A novel function for selenium in biological system: Selenite as a highly effective iron carrier for Chinese hamster ovary cell growth and monoclonal antibody production

Biotechnology and Bioengineering

Volumn 95, Issue 6, 2006, Pages 1188-1197

  Zhang, Jinyou ^a   Robinson, David ^a   Salmon, Peter ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Animal protein free medium; Antibody production; Cell culture; Cell growth; CHO; Ferric citrate; Iron; Iron carrier; Monoclonal antibody; Selenite; Selenium; Transferrin; Tropolone

Indexed keywords

BIOREACTORS; CELL CULTURE; CELLS; IRON; MONOCLONAL ANTIBODIES; PROTEINS; SELENIUM; SUBSTRATES;

ANIMAL PROTEIN-FREE MEDIUM; CELL GROWTH; CHO; FERRIC CITRATE; IRON CARRIER; SELENITE; TRANSFERRIN; TROPOLONE;

GROWTH KINETICS;

CHELATING AGENT; FREE RADICAL; GLUTATHIONE PEROXIDASE; IRON; MONOCLONAL ANTIBODY; SELENITE; SELENIUM; TRANSFERRIN; TROPOLONE;

ANIMAL CELL; ANTIBODY PRODUCTION; ARTICLE; BIOREACTOR; CELL CULTURE; CELL GROWTH; CELL MATURATION; CELL METABOLISM; CELL RESPIRATION; CHO CELL; CONTROLLED STUDY; DETOXIFICATION; ENZYME ACTIVATION; IRON TRANSPORT; NONHUMAN; REACTION TIME;

ANIMALS; ANTIBODIES, MONOCLONAL; BIOREACTORS; BIOTECHNOLOGY; CELL CULTURE TECHNIQUES; CHO CELLS; CRICETINAE; FERRIC COMPOUNDS; GLUTAMINE; IRON; PROTEINS; SELENIUM; SODIUM SELENITE; TRANSFERRIN; TROPOLONE;

ANIMALIA; CRICETULUS GRISEUS; MAMMALIA;

EID: 33845442172     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.21081     Document Type: Article

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