Gymnochromes e and F, Cytotoxic Phenanthroperylenequinones from a Deep-Water Crinoid, holopus rangii

Journal of Natural Products

Volumn 73, Issue 4, 2010, Pages 712-715

  Kemami Wangun, Hilaire V ^a   Wood, Alexander ^b   Fiorilla, Catherine ^b   Reed, John K ^a   McCarthy, Peter J ^b   Wright, Amy E ^a  

^a FLORIDA ATLANTIC UNIVERSITY   (United States)

^b NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7 BROMOEMODIC ACID; ANTHRAQUINONE DERIVATIVE; CYTOTOXIC AGENT; EMODIC ACID; GYMNOCHROME E; GYMNOCHROME F; HISTONE DEACETYLASE 1; ISOGYMNOCHROME B; PHENANTHROPERYLENEQUINONE DERIVATIVE; PROTEIN BAK; PROTEIN MCL 1; QUINONE DERIVATIVE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG ISOLATION; DRUG MECHANISM; DRUG SYNTHESIS; ECHINODERM; ENZYME INHIBITION; HOLOPUS RANGII; HUMAN; HUMAN CELL;

ANIMALS; ANTHRAQUINONES; ANTINEOPLASTIC AGENTS; CANDIDA ALBICANS; DRUG SCREENING ASSAYS, ANTITUMOR; ECHINODERMATA; HISTONE DEACETYLASE 1; HUMANS; INHIBITORY CONCENTRATION 50; MACROLIDES; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIAL SENSITIVITY TESTS; PSEUDOMONAS AERUGINOSA;

CRINOIDEA; HOLOPUS;

EID: 77951517792     PISSN: 01633864     EISSN: 15206025     Source Type: Journal    
DOI: 10.1021/np900526y     Document Type: Article

References (14)

1. Simmons, T. L., Andrianasolo, E., McPhail, K., Flatt, P., and Gerwick, W. H. Mol. Cancer Ther. 2005, 4, 333-342
2. Pettit, G. R., Yoshiaki Kamano, Y., Herald, C. L., Tuinman, A. A., Boettner, F. E., Kizu, H., Schmidt, J. M., Baczynskyj, L., Tomer, K. B., and Bontems, R. J. J. Am. Chem. Soc. 1987, 109, 6883-6885
3. Gunasekera, S. P., Gunasekera, M., Longley, R. E., and Schulte, G. K. J. Org. Chem. 1990, 55, 4912-4945
4. Bai, R., Paull, K. D., Heraldy, C. L., Malspeis, L., Pettit, G. R., and Hamel, E. J. Biol. Chem. 1991, 266, 15882-15889
5. Calcul, L., Chow, R., Oliver, A. G., Tenney, K., White, K. N., Wood, A. W., Fiorilla, C., and Crews, P. J. Nat. Prod. 2009, 72, 443-449
6. De Riccardis, F., Iorizzi, M., Minale, L., Riccio, R., De Forges, B. R., and Debitus, C. J. Org. Chem. 1991, 56, 6781-6787
7. Alvi, K. A., Nair, B., Gallo, C., and Baker, D. J. Antibiot. 1997, 50, 264-266
8. Skalkos, D., Tatsis, E., Gerothanassis, I. P., and Troganis, A. Tetrahedron 2002, 58, 4925-4626
9. Pace, N. and Mackinney, G. J. Am. Chem. Soc. 1941, 63, 2570-2574
10. Falk, H. Angew. Chem., Int. Ed. 1999, 38, 3116-3136
11. Gunasekera, S. P., Zuleta, I. A., Longley, R. E., Wright, A. E., and Pomponi, S. A. J. Nat. Prod. 2003, 66, 1615-1617
12. Sambucetti, L. C., Fischer, D. D., Zabludoff, S., Kwon, P. O., Chamberlin, H., Trogani, N., Xu, H., and Cohen, D. J. Biol. Chem. 1999, 274, 34940-34947
13. Remiszewski, S. W., Sambucetti, L. C., Atadja, P., Bair, K. W., Cornell, W. D., Green, M. A., Howell, K. L., Jung, M., Kwon, P., Trogani, N., and Walker, H. J. Med. Chem. 2002, 45, 753-757
14. Park, Y. C., Gunasekera, S. P., Lopez, J. V., McCarthy, P. J., and Wright, A. E. J. Nat. Prod. 2006, 69, 580-584