EBP50 exerts tumor suppressor activity by promoting cell apoptosis and retarding extracellular signal-regulated kinase activity

Amino Acids

Volumn 38, Issue 4, 2010, Pages 1261-1268

  Zheng, Jun Fang ^a   Sun, Li Cui ^a   Liu, Hua ^a   Huang, Yan ^a   Li, Yang ^a   He, Junqi ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Anchorage independent growth; Apoptosis; Cell cycle; Colony formation; MAPK

Indexed keywords

EZRIN RADIXIN MOESIN BINDING PHOSPHOPROTEIN 50; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOPROTEIN; UNCLASSIFIED DRUG;

ANCHORAGE INDEPENDENT GROWTH; APOPTOSIS; ARTICLE; ATTENUATION; BREAST CANCER; CANCER CELL CULTURE; CANCER INHIBITION; CELL PROLIFERATION; COLONY FORMING UNIT; CONTROLLED STUDY; ENZYME INHIBITION; FEMALE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; TUMOR GROWTH;

APOPTOSIS; BREAST NEOPLASMS; CELL ADHESION; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; DOWN-REGULATION; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; GENE EXPRESSION; HUMANS; MUTATION; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; SODIUM-HYDROGEN ANTIPORTER; TIME FACTORS; TRANSFECTION; TUMOR STEM CELL ASSAY; TUMOR SUPPRESSOR PROTEINS;

EID: 77951665829     PISSN: 09394451     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00726-009-0437-2     Document Type: Article

References (37)

1. A Bessard C Fremin F Ezan A Fautrel L Gailhouste G Baffet 2008 RNAi-mediated ERK2 knockdown inhibits growth of tumor cells in vitro and in vivo Oncogene 27 5315 5325 10.1038/onc.2008.163 1:CAS:528:DC%2BD1cXhtV2qtrrM 18521085
2. RA Cardone A Bellizzi G Busco EJ Weinman ME Dell'Aquila V Casavola A Azzariti A Mangia A Paradiso SJ Reshkin 2007 The NHERF1 PDZ2 domain regulates PKA-RhoA-p38-mediated NHE1 activation and invasion in breast tumor cells Mol Biol Cell 18 1768 1780 10.1091/mbc.E06-07-0617 1:CAS:528:DC%2BD2sXlt1OrsL4%3D 17332506 (Pubitemid 46717558)
3. M Curto BK Cole D Lallemand CH Liu AI McClatchey 2007 Contact-dependent inhibition of EGFR signaling by Nf2/Merlin J Cell Biol 177 893 903 10.1083/jcb.200703010 1:CAS:528:DC%2BD2sXmsV2hurk%3D 17548515 (Pubitemid 46873094)
4. + exchanger regulatory factor) gene mutations in human breast cancer Oncogene 23 8681 8687 10.1038/sj.onc.1207962 15467753 (Pubitemid 39576475)
5. C Forni R Braglia A Lentini M Nuccetelli B Provenzano C Tabolacci S Beninati 2009 Role of transglutaminase 2 in quercetin-induced differentiation of B16-F10 murine melanoma cells Amino Acids 36 731 738 10.1007/s00726-008-0158-y 1:CAS:528:DC%2BD1MXjt1Cqt7g%3D 18688565
6. MM Georgescu FC Morales JR Molina Y Hayashi 2008 Roles of NHERF1/EBP50 in cancer Curr Mol Med 8 459 468 10.2174/156652408785748031 1:CAS:528: DC%2BD1cXhtVGqu73P 18781953
7. A Goel AK Prasad VS Parmar B Ghosh N Saini 2007 7, 8-Dihydroxy-4- methylcoumarin induces apoptosis of human lung adenocarcinoma cells by ROS-independent mitochondrial pathway through partial inhibition of ERK/MAPK signaling FEBS Lett 581 2447 2454 10.1016/j.febslet.2007.04.052 1:CAS:528:DC%2BD2sXlvFamsL8%3D 17485089 (Pubitemid 46764704)
8. CA Hu S Khalil S Zhaorigetu Z Liu M Tyler G Wan D Valle 2008 Human Delta1-pyrroline-5-carboxylate synthase: function and regulation Amino Acids 35 665 672 10.1007/s00726-008-0075-0 1:CAS:528:DC%2BD1cXht1aisrfI 18401542
9. MF James RL Beauchamp N Manchanda A Kazlauskas V Ramesh 2004 A NHERF binding site links the betaPDGFR to the cytoskeleton and regulates cell spreading and migration J Cell Sci 117 2951 2961 10.1242/jcs.01156 1:CAS:528:DC%2BD2cXmtlCrtbg%3D 15161943 (Pubitemid 39117670)
10. M Jechlinger A Sommer R Moriggl P Seither N Kraut P Capodiecci M Donovan C Cordon-Cardo H Beug S Grunert 2006 Autocrine PDGFR signaling promotes mammary cancer metastasis J Clin Invest 116 1561 1570 10.1172/JCI24652 1:CAS:528:DC%2BD28XlsFWrtbc%3D 16741576 (Pubitemid 43911010)
11. EH Jo SJ Lee NS Ahn JS Park JW Hwang SH Kim OI Aruoma YS Lee KS Kang 2007 Induction of apoptosis in MCF-7 and MDA-MB-231 breast cancer cells by Oligonol is mediated by Bcl-2 family regulation and MEK/ERK signaling Eur J Cancer Prev 16 342 347 10.1097/01.cej.0000236247.86360.db 1:CAS:528:DC%2BD2sXpt1ektb8%3D 17554207 (Pubitemid 47165300)
12. R Konno T Okamura N Kasai KH Summer A Niwa 2009 Mutant rat strain lacking D-amino-acid oxidase Amino Acids 37 367 375 10.1007/s00726-008-0163-1 1:CAS:528:DC%2BD1MXotVKis7Y%3D 18716858
13. EL Kreimann FC Morales J de Orbeta-Cruz Y Takahashi H Adams TJ Liu PD McCrea MM Georgescu 2007 Cortical stabilization of beta-catenin contributes to NHERF1/EBP50 tumor suppressor function Oncogene 26 5290 5299 10.1038/sj.onc.1210336 1:CAS:528:DC%2BD2sXoslagtLY%3D 17325659 (Pubitemid 47237631)
14. + exchanger regulatory factor stabilizes epidermal growth factor receptors at the cell surface Mol Biol Cell 15 5470 5480 10.1091/mbc.E04-03-0239 1:CAS:528:DC%2BD2cXhtVGlsLjF 15469991 (Pubitemid 39564739)
15. D Li LJ Wu S Tashiro S Onodera T Ikejima 2007 Oridonin-induced A431 cell apoptosis partially through blockage of the Ras/Raf/ERK signal pathway J Pharmacol Sci 103 56 66 10.1254/jphs.FPJ06016X 1:CAS:528:DC%2BD2sXhvFGnu7w%3D 17251686 (Pubitemid 46175595)
16. T Maehama 2007 PTEN: its deregulation and tumorigenesis Biol Pharm Bull 30 1624 1627 10.1248/bpb.30.1624 1:CAS:528:DC%2BD2sXhtFelsrfI 17827710 (Pubitemid 47403234)
17. + exchanger regulatory factor potentiates receptor activity Mol Cell Biol 20 8352 8363 10.1128/MCB.20.22.8352-8363.2000 1:CAS:528:DC%2BD3cXotFWrt7w%3D 11046132
18. + exchange, is a common interactor for merlin and ERM (MERM) proteins J Biol Chem 273 1273 1276 10.1074/jbc.273.3.1273 1:CAS:528:DyaK1cXktFCrtQ%3D%3D 9430655 (Pubitemid 28133639)
19. GW Neill WJ Harrison MS Ikram TDL Williams LS Bianchi SK Nadendla JL Green L Ghali AM Frischauf EA O'Toole, et al. 2008 GLI1 repression of ERK activity correlates with colony formation and impaired migration in human epidermal keratinocytes Carcinogenesis 29 738 746 10.1093/carcin/bgn037 1:CAS:528:DC%2BD1cXktlOhurY%3D 18281251 (Pubitemid 351494160)
20. A Ostman CH Heldin 2007 PDGF receptors as targets in tumor treatment Adv Cancer Res 97 247 274 10.1016/S0065-230X(06)97011-0 17419949 (Pubitemid 46528991)
21. + exchanger regulatory factor 1 (NHERF1) Breast Cancer Res 8 R63 10.1186/bcr1616 17078868 (Pubitemid 44911887)
22. + exchanger regulatory factor 1 inhibits platelet-derived growth factor signaling in breast cancer cells Breast Cancer Res 10 R5 10.1186/bcr1846 18190691
23. CP Reddy Avula RA Lawrence K Zaman G Fernandes 2002 Inhibition of intracellular peroxides and apoptosis of lymphocytes in lupus-prone B/W mice by dietary n-6 and n-3 lipids with calorie restriction J Clin Immunol 22 206 219 10.1023/A:1016088708457 1:CAS:528:DC%2BD38Xkslyisb0%3D 12148595 (Pubitemid 34774984)
24. TP Rygiel AE Mertens K Strumane R van der Kammen JG Collard 2008 The Rac activator Tiam1 prevents keratinocyte apoptosis by controlling ROS-mediated ERK phosphorylation J Cell Sci 121 1183 1192 10.1242/jcs.017194 1:CAS:528: DC%2BD1cXmtFaltbs%3D 18349077 (Pubitemid 351753502)
25. S Schindelmann J Windisch R Grundmann R Kreienberg R Zeillinger H Deissler 2002 Expression profiling of mammary carcinoma cell lines: correlation of in vitro invasiveness with expression of CD24 Tumour Biol 23 139 145 10.1159/000064030 1:CAS:528:DC%2BD38XmvFajtb0%3D 12218294 (Pubitemid 44858305)
26. R Seger EG Krebs 1995 The MAPK signaling cascade Faseb J 9 726 735 1:CAS:528:DyaK2MXmvFCltb0%3D 7601337
27. T Shibata M Chuma A Kokubu M Sakamoto S Hirohashi 2003 EBP50, a beta-catenin-associating protein, enhances Wnt signaling and is over-expressed in hepatocellular carcinoma Hepatology 38 178 186 10.1053/jhep.2003.50270 1:CAS:528:DC%2BD3sXlvFaju7Y%3D 12830000 (Pubitemid 36775809)
28. WB Sneddon YM Yang JM Ba LM Harinstein PA Friedman 2007 Extracellular signal-regulated kinase activation by parathyroid hormone in distal tubule cells Am J Physiol Renal Physiol 292 F1028 F1034 10.1152/ajprenal.00288.2006 1:CAS:528:DC%2BD2sXjsVyksrc%3D 17107942 (Pubitemid 46393429)
29. J Song J Bai W Yang EW Gabrielson DW Chan Z Zhang 2007 Expression and clinicopathological significance of oestrogen-responsive ezrin-radixin-moesin- binding phosphoprotein 50 in breast cancer Histopathology 51 40 53 10.1111/j.1365-2559.2007.02730.x 1:CAS:528:DC%2BD2sXpsVGitLw%3D 17593079 (Pubitemid 46976376)
30. SM Soond PA Townsend SP Barry RA Knight DS Latchman A Stephanou 2008 ERK and the F-box protein betaTRCP target STAT1 for degradation J Biol Chem 283 16077 16083 10.1074/jbc.M800384200 1:CAS:528:DC%2BD1cXmsFerurc%3D 18378670
31. C Stevens Y Lin M Sanchez E Amin E Copson H White V Durston DM Eccles T Hupp 2007 A germ line mutation in the death domain of DAPK-1 inactivates ERK-induced apoptosis J Biol Chem 282 13791 13803 10.1074/jbc.M605649200 1:CAS:528:DC%2BD2sXks1GnsLw%3D 17244621 (Pubitemid 47100561)
32. CK Sun K Man KT Ng JW Ho ZX Lim Q Cheng CM Lo RT Poon ST Fan 2008 Proline-rich tyrosine kinase 2 (Pyk2) promotes proliferation and invasiveness of hepatocellular carcinoma cells through c-Src/ERK activation Carcinogenesis 29 2096 2105 10.1093/carcin/bgn203 1:CAS:528:DC%2BD1cXhtlalsLnK 18765415
33. Y Takahashi FC Morales EL Kreimann M-M Georgescu 2006 PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling EMBO J 25 910 920 10.1038/sj.emboj.7600979 1:CAS:528:DC%2BD28Xhs1ersbw%3D 16456542 (Pubitemid 43292451)
34. A Takeuchi Y Mishina O Miyaishi E Kojima T Hasegawa K Isobe 2003 Heterozygosity with respect to Zfp148 causes complete loss of fetal germ cells during mouse embryogenesis Nat Genet 33 172 176 10.1038/ng1072 1:CAS:528:DC%2BD3sXnsFSlug%3D%3D 12524542 (Pubitemid 36177069)
35. + exchange regulatory factor 1, a novel AKT-associating protein, regulates extracellular signal-regulated kinase signaling through a B-Raf-mediated pathway Mol Biol Cell 19 1637 1645 10.1091/mbc.E07-11-1114 18272783 (Pubitemid 351805116)
36. Zheng J, Shen H, Xiong Y, Yang X, He J (2008) The beta1-adrenergic receptor mediates extracellular signal-regulated kinase activation via Galphas. Amino Acids. doi: 10.1007/s00726-008-0207-6
37. JF Zheng SS Patil WQ Chen W An JQ He G Lubec 2009 Hippocampal protein levels related to spatial memory are different in the Barnes maze and in the multiple T-maze Amino Acids 37 122 10.1007/s00726-008-0172-0