Myc interacts with Max and Miz1 to repress C/EBPδ promoter activity and gene expression

Molecular Cancer

Volumn 9, Issue , 2010, Pages

  Si, Junling ^a,b   Yu, Xueyan ^a,b   Zhang, Yingjie ^a,b   DeWille, James W ^a,b  

^a OHIO STATE UNIVERSITY   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; BINDING PROTEIN; CCAAT ENHANCER BINDING PROTEIN ALPHA; MAX PROTEIN; MIZ1 PROTEIN; MYC PROTEIN; RUVBL1 PROTEIN; RUVBL2 PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; BASIC HELIX LOOP HELIX LEUCINE ZIPPER TRANSCRIPTION FACTOR; CCAAT ENHANCER BINDING PROTEIN DELTA; KRUPPEL LIKE FACTOR; MNT PROTEIN, HUMAN; MYC PROTEIN, HUMAN; REPRESSOR PROTEIN; ZBTB17 PROTEIN, HUMAN;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; EPITHELIUM CELL; GENE EXPRESSION; GENE REPRESSION; MOUSE; NONHUMAN; PROMOTER REGION; PROTEIN DNA INTERACTION; PROTEIN PROTEIN INTERACTION; TRANSCRIPTION REGULATION; TUMOR SUPPRESSOR GENE; ANIMAL; BIOSYNTHESIS; CHROMATIN IMMUNOPRECIPITATION; FEMALE; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; IMMUNOPRECIPITATION; METABOLISM; UDDER; WESTERN BLOTTING;

ANIMALS; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; BLOTTING, WESTERN; CCAAT-ENHANCER-BINDING PROTEIN-DELTA; CHROMATIN IMMUNOPRECIPITATION; ELECTROPHORETIC MOBILITY SHIFT ASSAY; EPITHELIAL CELLS; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION; IMMUNOPRECIPITATION; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MAMMARY GLANDS, ANIMAL; MICE; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS C-MYC; REPRESSOR PROTEINS; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 77951551352     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-9-92     Document Type: Article

References (62)

1. Ramji DP, Foka P. CCAAT/enhancer-binding proteins: structure, function and regulation. Biochem J 2002, 365:561-575. 1222736, 12006103.
2. Johnson PF. Molecular stop signs: regulation of cell-cycle arrest by C/EBP transcription factors. J Cell Sci 2005, 118:2545-2555. 10.1242/jcs.02459, 15944395.
3. Zhang Y, Liu T, Yan P, Huang T, Dewille J. Identification and characterization of CCAAT/Enhancer Binding proteindelta (C/EBPdelta) target genes in G0 growth arrested mammary epithelial cells. BMC Mol Biol 2008, 9:83. 10.1186/1471-2199-9-83, 2576343, 18828910.
4. O'Rourke J, Yuan R, DeWille J. CCAAT/enhancer-binding protein-delta (C/EBP-delta) is induced in growth-arrested mouse mammary epithelial cells. J Biol Chem 1997, 272:6291-6296. 10.1074/jbc.272.17.11205, 9045647.
5. O'Rourke JP, Newbound GC, Hutt JA, DeWille J. CCAAT/enhancer-binding protein delta regulates mammary epithelial cell G0 growth arrest and apoptosis. J Biol Chem 1999, 274:16582-16589. 10.1074/jbc.274.23.16582, 10347224.
6. O'Rourke JP, Hutt JA, DeWille J. Transcriptional regulation of C/EBPdelta in G(0) growth-arrested mouse mammary epithelial cells. Biochem Biophys Res Commun 1999, 262:696-701. 10.1006/bbrc.1999.1256, 10471388.
7. Hutt JA, O'Rourke JP, DeWille J. Signal transducer and activator of transcription 3 activates CCAAT enhancer-binding protein delta gene transcription in G0 growth-arrested mouse mammary epithelial cells and in involuting mouse mammary gland. J Biol Chem 2000, 275:29123-29131. 10.1074/jbc.M004476200, 10867011.
8. Hutt JA, DeWille JW. Oncostatin M induces growth arrest of mammary epithelium via a CCAAT/enhancer-binding protein delta-dependent pathway. Mol Cancer Ther 2002, 1:601-610.
9. Sivko GS, DeWille JW. CCAAT/Enhancer binding protein delta (c/EBPdelta) regulation and expression in human mammary epithelial cells: I. "Loss of function" alterations in the c/EBPdelta growth inhibitory pathway in breast cancer cell lines. J Cell Biochem 2004, 93:830-843. 10.1002/jcb.20223, 15389879.
10. Sivko GS, Sanford DC, Dearth LD, Tang D, DeWille JW. CCAAT/Enhancer binding protein delta (c/EBPdelta) regulation and expression in human mammary epithelial cells: II. Analysis of activating signal transduction pathways, transcriptional, post-transcriptional, and post-translational control. J Cell Biochem 2004, 93:844-856. 10.1002/jcb.20224, 15389878.
11. Tang D, Sivko GS, Dewille JW. Promoter methylation reduces C/EBPdelta (CEBPD) gene expression in the SUM-52PE human breast cancer cell line and in primary breast tumors. Breast Cancer Res Treat 2005, 1-10.
12. Gery S, Tanosaki S, Hofmann WK, Koppel A, Koeffler HP. C/EBPdelta expression in a BCR-ABL-positive cell line induces growth arrest and myeloid differentiation. Oncogene 2005, 24:1589-1597. 10.1038/sj.onc.1208393, 15674331.
13. Ikezoe T, Gery S, Yin D, O'Kelly J, Binderup L, Lemp N, Taguchi H, Koeffler HP. CCAAT/enhancer-binding protein delta: a molecular target of 1,25-dihydroxyvitamin D3 in androgen-responsive prostate cancer LNCaP cells. Cancer Res 2005, 65:4762-4768. 10.1158/0008-5472.CAN-03-3619, 15930295.
14. Huang AM, Montagna C, Sharan S, Ni Y, Ried T, Sterneck E. Loss of CCAAT/enhancer binding protein delta promotes chromosomal instability. Oncogene 2004, 23:1549-1557. 10.1038/sj.onc.1207285, 14716301.
15. Gigliotti AP, Johnson PF, Sterneck E, DeWille JW. Nulliparous CCAAT/enhancer binding proteindelta (C/EBPdelta) knockout mice exhibit mammary gland ductal hyperlasia. Exp Biol Med (Maywood) 2003, 228:278-285.
16. Porter D, Lahti-Domenici J, Keshaviah A, Bae YK, Argani P, Marks J, Richardson A, Cooper A, Strausberg R, Riggins GJ, et al. Molecular markers in ductal carcinoma in situ of the breast. MolCancer Res 2003, 1:362-375.
17. Porter DA, Krop IE, Nasser S, Sgroi D, Kaelin CM, Marks JR, Riggins G, Polyak K. A SAGE (serial analysis of gene expression) view of breast tumor progression. Cancer Res 2001, 61:5697-5702.
18. LaTulippe E, Satagopan J, Smith A, Scher H, Scardino P, Reuter V, Gerald WL. Comprehensive gene expression analysis of prostate cancer reveals distinct transcriptional programs associated with metastatic disease. Cancer Res 2002, 62:4499-4506.
19. Kuramoto T, Morimura K, Yamashita S, Okochi E, Watanabe N, Ohta T, Ohki M, Fukushima S, Sugimura T, Ushijima T. Etiology-specific gene expression profiles in rat mammary carcinomas. Cancer Res 2002, 62:3592-3597.
20. Dearth LR, Hutt J, Sattler A, Gigliotti A, DeWille J. Expression and function of CCAAT/enhancer binding proteinbeta (C/EBPbeta) LAP and LIP isoforms in mouse mammary gland, tumors and cultured mammary epithelial cells. J Cell Biochem 2001, 82:357-370. 10.1002/jcb.1167, 11500913.
21. Ko CY, Hsu HC, Shen MR, Chang WC, Wang JM. Epigenetic silencing of CCAAT/enhancer-binding protein delta activity by YY1/polycomb group/DNA methyltransferase complex. J Biol Chem 2008, 283:30919-30932. 10.1074/jbc.M804029200, 2662167, 18753137.
22. Agrawal S, Hofmann WK, Tidow N, Ehrich M, Boom D, Koschmieder S, Berdel WE, Serve H, Muller-Tidow C. The C/EBPdelta tumor suppressor is silenced by hypermethylation in acute myeloid leukemia. Blood 2007, 109:3895-3905. 10.1182/blood-2006-08-040147, 17234736.
23. Vegesna V, Takeuchi S, Hofmann WK, Ikezoe T, Tavor S, Krug U, Fermin AC, Heaney A, Miller CW, Koeffler HP. C/EBP-beta, C/EBP-delta, PU.1, AML1 genes: mutational analysis in 381 samples of hematopoietic and solid malignancies. Leuk Res 2002, 26:451-457. 10.1016/S0145-2126(01)00150-3, 11916518.
24. Tang D, DeWille J. Detection of base sequence changes in the CEBPD gene in human breast cancer cell lines and primary breast cancer isolates. Mol Cell Probes 2003, 17:11-14. 10.1016/S0890-8508(02)00112-3, 12628588.
25. Adhikary S, Eilers M. Transcriptional regulation and transformation by Myc proteins. Nat Rev Mol Cell Biol 2005, 6:635-645. 10.1038/nrm1703, 16064138.
26. Chen Y, Olopade OI. MYC in breast tumor progression. Expert Rev Anticancer Ther 2008, 8:1689-1698. 10.1586/14737140.8.10.1689, 18925859.
27. Hynes NE, Lane HA. Myc and mammary cancer: Myc is a downstream effector of the ErbB2 receptor tyrosine kinase. J Mammary Gland Biol Neoplasia 2001, 6:141-150. 10.1023/A:1009528918064, 11467449.
28. Gartel AL, Shchors K. Mechanisms of c-myc-mediated transcriptional repression of growth arrest genes. Exp Cell Res 2003, 283:17-21. 10.1016/S0014-4827(02)00020-4, 12565816.
29. Amundson SA, Zhan Q, Penn LZ, Fornace AJ. Myc suppresses induction of the growth arrest genes gadd34, gadd45, and gadd153 by DNA-damaging agents. Oncogene 1998, 17:2149-2154. 10.1038/sj.onc.1202136, 9811446.
30. Barsyte-Lovejoy D, Mao DY, Penn LZ. c-Myc represses the proximal promoters of GADD45a and GADD153 by a post-RNA polymerase II recruitment mechanism. Oncogene 2004, 23:3481-3486. 10.1038/sj.onc.1207487, 15021909.
31. Claassen GF, Hann SR. A role for transcriptional repression of p21CIP1 by c-Myc in overcoming transforming growth factor beta -induced cell-cycle arrest. Proc Natl Acad Sci USA 2000, 97:9498-9503. 10.1073/pnas.150006697, 16893, 10920185.
32. Conzen SD, Gottlob K, Kandel ES, Khanduri P, Wagner AJ, O'Leary M, Hay N. Induction of cell cycle progression and acceleration of apoptosis are two separable functions of c-Myc: transrepression correlates with acceleration of apoptosis. Mol Cell Biol 2000, 20:6008-6018. 10.1128/MCB.20.16.6008-6018.2000, 86077, 10913183.
33. Feng XH, Liang YY, Liang M, Zhai W, Lin X. Direct interaction of c-Myc with Smad2 and Smad3 to inhibit TGF-beta-mediated induction of the CDK inhibitor p15(Ink4B). Mol Cell 2002, 9:133-143. 10.1016/S1097-2765(01)00430-0, 11804592.
34. Wanzel M, Herold S, Eilers M. Transcriptional repression by Myc. Trends Cell Biol 2003, 13:146-150. 10.1016/S0962-8924(03)00003-5, 12628347.
35. Lee TC, Li L, Philipson L, Ziff EB. Myc represses transcription of the growth arrest gene gas1. Proc Natl Acad Sci USA 1997, 94:12886-12891. 10.1073/pnas.94.24.12886, 24233, 9371770.
36. Marhin WW, Chen S, Facchini LM, Fornace AJ, Penn LZ. Myc represses the growth arrest gene gadd45. Oncogene 1997, 14:2825-2834. 10.1038/sj.onc.1201138, 9190899.
37. Seoane J, Le HV, Massague J. Myc suppression of the p21(Cip1) Cdk inhibitor influences the outcome of the p53 response to DNA damage. Nature 2002, 419:729-734. 10.1038/nature01119, 12384701.
38. Seoane J, Pouponnot C, Staller P, Schader M, Eilers M, Massague J. TGFbeta influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b. Nat Cell Biol 2001, 3:400-408. 10.1038/35070086, 11283614.
39. Staller P, Peukert K, Kiermaier A, Seoane J, Lukas J, Karsunky H, Moroy T, Bartek J, Massague J, Hanel F, Eilers M. Repression of p15INK4b expression by Myc through association with Miz-1. Nat Cell Biol 2001, 3:392-399. 10.1038/35070076, 11283613.
40. Lee Y, Schwarz E, Davies M, Jo M, Gates J, Wu J, Zhang X, Lieberman JR. Differences in the cytokine profiles associated with prostate cancer cell induced osteoblastic and osteolytic lesions in bone. J Orthop Res 2003, 21:62-72. 10.1016/S0736-0266(02)00095-5, 12507581.
41. Yang W, Shen J, Wu M, Arsura M, FitzGerald M, Suldan Z, Kim DW, Hofmann CS, Pianetti S, Romieu-Mourez R, et al. Repression of transcription of the p27(Kip1) cyclin-dependent kinase inhibitor gene by c-Myc. Oncogene 2001, 20:1688-1702. 10.1038/sj.onc.1204245, 11313917.
42. Antonson P, Pray MG, Jacobsson A, Xanthopoulos KG. Myc inhibits CCAAT/enhancer-binding protein alpha-gene expression in HIB-1B hibernoma cells through interactions with the core promoter region. Eur J Biochem 1995, 232:397-403. 10.1111/j.1432-1033.1995.397zz.x, 7556187.
43. Zhang Y, Sif S, Dewille J. The mouse C/EBPdelta gene promoter is regulated by STAT3 and Sp1 transcriptional activators, chromatin remodeling and c-Myc repression. J Cell Biochem 2007,
44. Kleine-Kohlbrecher D, Adhikary S, Eilers M. Mechanisms of transcriptional repression by Myc. Curr Top Microbiol Immunol 2006, 302:51-62. full_text, 16620025.
45. Huber O, Menard L, Haurie V, Nicou A, Taras D, Rosenbaum J. Pontin and reptin, two related ATPases with multiple roles in cancer. Cancer Res 2008, 68:6873-6876. 10.1158/0008-5472.CAN-08-0547, 18757398.
46. Blagosklonny MV, Pardee AB. The restriction point of the cell cycle. Cell Cycle 2002, 1:103-110.
47. Roy PG, Thompson AM. Cyclin D1 and breast cancer. Breast 2006, 15:718-727. 10.1016/j.breast.2006.02.005, 16675218.
48. Sanford DC, DeWille JW. C/EBPdelta is a downstream mediator of IL-6 induced growth inhibition of prostate cancer cells. Prostate 2005, 63:143-154. 10.1002/pros.20159, 15486993.
49. Sivko GS, Sanford DC, Dearth LD, Tang D, DeWille JW. CCAAT/enhancer binding protein delta (C/EBPdelta) regulation and expression in human mammary epithelial cells: II. Analysis of activating signal transduction pathways, transcriptional, post-transcriptional, and post-translational control. JCell Biochem 2004, 93:844-856.
50. Ziegelbauer J, Shan B, Yager D, Larabell C, Hoffmann B, Tjian R. Transcription factor MIZ-1 is regulated via microtubule association. Mol Cell 2001, 8:339-349. 10.1016/S1097-2765(01)00313-6, 11545736.
51. Hurlin PJ, Huang J. The MAX-interacting transcription factor network. Semin Cancer Biol 2006, 16:265-274. 10.1016/j.semcancer.2006.07.009, 16908182.
52. Mao DY, Watson JD, Yan PS, Barsyte-Lovejoy D, Khosravi F, Wong WW, Farnham PJ, Huang TH, Penn LZ. Analysis of Myc bound loci identified by CpG island arrays shows that Max is essential for Myc-dependent repression. Curr Biol 2003, 13:882-886. 10.1016/S0960-9822(03)00297-5, 12747840.
53. Ponzielli R, Katz S, Barsyte-Lovejoy D, Penn LZ. Cancer therapeutics: targeting the dark side of Myc. Eur J Cancer 2005, 41:2485-2501. 10.1016/j.ejca.2005.08.017, 16243519.
54. Cantwell CA, Sterneck E, Johnson PF. Interleukin-6-specific activation of the C/EBPdelta gene in hepatocytes is mediated by Stat3 and Sp1. Mol Cell Biol 1998, 18:2108-2117. 121443, 9528783.
55. Wood MA, McMahon SB, Cole MD. An ATPase/helicase complex is an essential cofactor for oncogenic transformation by c-Myc. Mol Cell 2000, 5:321-330. 10.1016/S1097-2765(00)80427-X, 10882073.
56. Gallant P. Control of transcription by Pontin and Reptin. Trends Cell Biol 2007, 17:187-192. 10.1016/j.tcb.2007.02.005, 17320397.
57. Jha S, Dutta A. RVB1/RVB2: running rings around molecular biology. Mol Cell 2009, 34:521-533. 10.1016/j.molcel.2009.05.016, 19524533.
58. Etard C, Gradl D, Kunz M, Eilers M, Wedlich D. Pontin and Reptin regulate cell proliferation in early Xenopus embryos in collaboration with c-Myc and Miz-1. Mech Dev 2005, 122:545-556. 10.1016/j.mod.2004.11.010, 15804567.
59. Brenner C, Deplus R, Didelot C, Loriot A, Vire E, De Smet C, Gutierrez A, Danovi D, Bernard D, Boon T, et al. Myc represses transcription through recruitment of DNA methyltransferase corepressor. Embo J 2005, 24:336-346. 10.1038/sj.emboj.7600509, 545804, 15616584.
60. Zhang Y, Sif S, Dewille J. The mouse C/EBPdelta gene promoter is regulated by STAT3 and Sp1 transcriptional activators, chromatin remodeling and c-Myc repression. J Cell Biochem 2007, 102:1256-1270. 10.1002/jcb.21356, 17471507.
61. Zhou S, Dewille JW. Proteasome-mediated CCAAT/enhancer-binding protein delta (C/EBPdelta) degradation is ubiquitin-independent. Biochem J 2007, 405:341-349. 10.1042/BJ20061873, 1904515, 17373909.
62. Zhou S, Si J, Liu T, DeWille JW. PIASy represses CCAAT/enhancer-binding protein delta (C/EBPdelta) transcriptional activity by sequestering C/EBPdelta to the nuclear periphery. J Biol Chem 2008, 283:20137-20148. 10.1074/jbc.M801307200, 2459298, 18477566.