Comparison of two metal-dependent pyruvate aldolases related by convergent evolution: Substrate specificity, kinetic mechanism, and substrate channeling

Biochemistry

Volumn 49, Issue 17, 2010, Pages 3774-3782

  Wang, Weijun ^a   Baker, Perrin ^a   Seah, Stephen Y K ^a  

^a UNIVERSITY OF GUELPH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

[CARBONYL; ACETYL-COA; ACTIVE SITE; ALDEHYDE DEHYDROGENASE; ALDOL ADDITION; ALDOLASES; ALKYL CHAIN; ALLOSTERIC ACTIVATION; BIDIRECTIONALITY; CLASS II; CONVERGENT EVOLUTION; DEACYLATION; DEGRADATION PATHWAYS; ENZYME COMPLEXES; KETO ACIDS; KINETIC MECHANISM; META-CLEAVAGE; PRODUCT INHIBITION; PYRUVATES; RACEMIC MIXTURES; RAPID EQUILIBRIUM; STEADY-STATE KINETICS; STEREOSPECIFIC; SUBSTRATE SPECIFICITY;

ALDEHYDES; ENZYMES; HYDROCARBONS;

ADDITION REACTIONS;

ACETALDEHYDE; ALDEHYDE DEHYDROGENASE; CARBON; FRUCTOSE BISPHOSPHATE ALDOLASE; HOPANTENIC ACID; OXOACID; PROTEIN BPHI; PROTEIN HPAI; PYRUVIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ALDOL REACTION; ALLOSTERISM; ARTICLE; BIOREMEDIATION; COMPARATIVE STUDY; CONTROLLED STUDY; DEACYLATION; ENZYME BINDING; ENZYME INHIBITION; ENZYME KINETICS; ENZYME SPECIFICITY; ENZYME SUBSTRATE; PRIORITY JOURNAL; STEADY STATE; STEREOSPECIFICITY;

ALDEHYDE DEHYDROGENASE; ALDEHYDE-LYASES; ALDEHYDES; BINDING SITES; CATALYSIS; CATALYTIC DOMAIN; ESCHERICHIA COLI PROTEINS; EVOLUTION, MOLECULAR; KINETICS; PROTEIN CONFORMATION; PYRUVATES; STEREOISOMERISM; SUBSTRATE SPECIFICITY;

EID: 77951690871     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi100251u     Document Type: Article

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