Screening of microbial extracts for tyrosine kinase inhibitors

Journal of Antibiotics

Volumn 50, Issue 3, 1997, Pages 264-266

  Alvi, Khisal A ^a   Nair, Bipin ^a   Gallo, Cathy ^a   Baker, Dwight ^a  

^a MDS Inc   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CHARTREUSIN; EMODIC ACID; PROTEIN TYROSINE KINASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIBIOTIC BIOSYNTHESIS; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG SCREENING; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE;

EID: 0030966151     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.50.264     Document Type: Article

References (15)

1. HUNTER, T. & J. A. COOPER: Protein tyrosine kinases. Ann. Rev. Biochem. 54: 897-930, 1985
2. CARPENTER, G.: Receptors for EGF and other polypeptide mitogens. Ann. Rev. Biochem. 56: 881-914, 1987
3. HELDIN, C. H. & B. WESTERMARK: Growth factors: Mechanism of action and relation to oncogenes. Cell 37: 9-20, 1984
4. YARDEN, Y. & A. ULLRICH: Growth factor receptor tyrosine kinases. Ann. Rev. Biochem. 57: 443-478, 1988
5. BISHOP, J. M.: The molecular genetics of cancer. Science 335: 305-311, 1987
6. ROSS, R.: Platelet derived growth factor. Lancet 1: 1179-1182, 1989
7. ELDER, J. T.; G. J. FISHER, P. B. LINDQUIST, G. L. BENNET, J. J. PITTELKOW, M. R. COFFEY Jr, R. J. ELLINGSWORTH, L. R. DERYNCK & J. J. VOORHEESS: Overexpression of transforming growth factor α in psoriatic epidermis. Science 243: 811-814, 1989
8. LEVITZKI, A.: Tyrophostins: potential antiproliferation agents and novel molecular tools. Biochem. Pharmacol. 40: 313-313, 1990
9. YAISH, P.; A. GAZIT, C. GILON & A. LEVITZKI: Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors. Science 242: 933-935, 1988
10. UMEZAWA, H.; M. IMOTO, T. SAWA, K. ISSHIKI, N. MATSUDA, T. UCHIDA, H. IINUMA, M. HAMADA & T. TAKEUCHI: Study on new epidermal growth factor-receptor kinase inhibitor, erbstatin, produced by MH435-hF3. J. Antibiotics 39: 170-173, 1986
11. AKIYAMA, T.; J. ISHIDA, S. NAKAGAWA, H. OGAWARA, S. WATANABE, N. ITOH, M. SHIBUYA & Y. FUKAMI: Genistein, a specific inhibitor of tyrosin-specific protein kinase. J. Biol. Chem.. 262: 5592-5595, 1987
12. LEE, R. H.; D. L. SLATE, R. MORETTI, K. A. ALVI & P. CREWS: Marine sponge polyketide inhibitors of protein tyrosine kinase. Biochem. Biophys. Res. Commun. 184: 765-772, 1992
13. ALVI, K. A.; J. PETERSON & B. HOFMANN: Rapid identification of elaiophylin and geldanamycin in Streptomyces fermentation broths using CPC coupled with a photodiode array detector and LC-MS methodologies. J. Ind. Microbiol. 15: 80-84, 1995
14. SUGAWARA, K.; M. TSUNAKAWA, M. KONISHI & H. KAWAGUCHI: Elsamicins A and B, new antitumor antibiotics related to chartreusin. 2. Structure of elsamicins A and B. J. O. C. 52: 996-1001, 1987
15. ANSLOW, W. K.; J. BREEN & H. RAISTRICK: Study in the biochemistry of microorganisms: Emodic acid (4: 5: 7-trihydroxyanthraquinone-2-carboxylic acid) and ω-hydroxy emodin (4: 5 : 7-trihydroxy-2-(hydroxymethyl)-anthraquinone), metabolic products of a strain of Penicillium cyclopium Westling. Biochem. J. 34: 159-168, 1940