Design, synthesis, and biological evaluation of 3-benzazepin-1-ols as NR2B-selective NMDA receptor antagonists

ChemMedChem

Volumn 5, Issue 5, 2010, Pages 687-695

  Tewes, Bastian ^a   Frehland, Bastian ^a   Schepmann, Dirk ^a   Schmidtke, Kai Uwe ^b   Winckler, Thomas ^b   Wünsch, Bernhard ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

3 Benzazepines; Functional activity; Medicinal chemistry; NR2B selective NMDA antagonists; Structure affinity relationships

Indexed keywords

3 BENZAZEPINE DERIVATIVE; 3 BENZYL 7 METHOXY 2,3,4,5 TETRAHYDRO 1H 3 BENZAZEPIN 1 OL; 7 METHOXY 2,3,4,5 TETRAHYDRO 1H 3 BENZAZEPIN 1 OL; 7 METHOXY 3 (4 PHENYLBUTYL) 2,3,4,5 TETRAHYDRO 1H 3 BENZAZEPIN 1 OL; 7 METHOXY 3 (4 PHENYLCYCLOHEXYL) 2,3,4,5 TETRAHYDRO 1H 3 BENZAZEPIN 1 OL; 7 METHOXY 3 (5 PHENYLPENTYL) 2,3,4,5 TETRAHYDRO 1H 3 BENZAZEPIN 1 OL; BENZENE DERIVATIVE; CARBENE; DEXOXADROL; DI O TOLYLGUANIDINE; ELIPRODIL; GLUTAMIC ACID; GUANIDINE; HALOPERIDOL; IFENPRODIL; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NITROGEN; PHENETHYLAMINE; PIPERIDINE; UNCLASSIFIED DRUG; WMS 1405;

ANIMAL CELL; ARTICLE; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG CONFORMATION; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; EXCITOTOXICITY; IC 50; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; BENZAZEPINES; BINDING SITES; CELL LINE; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; MICE; PIPERIDINES; RECEPTORS, N-METHYL-D-ASPARTATE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77951691824     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201000005     Document Type: Article

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