Simvastatin decreases endothelial progenitor cell apoptosis in the kidney of hypertensive hypercholesterolemic pigs

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 30, Issue 5, 2010, Pages 976-983

  Lavi, Ronit ^a   Zhu, Xiang Yang ^a   Chade, Alejandro R ^a,c   Lin, Jing ^a   Lerman, Amir ^a   Lerman, Lilach O ^a,b  

^a MAYO CLINIC   (United States)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

^c UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Fibrosis; Hypercholesterolemia; Hypertension; Simvastatin

Indexed keywords

CD34 ANTIGEN; OXIDIZED LOW DENSITY LIPOPROTEIN; SIMVASTATIN; VASCULOTROPIN RECEPTOR 2;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BLOOD PRESSURE; CELL FUNCTION; CELL INFILTRATION; CELL ISOLATION; CELL SURVIVAL; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DRUG DOSE INCREASE; DRUG EFFECT; DRUG EFFICACY; ENDOTHELIAL DYSFUNCTION; EPITHELIUM CELL; EX VIVO STUDY; HYPERCHOLESTEROLEMIA; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; KIDNEY BLOOD FLOW; KIDNEY EPITHELIUM; KIDNEY FIBROSIS; KIDNEY FUNCTION; KIDNEY PARENCHYMA; KIDNEY VASCULAR RESISTANCE; MACROPHAGE; MEAN ARTERIAL PRESSURE; MICROENVIRONMENT; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RENAL PROTECTION; RENOVASCULAR HYPERTENSION; STEM CELL; SWINE;

ADMINISTRATION, ORAL; ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; APOPTOSIS; CELL SURVIVAL; DISEASE MODELS, ANIMAL; ENDOTHELIAL CELLS; FIBROSIS; HEMODYNAMICS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; HYPERCHOLESTEROLEMIA; HYPERTENSION, RENOVASCULAR; INFLAMMATION; KIDNEY; LIPOPROTEINS, LDL; MACROPHAGES; OXIDATIVE STRESS; RENAL CIRCULATION; SIMVASTATIN; STEM CELLS; SUS SCROFA;

EID: 77951454993     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/ATVBAHA.109.201475     Document Type: Article

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