Eradication of helicobacter pylori increases ghrelin mRNA expression in the gastric mucosa

Journal of Korean Medical Science

Volumn 25, Issue 2, 2010, Pages 265-271

  Lee, Eon Sook ^a   Yoon, Yeong Sook ^a   Park, Cheol Young ^b   Kim, Han Seong ^a   Um, Tae Hyun ^a   Baik, Hyun Wook ^c   Jang, Eun Jeong ^c   Lee, Sangyeoup ^d   Park, Hee Soon ^b   Oh, Sang Woo ^e  

^a Inje University   (South Korea)

^b Sungkyunkwan University   (South Korea)

^c Bundang Jesaeng Hospital   (South Korea)

^d Pusan National University Hospital   (South Korea)

^e Dongguk University Ilsan Hospital   (South Korea)

Author keywords

Appetite; Gastritis; Ghrelin; Helicobacter pylori

Indexed keywords

ANTIINFECTIVE AGENT; GHRELIN; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ARTICLE; BLOOD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; GASTROSCOPY; GENETICS; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HUMAN; MALE; METABOLISM; MICROBIOLOGY; RANDOMIZED CONTROLLED TRIAL; STOMACH MUCOSA;

ADULT; AGED; ANTI-BACTERIAL AGENTS; FEMALE; GASTRIC MUCOSA; GASTROSCOPY; GHRELIN; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; MALE; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77951629189     PISSN: 10118934     EISSN: 15986357     Source Type: Journal    
DOI: 10.3346/jkms.2010.25.2.265     Document Type: Article

References (30)

1. Marshall BJ, Warren JR. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet 1984; 1: 1311-5.
2. Correa P, Houghton J. Carcinogenesis of Helicobacter pylori. Gastroenterology 2007; 133: 659-72.
3. Bravo LE, Mera R, Reina JC, Pradilla A, Alzate A, Fontham E, Correa P. Impact of Helicobacter pylori infection on growth of children: a prospective cohort study. J Pediatr Gastroenterol Nutr 2003; 37: 614-9.
4. Cho I, Blaser MJ, Francois F, Mathew JP, Ye XY, Goldberg JD, Bini EJ. Helicobacter pylori and overweight status in the United States: data from the Third National Health and Nutrition Examination Survey. Am J Epidemiol 2005; 162: 579-84.
5. Azuma T, Suto H, Ito Y, Muramatsu A, Ohtani M, Dojo M, Yamazaki Y, Kuriyama M, Kato T. Eradication of Helicobacter pylori infection induces an increase in body mass index. Aliment Pharmacol Ther 2002; 16 (Suppl 2): 240-4.
6. Furuta T, Shirai N, Xiao F, Takashima M, Hanai H. Effect of Helicobacter pylori infection and its eradication on nutrition. Aliment Pharmacol Ther 2002; 16: 799-806.
7. Kojima M, Kangawa K. Ghrelin: structure and function. Physiol Rev 2005; 85: 495-522.
8. St-Pierre DH, Wang L, Tache Y. Ghrelin: a novel player in the gut-brain regulation of growth hormone and energy balance. News Physiol Sci 2003; 18: 242-6.
9. Wren AM, Seal LJ, Cohen MA, Brynes AE, Frost GS, Murphy KG, Dhillo WS, Ghatei MA, Bloom SR. Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab 2001; 86: 5992.
10. Osawa H, Nakazato M, Date Y, Kita H, Ohnishi H, Ueno H, Shiiya T, Satoh K, Ishino Y, Sugano K. Impaired production of gastric ghrelin in chronic gastritis associated with Helicobacter pylori. J Clin Endocrinol Metab 2005; 90: 10-6.
11. Nwokolo CU, Freshwater DA, O'Hare P, Randeva HS. Plasma ghrelin following cure of Helicobacter pylori. Gut 2003; 52: 637-40.
12. Tatsuguchi A, Miyake K, Gudis K, Futagami S, Tsukui T, Wada K, Kishida T, Fukuda Y, Sugisaki Y, Sakamoto C. Effect of Helicobacter pylori infection on ghrelin expression in human gastric mucosa. Am J Gastroenterol 2004; 99: 2121-7.
13. Shinomiya T, Fukunaga M, Akamizu T, Irako T, Yokode M, Kangawa K, Nakai Y, Nakai Y. Plasma acylated ghrelin levels correlate with subjective symptoms of functional dyspepsia in female patients. Scand J Gastroenterol 2005; 40: 648-53.
14. Zhang JV, Ren PG, Avsian-Kretchmer O, Luo CW, Rauch R, Klein C, Hsueh AJ. Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake. Science 2005; 310: 996-9.
15. Guo ZF, Zheng X, Qin YW, Hu JQ, Chen SP, Zhang Z. Circulating preprandial ghrelin to obestatin ratio is increased in human obesity. J Clin Endocrinol Metab 2007; 92: 1875-80.
16. Huda MS, Durham BH, Wong SP, Deepak D, Kerrigan D, McCulloch P, Ranganath L, Pinkney J, Wilding JP. Plasma obestatin levels are lower in obese and post-gastrectomy subjects, but do not change in response to a meal. Int J Obes (Lond) 2008; 32: 129-35.
17. Jang EJ, Park SW, Park JS, Park SJ, Hahm KB, Paik SY, Sin MK, Lee ES, Oh SW, Park CY, Baik HW. The influence of the eradication of Helicobacter pylori on gastric ghrelin, appetite, and body mass index in patients with peptic ulcer disease. J Gastroenterol Hepatol 2008; 23 (Suppl 2): S278-85.
18. Isomoto H, Ueno H, Nishi Y, Wen CY, Nakazato M, Kohno S. Impact of Helicobacter pylori infection on ghrelin and various neuroendocrine hormones in plasma. World J Gastroenterol 2005; 11: 1644-8.
19. Kim HB, Lee ES, Oh SW, Kim YH, Lee DE, Hwang CK, Lee EY, Yoon YS, Yang YJ. Validity, reproducibility of visual analogue scales in assessment of appetite sensations. J Korean Acad Fam Med 2008; 29: 736-45.
20. Dixon MF, Genta RM, Yardley JH, Correa P. Classification and grading of gastritis. The updated Sydney System. International Workshop on the Histopathology of Gastritis, Houston 1994. Am J Surg Pathol 1996; 20: 1161-81.
21. Konturek PC, Cześnikiewicz-Guzik M, Bielanski W, Konturek SJ. Involvement of Helicobacter pylori infection in neuro-hormonal control of food intake. J Physiol Pharmacol 2006; 57 (Suppl 5): 67-81.
22. Moayyedi P, Soo S, Deeks J, Delaney B, Harris A, Innes M, Oakes R, Wilson S, Roalfe A, Bennett C, Forman D. Eradication of Helicobacter pylori for non-ulcer dyspepsia. Cochrane Database Syst Rev 2006; 2: CD002096.
23. Isomoto H, Ueno H, Saenko VA, Mondal MS, Nishi Y, Kawano N, Ohnita K, Mizuta Y, Ohtsuru A, Yamashita S, Nakazato M, Kohno S. Impact of Helicobacter pylori infection on gastric and plasma ghrelin dynamics in humans. Am J Gastroenterol 2005; 100: 1711-20.
24. Cummings DE. Helicobacter pylori and ghrelin: interrelated players in body-weight regulation? Am J Med 2004; 117: 436-9.
25. Blaser MJ, Atherton JC. Helicobacter pylori persistence: biology and disease. J Clin Invest 2004; 113: 321-33.
26. Bresciani E, Rapetti D, Donaà F, Bulgarelli I, Tamiazzo L, Locatelli V, Torsello A. Obestatin inhibits feeding but does not modulate GH and corticosterone secretion in the rat. J Endocrinol Invest 2006; 29: RC16-8.
27. Zizzari P, Longchamps R, Epelbaum J, Bluet-Pajot MT. Obestatin partially affects ghrelin stimulation of food intake and growth hormone secretion in rodents. Endocrinology 2007; 148: 1648-53.
28. Nogueiras R, Pfluger P, Tovar S, Arnold M, Mitchell S, Morris A, Perez-Tilve D, Vázquez MJ, Wiedmer P, Castañeda TR, DiMarchi R, Tschöp M, Schurmann A, Joost HG, Williams LM, Langhans W, Diéguez C. Effects of obestatin on energy balance and growth hormone secretion in rodents. Endocrinology 2007; 148: 21-6.
29. Seoane LM, Al-Massadi O, Pazos Y, Pagotto U, Casanueva FF. Central obestatin administration does not modify either spontaneous or ghrelin-induced food intake in rats. J Endocrinol Invest 2006; 29: RC13-5.
30. Vicennati V, Genghini S, De Iasio R, Pasqui F, Pagotto U, Pasquali R. Circulating obestatin levels and the ghrelin/obestatin ratio in obese women. Eur J Endocrinol. 2007; 157: 295-301.