Solubility improvement of an anthrax toxin peptide inhibitor by rational aminoacid randomization

Protein and Peptide Letters

Volumn 15, Issue 6, 2008, Pages 562-566

  Pini, Alessandro ^a   Brunetti, Jlenia ^a   Falciani, Chiara ^a   Fabbrini, Monica ^a   Bracci, Luisa ^a  

^a UNIVERSITY OF SIENA   (Italy)

Author keywords

Anthrax toxin inhibitor; Branched peptides; Dendrimeric peptides; MAP; Peptide solubility; Peptide stability

Indexed keywords

ANTHRAX TOXIN; BACTERIAL ANTIGEN; BACTERIAL TOXIN; PEPTIDE; PEPTIDE LIBRARY;

ARTICLE; BIOLOGICAL MODEL; CHEMISTRY; DRUG ANTAGONISM; METABOLISM; SOLUBILITY; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTIGENS, BACTERIAL; BACTERIAL TOXINS; MODELS, BIOLOGICAL; PEPTIDE LIBRARY; PEPTIDES; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP;

TETRA;

EID: 47249102594     PISSN: 09298665     EISSN: None     Source Type: Journal    
DOI: 10.2174/092986608784966958     Document Type: Article

References (14)

1. Bradley, K.A., Mogridge, J., Mourez, M., Collier, R.J. and Young, J.A. (2001) Nature, 414, 225
2. Pini, A., Runci, Y., Falciani, C, Lelli, B., Brunetti J., Pileri, S., Fabbrini M., Lozzi L., Ricci C, Bernini A., Tonello, F., Dal Molin,F., Neri, P., Niccolai, N., Bracci, L. (2006)Biochem. J., 395, 157,
3. Tarn, J.P., (1988) Proc. Natl. Acud. Sci. USA, 85, 5409.
4. Tarn, J.P., Lu, Y.A., Yang, J.L. (2002) Eur. J. Biochem., 269, 923.
5. Bracci, L., Falciani, C, Lelli, B., Lozzi, L., Runci, Y., Pini. A., De Montis, M.G., Tagliamonte, A., Neri, P. (2003) J. Biol. Chem., 278, 46590.
6. Falciani, C, Lozzi, L., Pini, A., Corti, F., Fabbrini, M., Bernini, A., Lelli. B.. Niccolai, N., Bracci, L. (2007) Chem. Biol. Drug Des., 69, 216.
7. Bracci, L., Lozzi, L., Pini, A., Lelli, B., Falciani, C, Niccolai, N., Bernini, A., Spreafico, A., Soldani, P., Neri, P. (2002) Biochemistry, 41, 10194.
8. Lozzi, L., Lelli, B., Runci, Y., Scali, S., Bernini, A., Falciani, C, Pini, A., Niccolai, N., Neri, P., Bracci, L. (2003) Chem. Biol., 10, 411.
9. Falciani, C, Fabbrini, M., Pini, A., Lozzi, L., Lelli, B., Pileri, S., Brunetti, J., Bindi, S., Scali, S., Bracci, L. (2007) Mol. Cancer Ther.,6, 2441.
10. Mourez, M., Kane, R.S., Mogridge, J., Metallo, S., Deschatelets,P., Sellman, B.R., Whitesides, G.M., Collier, R.J. (2001) Nat. Bio-technol, 19, 958.
11. Paccani, S. R., Tonello, F., Ghiottoni, R., Natale, M., Muraro, L., D'Elios, M. M., Tang, W. J., Montecucco, C. and Baldari, C. T. (2005) J. Exp. Med., 201, 325.
12. Tournier, J. N., Quesnel-Heilmann, A., Mathieu, J., Montecucco,C, Tang, W. J., Mock, M., Vidal, D. R. and Goossens, P. L. (2005) J Immunol, 174, 4934.
13. Decathelineau, A.M., Bokoch, G.M. (2006) Biochem. J., 395, el-3
14. Cunningham, K., Lacy, D.B., Mogridge, J., Collier, R.J. (2002) Proc. Natl. Acad. Sci. USA, 99, 7049.