Defining the binding site of levosimendan and its analogues in a regulatory cardiac troponin C-troponin I complex

Biochemistry

Volumn 47, Issue 28, 2008, Pages 7485-7495

  Robertson, Ian M ^a   Baryshnikova, Olga K ^a   Li, Monica X ^a   Sykes, Brian D ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; CALCIUM;

CARDIAC TROPONIN C; CARDIAC TROPONIN I; TROPONIN I (TNI);

BINDING SITES;

4,5 DIHYDRO 6 [4 (1H IMIDAZOL 1 YL)PHENYL] 5 METHYL 3(2H) PYRIDAZINONE; 6 (4 AMINOPHENYL) 5 METHYL 4,5 DIHYDRO 3(2H) PYRIDAZINONE; 6 (4 CHLOROPHENYL) 5 METHYL 4,5 DIHYDRO 3(2H) PYRIDAZINONE; 6 (4 METHOXYPHENYL) 4,5 DIHYDRO 3(2H) PYRIDAZINONE; IMAZODAN; LEVOSIMENDAN; TROPONIN C; TROPONIN I;

AMINO TERMINAL SEQUENCE; ARTICLE; CALCIUM SIGNALING; DRUG BINDING SITE; HEART CONTRACTION; HETERONUCLEAR SINGLE QUANTUM COHERENCE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION;

AMINO ACID SUBSTITUTION; BINDING SITES; HEART; HUMANS; HYDRAZONES; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MYOCARDIAL CONTRACTION; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN CONFORMATION; PYRIDAZINES; RECOMBINANT PROTEINS; TROPONIN C; TROPONIN I;

EID: 47249143378     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi800438k     Document Type: Article

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