Pharmacogenomics-10 years of progress: A cardiovascular perspective

Pharmacogenomics

Volumn 11, Issue 5, 2010, Pages 613-616

  Winkelmann, Bernhard R ^a   Herrington, David ^b  

^a GOETHE UNIVERSITY   (Germany)

^b WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Cardiology; Emerging diagnostics; Genome wide association study; New therapy; Personalized medicine; SNP

Indexed keywords

CLOPIDOGREL; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; EPIDERMAL GROWTH FACTOR RECEPTOR 2; PRASUGREL;

BLOOD CLOT LYSIS; BLOOD CLOTTING; CARDIOLOGY; CAUCASIAN; CORONARY ARTERY DISEASE; ENZYME METABOLISM; GENE DUPLICATION; GENE EXPRESSION; GENE LOCUS; GENE MAPPING; GENE MUTATION; GENE SEQUENCE; GENE STRUCTURE; GENETIC ASSOCIATION; GENETIC CODE; GENETIC VARIABILITY; HAPLOTYPE; HEART ATRIUM FIBRILLATION; HUMAN; NOTE; PHARMACOGENOMICS; SINGLE NUCLEOTIDE POLYMORPHISM;

CARDIOVASCULAR SYSTEM; CLINICAL TRIALS AS TOPIC; GENOME, HUMAN; GENOME-WIDE ASSOCIATION STUDY; HAPLOTYPES; HUMANS; INDIVIDUALIZED MEDICINE; PHARMACEUTICAL PREPARATIONS; PHARMACOGENETICS; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 77951558551     PISSN: 14622416     EISSN: 17448042     Source Type: Journal    
DOI: 10.2217/pgs.10.68     Document Type: Note

References (17)

1. International Human Genome Sequencing Consortium: Initial sequencing and analysis of the human genome. Nature 409(6822), 860-921 (2001).
2. Venter JC, Adams MD, Myers EW et al.: The sequence of the human genome. Science 291(5507), 1304-1351 (2001).
3. Cornelis MC, Agrawal A, Cole JW et al.: The gene, environment association studies consortium (GENEVA): maximizing the knowledge obtained from GWAS by collaboration across studies of multiple conditions. Genet. Epidemiol. (2010) (Epub ahead of print).
4. Moore JH, Asselbergs FW, Williams SM: Bioinformatics challenges for genome-wide association studies. Bioinformatics 26, 445-455 (2010).
5. Cantor RM, Lange K, Sinsheimer JS: Prioritizing GWAS results: a review of statistical methods and recommendations for their application. Am. J. Hum. Genet. 86, 6-22 (2010).
6. Keating BJ, Tischfeld S, Murray SS et al.: Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies. PLoS One 3, E3583 (2008).
7. McCarroll SA: Extending genome-wide association studies to copy-number variation. Hum. Mol. Genet. 17, R135-R142 (2008).
8. Conrad DF, Pinto D, Redon R et al.: Origins and functional impact of copy number variation in the human genome. Nature 464(7289), 704-712 (2009).
9. Stein CM, Elston RC: Finding genes underlying human disease. Clin. Genet. 75, 101-106 (2009).
10. McPherson R, Pertsemlidis A, Kavaslar N et al.: A common allele on chromosome 9 associated with coronary heart disease. Science 316, 1488-1491 (2007).
11. Helgadottir A, Thorleifsson G, Manolescu A et al.: A common variant on chromosome 9p21 affects the risk of myocardial infarction. Science 316, 1491-1493 (2007). (Pubitemid 46906618)
12. Samani NJ, Erdmann J, Hall AS et al.: Genomewide association analysis of coronary artery disease N. Engl. J. Med. 357, 443-453 (2007). (Pubitemid 47204873)
13. Visel A, Zhu Y, May D et al.: Targeted deletion of the 9p21 non-coding coronary artery disease risk interval in mice. Nature 464, 409-412 (2010).
14. Liu Y, Sanoff HK, Cho H et al.: INK4/ARF transcript expression is associated with chromosome 9p21 variants linked to atherosclerosis. PLoS One 4, E5027 (2009).
15. Jarinova O, Stewart AF, Roberts R et al.: Functional analysis of the chromosome 9p21.3 coronary artery risk locus. Arterioscler. Thromb. Vasc. Biol. 29, 1671-1677 (2009).
16. Epstein RS, Moyer TP, Aubert RE et al.: Effect of genotyping warfarin patients on outcomes: results from the National Community-based Medco-Mayo Warfarin Effectiveness Study (MM-WES). Presented at: 59th Annual Scientifc Sessions, American College of Cardiology, GA, USA, 14-16 March (2010).
17. Mega JL, Close SL, Wiviott SD et al.: Cytochrome p-450 polymorphisms and response to clopidogrel. N. Engl. J. Med. 360, 354-362 (2009).