In vitro genotoxicity assays to evaluate the role of vitamin A on arsenic in human lymphocytes

Ecotoxicology and Environmental Safety

Volumn 72, Issue 2, 2009, Pages 635-638

  Avani, G ^a   Rao, M V ^a  

^a GUJARAT UNIVERSITY   (India)

Author keywords

Aberrations; Aneuploidy; Arsenic; Micronuclei; Vitamin A

Indexed keywords

ARSENIC; MITOMYCIN C; MUTAGENIC AGENT; RETINOL;

ANTIOXIDANT; ARSENIC; BIOASSAY; CHROMOSOME; CONCENTRATION (COMPOSITION); CYTOLOGY; DRINKING WATER; GENOTOXICITY; GROUNDWATER POLLUTION; VITAMIN;

ARTICLE; BLOOD CULTURE; CELL PROTECTION; CHROMOSOME ABERRATION; GENOTOXICITY; HUMAN; HUMAN CELL; LYMPHOCYTE; LYMPHOCYTE CULTURE; MICRONUCLEUS;

ANTIOXIDANTS; ARSENIC; ARSENIC POISONING; CELLS, CULTURED; CHROMOSOME ABERRATIONS; HUMANS; LYMPHOCYTES; MUTAGENICITY TESTS; TIME FACTORS; VITAMIN A; WATER POLLUTANTS, CHEMICAL;

EID: 54949120187     PISSN: 01476513     EISSN: 10902414     Source Type: Journal    
DOI: 10.1016/j.ecoenv.2008.03.011     Document Type: Article

References (32)

1. AlDosari A., McDonald J., Olson B., Noblitt T., Li Y., and Stookey G. Influence of benzylisothiocyanate and 13-cis-reinoic acid on micronucleus in bone marrow cells of rats. Mutat. Res. 19 (1996) 231-236
2. ATSDR (Agency for Toxic Substances and Disease Registry), 2007. Department of Health and Human Services, Toxicological profile for arsenic (CAS#: 7440-38-2).
3. Avani G., and Rao M.V. Genotoxic effects in human lymphocytes exposed to arsenic and vitamin A. Toxicol. In Vitro 21 (2007) 626-631
4. Avani G., and Rao M.V. In vitro cytogenetic effects of Andrographis paniculata (kalmegh) on arsenic. Phytomedicine 15 (2008) 221-225
5. Badr F.M., El-Habit O.H.M., Hamdy M., and Hassan G.A.R. The mutagenic versus protective role of vitamin A on the induction of chromosomal aberrations in human lymphocyte cultures. Mutat. Res. 414 (1998) 157-163
6. Basu A., Ghosh P., Das J.K., Banerjee A., Ray K., and Giri A.K. Micronuclei as biomarkers of carcinogen exposure in populations exposed to arsenic through drinking water in West Bengal, India: a comparative study in three cell types. Cancer Epidemiol. Biomarkers Prevent. 13 (2004) 820-827
7. Chen C.Y., Huang Y.L., and Lin T.H. Effect of vitamin A pretreatment of nickel induced lipid peroxidation and concentration of essential metals in liver, kidney and lung of mice. Arch. Toxicol. 72 (1998) 381-386
8. De Flora S., Bagnasco M., and Vainio H. Modulation of genotoxic and related effects by carotenoids and vitamin A in experimental models: mechanistic issues. Mutagenesis 14 (1999) 153-172
9. Fan S.R., Ho I.C., Yeoh F.L., Lin C.J., and Lee T.-C. Squalene inhibits sodium-arsenite induced sister chromatid exchanges and micronuclei in Chinese hamster ovary- K1 cells. Mutat. Res. 368 (1996) 165-169
10. Florea A.-M., Yamoah E.N., and Dopp E. Intracellular calcium disturbances induced by arsenic and its methylated derivatives in relation to genomic damage and apoptosis induction. Environ. Health Perspect. 113 (2005) 659-664
11. Ford J.H., Schultz C.J., and Corell A.T. Chromosome elimination in micronucleus: a common cause of hypoploidy. Am. J. Hum. Genet. 43 (1988) 733-740
12. Gebel T.W. Review: genotoxicity of arsenical compounds. Int. J. Hyg. Environ. Health 203 (2001) 249-262
13. Gonsebatt M.E., Vega L., and Salaza A.M. Cytogenetic effects in human exposure to arsenic. Mutat. Res. 386 (1997) 219-228
14. Grosse Y., Chekir-Ghedhira L., Huc A., Obrecnt-Pfluminos S., Drhemer G., Bacha H., and pfonl-Leszkoucas. Retinol, ascorbic acid and α-tocopherol prevent DNA adduct formation in mice treated with mycotoxin ochrotoxin A and zearalenone. Cancer Lett. 114 (1997) 225-229
15. Gülkaç G., Akpinar G., Üstün H., Kanli A., and Özön. Effects of vitamin A on doxorubicin-induced chromosomal aberrations in bone marrow cells of rats. Mutat. Res. 19 (2004) 231-236
16. Hei T.K., and Filipic M. Role of oxidative damage in the genotoxicity of arsenic. Free Radical Biol. Med. 37 (2004) 574-581
17. Hei, T. K., Liu, S. X., Waldren, C., 1998. Mutagenicity of arsenite in mammalian cells: role of reactive oxygen species. Proc. Natl. Acad. Sci. USA 95, 8103-8107.
18. Ho I.H., Yih L.H., Kao C.Y., and Lee T.-C. Tin protoporphyrin potentiates arsenite-induced DNA strand breaks and kinetochore-negative micronuclei in human fibroblasts. Mutat. Res. 452 (2000) 41-50
19. Hsu Y.H., Li S.Y., Chiou H.Y., Yeh P.M., Liou J.C., Hseuh Y.M., Chang S.H., and Chen C.J. Spontaneous and induced sister chromatid exchanges and delayed cell proliferation in peripheral lymphocytes of Bowen's disease patients and matched controls of arseniasis-hyperendemic villages in Taiwan. Mutat. Res. 386 (1997) 241-257
20. Jha A.N., Noditi M., Nilsson R., and Natarajan A.T. Genotoxic effects of sodium arsenite on human cells. Mutat. Res. 16 (1992) 215-221
21. Kessel M., Liu S.X., Xu A., Santella R., and Hei T.K. Arsenic induces oxidative DNA damage in mammalian cells. Mol. Cell. Biochem. 234/235 (2002) 301-308
22. Liu S.X., Athar M., Lippai I., Waldren C., and Hei T.K. Induction of oxyradicals by arsenic: implication for mechanism of genotoxicity. Proc. Natl. Acad. Sci. USA 98 (2001) 1643-1648
23. Mahata J., Basu A., Ghoshal S., Sarkar J.N., Roy A.K., Poddar G., Nandy A.K., Banerjee A., Ray A., Natarajan A.T., Nilsson R., and Giri A.K. Chromosomal aberrations and sister chromatid exchanges in individuals exposed to arsenic through drinking water in West Bengal, India. Mutat. Res. 534 (2003) 133-143
24. McCabe Jr. M.J., Singh P., Reddy R.A., Chellandurai B., Pounds J.G., Reiners Jr. J.J., and States J.C. Sensitivity of myelomonocytic leukemia cells to arsenite-induce cell cycle disruption, apoptosis and enhanced differentiation is dependent on the interrelationship between arsenic concentration, duration of treatment and cell cycle phase. J. Pharmacol. Exp. Ther. 269 (2000) 724-733
25. Nair S.B., Jhala D.D., and Chinoy N.J. Mitigation of genotoxic effects of fluoride and arsenic by ascorbic acid in human lymphocyte cultures. Fluoride 37 (2004) 249-256
26. Rao M.V., and Avani G. Arsenic induced free radical toxicity in brain of mice. Ind. J. Exp. Biol. 42 (2004) 495-498
27. Rao M.V., and Tiwari H. Amelioration by melatonin of chromosomal anomalies induced by arsenic and/or fluoride in human blood lymphocyte cultures. Fluoride 39 (2006) 255-260
28. Rencuzogullari E., Tuylu B.A., Topaktas M., Ila H.B., Kayraldiz A., Arslan M., and Diler S.B. Genotoxicity of aspartame in human lymphocytes. Drug Chem. Toxicol. 27 (2004) 257-268
29. Robichová S., Salmeňová D., Chalupa I., and Šebová L. DNA lesions and cytogenetic changes induced by N-nitrosomorpholine in HepG2, V79 and VH10 cells: the protective effects of vitamins A, C and E. Mutat. Res. 560 (2004) 91-99
30. Schwerdtle T., Walter I., Mackiw I., and Hartwig A. Induction of oxidative DNA damage by arsenite and its trivalent and pentavalent methylated metabolites in cultured human cells and isolated DNA. Carcinogenesis 24 (2003) 967-974
31. Staessen C., Maes A.M., Kirch-Volders M., and Susanne C. Is there a prediposition for meiotic nondisjunction that may be detected by mitotic instability?. Clin. Genet. 24 (1983) 184-190
32. Yih L.-H., and Lee T.-C. Effects of exposure protocols on induction of kinetochore-plus micronuclei by arsenite in diploid human fibroblasts. Mutat. Res. 440 (1999) 75-82