Micronutrients versus standard medication management in autism: A naturalistic case-control study

Journal of Child and Adolescent Psychopharmacology

Volumn 20, Issue 2, 2010, Pages 95-103

  Mehl Madrona, Lewis ^a,b   Leung, Brenda ^c   Kennedy, Carla ^d   Paul, Sarah ^e   Kaplan, Bonnie J ^c  

^a ARGOSY UNIVERSITY   (United States)

^b UNIVERSITY OF HAWAII   (United States)

^c UNIVERSITY OF CALGARY   (Canada)

^d UNIVERSITY OF MANITOBA   (Canada)

^e UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; AMFEBUTAMONE; CENTRAL STIMULANT AGENT; MINERAL; MOOD STABILIZER; NEUROLEPTIC AGENT; OMEGA 3 FATTY ACID; SEROTONIN UPTAKE INHIBITOR; TRACE ELEMENT; VITAMIN;

ABERRANT BEHAVIOR CHECKLIST; ADOLESCENT; ADULT; ARTICLE; AUTISM; BEHAVIOR; CHILD; CHILDHOOD PSYCHIATRIC RATING SCALE; CHLDHOOD AUTISM RATING SCALE; DECISION MAKING; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; RATING SCALE; UNSPECIFIED SIDE EFFECT;

ADOLESCENT; ADULT; AUTISTIC DISORDER; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; FEMALE; FISH OILS; HUMANS; MALE; MICRONUTRIENTS; PSYCHOTROPIC DRUGS; SELF-INJURIOUS BEHAVIOR;

EID: 77951695886     PISSN: 10445463     EISSN: None     Source Type: Journal    
DOI: 10.1089/cap.2009.0011     Document Type: Article

References (45)

1. Adams JB, Holloway C: Pilot study of a moderate dose multivitamin= mineral supplement for children with autistic spectrum disorder. J Altern Complement Med 10:1033-1039, 2004.
2. Aman M, Arnold L, McDougle C, Vitiello B, Scahill L, Davies M, McCracken JT, Tierney E, Nash PL, Posey DJ, Chuang S, Martin A, Shah B, Gonzalez NM, Swiezy NB, Ritz L, Koenig K, McGough J, Ghuman JK, Lindsay RL. Acute and long-term safety and tol-erability of risperidone in children with autism. J Child Adolesc Psychopharmacol 15:869-884, 2005.
3. Aman MG, Singh NN, Stewart AW, Field CJ: The aberrant behavior checklist: A behavior rating scale for the assessment of treatment effects. Am J Ment Defic 89:485-491, 1985.
4. th ed. (DSM-IV). Washington (DC): American Psychiatric Association, 1994.
5. Ames BN: The metabolic tune-up: Metabolic harmony and disease prevention. J Nutr 133:1544S-1548S), 2003.
6. Ames BN: A role for supplements in optimizing health: The metabolic tune-up. Arch Biochem Biophys 423:227-234, 2004.
7. Ames BN, Elson-Schwab I, Silver, EA: High-dose vitamin therapy stimulates variant enzymes with decreased coenzyme binding affinity (increased Km): Relevance to genetic disease and polymorphisms. Am J Clin Nutr 75:616-658, 2002.
8. Amminger, GP, Berger, GE, Schafer, MR, Klier, C, Friedrich, MH, Feucht, M: Omega-3 fatty acids supplementation in children with autism: A double-blind randomized, placebo-controlled pilot study. Biol Psychiatry, 61:551-553, 2007.
9. Baghdadi A, Pascal C, Grisi S, Aussiloux C: Risk factors for self-injurious behaviours among 222 young children with autistic disorders. J Intellect Disabil Res 47(Pt 8):622-627, 2003.
10. Campbell M, Palij M: Behavioral and cognitive measures used in psychopharmacological studies of infantile autism. Psycho-pharmacol Bull 21:1047-1053, 1985.
11. Canitano R: Self injurious behavior in autism: Clinical aspects and treatment with risperidone. J Neural Transm 113:425-431, 2006.
12. Fish B: Children's Psychiatric Rating Scale. Psychopharmacol Bull 21:753-764, 1985.
13. Frazier EA, Fristad MA, Arnold LE: Multinutrient supplement as treatment: Literature review and case report of a 12-year-old boy with bipolar disorder. J Child Adolesc Psychopharm 19:453-460, 2009.
14. Gardner A, Boles RG: Is a "mitochondrial psychiatry" in the future? A review. Curr Psychiatry Rev 1:255-271, 2005.
15. Gately D, Kaplan B: Database analysis of adults with bipolar disorder consuming a micronutrient formula. Clin Med:Psychiatry 4:3-16, 2009.
16. Gesch CB, Hammon SM, Hampson SE, Eves A, Crowder MJ: Influence of supplementary vitamins, minerals and essential fatty acids on the antisocial behaviour of young adult prisoners. Br J Psychiatry 181:22-28, 2002.
17. Guy W (ed). ECDEU Assessment Manual for Psychopharmacology: Publication ADM 76-338. Washington (DC): U.S. Department of Healthand Human Services, 1976.
18. Hallahan B, Hibbeln JR, Davis JM, Garland MR: Omega-3 fatty acid supplementation in patients with recurrent self-harm. Single-centre double-blind randomised controlled trial. Br J Psychiatry 190:118-122, 2007.
19. Itomura M, Hamazaki K, Sawazaki S, Kobayashi M, Terasawa K, Watanabe S, Hamazaki T. The effect of fish oil on physical aggression in schoolchildren\a randomized, double-blind, placebo-controlled trial. J Nutr Biochem 16:163-171, 2005.
20. James S, Melnyk S, Fuchs G, Reid T, Jernigan S, Pavliv O, Hubanks A, Gaylor DW. Efficacy of methylcobalamin and folinic acid treatment on glutathione redox status in children with autism. Am J Clin Nutr 89:425-430, 2009.
21. Kaplan BJ, Simpson JSA, Ferre RC, Gorman C, McMullen D, Crawford SG: Effective mood stabilization in bipolar disorder with a chelated mineral supplement. J Clin Psychiatry 62: 936-944, 2001.
22. Kaplan BJ, Crawford SG, Gardner B, Farrelly G: Treatment of mood lability and explosive rage with minerals and vitamins: Two case studies in children. J Child Adolesc Psychopharmacol 12:203-218, 2002.
23. Kaplan BJ, Fisher JE, Crawford SG, Field CJ, Kolb B: Improved mood and behavior during treatment with a mineral-vitamin supplement: An open-label case series. J Child Adolesc Psycho-pharmacol 14:115-122, 2004.
24. Kaplan BJ, Crawford S, Field C, Simpson JSA: Vitamins, minerals and mood: A scientific review. Psychol Bull 133:747-760, 2007.
25. Kato T, Kato N: Mitochondrial dysfunction in bipolar disorder. Bipolar Disorder 2:180-190, 2000.
26. Kemper KJ, Hood KL: Does pharmaceutical advertising affect journal publication about dietary supplements? BMC Complement Altern Med 8:11, 2008.
27. Konradi C, Eaton M, MacDonald ML, Walsh J, Benes FM, Heckers S: Molecular evidence for mitochondrial dysfunction in bipolar disorder. Arch Gen Psychiatry 61:300-308, 2004.
28. Marshburn EC, Aman MG: Factor validity and norms for the Aberrant Behavior Checklist in a community sample of children with mental retardation. J Autism Dev Disord 22:357-373, 1992.
29. Masi G, Cosenza A, Mucci M, Brovedani P: Open trial of risperidone in 24 young children with pervasive developmental disorders. J Am Acad Child Adolesc Psychiatry 40:1206-1214, 2001. (Pubitemid 32917087)
30. McCracken JT, McGough J, Shah B, Cronin P, Hong D, Aman MG, Arnold LE, Lindsay R, Nash P, Hollway J, McDougle CJ, Posey D, Swiezy N, Kohn A, Scahill L, Martin A, Koenig K, Volkmar F, Carroll D, Lancor A, Tierney E, Ghuman J, Gonzalez NM, Grados M, Vitiello B, Ritz L, Davies M, Robinson J, McMahon D; Research Units on Pediatric Psychopharmacology Autism Network. Risperidone in children with autism and serious behavioral problems. NEJM 347:314-321, 2002.
31. McDougle CJ, Stigler KA, Erickson CA, Posey DJ: Atypical antipsychotics in children and adolescents with autistic and other pervasive developmental disorders. J Clin Psychiatry 69(Suppl 4): 15-20, 2008.
32. Meguid N, Atta H, Gouda A, Khalil R: Role of polyunsaturated fatty acids in the management of Egyptian children with autism. Clin Biochem 41:1044-1048, 2008.
33. Mehl-Madrona L: Narrative Medicine: The Use of History and Story in the Healing Process. Rochester (Vermont): Bear & Company, 2007.
34. Mousain-Bosc M, Roche M, Polge A, Pradal-Pra D, Rapin J, Bali JP: Improvement of neurobehavioral disorders in children supplemented with magnesium-vitamin B6. Magnesium Res 19:53-62, 2006.
35. Nye C, Brice A: Combined vitamin B6-magnesium treatment in autism spectrum disorder. Cochrane Database Syst Rev 4:CD003497, 2005.
36. Overall JE, Campbell M: Behavioral assessment of psychopathology in children: Infantile autism. J Clin Psychol 44:708-716, 1988.
37. Parikh MS, Kolevzon A, Hollander E: Psychopharmacology of aggression in children and adolescents with autism: A critical review of efficacy and tolerability. J Child Adolesc Psychopharmacol 18:157-178, 2008.
38. Popper CW: Do vitamins or minerals (apart from lithium) have mood-stabilizing effects? J Clin Psychiatry 62:933-935, 2001.
39. Posey DJ, Stigler KA, Erickson CA, McDougle CJ: Antipsychotics in the treatment of autism. J Clin Invest 118:6-14, 2008.
40. Rimland B: Controversies in the treatment of autistic children: Vitamin and drug therapy. J Child Neurol 3(Suppl):S68-S72, 1988.
41. Rimland B, Callaway E, Dreyfus P: The effect of high doses of vitamin B6 on autistic children: A double-blind crossover study. Am J Psychiatry 135:472-475, 1978.
42. Rucklidge JJ: Successful treatment of OCD with a micronutrient formula following partial response to CBT: A case study. J Anxiety Dis 23:836-840.
43. Schopler E, Reichler RJ, DeVellis RF, Daly K: Toward objective classification of childhood autism: Childhood Autism Rating Scale (CARS). J Autism Dev Disord 10:91-103, 1980.
44. Simmons M: Nutritional approach to bipolar disorder. J Clin Psychiatry 64:338, 2002.
45. Young LT: Is bipolar disorder a mitochondrial disease? J Psychiatry Neurosci 32:160-161, 2007.