Transforming growth factor-β activated kinase 1 signaling pathways regulate TNF-α production by titanium alloy particles in RAW 264.7 cells

Journal of Biomedical Materials Research - Part A

Volumn 93, Issue 4, 2010, Pages 1493-1499

  Cheng, Tao ^a   Peng, Xiao Chun ^a   Li, Feng Feng ^a   Zhang, Xian Long ^a   Hu, Kong Zu ^a   Zhu, Jun Feng ^a   Zeng, Bing Fang ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

Cytokine; Inflammation; Macrophage; Signaling pathway; TAK1

Indexed keywords

ARTHROPLASTIES; CYTOKINE; CYTOKINES; INFLAMMATORY RESPONSE; INTERLEUKIN-1; MITOGEN ACTIVATED PROTEIN KINASE; NUCLEAR FACTORS; RECEPTOR ACTIVATOR; SELECTIVE INHIBITORS; SIGNALING CASCADES; SIGNALING PATHWAYS; TRANSFORMING GROWTH FACTORS; TUMOR NECROSIS FACTORS;

ALLOYS; BIOACTIVITY; CHEMICAL ACTIVATION; ENZYME ACTIVITY; MACROPHAGES; PATHOLOGY; PEPTIDES; PHOSPHORYLATION; PIGMENTS; TITANIUM; TITANIUM ALLOYS;

SIGNALING;

5Z 7 OXOZEAENOL; ENZYME INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE P38; TITANIUM; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FOREIGN BODY REACTION; MOUSE; NONHUMAN; PROSTHESIS FAILURE; PROTEIN TARGETING; SIGNAL TRANSDUCTION;

ALLOYS; ANIMALS; ARTHROPLASTY; CELL LINE; INFLAMMATION; LIPOPOLYSACCHARIDES; MACROPHAGES; MAP KINASE KINASE KINASES; MAP KINASE SIGNALING SYSTEM; MICE; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TITANIUM; TUMOR NECROSIS FACTOR-ALPHA; ZEARALENONE;

EID: 77951583546     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.32618     Document Type: Article

References (47)

1. Goodman SB. Wear particles, periprosthetic osteolysis and the immune system. Biomaterials 2007;28:5044-5048.
2. Purdue PE, Koulouvaris P, Potter HG, Nestor BJ, Sculco TP. The cellular and molecular biology of periprosthetic osteolysis. Clin Orthop Relat Res 2007;454:251-261. (Pubitemid 46074927)
3. Tunyogi-Csapo M, Koreny T, Vermes C, Galante JO, Jacobs JJ, Glant TT. Role of fibroblasts and fibroblast-derived growth factors in periprosthetic angiogenesis. J Orthop Res 2007;25:1378-1388. (Pubitemid 47523368)
4. Abu-Amer Y, Darwech I, Clohisy JC. Aseptic loosening of total joint replacements: Mechanisms underlying osteolysis and potential therapies. Arthritis Res Ther 2007;9(Suppl 1):S6. (Pubitemid 351803970)
5. Li Y, Schutte RJ, Abu-Shakra A, Reichert WM. Protein array method for assessing in vitro biomaterial-induced cytokine expression. Biomaterials 2005;26:1081-1085. (Pubitemid 39286818)
6. Wooley PH, Morren R, Andary J, Sud S, Yang SY, Mayton L, Markel D, Sieving A, Nasser S. Inflammatory responses to orthopaedic biomaterials in the murine air pouch. Biomaterials 2002;23:517-526. (Pubitemid 33051040)
7. Bylski D, Wedemeyer C, Xu J, Sterner T, Löer F, von Knoch M. Alumina ceramic particles, in comparison with titanium particles, hardly affect the expression of RANK. TNF-alpha, and OPG-mRNA in the THP-1 human monocytic cell line. J Biomed Mater Res A 2009;89:707-716.
8. Kaufman AM, Alabre CI, Rubash HE, Shanbhag AS. Human macrophage response to UHMWPE. TiAlV, CoCr, and alumina particles: Analysis of multiple cytokines using protein arrays. J Biomed Mater Res A 2008;84:464-474.
9. Peng X, Tao K, Cheng T, Zhu J, Zhang X. Efficient Inhibition of wear debris-induced inflammation by locally delivered siRNA. Biochem Biophys Res Commun 2008;377:532-537.
10. Childs LM, Goater JJ, O'Keefe RJ, Schwarz EM. Effect of anti-tumor necrosis factor-alpha gene therapy on wear debris-induced osteolysis. J Bone Joint Surg Am 2001;83:1789-1797.
11. Dong L, Wang R, Zhu YA, Wang C, Diao H, Zhang C, Zhao J, Zhang J. Antisense oligonucleotide targeting TNF-alpha can suppress co-cr-mo particle-induced osteolysis. J Orthop Res 2008;26:1114-1120.
12. Goodman SB, Trindade M, Ma T, Genovese M, Smith RL. Pharmacologic modulation of periprosthetic osteolysis. Clin Orthop Relat Res 2005;430:39-45.
13. Abbas S, Clohisy JC, Abu-Amer Y. Mitogen-activated protein (MAP) kinases mediate PMMA-induction of osteoclasts. J Orthop Res 2003;21:1041-1048. (Pubitemid 37322386)
14. Baumann B, Seufert J, Jakob F, Nöth U, Rolf O, Eulert J, Rader CP. Activation of NF-kappaB signalling and TNFalpha-expression in THP-1 macrophages by TiAlV- and polyethylene-wear particles. J Orthop Res 2005;23:1241-1248. (Pubitemid 41554653)
15. Beidelschies MA, Huang H, McMullen MR, Smith MV, Islam AS, Goldberg VM, Chen X, Nagy LE, Greenfield EM. Stimulation of macrophage TNFalpha production by orthopaedic wear particles requires activation of the ERK1/2/Egr-1 and NF-kappaB pathways but is independent of p38 and JNK. J Cell Physiol 2008;217:652-666.
16. Clohisy JC, Yamanaka Y, Faccio R, Abu-Amer Y. Inhibition of IKK activation, through sequestering NEMO, blocks PMMA-induced osteoclastogenesis and calvarial inflammatory osteolysis. J Orthop Res 2006;24:1358-1365. (Pubitemid 44083251)
17. Clohisy JC, Hirayama T, Frazier E, Han SK, Abu-Amer Y. NF-kB signaling blockade abolishes implant particle-induced osteoclastogenesis. J Orthop Res 2004;22:13-20. (Pubitemid 38035440)
18. Smith MV, Lee MJ, Islam AS, Rohrer JL, Goldberg VM, Beidelschies MA, Greenfield EM. Inhibition of the PI3K-Akt signaling pathway reduces tumor necrosis factor-alpha production in response to titanium particles in vitro. J Bone Joint Surg Am 2007;89:1019-1027.
19. Yamanaka Y, Abu-Amer Y, Faccio R, Clohisy JC. Map kinase c-JUN N-terminal kinase mediates PMMA induction of osteoclasts. J Orthop Res 2006;24:1349-1357. (Pubitemid 44083250)
20. Minematsu H, Shin MJ, Celil Aydemir AB, Seo SW, Kim DW, Blaine TA, Macián F, Yang J, Lee FY. Orthopedic implant particle-induced tumor necrosis factor-alpha production in macrophage-monocyte lineage cells is mediated by nuclear factor of activated T cells. Ann N Y Acad Sci 2007;1117:143-150. (Pubitemid 350191271)
21. Rakshit DS, Ly K, Sengupta TK, Nestor BJ, Sculco TP, Ivashkiv LB, Purdue PE. Wear debris inhibition of anti-osteoclastogenic signaling by interleukin-6 and interferon-gamma. Mechanistic insights and implications for periprosthetic osteolysis. J Bone Joint Surg Am 2006;88:788-799.
22. Akisue T, Bauer TW, Farver CF, Mochida Y. The effect of particle wear debris on NFkappaB activation and pro-inflammatory cytokine release in differentiated THP-1 cells. J Biomed Mater Res 2002;59:507-515. (Pubitemid 34037495)
23. Huang H, Ryu J, Ha J, Chang EJ, Kim HJ, Kim HM, Kitamura T, Lee ZH, Kim HH. Osteoclast differentiation requires TAK1 and MKK6 for NFATc1 induction and NF-kappaB transactivation by RANKL. Cell Death Differ 2006;13:1879-1891. (Pubitemid 44542401)
24. Mizukami J, Takaesu G, Akatsuka H, Sakurai H, Ninomiya-Tsuji J, Matsumoto K, Sakurai N. Receptor activator of NF-kappaB ligand (RANKL) activates TAK1 mitogen-activated protein kinase through a signaling complex containing RANK. TAB2 and TRAF6. Mol Cell Biol 2002;22:992-1000. (Pubitemid 34094837)
25. Besse A, Lamothe B, Campos AD, Webster WK, Maddineni U, Lin SC, Wu H, Darnay BG. TAK1-dependent signaling requires functional interaction with TAB2/TAB3. J Biol Chem 2007;282:3918-3928. (Pubitemid 47084482)
26. Cheung PC, Nebreda AR. Cohen P TAB3, a new binding partner of the protein kinase TAK1. Biochem J 2004;378(Part 1): 27-34. (Pubitemid 38299541)
27. Irie T, Muta T, Takeshige K. TAK1 mediates an activation signal from toll-like receptor to nuclear factor-kappaB in lipopolysaccharide-stimulated macrophages. FEBS Lett 2000;467:160-164. (Pubitemid 30081726)
28. Kanayama A, Seth RB, Sun L, Ea CK, Hong M, Shaito A, Chiu YH, Deng L, Chen ZJ. TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains. Mol Cell 2004;15:535-548. (Pubitemid 39141781)
29. Ninomiya-Tsuji J, Kishimoto K, Hiyama A, Inoue J, Cao Z, Matsumoto K. The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway. Nature 1999;398:252-256. (Pubitemid 29142861)
30. Holt G, Murnaghan C, Reilly J, Meek RM. The biology of aseptic osteolysis. Clin Orthop Relat Res 2007;460:240-252.
31. Ingham E, Fisher J. The role of macrophages in osteolysis of total joint replacement. Biomaterials 2005;26:1271-1286. (Pubitemid 39314501)
32. Smith MV, Lee MJ, Islam AS, Rohrer JL, Goldberg VM, Beidelschies MA, Greenfield EM. Effect of etidronate on COX-2 expression and PGE (2) production in macrophage-like RAW 264.7 cells stimulated by titanium particles. J Orthop Sci 2007;12:568-577.
33. Ren W, Yang SY, Fang HW, Hsu S, Wooley PH. Distinct gene expression of receptor activator of nuclear factor-kappaB and rank ligand in the inflammatory response to variant morphologies of UHMWPE particles. Biomaterials 2003;24:4819-14626 (Pubitemid 37188661)
34. Childs LM, Goater JJ, O'Keefe RJ, Schwartz EM. Efficacy of etanercept for wear debris-induced osteolysis. J Bone Miner Res 2001;16:338-347.
35. Ninomiya-Tsuji J, Kajino T, Ono K, Ohtomo T, Matsumoto M, Shiina M, Mihara M, Tsuchiya M, Matsumoto K. A resorcylic acid lactone, 5Z-7-oxozeaenol, prevents inflammation by inhibiting the catalytic activity of TAK1 MAPK kinase. J Biol Chem 2003;278:18485-18490. (Pubitemid 36799472)
36. Choo MK, Kawasaki N, Singhirunnusorn P, Koizumi K, Sato S, Akira S, Saiki I, Sakurai H. Blockade of transforming growth factor-beta-activated kinase 1 activity enhances TRAIL-induced apoptosis through activation of a caspase cascade. Mol Cancer Ther 2006;5:2970-2976. (Pubitemid 46092038)
37. Carmody EE, Schwarz EM, Puzas JE, Rosier RN, O'Keefe RJ. Viral interleukin-10 gene inhibition of inflammation, osteoclastogenesis, and bone resorption in response to titanium particles. Arthritis Rheum 2002;46:1298-1308.
38. Yang SY, Wu B, Mayton L, Mukherjee P, Robbins PD, Evans CH. Protective effects of IL-1Ra or vIL-10 gene transfer on a murine model of wear debris-induced osteolysis. Gene Ther 2004;11:483-491. (Pubitemid 38313169)
39. Ren W, Yang SY, Fang HW, Hsu S, Wooley PH. Implant wear induces inflammation, but not osteoclastic bone resorption, in RANK(-/-) mice. J Orthop Res 2006;24:1575-1586. (Pubitemid 44203289)
40. von Knoch F, Eckhardt C, Alabre CI, Schneider E, Rubash HE, Shanbhag AS. Anabolic effects of bisphosphonates on peri-implant bone stock. Biomaterials 2007;28:3549-3559. (Pubitemid 46817651)
41. von Knoch F, Heckelei A, Wedemeyer C, Saxler G, Hilken G, Brankamp J, Sterner T, Landgraeber S, Henschke F, Löer F, von Knoch M. Suppression of polyethylene particle-induced osteolysis by exogenous osteoprotegerin. J Biomed Mater Res A 2005;75:288-294. (Pubitemid 41463897)
42. Cheng T, Zhang X. NFkappaB gene silencing inhibits wear particles-induced inflammatory osteolysis. Med Hypotheses 2008;71:727-729.
43. Cheung PC, Campbell DG, Nebreda AR, Cohen P. Feedback control of the protein kinase TAK1 by SAPK2a/p38alpha. EMBO J 2003;22:5793-5805. (Pubitemid 37408818)
44. Hoffmann E, Dittrich-Breiholz O, Holtmann H, Kracht M. Multiple control of interleukin-8 gene expression. J Leukoc Biol 2002;72:847-855. (Pubitemid 35365158)
45. Ma T, Ren PG, Larsen DM, Suenaga E, Zilber S, Genovese M, Smith RL, Goodman SB. Efficacy of a p38 mitogen activated protein kinase inhibitor in mitigating an established inflammatory reaction to polyethylene particles in vivo. J Biomed Mater Res A 2008;89:117-123.
46. Goodman SB, Ma T, Spanogle J, Chiu R, Miyanishi K, Oh K, Plouhar P, Wadsworth S, Smith RL. Effects of a p38 MAP kinase inhibitor on bone ingrowth and tissue differentiation in rabbit chambers. J Biomed Mater Res A 2007;81:310-316. (Pubitemid 46668844)
47. Klatt AR, Klinger G, Neumüller O, Eidenmüller B, Wagner I, Achenbach T, Aigner T, Bartnik E. TAK1 downregulation reduces IL-1beta induced expression of MMP13. MMP1 and TNF-alpha. Biomed Pharmacother 2006;60:55-61.