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Volumn 16, Issue 5, 2009, Pages 539-542

Endotoxin-neutralizing peptides as gram-negative sepsis therapeutics

Author keywords

Anti microbial peptide; BPIP; CD18; Endotoxin neutralizing peptide; Gram negative sepsis

Indexed keywords

ANTIMICROBIAL CATIONIC PEPTIDE; CD18 ANTIGEN; ENDOTOXIN; PEPTIDE;

EID: 67649385970     PISSN: 09298665     EISSN: None     Source Type: Journal    
DOI: 10.2174/092986609788167761     Document Type: Article
Times cited : (12)

References (30)
  • 2
    • 33750047495 scopus 로고    scopus 로고
    • Management of sepsis
    • Russell, J.A. Management of sepsis. N. Engl. J. Med., 2006,355(16), 1699-1713.
    • (2006) N. Engl. J. Med , vol.355 , Issue.16 , pp. 1699-1713
    • Russell, J.A.1
  • 3
    • 14544299688 scopus 로고    scopus 로고
    • Therapeutic intervention and targets for sepsis
    • Rice, T.W.; Bernard, G.R. Therapeutic intervention and targets for sepsis. Annu. Rev. Med., 2005, 56, 225-248.
    • (2005) Annu. Rev. Med , vol.56 , pp. 225-248
    • Rice, T.W.1    Bernard, G.R.2
  • 4
    • 0029043636 scopus 로고
    • A second large controlled clinical study of E5, a monoclonal antibody to endotoxin: Results of a prospective, multicenter, randomized, controlled trial. The E5 Sepsis Study Group
    • Bone, R.C.; Balk, R.A.; Fein, A.M.; Perl, T.M.; Wenzel, R.P.; Reines, H.D.; Quenzer, R.W.; Iberti, T.J.; Macintyre, N.; Schein, R.M. A second large controlled clinical study of E5, a monoclonal antibody to endotoxin: results of a prospective, multicenter, randomized, controlled trial. The E5 Sepsis Study Group. Crit. Care Med., 1995, 23(6), 994-1006.
    • (1995) Crit. Care Med , vol.23 , Issue.6 , pp. 994-1006
    • Bone, R.C.1    Balk, R.A.2    Fein, A.M.3    Perl, T.M.4    Wenzel, R.P.5    Reines, H.D.6    Quenzer, R.W.7    Iberti, T.J.8    Macintyre, N.9    Schein, R.M.10
  • 5
    • 34247403460 scopus 로고    scopus 로고
    • Sepsis since the discovery of Toll-like receptors: Disease concepts and therapeutic opportunities
    • Leaver, S.K.; Finney, S.J.; Burke-Gaffney, A.; Evans, T.W. Sepsis since the discovery of Toll-like receptors: Disease concepts and therapeutic opportunities. Crit. Care Med., 2007, 35(5), 1404-1410.
    • (2007) Crit. Care Med , vol.35 , Issue.5 , pp. 1404-1410
    • Leaver, S.K.1    Finney, S.J.2    Burke-Gaffney, A.3    Evans, T.W.4
  • 6
    • 2442565752 scopus 로고    scopus 로고
    • Reinhart, K.; Gluck, T.; Ligtenberg, J.; Tschaikowsky, K.; Bruin- ing, A.; Bakker, J.; Opal, S.; Moldawer, L.L.; Axtelle, T.; Turner, T.; Souza, S.; Pribble, J. CD14 receptor occupancy in severe sepsis: results of a phase I clinical trial with a recombinant chimeric CD14 monoclonal antibody (IC14). Crit. Care Med., 2004, 32(5), 11001108.
    • Reinhart, K.; Gluck, T.; Ligtenberg, J.; Tschaikowsky, K.; Bruin- ing, A.; Bakker, J.; Opal, S.; Moldawer, L.L.; Axtelle, T.; Turner, T.; Souza, S.; Pribble, J. CD14 receptor occupancy in severe sepsis: results of a phase I clinical trial with a recombinant chimeric CD14 monoclonal antibody (IC14). Crit. Care Med., 2004, 32(5), 11001108.
  • 7
    • 0026016470 scopus 로고
    • Treatment of gram-negative bacteremia and septic shock with HA-1A human monoclonal antibody against endotoxin. A randomized, double-blind, placebo-controlled trial. The HA-1A Sepsis Study Group
    • Ziegler, E.J.; Fisher, C.J., Jr.; Sprung, C.L.; Straube, R.C.; Sadoff, J.C.; Foulke, G.E.; Wortel, C.H.; Fink, M.P.; Dellinger, R.P.; Teng,N.N.; et. al. Treatment of gram-negative bacteremia and septic shock with HA-1A human monoclonal antibody against endotoxin. A randomized, double-blind, placebo-controlled trial. The HA-1A Sepsis Study Group. N. Engl. J. Med., 1991, 324(7), 429-436.
    • (1991) N. Engl. J. Med , vol.324 , Issue.7 , pp. 429-436
    • Ziegler, E.J.1    Fisher Jr., C.J.2    Sprung, C.L.3    Straube, R.C.4    Sadoff, J.C.5    Foulke, G.E.6    Wortel, C.H.7    Fink, M.P.8    Dellinger, R.P.9    Teng, N.N.10    et., al.11
  • 8
    • 0017804093 scopus 로고
    • Purification and characterization of a potent bactericidal and membrane active protein from the granules of human polymorphonuclear leukocytes
    • Weiss, J.; Elsbach, P.; Olsson, I.; Odeberg, H. Purification and characterization of a potent bactericidal and membrane active protein from the granules of human polymorphonuclear leukocytes. J. Biol. Chem., 1978, 253(8), 2664-2672.
    • (1978) J. Biol. Chem , vol.253 , Issue.8 , pp. 2664-2672
    • Weiss, J.1    Elsbach, P.2    Olsson, I.3    Odeberg, H.4
  • 9
    • 0026497337 scopus 로고
    • High- affinity binding of the bactericidal/permeability-increasing protein and a recombinant amino-terminal fragment to the lipid A region of lipopolysaccharide
    • Gazzano-Santoro, H.; Parent, J.B.; Grinna, L.; Horwitz, A.; Parsons, T.; Theofan, G.; Elsbach, P.; Weiss, J.; Conlon, P.J. High- affinity binding of the bactericidal/permeability-increasing protein and a recombinant amino-terminal fragment to the lipid A region of lipopolysaccharide. Infect. Immun., 1992, 60(11), 4754-4761.
    • (1992) Infect. Immun , vol.60 , Issue.11 , pp. 4754-4761
    • Gazzano-Santoro, H.1    Parent, J.B.2    Grinna, L.3    Horwitz, A.4    Parsons, T.5    Theofan, G.6    Elsbach, P.7    Weiss, J.8    Conlon, P.J.9
  • 12
    • 0025883775 scopus 로고
    • Endotoxin neutralizing properties of the 25 kD N-terminal fragment and a newly isolated 30 kD C-terminal fragment of the 55-60 kD bactericidal/permeability-increasing protein of human neutrophils
    • Ooi, C.E.; Weiss, J.; Doerfler, M.E.; Elsbach, P. Endotoxin neutralizing properties of the 25 kD N-terminal fragment and a newly isolated 30 kD C-terminal fragment of the 55-60 kD bactericidal/permeability-increasing protein of human neutrophils. J. Exp. Med., 1991, 174(3), 649-655.
    • (1991) J. Exp. Med , vol.174 , Issue.3 , pp. 649-655
    • Ooi, C.E.1    Weiss, J.2    Doerfler, M.E.3    Elsbach, P.4
  • 13
    • 0023525873 scopus 로고
    • A 25- kDa NH2-terminal fragment carries all the antibacterial activities of the human neutrophil 60-kDa bactericidal/permeability-increasing protein
    • Ooi, C.E.; Weiss, J.; Elsbach, P.; Frangione, B.; Mannion, B. A 25- kDa NH2-terminal fragment carries all the antibacterial activities of the human neutrophil 60-kDa bactericidal/permeability-increasing protein. J. Biol. Chem., 1987, 262(31), 14891-14894.
    • (1987) J. Biol. Chem , vol.262 , Issue.31 , pp. 14891-14894
    • Ooi, C.E.1    Weiss, J.2    Elsbach, P.3    Frangione, B.4    Mannion, B.5
  • 14
    • 0028542299 scopus 로고
    • Protective effects of a recombinant N-terminal fragment of bactericidal/ permeability increasing protein on endotoxic shock in conscious rabbits
    • Lin, Y.; Ammons, W.S.; Leach, W.J.; Kung, A.H. Protective effects of a recombinant N-terminal fragment of bactericidal/ permeability increasing protein on endotoxic shock in conscious rabbits. Shock, 1994, 2(5), 324-331.
    • (1994) Shock , vol.2 , Issue.5 , pp. 324-331
    • Lin, Y.1    Ammons, W.S.2    Leach, W.J.3    Kung, A.H.4
  • 15
    • 0029385205 scopus 로고
    • The recombinant 23-kDa N-terminal fragment of bactericidal/permeability-increasing protein (rBPI23) decreases Es- cherichia coli-induced mortality and organ injury during immuno- suppression-related neutropenia
    • Lechner, A.J.; Lamprech, K.E.; Johanns, C.A.; Matuschak, G.M. The recombinant 23-kDa N-terminal fragment of bactericidal/permeability-increasing protein (rBPI23) decreases Es- cherichia coli-induced mortality and organ injury during immuno- suppression-related neutropenia. Shock, 1995, 4(4), 298-306.
    • (1995) Shock , vol.4 , Issue.4 , pp. 298-306
    • Lechner, A.J.1    Lamprech, K.E.2    Johanns, C.A.3    Matuschak, G.M.4
  • 16
    • 0028798378 scopus 로고
    • Protective effects of a recombinant amino-terminal fragment of human bactericidal/ permeability-increasing protein in an animal model of gram-negative sepsis
    • Evans, T.J.; Carpenter, A.; Moyes, D.; Martin, R.; Cohen, J. Protective effects of a recombinant amino-terminal fragment of human bactericidal/ permeability-increasing protein in an animal model of gram-negative sepsis. J. Infect. Dis., 1995, 171(1), 153-160.
    • (1995) J. Infect. Dis , vol.171 , Issue.1 , pp. 153-160
    • Evans, T.J.1    Carpenter, A.2    Moyes, D.3    Martin, R.4    Cohen, J.5
  • 17
    • 0032941856 scopus 로고    scopus 로고
    • Bactericidal/permeability-increasing protein (rBPI21) in patients with hemorrhage due to trauma: Results of a multicenter phase II clinical trial. rBPI21 Acute Hemorrhagic Trauma Study Group
    • discussion 676-667
    • Demetriades, D.; Smith, J.S.; Jacobson, L.E.; Moncure, M.; Minei, J.; Nelson, B.J.; Scannon, P.J. Bactericidal/permeability-increasing protein (rBPI21) in patients with hemorrhage due to trauma: results of a multicenter phase II clinical trial. rBPI21 Acute Hemorrhagic Trauma Study Group. J. Trauma., 1999, 46(4), 667-676; discussion 676-667.
    • (1999) J. Trauma , vol.46 , Issue.4 , pp. 667-676
    • Demetriades, D.1    Smith, J.S.2    Jacobson, L.E.3    Moncure, M.4    Minei, J.5    Nelson, B.J.6    Scannon, P.J.7
  • 18
    • 0034675328 scopus 로고    scopus 로고
    • Recombinant bactericidal/permeability-increasing protein (rBPI21) as adjunctive treatment for children with severe meningo- coccal sepsis: A randomised trial. rBPI21 Meningococcal Sepsis Study Group
    • Levin, M.; Quint, P.A.; Goldstein, B.; Barton, P.; Bradley, J.S.;Shemie, S.D.; Yeh, T.; Kim, S.S.; Cafaro, D.P.; Scannon, P.J.; Gi roir, B.P. Recombinant bactericidal/permeability-increasing protein (rBPI21) as adjunctive treatment for children with severe meningo- coccal sepsis: a randomised trial. rBPI21 Meningococcal Sepsis Study Group. Lancet, 2000, 356(9234), 961-967.
    • (2000) Lancet , vol.356 , Issue.9234 , pp. 961-967
    • Levin, M.1    Quint, P.A.2    Goldstein, B.3    Barton, P.4    Bradley, J.S.5    Shemie, S.D.6    Yeh, T.7    Kim, S.S.8    Cafaro, D.P.9    Scannon, P.J.10    Gi roir, B.P.11
  • 19
    • 0031583752 scopus 로고    scopus 로고
    • Preliminary evaluation of recombinant amino-terminal fragment of human bactericidal/permeability-increasing protein in children with severe meningococcal sepsis
    • Giroir, B.P.; Quint, P.A.; Barton, P.; Kirsch, E.A.; Kitchen, L.;Goldstein, B.; Nelson, B.J.; Wedel, N.J.; Carroll, S.F.; Scannon,.J. Preliminary evaluation of recombinant amino-terminal fragment of human bactericidal/permeability-increasing protein in children with severe meningococcal sepsis. Lancet, 1997, 350(9089), 1439-1443.
    • (1997) Lancet , vol.350 , Issue.9089 , pp. 1439-1443
    • Giroir, B.P.1    Quint, P.A.2    Barton, P.3    Kirsch, E.A.4    Kitchen, L.5    Goldstein, B.6    Nelson, B.J.7    Wedel, N.J.8    Carroll, S.F.9    Scannon, J.10
  • 20
    • 29144521244 scopus 로고    scopus 로고
    • Human antimicrobial peptides: Defens- ins, cathelicidins and histatins
    • De Smet, K.; Contreras, R. Human antimicrobial peptides: defens- ins, cathelicidins and histatins. Biotechnol. Lett., 2005, 27(18),1337-1347.
    • (2005) Biotechnol. Lett , vol.27 , Issue.18 , pp. 1337-1347
    • De Smet, K.1    Contreras, R.2
  • 21
    • 0037165196 scopus 로고    scopus 로고
    • Antimicrobial peptides of multicellular organisms
    • Zasloff, M. Antimicrobial peptides of multicellular organisms. Nature, 2002, 415(6870), 389-395.
    • (2002) Nature , vol.415 , Issue.6870 , pp. 389-395
    • Zasloff, M.1
  • 22
    • 0028933794 scopus 로고
    • Peptide antibiotics and their role in innate immunity
    • Boman, H.G. Peptide antibiotics and their role in innate immunity. Annu. Rev. Immunol., 1995, 13,. 61-92.
    • (1995) Annu. Rev. Immunol , vol.13 , pp. 61-92
    • Boman, H.G.1
  • 23
    • 0028949278 scopus 로고
    • Human CAP18: A novel antimicrobial lipopolysaccharide- binding protein
    • Larrick, J.W.; Hirata, M.; Balint, R.F.; Lee, J.; Zhong, J.; Wright,S.C. Human CAP18: a novel antimicrobial lipopolysaccharide- binding protein. Infect. Immun., 1995, 63(4), 1291-1297.
    • (1995) Infect. Immun , vol.63 , Issue.4 , pp. 1291-1297
    • Larrick, J.W.1    Hirata, M.2    Balint, R.F.3    Lee, J.4    Zhong, J.5    Wright, S.C.6
  • 24
    • 33644978944 scopus 로고    scopus 로고
    • Endotoxin (lipopolysaccharide) neutralization by innate immunity host-defense peptides. Peptide properties and plausible modes of action
    • Rosenfeld, Y.; Papo, N.; Shai, Y. Endotoxin (lipopolysaccharide) neutralization by innate immunity host-defense peptides. Peptide properties and plausible modes of action. J. Biol. Chem., 2006, 281(3), 1636-1643.
    • (2006) J. Biol. Chem , vol.281 , Issue.3 , pp. 1636-1643
    • Rosenfeld, Y.1    Papo, N.2    Shai, Y.3
  • 25
    • 0024590613 scopus 로고
    • GCR3 (CD11b/CD18) expresses one binding site for Arg-Gly-Asp containing peptides and a second site for bacterial lipopolysaccha ride
    • Wright, S.D.; Levin, S.M.; Jong, M.T.; Chad, Z.; Kabbash, L.GCR3 (CD11b/CD18) expresses one binding site for Arg-Gly-Asp containing peptides and a second site for bacterial lipopolysaccha ride. J. Exp. Med., 1989, 169(1), 175-183.
    • (1989) J. Exp. Med , vol.169 , Issue.1 , pp. 175-183
    • Wright, S.D.1    Levin, S.M.2    Jong, M.T.3    Chad, Z.4    Kabbash, L.5
  • 26
    • 0023026362 scopus 로고
    • Adhesion-promoting receptors on humanmacrophages recognize Escherichia coli by binding to lipopolysac- haride
    • Wright, S.D.; Jong, M.T. Adhesion-promoting receptors on humanmacrophages recognize Escherichia coli by binding to lipopolysac- haride. J. Exp. Med., 1986, 164(6), 1876-1888.
    • (1986) J. Exp. Med , vol.164 , Issue.6 , pp. 1876-1888
    • Wright, S.D.1    Jong, M.T.2
  • 27
    • 0028909814 scopus 로고
    • CD11c/CD18, a transmembrane signaling receptor for lipopolysaccharide
    • Ingalls, R.R.; Golenbock, D.T. CD11c/CD18, a transmembrane signaling receptor for lipopolysaccharide. J. Exp. Med., 1995,181(4), 1473-1479.
    • (1995) J. Exp. Med , vol.181 , Issue.4 , pp. 1473-1479
    • Ingalls, R.R.1    Golenbock, D.T.2
  • 28
    • 0031278065 scopus 로고    scopus 로고
    • CD11/CD18 leukocyte integrins: New signaling receptors for bacterial endotoxin
    • Flaherty, S.F.; Golenbock, D.T.; Milham, F.H.; Ingalls, R.R.CD11/CD18 leukocyte integrins: new signaling receptors for bacterial endotoxin. J. Surg. Res., 1997, 73(1), 85-89.
    • (1997) J. Surg. Res , vol.73 , Issue.1 , pp. 85-89
    • Flaherty, S.F.1    Golenbock, D.T.2    Milham, F.H.3    Ingalls, R.R.4
  • 29
    • 35248867073 scopus 로고    scopus 로고
    • Characterization of two novel LPS-binding sites in leukocyte in- tegrin {beta}A domain
    • Wong, K.F.; Luk, J.M.; Cheng, R.H.; Klickstein, L.B.; Fan, S.T.Characterization of two novel LPS-binding sites in leukocyte in- tegrin {beta}A domain. FASEB J., 2007, 21(12), 3231-3239.
    • (2007) FASEB J , vol.21 , Issue.12 , pp. 3231-3239
    • Wong, K.F.1    Luk, J.M.2    Cheng, R.H.3    Klickstein, L.B.4    Fan, S.T.5
  • 30
    • 0035884820 scopus 로고    scopus 로고
    • Cathelicidin family of antibacterial pep- tides CAP18 and CAP11 inhibit the expression of TNF-alpha by blocking the binding of LPS to CD14(+) cells
    • Nagaoka, I.; Hirota, S.; Niyonsaba, F.; Hirata, M.; Adachi, Y.; Tamura, H.; Heumann, D. Cathelicidin family of antibacterial pep- tides CAP18 and CAP11 inhibit the expression of TNF-alpha by blocking the binding of LPS to CD14(+) cells. J. Immunol., 2001, 167(6), 3329-3338.
    • (2001) J. Immunol , vol.167 , Issue.6 , pp. 3329-3338
    • Nagaoka, I.1    Hirota, S.2    Niyonsaba, F.3    Hirata, M.4    Adachi, Y.5    Tamura, H.6    Heumann, D.7


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