Effects of a p38 MAP kinase inhibitor on bone ingrowth and tissue differentiation in rabbit chambers

Journal of Biomedical Materials Research - Part A

Volumn 81, Issue 2, 2007, Pages 310-316

  Goodman, S B ^a   Ma, T ^a   Spanogle, J ^a   Chiu, R ^a   Miyanishi, K ^a   Oh, K ^b   Plouhar, P ^c   Wadsworth, S ^d   Smith, R L ^a  

^a STANFORD UNIVERSITY   (United States)

^b Konkuk University Hospital   (South Korea)

^c Johnson Johnson Company   (United States)

^d J and J Pharmaceutical Research and Development   (United States)

Author keywords

Animal model; Bone ingrowth; Joint replacement; p 38 MAPK inhibitor; Polyethylene particles

Indexed keywords

ANIMALS; BIOMARKERS; BONE; OSTEOBLASTS; PHYSIOLOGICAL MODELS; POLYETHYLENES;

ANIMAL MODEL; ANTI-INFLAMMATORY DRUGS; BONE INGROWTH; JOINT REPLACEMENT; P-38 MAPK INHIBITOR;

ENZYME INHIBITION;

ALKALINE PHOSPHATASE; CD51 ANTIGEN; HYALURONIC ACID; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; NONSTEROID ANTIINFLAMMATORY AGENT; POLYETHYLENE; VITRONECTIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE GROWTH; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG EFFICACY; FOREIGN BODY REACTION; INFLAMMATION; MORPHOMETRICS; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOCLAST; RABBIT; SINGLE DRUG DOSE; TISSUE DIFFERENTIATION;

ADMINISTRATION, ORAL; ANIMALS; BIOCOMPATIBLE MATERIALS; DIFFUSION CHAMBERS, CULTURE; JOINT PROSTHESIS; MALE; MATERIALS TESTING; OSSEOINTEGRATION; OSTEOLYSIS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; POLYETHYLENES; PROSTHESIS FAILURE; PROTEIN KINASE INHIBITORS; RABBITS; TIBIA; TISSUE ENGINEERING;

EID: 34247575283     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.30983     Document Type: Article

References (30)

1. Wright T, Goodman SB, editor. Implant Wear in Total Joint Replacement. Rosemont, IL: American Academy of Orthopaedic Surgeons; 2001.
2. Childs LM, Goater JJ, O'Keefe RJ, Schwarz EM. Effect of antitumor necrosis factor-α gene therapy on wear debris-induced osteolysis. J Bone Joint Surg Am 2001;83:1789-1797.
3. Childs LM, Goater JJ, O'Keefe RJ, Schwarz EM. Efficacy of etanercept for wear debris-induced osteolysis. J Bone Miner Res 2001;16:338-347.
4. Childs LM, Paschalis EP, Xing L, Dougall WC, Anderson D, Boskey AL, Puzas JE, Rosier RN, O'Keefe RJ, Boyce BF, Schwarz EM. In vivo RANK signaling blockade using the receptor activator of NF-κB: Fc effectively prevents and ameliorates wear debris-induced osteolysis via osteoclast depletion without inhibiting osteogenesis. J Bone Miner Res 2002;17:192-199.
5. Millet PJ, Allen MJ, Bostrom MP. Effects of alendronate on particle-induced osteolysis in a rat model. J Bone Joint Surg Am 2002;84:236-249.
6. Pandey R, Quinn JM, Sabokbar A, Athanasou NA. Bisphosphonate inhibition of bone resorption induced by particulate biomaterial-associated macrophages. Acta Orthop Scand 1996;67:221-228.
7. Papatheofanis FJ, Barmada R. Misoprostol inhibits polymethylmethacrylate- stimulated lysosomal degranulation and IL-1 release from neutrophils. Am J Ther 1996;3:21-36.
8. Pollice PF, Hsu J, Hicks DG, Bukata S, Rosier RN, Reynolds PR, Puzas JE, O'Keefe RJ. Interleukin-10 inhibits cytokine synthesis in monocytes stimulated by titanium particles: Evidence of an anti-inflammatory regulatory pathway. J Orthop Res 1998;16:697-704.
9. Pollice PF, Rosier RN, Looney RJ, Puzas JE, Schwarz EM, O'Keefe RJ. Oral pentoxyfylline inhibits the release of tumor necrosis-α from human peripheral blood moncytes: A potential treatment for aseptic loosening of total joint components. J Bone Joint Surg Am 2001;83:1057-1061.
10. Shanbhag AS, Hasselman CT, Rubash HE. The John Charnley Award. Inhibition of wear debris mediated osteolysis in a canine total hip arthroplasty model. Clin Orthop Relat Res 1997;344:33-43.
11. Schwarz EM, Looney RJ, O'Keefe RJ. Anti-TNF-α therapy as a clinical intervention for periprosthetic osteolysis. Arthritis Res 2000;2:165-168.
12. Thadani PJ, Waxman B, Sladek E, Barmada R, Gonzalez MH. Inhibition of particulate debris-induced osteolysis by alendronate in a rat model. Orthopedics 2002;25:59-63.
13. Ren W, Li XH, Chen BD, Wooley PH. Erythromycin inhibits wear debris-induced osteoclastogenesis by modulation of murine macrophage NF-κB activity. J Orthop Res 2004;22:21-29.
14. Goodman S, Song Y, Chun L, Aspenberg P, Regula D. Effects of TGFβ on bone ingrowth in the presence of polyethylene particles. J Bone Joint Surg Br 1999;81:1069-1075.
15. Goodman SB, Song Y, Yoo JY, Fox N, Trindade MCD, Kajiyama G, Ma T, Regula D, Brown J, Smith RL. Local infusion of FGF-2 enhances bone ingrowth in rabbit chambers in the presence of polyethylene particles. J Biomed Mater Res A 2003;65:454-461.
16. Goodman SB, Trindade M, Ma T, Lee M, Fox N, Regula D, Genovese M, Klein J, Bloch D, Smith RL. Modulation of bone ingrowth by local infusion of IL-10 in the presence of UHMWPE wear particles. J Biomed Mater Res A 2003;65:43-50.
17. Trindade MCD, Lind M, Nakashima Y, Sun D, Goodman SB, Schurman DJ, Smith RL. Interleukin-10 inhibits polymethylmethacrylate particle-induced interleukin-6 and tumor necrosis factor-α release by human monocyte/macrophages in vitro. Biomaterials 2001;15:2067-2073.
18. Trindade MCD, Nakashima Y, Lind M, Sun DH, Goodman SB, Maloney WJ, Schurman DJ, Smith RL. Interleukin-4 inhibits granulocyte macrophage colony stimulating factor expression by human monocytes in response to PMMA particle challenge in vitro. J Orthop Res 1999;17:797-802.
19. Vermes C, Chandrasekaran R, Dobai JG, Jacobs JJ, Andersson GB, An H, Hallab NJ, Galante JO, Glant TT. The combination of pamidronate and calcitriol reverses particle- and TNF-α-induced altered functions of bone-marrow-derived stromal cells with osteoblastic phenotype. J Bone Joint Surg Br 2004;86:759-770.
20. Archibeck MJ, Jacobs JJ, Roebuck KA, Glant TT. The basic science of periprosthetic osteolysis. Instr Course Lect 2001;50:185-195.
21. Lee JC, Laydon JT, McDonnell PC, Gallagher TF, Kumar S, Green D, McNulty D, Blumenthal MJ, Heys JR, Landvatter SW. A protein kinase involved in the regulation of inflammatory cytokine synthesis. Nature 1994;372:739-746.
22. Henry JR, Cavender DE, Wadsworth SA. p38 Mitogen-activated protein kinase as a target for drug discovery. Drugs Future 1999;24:1345-1354.
23. Li X, Udagawa N, Takami M, Sato N, Kobayashi Y, Takahashi N. p38 mitogen-actiated protein kinase is crucially involved in osteoclast differentiation but not cytokine production, phagocytosis, or dendritic cell differentiation of bone marrow macrophages. Endocrinology 2003;144:4999-5005.
24. Goodman SB. The effects of micromotion and particlulate materials on tissue differentiation. Bone chamber studies in rabbits. Acta Orthop Scand Suppl. 1994;258:65.
25. Campbell P, Ma S, Yeom B, McKellop H, Schmalzried TP, Amstutz HC. Isolation of predominantly submicron-sized UHMWPE wear particles from periprosthetic tissues. J Biomed Mater Res 1995;29:127-131.
26. Goodman SB, Aspenberg P, Song, Y, Knoblich G, Huie P, Regula D, Lidgren L. Tissue ingrowth and differentiation in the bone-harvest chamber in the presence of cobalt-chromium-alloy and high-density-polyethylene particles. J Bone Joint Surg Am 1995;77:1025-1035.
27. Hu Y, Chan E, Wang SX, Li B. Activation of p38 mitogen-activated protein kinase is required for osteoblast differentiation. Endocrinology 2003;144:2068-2074.
28. Suzuki A, Guicheux J, Palmer G, Miura Y, Oiso Y, Bonjour JP, Caverzasio J. Evidence for a role of p38 MAP kinase in expression of alkaline phosphatase during osteoblastic cell differentiation. Bone 2002;30:91-98.
29. Goodman SB, Ma T, Trindade M, Ikenoue T, Matsuura I, Wong N, Fox N, Genovese M, Regula D, Smith RL. COX-2 selective NSAID decreases bone ingrowth in vivo. J Orthop Res 2002;20:1164-1169.
30. Ma T, Miyanishi K, Trindade MCD, Genovese M, Regula D, Smith RL, Goodman SB. Interleukin-1 receptor antagonist inhibits localized bone formation in vivo. J Rheumatol 2003;30:2547-2552.