    Holmyard, D.P.3
  • 8
    • 0037229065 scopus 로고    scopus 로고
    • Nf1 has an essential role in endothelial cells
    • Gitler AD, Zhu Y, Ismat FA, et al. Nf1 has an essential role in endothelial cells. Nat Genet 2003;33:75-79
    • (2003) Nat Genet , vol.33 , pp. 75-79
    • Gitler, A.D.1    Zhu, Y.2    Ismat, F.A.3
  • 9
    • 33646158223 scopus 로고    scopus 로고
    • Nf1 haploinsufficiency augments angiogenesis
    • Wu M, Wallace MR, Muir D. Nf1 haploinsufficiency augments angiogenesis. Oncogene 2006;25:2297-2303
    • (2006) Oncogene , vol.25 , pp. 2297-2303
    • Wu, M.1    Wallace, M.R.2    Muir, D.3
  • 10
    • 0031036909 scopus 로고    scopus 로고
    • Sporadic and thorotrast-induced angiosarcomas of the liver manifest frequent and multiple point mutations in K-ras-2
    • Przygodzki RM, Finkelstein SD, Keohavong P, et al. Sporadic and thorotrast-induced angiosarcomas of the liver manifest frequent and multiple point mutations in K-ras-2. Lab Invest 1997;76:153-159
    • (1997) Lab Invest , vol.76 , pp. 153-159
    • Przygodzki, R.M.1    Finkelstein, S.D.2    Keohavong, P.3
  • 11
    • 0036328439 scopus 로고    scopus 로고
    • Mutation analysis of K-ras-2 in liver angiosarcoma and adjacent nonneoplastic liver tissue from patients occupationally exposed to vinyl chloride
    • Weihrauch M, Bader M, Lehnert G, et al. Mutation analysis of K-ras-2 in liver angiosarcoma and adjacent nonneoplastic liver tissue from patients occupationally exposed to vinyl chloride. Environ Mol Mutagen 2002;40:36-40.
    • (2002) Environ Mol Mutagen , vol.40 , pp. 36-40
    • Weihrauch, M.1    Bader, M.2    Lehnert, G.3
  • 12
    • 23244447037 scopus 로고    scopus 로고
    • BRAFE600-associated senescence-like cell cycle arrest of human naevi
    • Michaloglou C, Vredeveld LC, Soengas MS, et al. BRAFE600-associated senescence-like cell cycle arrest of human naevi. Nature 2005;436:720-724
    • (2005) Nature , vol.436 , pp. 720-724
    • Michaloglou, C.1    Vredeveld, L.C.2    Soengas, M.S.3
  • 13
    • 0030944985 scopus 로고    scopus 로고
    • Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
    • Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 1997;88:593-602.
    • (1997) Cell , vol.88 , pp. 593-602
    • Serrano, M.1    Lin, A.W.2    McCurrach, M.E.3    Beach, D.4    Lowe, S.W.5
  • 14
    • 23244461708 scopus 로고    scopus 로고
    • Oncogene-induced senescence as an initial barrier in lymphoma development
    • Braig M, Lee S, Loddenkemper C, et al. Oncogene-induced senescence as an initial barrier in lymphoma development. Nature 2005;436:660-665
    • (2005) Nature , vol.436 , pp. 660-665
    • Braig, M.1    Lee, S.2    Loddenkemper, C.3
  • 16
    • 0035966004 scopus 로고    scopus 로고
    • Vascular endothelial growth factor induction of the angiogenic phenotype requires Ras activation
    • Meadows KN, Bryant P, Pumiglia K. Vascular endothelial growth factor induction of the angiogenic phenotype requires Ras activation. J Biol Chem 2001;276:49289-49298
    • (2001) J Biol Chem , vol.276 , pp. 49289-49298
    • Meadows, K.N.1    Bryant, P.2    Pumiglia, K.3
  • 17
    • 0942301171 scopus 로고    scopus 로고
    • Activated Ras induces a proangiogenic phenotype in primary endothelial cells
    • Meadows KN, Bryant P, Vincent PA, Pumiglia KM. Activated Ras induces a proangiogenic phenotype in primary endothelial cells. Oncogene 2004;23:192-200.
    • (2004) Oncogene , vol.23 , pp. 192-200
    • Meadows, K.N.1    Bryant, P.2    Vincent, P.A.3    Pumiglia, K.M.4
  • 19
    • 0033538057 scopus 로고    scopus 로고
    • The role of phosphatidylinositol 3-kinase in vascular endothelial growth factor signaling
    • Thakker GD, Hajjar DP, Muller WA, Rosengart TK. The role of phosphatidylinositol 3-kinase in vascular endothelial growth factor signaling. J Biol Chem 1999;274:10002-10007
    • (1999) J Biol Chem , vol.274 , pp. 10002-10007
    • Thakker, G.D.1    Hajjar, D.P.2    Muller, W.A.3    Rosengart, T.K.4
  • 20
    • 0032932912 scopus 로고    scopus 로고
    • MAP kinases, phosphatidylinositol 3-kinase, and p70 S6 kinase mediate the mitogenic response of human endothelial cells to vascular endothelial growth factor
    • Yu Y, Sato JD. MAP kinases, phosphatidylinositol 3-kinase, and p70 S6 kinase mediate the mitogenic response of human endothelial cells to vascular endothelial growth factor. J Cell Physiol 1999;178:235-246
    • (1999) J Cell Physiol , vol.178 , pp. 235-246
    • Yu, Y.1    Sato, J.D.2
  • 21
    • 33845292259 scopus 로고    scopus 로고
    • A negative feedback signaling network underlies oncogene-induced senescence
    • Courtois-Cox S, Genther Williams SM, Reczek EE, et al. A negative feedback signaling network underlies oncogene-induced senescence. Cancer Cell 2006;10:459-472
    • (2006) Cancer Cell , vol.10 , pp. 459-472
    • Courtois-Cox, S.1    Genther Williams, S.M.2    Reczek, E.E.3
  • 22
    • 0345932931 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway
    • DOI 10.1046/j.1365-2443.2003.00620.x
    • Iwasa H, Han J, Ishikawa F. Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway. Genes Cells 2003;8:131-144 (Pubitemid 36511698)
    • (2003) Genes to Cells , vol.8 , Issue.2 , pp. 131-144
    • Iwasa, H.1    Han, J.2    Ishikawa, F.3
  • 23
    • 33846282393 scopus 로고    scopus 로고
    • PRAK is essential for ras-induced senescence and tumor suppression
    • Sun P, Yoshizuka N, New L, et al. PRAK is essential for ras-induced senescence and tumor suppression. Cell 2007;128:295-308.
    • (2007) Cell , vol.128 , pp. 295-308
    • Sun, P.1    Yoshizuka, N.2    New, L.3
  • 24
    • 0036242247 scopus 로고    scopus 로고
    • Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescence
    • Wang W, Chen JX, Liao R, et al. Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescence. Mol Cell Biol 2002;22:3389-3403
    • (2002) Mol Cell Biol , vol.22 , pp. 3389-3403
    • Wang, W.1    Chen, J.X.2    Liao, R.3
  • 25
    • 0029047362 scopus 로고
    • A biomarker that identifies senescent human cells in culture and in aging skin in vivo
    • Dimri GP, Lee X, Basile G, et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci U S A 1995;92:9363-9367
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 9363-9367
    • Dimri, G.P.1    Lee, X.2    Basile, G.3
  • 26
    • 33746800144 scopus 로고    scopus 로고
    • Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin
    • Phung TL, Ziv K, Dabydeen D, et al. Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin. Cancer Cell 2006;10:159-170
    • (2006) Cancer Cell , vol.10 , pp. 159-170
    • Phung, T.L.1    Ziv, K.2    Dabydeen, D.3
  • 27
    • 0037040225 scopus 로고    scopus 로고
    • Flt-1-mediated down-regulation of endothelial cell proliferation through pertussis toxin-sensitive G proteins, βγ subunits, small GTPase CDC42, and partly by Rac-1
    • Zeng H, Zhao D, Mukhopadhyay D. Flt-1-mediated down-regulation of endothelial cell proliferation through pertussis toxin-sensitive G proteins, βγ subunits, small GTPase CDC42, and partly by Rac-1. J Biol Chem 2002;277:4003-4009
    • (2002) J Biol Chem , vol.277 , pp. 4003-4009
    • Zeng, H.1    Zhao, D.2    Mukhopadhyay, D.3
  • 28
    • 44949153658 scopus 로고    scopus 로고
    • H-ras regulates angiogenesis and vascular permeability by activation of distinct downstream effectors
    • Serban D, Leng J, Cheresh D. H-ras regulates angiogenesis and vascular permeability by activation of distinct downstream effectors. Circ Res 2008;102:1350-1358
    • (2008) Circ Res , vol.102 , pp. 1350-1358
    • Serban, D.1    Leng, J.2    Cheresh, D.3
  • 29
    • 0032192153 scopus 로고    scopus 로고
    • Senescence of human fibroblasts induced by oncogenic Raf
    • Zhu J, Woods D, McMahon M, Bishop JM. Senescence of human fibroblasts induced by oncogenic Raf. Genes Dev 1998;12:2997-3007.
    • (1998) Genes Dev , vol.12 , pp. 2997-3007
    • Zhu, J.1    Woods, D.2    McMahon, M.3    Bishop, J.M.4
  • 30
    • 0031028381 scopus 로고    scopus 로고
    • Cell cycle arrest mediated by the MEK/-mitogen-activated protein kinase pathway
    • Pumiglia KM, Decker SJ. Cell cycle arrest mediated by the MEK/-mitogen-activated protein kinase pathway. Proc Natl Acad Sci U S A 1997;94:448-452
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 448-452
    • Pumiglia, K.M.1    Decker, S.J.2
  • 31
    • 0037188941 scopus 로고    scopus 로고
    • Role of Akt signaling in vascular homeostasis and angiogenesis
    • DOI 10.1161/01.RES.0000022200.71892.9F
    • Shiojima I, Walsh K. Role of Akt signaling in vascular homeostasis and angiogenesis. Circ Res 2002;90:1243-1250 (Pubitemid 34787405)
    • (2002) Circulation Research , vol.90 , Issue.12 , pp. 1243-1250
    • Shiojima, I.1    Walsh, K.2
  • 32
    • 0034532027 scopus 로고    scopus 로고
    • The controls of microvascular survival
    • Benjamin LE. The controls of microvascular survival. Cancer Metastasis Rev 2000;19:75-81.
    • (2000) Cancer Metastasis Rev , vol.19 , pp. 75-81
    • Benjamin, L.E.1
  • 33
    • 0035671571 scopus 로고    scopus 로고
    • Comparison of three in vitro human 'angiogenesis' assays with capillaries formed in vivo
    • Donovan D, Brown NJ, Bishop ET, Lewis CE. Comparison of three in vitro human 'angiogenesis' assays with capillaries formed in vivo. Angiogenesis 2001;4:113-121
    • (2001) Angiogenesis , vol.4 , pp. 113-121
    • Donovan, D.1    Brown, N.J.2    Bishop, E.T.3    Lewis, C.E.4
  • 34
    • 0025916059 scopus 로고
    • Micromotion of mammalian cells measured electrically
    • Giaever I, Keese CR. Micromotion of mammalian cells measured electrically. Proc Natl Acad Sci U S A 1991;88:7896-7900
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 7896-7900
    • Giaever, I.1    Keese, C.R.2
  • 35
    • 23244460597 scopus 로고    scopus 로고
    • Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis
    • Chen Z, Trotman LC, Shaffer D, et al. Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature 2005;436:725-730
    • (2005) Nature , vol.436 , pp. 725-730
    • Chen, Z.1    Trotman, L.C.2    Shaffer, D.3
  • 36
    • 23244447893 scopus 로고    scopus 로고
    • Tumour biology: Senescence in premalignant tumours
    • Collado M, Gil J, Efeyan A, et al. Tumour biology: senescence in premalignant tumours. Nature 2005;436:642.
    • (2005) Nature , vol.436 , pp. 642
    • Collado, M.1    Gil, J.2    Efeyan, A.3
  • 37
    • 0025663043 scopus 로고
    • Partial transformation of human thyroid epithelial cells by mutant Ha-ras oncogene
    • Lemoine NR, Staddon S, Bond J, Wyllie FS, Shaw JJ, Wynford-Thomas D. Partial transformation of human thyroid epithelial cells by mutant Ha-ras oncogene. Oncogene 1990;5:1833-1837 (Pubitemid 120034711)
    • (1990) Oncogene , vol.5 , Issue.12 , pp. 1833-1837
    • Lemoine, N.R.1    Staddon, S.2    Bond, J.3    Wyllie, F.S.4    Shaw, J.J.5    Wynford-Thomas, D.6
  • 38
    • 11144356354 scopus 로고    scopus 로고
    • Endogenous oncogenic K-ras (G12D) stimulates proliferation and widespread neoplastic and developmental defects
    • Tuveson DA, Shaw AT, Willis NA, et al. Endogenous oncogenic K-ras (G12D) stimulates proliferation and widespread neoplastic and developmental defects. Cancer Cell 2004;5:375-387
    • (2004) Cancer Cell , vol.5 , pp. 375-387
    • Tuveson, D.A.1    Shaw, A.T.2    Willis, N.A.3
  • 39
    • 0030871667 scopus 로고    scopus 로고
    • High-intensity Raf signal causes cell cycle arrest mediated by p21Cip1
    • Sewing A, Wiseman B, Lloyd AC, Land H. High-intensity Raf signal causes cell cycle arrest mediated by p21Cip1. Mol Cell Biol 1997;17:5588-5597
    • (1997) Mol Cell Biol , vol.17 , pp. 5588-5597
    • Sewing, A.1    Wiseman, B.2    Lloyd, A.C.3    Land, H.4
  • 40
    • 10944272639 scopus 로고    scopus 로고
    • Aging, tumor suppression and cancer: High wire-act!
    • Campisi J. Aging, tumor suppression and cancer: high wire-act! Mech Ageing Dev 2005;126:51-58
    • (2005) Mech Ageing Dev , vol.126 , pp. 51-58
    • Campisi, J.1
  • 41
    • 29244485921 scopus 로고    scopus 로고
    • The senescent side of tumor suppression
    • Collado M, Serrano M. The senescent side of tumor suppression. Cell Cycle 2005;4:1722-1724
    • (2005) Cell Cycle , vol.4 , pp. 1722-1724
    • Collado, M.1    Serrano, M.2
  • 42
    • 0034650636 scopus 로고    scopus 로고
    • Ras gene mutations in vinyl chloride-induced liver tumours are carcinogen-specific but vary with cell type and species
    • Boivin-Angele S, Lefrancois L, Froment O, et al. Ras gene mutations in vinyl chloride-induced liver tumours are carcinogen-specific but vary with cell type and species. Int J Cancer 2000;85:223-227
    • (2000) Int J Cancer , vol.85 , pp. 223-227
    • Boivin-Angele, S.1    Lefrancois, L.2    Froment, O.3
  • 43
    • 0028127075 scopus 로고
    • Mutagenesis of ras proto-oncogenes in rat liver tumors induced by vinyl chloride
    • Froment O, Boivin S, Barbin A, Bancel B, Trepo C, Marion MJ. Mutagenesis of ras proto-oncogenes in rat liver tumors induced by vinyl chloride. Cancer Res 1994;54:5340-5345
    • (1994) Cancer Res , vol.54 , pp. 5340-5345
    • Froment, O.1    Boivin, S.2    Barbin, A.3    Bancel, B.4    Trepo, C.5    Marion, M.J.6
  • 44
    • 0020308828 scopus 로고
    • In vitro characteristics of endothelium from hemangiomas and vascular malformations
    • Mulliken JB, Zetter BR, Folkman J. In vitro characteristics of endothelium from hemangiomas and vascular malformations. Surgery 1982;92:348-353
    • (1982) Surgery , vol.92 , pp. 348-353
    • Mulliken, J.B.1    Zetter, B.R.2    Folkman, J.3
  • 45
    • 40549093336 scopus 로고    scopus 로고
    • Malignant tumors of blood vessels: Angiosarcomas, hemangioendotheliomas, and hemangiopericytomas
    • Koch M, Nielsen GP, Yoon SS. Malignant tumors of blood vessels: angiosarcomas, hemangioendotheliomas, and hemangiopericytomas. J Surg Oncol 2008;97:321-329
    • (2008) J Surg Oncol , vol.97 , pp. 321-329
    • Koch, M.1    Nielsen, G.P.2    Yoon, S.S.3
  • 46
    • 0034645518 scopus 로고    scopus 로고
    • Cardiovascular malformations and other cardiovascular abnormalities in neurofibromatosis 1
    • Lin AE, Birch PH, Korf BR, et al. Cardiovascular malformations and other cardiovascular abnormalities in neurofibromatosis 1. Am J Med Genet 2000;95:108-117
    • (2000) Am J Med Genet , vol.95 , pp. 108-117
    • Lin, A.E.1    Birch, P.H.2    Korf, B.R.3
  • 47
    • 8544249895 scopus 로고    scopus 로고
    • Tumor-associated endothelial cells with cytogenetic abnormalities
    • Hida K, Hida Y, Amin DN, et al. Tumor-associated endothelial cells with cytogenetic abnormalities. Cancer Res 2004;64:8249-8255
    • (2004) Cancer Res , vol.64 , pp. 8249-8255
    • Hida, K.1    Hida, Y.2    Amin, D.N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.