Death to sepsis: Targeting apoptosis pathways in sepsis

Critical Care

Volumn 13, Issue 6, 2009, Pages

  Wheeler, Derek S ^a,b,c  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b CINCINNATI CHILDREN S HOSPITAL RESEARCH FOUNDATION   (United States)

^c UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS; DEATH; HUMAN; LUNG INJURY; MORTALITY; NOTE; PRIORITY JOURNAL; SEPSIS; CAUSE OF DEATH; CORONARY ARTERY DISEASE; CRITICAL ILLNESS; DRUG ANTAGONISM; INCIDENCE; LYMPHOCYTE; NEOPLASM; PATHOLOGY; STROKE; UNITED STATES;

CASPASE;

APOPTOSIS; CASPASES; CAUSE OF DEATH; CORONARY DISEASE; CRITICAL ILLNESS; HUMANS; INCIDENCE; LYMPHOCYTES; NEOPLASMS; SEPSIS; STROKE; UNITED STATES;

EID: 77951638527     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc8162     Document Type: Note

References (18)

1. Weber P, Wang P, Maddens S, Wang PSH, Wu R, Miksa M, Dong W, Mortimore M, Golec JMC, Charlton P. VX-166: a novel potent small molecule caspase inhibitor as a potential therapy for sepsis. Crit Care 2009, 13:R146. 10.1186/cc8041, 2784364, 19740426.
2. Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001, 29:1303-1310. 10.1097/00003246-200107000-00002, 11445675.
3. Dombrovskiy VY, Martin AA, Sunderram J, Paz HL. Rapid increase in hospitalization and mortality rates for severe sepsis in the United States: a trend analysis from 1993 to 2003. Crit Care Med 2007, 35:1244-1250. 10.1097/01.CCM.0000261890.41311.E9, 17414736.
4. Martin GS, Mannino DM, Eaton S, Moss M. The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 2003, 348:1546-1554. 10.1056/NEJMoa022139, 12700374.
5. Murch O, Collin M, Hinds CJ, Thiemermann C. Lipoproteins in inflammation and sepsis. I. Basic science. Intensive Care Med 2007, 33:13-24. 10.1007/s00134-006-0432-y, 17093985.
6. Watson RS, Carcillo JA, Linde-Zwirble WT, Clermont G, Lidicker J, Angus DC. The epidemiology of severe sepsis in children in the United States. Am J Respir Crit Care Med 2003, 167:695-701. 10.1164/rccm.200207-682OC, 12433670.
7. Wheeler DS, Zingarelli B, Wheeler WJ, Wong HR. Novel pharmacologic approaches to the management of sepsis: targeting the host inflammatory response. Recent Pat Inflamm Allergy Drug Discov 2009, 3:96-112. 10.2174/187221309788489779, 19519586.
8. Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, Peterson E, Tomlanovich M. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001, 345:1368-1377. 10.1056/NEJMoa010307, 11794169.
9. Bernard G, Vincent JL, Laterre PF, LaRosa SP, Dhainaut JF, Lopez-Rodriguez A, Steingrub JS, Garber GE, Helterbrand JD, Ely EW, Fisher CJ, . Recombinant human protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study group Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 2001, 344:699-709. 10.1056/NEJM200103083441001, 11236773, Recombinant human protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study group.
10. Annane D, Sebille V, Charpentier C, Bollaert PE, Francois B, Korach JM, Capellier G, Cohen Y, Azoulay E, Troche G, Chaumet-Riffaud P, Bellisant E. Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA 2002, 288:862-871. 10.1001/jama.288.7.862, 12186604.
11. Sprung CL, Annane D, Keh D, Moreno R, Singer M, Freivogel K, Weiss YG, Benbenishty J, Kalenka A, Forst H, Laterre PF, Reinhart K, Cuthbertson BH, Payen D, Briegel J, . CORTICUS Study Group Hydrocortisone therapy for patients with septic shock. N Engl J Med 2008, 358:111-124. 10.1056/NEJMoa071366, 18184957, CORTICUS Study Group.
12. Laupland KB, Kirkpatrick AW, Delaney A. Polyclonal intravenous immunoglobulin for the treatment of severe sepsis and septic shock in critically ill adults: a systematic review and meta-analysis. Crit Care Med 2007, 35:2686-2692. 10.1097/01.CCM.0000295312.13466.1C, 18074465.
13. Wesche-Soldato DE, Swan RZ, Chung CS, Ayala A. The apoptotic pathway as a therapeutic target in sepsis. Curr Drug Targets 2007, 8:493-500. 10.2174/138945007780362764, 1852483, 17430119.
14. Kerr JF, Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 1972, 26:239-257. 2008650, 4561027.
15. Jin Z, El-Deiry WS. Overview of cell death signaling pathways. Cancer Biol Ther 2005, 4:139-163.
16. Hotchkiss RS, Nicholson DW. Apoptosis and caspases regulate death and inflammation in sepsis. Nat Rev Immunol 2006, 6:813-822. 10.1038/nri1943, 17039247.
17. Tang PS, Mura M, Seth R, Liu M. Acute lung injury and cell death: how many ways can cells die?. Am J Physiol Lung Cell Mol Physiol 2008, 294:L632-L641. 10.1152/ajplung.00262.2007, 18203816.
18. Hotchkiss RS, Coopersmith CM, Karl IE. Prevention of lymphocyte apoptosis - a potential treatment of sepsis?. Clin Infect Dis 2005, 41:S465-S469. 10.1086/431998, 16237649.