Interaction of cardiac troponin C and troponin I with W7 in the presence of three functional regions of cardiac troponin I

Biochemistry

Volumn 45, Issue 32, 2006, Pages 9833-9840

  Li, Monica X ^a   Hoffman, Ryan M B ^a   Sykes, Brian D ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

MUSCLE; NUCLEAR MAGNETIC RESONANCE; SENSITIVITY ANALYSIS; STOICHIOMETRY;

CHEMICAL SHIFT; MUSCLE CONTRACTION;

PROTEINS;

AMINO ACID; CALCIUM; CALMODULIN INHIBITOR; CARDIAC TROPONIN C; CARDIAC TROPONIN I; N (6 AMINOHEXYL) 5 CHLORO 1 NAPHTHALENESULFONAMIDE; PEPTIDE; TROPONIN C; TROPONIN I; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; DRUG MECHANISM; DRUG PROTEIN BINDING; HEART CONTRACTION; HUMAN; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTON NUCLEAR MAGNETIC RESONANCE; STOICHIOMETRY; TITRIMETRY;

CALCIUM; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HUMANS; MYOCARDIUM; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PEPTIDES; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; SULFONAMIDES; TITRIMETRY; TROPONIN C; TROPONIN I;

EID: 33747480590     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi060779a     Document Type: Article

References (36)

1. Hidaka, H., Yamaki, T., Naka, M., Tanaka, T., Hayashi, H., and Kobayashi, R. (1980) Calcium-regulated modulator protein interacting agents inhibit smooth muscle calcium-stimulated protein kinase and ATPase, Mol. Pharmacol. 17, 66-72.
2. Adhikari, B. B., and Wang, K. (2004) Interplay of troponin- and myosin-based pathways of calcium activation in skeletal and cardiac muscle: The use of W7 as an inhibitor of thin filament activation, Biophys. J. 86, 359-370.
3. Sia, S. K., Li, M. X., Spyracopoulos, L., Gagné, S. M., Liu, W., Putkey, J. A., and Sykes, B. D. (1997) NMR structure of cardiac troponin C reveals an unexpected closed regulatory domain, J. Biol. Chem. 272, 18216-18221.
4. Li, M. X., Wang, X., and Sykes, B. D. (2004) Structural based insights into the role of troponin in cardiac muscle pathophysiology, J. Muscle Res. Cell Motil. 25, 559-579.
5. Spyracopoulos, L., Li, M. X., Sia, S. K., Gagné, S. M., Chandra, M., Solaro, R. J., and Sykes, B. D. (1997) Calcium-induced structural transition in the regulatory domain of human cardiac troponin C, Biochemistry 36, 12138-12146.
6. 2+ and troponin I peptide binding to the E41A mutant of the N-domain of skeletal troponin C, Biochemistry 39, 12731-12738.
7. Li, M. X., Spyracopoulos, L., and Sykes, B. D. (1999) Binding of cardiac troponin-I 147-163 induces a structural opening in human cardiac troponin-C, Biochemistry 38, 8289-8298.
8. 2+-saturated form, Nature 424, 35-41.
9. 2+- regulated structural changes in troponin, Proc. Natl. Acad. Sci. U.S.A. 102, 5038-5043.
10. Lindhout, D. A., and Sykes, B. D. (2003) Structure and dynamics of the C-domain of human cardiac troponin C in complex with the inhibitory region of human cardiac troponin I, J. Biol. Chem. 278, 27024-27034.
11. Lindhout, D. A., Boyko, R. F., Corson, D. C., Li, M. X., and Sykes, B. D. (2005) The role of electrostatics in the interaction of the inhibitory region of troponin I with troponin C, Biochemistry 44, 14750-14759.
12. 2+, Ann. Med. 34, 248-258.
13. Rosevear, P. R., and Finley, N. (2003) Molecular mechanism of levosimendan action: An update, J. Mol. Cell. Cardiol. 35, 1011-1015.
14. Sorsa, T., Pollesello, P., and Solaro, R. J. (2004) The contractile apparatus as a target for drugs against heart failure: Interaction of levosimendan, a calcium sensitizer, with cardiac troponin C, Mol. Cell. Biochem. 266, 87-107.
15. Kass, D. A., and Solaro, R. J. (2006) Mechanisms and use of calcium-sensitizing agents in the failing heart, Circulation 113, 305-315.
16. Kleerekoper, Q., Liu, W., Choi, D., and Putkey, J. A. (1998) Identification of binding sites for bepridil and trifluoperazine on cardiac troponin C, J. Biol. Chem. 273, 8153-8160.
17. Li, Y., Love, M. L., Putkey, J. A., and Cohen, C. (2000) Bepridil opens the regulatory N-terminal lobe of cardiac troponin C, Proc. Nad. Acad. Sci. U.S.A. 97, 5140-5145.
18. 147-163 and bepridil, J. Biol. Chem. 277, 31124-31133.
19. 2+ sensitizing drug EMD 57033, J. Biol. Chem. 276, 25456-25466.
20. Sorsa, T., Pollesello, P., Permi, P., Drakenberg, T., and Kilpelainen, I. (2003) Interaction of levosimendan with cardiac troponin C in the presence of cardiac troponin I peptides, J. Mol. Cell. Cardiol. 35, 1055-1061.
21. Li, M. X., Saude, E. J., Wang, X., Pearlstone, J. R., Smillie, L. B., and Sykes, B. D. (2002) Kinetic studies of calcium and cardiac troponin I peptide binding to human cardiac troponin C using NMR spectroscopy, Eur. Biophys. J. 31, 245-256.
22. 2+ dependent regulation of muscle contraction, J. Mol. Biol. 271, 728-750.
23. Delaglio, F., Grzesiek, S., Vuister, G. W., Zhu, G., Pfeifer, J., and Bax, A. (1995) NMRPipe: A multidimensional spectral processing system based on UNIX pipes, J. Biomol. NMR 6, 277-293.
24. Osawa, M., Kuwamoto, S., Izumi, Y., Yap, K. L., Ikura, M., Shibanuma, T., Yokokura, H., Hidaka, H., and Matsushima, N. (1999) Evidence for calmodulin inter-domain compaction in solution induced by W-7 binding, FEBS Lett. 442, 173-177.
25. Hoffman, R. M. B., Li, M. X., and Sykes, B. D. (2005) The binding of W7, an inhibitor of striated muscle contraction, to cardiac troponin C, Biochemistry 44, 15750-15759.
26. Craven, C. J., Whitehead, B., Jones, S. K., Thulin, E., Blackburn, G. M., and Waltho, J. P. (1996) Complexes formed between calmodulin and the antagonists J-8 and TFP in solution, Biochemistry 35, 10287-10299.
27. Cook, W. J., Walter, L. J., and Walter, M. R. (1994) Drug binding by calmodulin: Crystal structure of a calmodulin-trifluoperazine complex, Biochemistry 33, 15259-15265.
28. 2+-calmodulin, Nat. Struct. Biol. 1, 795-801.
29. Kleerekoper, Q., and Putkey, J. A. (1999) Drug binding to cardiac troponin C, J. Biol. Chem. 274, 23932-23939.
30. Osawa, M., Swindells, M. B., Tanikawa, J., Tanaka, T., Mase, T., Furuya, T., and Ikura, M. (1998) Solution structure of calmodulin-W-7 complex: The basis of diversity in molecular recognition, J. Mol. Biol. 276, 165-176.
31. 1H NMR spectroscopy, FEBS Lett. 123, 25-29.
32. Ikura, M., Clore, G. M., Gronenborn, A. M., Zhu, G., Klee, C. B., and Bax, A. (1992) Solution structure of a calmodulin-target peptide complex by multidimensional NMR, Science 256, 632-638.
33. Sorsa, T., Heikkinen, S., Abbott, M. B., Abusamhadneh, E., Laakso, T., Tilgmann, C., Serimaa, R., Annila, A., Rosevear, P. R., Drakenberg, T., Pollesello, P., and Kilpelainen, I. (2001) Binding of levosimendan, a calcium sensitizer, to cardiac troponin C, J. Biol. Chem. 276, 9337-9343.
34. Attwood, D., and Natarajan, R. (1981) Effect of pH on the micellar properties of amphiphilic drugs in aqueous solution, J. Pharm. Pharmacol. 33, 136-140.
35. Ravin, L. J., and Warren, R. J. (1971) Micelle formation and its significance in interpretation of NMR spectra of phenothiazine, J. Pharm. Sci. 60, 329.
36. 2+-activated states, J. Mol. Biol. 357, 707-717.