Curcumin supplementation protects from genotoxic effects of arsenic and fluoride

Food and Chemical Toxicology

Volumn 48, Issue 5, 2010, Pages 1234-1238

  Tiwari, Hemlata ^a   Rao, Mandava V ^a  

^a GUJARAT UNIVERSITY   (India)

Author keywords

Arsenic; Chromosomal aberrations; Comet assay; Curcumin; Fluoride

Indexed keywords

ARSENIC TRIOXIDE; CURCUMIN; DNA; FLUORIDE SODIUM; MESYLIC ACID ETHYL ESTER;

ADULT; ARTICLE; BLOOD CULTURE; CHROMOSOME ABERRATION; COMET ASSAY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DAMAGE; DRUG EFFICACY; EXPOSURE; GENOTOXICITY; HUMAN; HUMAN CELL; IN VITRO STUDY; NORMAL HUMAN; PERIPHERAL LYMPHOCYTE; SUPPLEMENTATION;

ADULT; ANEUPLOIDY; ANTIMUTAGENIC AGENTS; ANTIOXIDANTS; ARSENICALS; CELLS, CULTURED; CHROMOSOME ABERRATIONS; CHROMOSOME BREAKAGE; COMET ASSAY; CURCUMIN; DNA DAMAGE; HUMANS; LYMPHOCYTES; OXIDES; PHYTOHEMAGGLUTININS; SODIUM FLUORIDE; YOUNG ADULT;

EID: 77951620567     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2010.02.015     Document Type: Article

References (36)

1. Aardema M.J., Aibson D.P., Le Boeufm R.A. NaF induced chromosome aberrations, in different stage of the cell cycle: a proposed mechanism. Mutat. Res. 1989, 223:191-203.
2. Abraham S.K., Sarma L., Kesavan P.C. Protective effects of chlorogenic acid, curcumin and β-carotene against γ-radiation-induced in vivo chromosomal damage. Mutat. Res. 1993, 303:109-112.
3. Aggarwal B.B., Sundaram C., Malani N., Ichikawa H. Curcumin: the Indian solid gold. Adv. Exp. Med. Biol. 2007, 595:1-75.
4. Agency for Toxic Substances and Disease Research (ATSDR), 2003. Toxicological Profile for Fluorides, Hydrogen Fluoride and Fluorine. US Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Research. Toxicological Profile for Arsenic (update).
5. Agency for Toxic Substances and Disease Research (ATSDR), Toxicological Profile for Arsenic. US Department of Health and Human Services, Public Health Service. Atlanta, GA.
6. Albanese R. Sodium fluoride and chromosome damage in vitro human lymphocyte and in vivo micronucleus assay. Mutagenesis 1987, 2:497-499.
7. An Y., Gao Z., Wang Z., Yang S., Liang F., Feng Y., Kato K., Nakano M., Okada S., Yamanaka K. Immunohistochemical analysis of oxidative DNA damage in arsenic-related human skin samples from arsenic-contaminated area of China. Cancer Lett. 2004, 214(1):11-18.
8. Avani G., Rao M.V. In vitro genotoxicity assays to evaluate the role of vitamin A on arsenic in human lymphocytes. Ecotoxicol. Environ. Saf. 2009, 72:635-638.
9. Barclay L.R., Vinqvist M.R., Mukai K., Goto H., Hashimoto Y., Tokunaga A., Uno H. On the antioxidant mechanism of curcumin: classical methods are needed to determine antioxidant mechanism and activity. Org. Lett. 2000, 2:2841-2843.
10. Caspary W.J., Myhr B., Bawers C., McGregor D., Riach C., Brown A. Mutagenic activity of fluoride in mouse lymphoma cells. Mutat. Res. 1987, 187:165-180.
11. Das K.C., Das C.K. Curcumin (diferuloylmethane), a singlet oxygen (O-1(2)) quencher. Biochem. Biophys. Res. Commun. 2002, 295(1):62-66.
12. El-Demerdash F.M., Yousef M.I., Radwan F.M. Ameliorating effect of curcumin on sodium arsenite-induced oxidative damage and lipid peroxidation in different rat organs. Food Chem. Toxicol. 2009, 47:249-254.
13. Hayakawa T., Kobayashi Y., Cui X., Hirano S. A new metabolic pathway of arsenite:arsenic-glutathione complexes are substrates for human arsenic methyltransferase Cyt19. Arch. Toxicol. 2005, 79:183-191.
14. He L.F., Chen J.G. DNA damage, apoptosis and cell cycle changes induced in rat oral mucosal cells and hepatocytes. World J. Gastroenterol. 2006, 12(7):1144-1148.
15. Huang S.C., Lee T.C. Arsenite inhibits mitotic division and perturbs spindle dynamics in Hela S3 cells. Carcinogenesis 1998, 19:889-896.
16. Hungerford D.A. Leukocytes cultured from small inocula of whole blood and the preparation of metaphase chromosome by treatment with hypotonic potassium chloride. Stain Technol. 1965, 40:333-338.
17. Iqbal M., Sharma S.D., Okazaki Y., Fujisawa M., Okada S. Dietary supplementation of curcumin enhances antioxidant and phase II metabolizing enzymes in ddY male mice: possible role in protection against chemical carcinogenesis and toxicity. Pharmacol. Toxicol. 2003, 92(1):33-38.
18. Jhala D.D., Chinoy N.J., Rao M.V. Mitigating effects of some antidotes on fluoride and arsenic induced free radical toxicity in mice ovary. Food Chem. Toxicol. 2008, 46(3):1138-1142.
19. Jung J.Y., Park J.H., Jeong Y.J., Yang K.H., Choi N.K., Kim S.H., Kim W.J. Involvement of Bcl-2 family and caspases cascade in sodium. Fluoride-induced apoptosis of human gingival fibroblasts. Korean J. Physiol. Pharmacol. 2006, 10:289-295.
20. Mahata J., Basu A., Ghoshal S., Sarkar J.N., Roy A.K., Poddar G., Nandy A.K., Banerjee A., Ray K., Natarajan A.T., Nilsson R., Giri A.K. Chromosomal aberrations and sister chromatid exchanges in individuals exposed to arsenic through drinking water in West Bengal, India. Mutat. Res. 2003, 534:133-143.
21. Mandal B.K., Ogra Y., Anzai K., Suzuki T.K. Speciation of arsenic in biological samples. Toxicol. Appl. Pharmacol. 2004, 198:307-318.
22. Mittal M., Flora S.J. Vitamin E supplementation protects oxidative stress during arsenic and fluoride antagonism in male mice. Drug Chem. Toxicol. 2007, 30(3):263-281.
23. Motterlini R., Foresti R., Bassi R., Green C.J. Curcumin, an antioxidant and anti-inflammatory agent, induces heme oxygenase-1 and protects endothelial cells against oxidative stress. Free Radic. Biol. Med. 2000, 28:1303-1312.
24. Nagabhushan M., Bhide S.V. Curcumin as an inhibitor of cancer. J. Am. Coll. Nutr. 1992, 11:192-198.
25. Niture S.K., Velu C.S., Smith Q.R., Bhat G.J., Srivenugopal K.S. Increased expression of the MGMT repair protein mediated by cysteine prodrugs and chemopreventative natural products in human lymphocytes and tumor cell lines. Carcinogenesis 2007, 28:378-389.
26. Onoda M., Inano H. Effect of curcumin on the production of nitric oxide by cultured rat mammary gland. Nitric Oxide 2000, 4:505-515.
27. 3. Cancer Res. 2007, 67:5239-5247.
28. Rajeswari A. Curcumin protects mouse brain from oxidative stress caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Eur. Rev. Med. Pharmacol. Sci. 2006, 10:157-161.
29. Rao M.V., Tiwari H. Amelioration by melatonin of chromosomal anomalies induced by arsenic and/or fluoride in human blood lymphocyte cultures. Fluoride 2006, 39(4):255-260.
30. Reddy A.C.P., Lokesh B.R. Studies on spice principles as antioxidants in the inhibition of lipid peroxidation of rat liver microsomes. Mol. Cell. Biochem. 1992, 111:117-124.
31. Rudel R., Slayton T.M., Beck B.D. Implications of arsenic genotoxicity for dose response of carcinogenic effects. Regul. Toxicol. Pharmacol. 1996, 23(2):87-105.
32. Sordo M., Herrera L.A., Ostrosky-Wegman P., Rojas E. Cytotoxic and genotoxic effects of As, MMA, and DMA on leukocytes and stimulated human lymphocytes. Teratog. Carcinog. Mutagen. 2001, 21:249-260.
33. Sreejayan N., Rao M.N. Curcuminoids as potent inhibitors of lipid peroxidation. J. Pharm. Pharmacol. 1994, 46:1013-1016.
34. Stassen C., Maes A.M., Krinch-Volders M., Sussane C. Is there a predisposition for meiotic non-disjunction that may be detected by mitotic hyperploidy?. Clin. Genet. 1953, 24:184-190.
35. Tice R.R., Yager J.W., Andrews P., Crecelius E. Effect of hepatic methyl donor status on urinary excretion and DNA damage in B6C3F1 mice treated with sodium arsenite. Mutat. Res. 1997, 386:315-334.
36. Zhang M., Wang A., Xia T., He P. Effects of fluoride on DNA damage, S-phase cell-cycle arrest and the expression of NF-kappaB in primary cultured rat hippocampal neurons. Toxicol. Lett. 2008, 179:1-5.